journal
MENU ▼
Read by QxMD icon Read
search

Seminars in Cell & Developmental Biology

journal
https://read.qxmd.com/read/30991117/chromatin-dynamics-underlying-the-precise-regeneration-of-a-vertebrate-limb-epigenetic-regulation-and-cellular-memory
#1
REVIEW
Shinichi Hayashi, Koji Tamura, Hitoshi Yokoyama
Wound healing, tissue regeneration, and organ regrowth are all regeneration phenomena observed in vertebrates after an injury. However, the ability to regenerate differs greatly among species. Mammals can undergo wound healing and tissue regeneration, but cannot regenerate an organ; for example, they cannot regrow an amputated limb. In contrast, amphibians and fish have much higher capabilities for organ-level regeneration. In addition to medical studies and those in conventional mammalian models such as mice, studies in amphibians and fish have revealed essential factors for and mechanisms of regeneration, including the regrowth of a limb, tail, or fin...
April 13, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30986568/a-crispr-cas9-based-polymeric-nanoparticles-to-treat-inhibit-microbial-infections
#2
REVIEW
Richa Verma, Rajnish Sahu, Desh Deepak Singh, Timothy E Egbo
The latest breakthrough towards the adequate and decisive methods of gene editing tools provided by CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeat/CRISPR Associated System), has been repurposed into a tool for genetically engineering eukaryotic cells and now considered as major innovation in gene related disorders. Nanotechnology has provided an alternate way to overcome the conventional problems where methods to deliver therapeutic agents have failed. The use of nanotechnology has the potential to safe-side the CRISPR/Cas9 components delivery by using customized polymeric nanoparticles for safety and efficacy...
April 12, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30974171/what-plant-roots-know
#3
REVIEW
Ariel Novoplansky
Despite their paramount role in plant life, the study of roots has been largely neglected until recently. Here, I shortly describe a few newly-discovered abilities of plants to undergo adaptive changes and execute developmental decisions based on roots' perception of non-resource information pertaining to imminent challenges and opportunities. Seemingly simple in their morphology and architecture and lacking central information-processing centres, roots are able to sense and integrate complex cues and signals over time and space that allow plants to perform elaborate behaviours analogous, some claim even homologous, to those of intelligent animals...
April 8, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30965110/sound-perception-in-plants
#4
REVIEW
I Khait, U Obolski, Y Yovel, L Hadany
Can plants perceive sound? And what sounds are they likely to be "listening" to? The environment of plants includes many informative sounds, produced by biotic and abiotic sources. An ability to respond to these sounds could thus have a significant adaptive value for plants. We suggest the term phytoacoustics to describe the emerging field exploring sound emission and sound detection in plants, and review the recent studies published on these topics. We describe evidence of plant responses to sounds, varying from changes in gene expression to changes in pathogen resistance and nectar composition...
April 6, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30954657/microglia-immunometabolism-from-metabolic-disorders-to-single-cell-metabolism
#5
REVIEW
Rosa C Paolicelli, Stefano Angiari
Since the observation that obesity-associated low-grade chronic inflammation is a crucial driver for the onset of systemic metabolic disorders such as type 2 diabetes, a number of studies have highlighted the role of both the innate and the adaptive immune system in such pathologies. Moreover, researchers have recently demonstrated that immune cells can modulate their intracellular metabolic profile to control their activation and effector functions. These discoveries represent the foundations of a research area known as "immunometabolism", an emerging field of investigation that may lead to the development of new-generation therapies for the treatment of inflammatory and metabolic diseases...
April 4, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30953741/crispr-cas-based-targeting-of-host-and-viral-genes-as-an-antiviral-strategy
#6
REVIEW
Lulia Koujah, Deepak Shukla, Afsar R Naqvi
Viral infections in human are leading cause of mortality and morbidity across the globe. Several viruses (including HIV and Herpesvirus), have evolved ingenious strategies to evade host-immune system and persist life-long. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated (Cas) is an ancient antiviral system recently discovered in bacteria that has shown tremendous potential as a precise, invariant genome editing tool. Using CRISPR-Cas based system to activate host defenses or genetic modification of viral genome can provide novel, exciting and successful antiviral mechanisms and treatment modalities...
April 3, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30953740/regeneration-enhancers-starting-a-journey-to-unravel-regulatory-events-in-tissue-regeneration
#7
REVIEW
Anjelica M Rodriguez, Junsu Kang
Regeneration, an ability to replace lost body parts, is widespread across animal species. While mammals poorly regenerate most tissues, teleost fish and urodele amphibians possess remarkable regenerative capacity. Earlier work demonstrated that genes driving regeneration are evolutionarily conserved, indicating that a key factor in diverse tissue regeneration is not the presence or absence of regeneration-driving genes but the mechanisms controlling activation of these genes after injury. Thus, understanding the regulatory events of tissue regeneration could provide the means for unlocking latent capacities for tissue regeneration...
April 3, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30922957/mesenchymal-stem-cell-therapies-in-brain-disease
#8
REVIEW
Lauren S Sherman, Matthew P Romagano, Shauna F Williams, Pranela Rameshwar
As treatments for diseases throughout the body progress, treatment for many brain diseases has been at a standstill due to difficulties in drug delivery. While new drugs are being discovered in vitro, these therapies are often hindered by inefficient tissue distribution and, more commonly, an inability to cross the blood brain barrier. Mesenchymal stem cells are thus being investigated as a delivery tool to directly target therapies to the brain to treat wide array of brain diseases. This review discusses the use of mesenchymal stem cells in hypoxic disease (hypoxic ischemic encephalopathy), an inflammatory neurodegenerative disease (multiple sclerosis), and a malignant condition (glioma)...
April 3, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30951895/the-astrocyte-biochemistry
#9
REVIEW
Débora G Souza, Roberto F Almeida, Diogo O Souza, Eduardo R Zimmer
Astrocytes are a unique and dynamic subtype of glial cells in the central nervous system (CNS). Understanding their biochemical reactions and their influence in the surrounding cells is extremely important in the neuroscience field. They exert important influence in the neurotransmission, ionic homeostasis and also release neuroactive molecules termed gliotransmitters. Additionally, they metabolize, store and release metabolic substrates to meet high brain energy requirements. In this review, we highlight the main biochemical reactions regarding energy metabolism that take place in astrocytes...
April 2, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30951894/epigenetics-in-neuronal-regeneration
#10
REVIEW
Leah S VandenBosch, Thomas A Reh
Damage to neuronal tissues in mammals leads to permanent loss of tissue function that can have major health consequences. While mammals have no inherent regenerative capacity to functionally repair neuronal tissue, other species such as amphibians and teleost fish readily replace damaged tissue. The exploration of development and native regeneration can thus inform the process of inducing regeneration in non-regenerative systems, which can be used to develop new therapeutics. Increasing evidence points to an epigenetic component in the regulation of the changes in cellular gene expression necessary for regeneration...
April 2, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30951893/the-potential-application-of-genome-editing-by-using-crispr-cas9-and-its-engineered-and-ortholog-variants-for-studying-the-transcription-factors-involved-in-the-maintenance-of-phosphate-homeostasis-in-model-plants
#11
REVIEW
Anupam Jyoti, Sanket Kaushik, Vijay Kumar Srivastava, Manali Datta, Shailesh Kumar, Poli Yugandhar, Shanker L Kothari, Vandna Rai, Ajay Jain
Phosphorus (P), an essential macronutrient, is pivotal for growth and development of plants. Availability of phosphate (Pi), the only assimilable P, is often suboptimal in rhizospheres. Pi deficiency triggers an array of spatiotemporal adaptive responses including the differential regulation of several transcription factors (TFs). Studies on MYB TF PHR1 in Arabidopsis thaliana (Arabidopsis) and its orthologs OsPHRs in Oryza sativa (rice) have provided empirical evidence of their significant roles in the maintenance of Pi homeostasis...
April 2, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30946988/plant-photoreceptors-multi-functional-sensory-proteins-and-their-signaling-networks
#12
REVIEW
Inyup Paik, Enamul Huq
Light is a crucial environmental cue not only for photosynthetic energy production but also for plant growth and development. Plants employ sophisticated methods to detect and interpret information from incoming light. Five classes of photoreceptors have been discovered in the model plant Arabidopsis thaliana. These photoreceptors act either distinctly and/or redundantly in fine-tuning many aspects of plant life cycle. Unlike mobile animals, sessile plants have developed an enormous plasticity to adapt and survive in changing environment...
April 1, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30940574/chromatin-dynamics-during-liver-regeneration
#13
REVIEW
Maria Arechederra, Carmen Berasain, Matias A Avila, Maite G Fernández-Barrena
Liver regeneration is the most important reaction of the liver to an injury. Indeed, the liver possesses an extraordinary regenerative capacity orchestrated by a highly coordinated response of all the different cell types in order to recover the tissue lost, while maintaining homeostasis and all the hepatic functions. To achieve this impressive physiological accomplishment, the liver experiences a transient but precisely controlled transcriptional reprogramming that allows the simultaneous activation and silencing of multiple genes at different stages of the regeneration process...
March 30, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30935973/what-do-plants-really-know
#14
EDITORIAL
Daniel A Chamovitz
No abstract text is available yet for this article.
March 29, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30935972/plant-responses-to-gravity
#15
REVIEW
Joshua P Vandenbrink, John Z Kiss
Tropisms are directed growth-mediated plant movements which allow plants to respond to their environment. Gravitropism is the ability of plants to perceive and respond to the gravity vector and orient themselves accordingly. The gravitropic response can be divided into three main components: perception, biochemical signaling, and differential growth. Perception of the gravity signal occurs through the movement/sedimentation of starch-filled plastids (termed statoliths) in gravity sensing cells. Once perceived, proteins interact with the settling statoliths to set a cascade of plant hormones to the elongation zones in the roots or shoots...
March 29, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30904636/brain-organoids-as-a-model-system-for-human-neurodevelopment-and-disease
#16
REVIEW
Harpreet Setia, Alysson R Muotri
The ability to reproduce early stages of human neurodevelopment in the laboratory is one of the most exciting fields in modern neuroscience. The inaccessibility of the healthy human brain developing in utero has delayed our understanding of the initial steps in the formation of one of the most complex tissues in the body. Animal models, postmortem human tissues and cellular systems have been instrumental in contributing to our understanding of the human brain. However, all model systems have intrinsic limitations...
March 22, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30826549/rod-microglia-and-their-role-in-neurological-diseases
#17
REVIEW
Olivia G Holloway, Alison J Canty, Anna E King, Jenna M Ziebell
The striking morphology of microglia is one of their most prominent characteristics, with many studies categorising microglial function based on morphology e.g. ramified, hyper-ramified, activated, or amoeboid. Communications regarding rod microglia in neurological disease are scant, and where reported, these cells are rarely the focus of discussion. These factors make it difficult to determine how widespread these cells are not only through the brain but also across diseases. Studies in experimental diffuse brain injury are the first reports of not only significant numbers of rod microglia, but distinct arrangements of these cells, reminiscent of carriages of a train...
March 8, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30826548/synaptic-vesicle-protein-2-a-multi-faceted-regulator-of-secretion
#18
REVIEW
Kristine Ciruelas, Daniele Marcotulli, Sandra M Bajjalieh
No abstract text is available yet for this article.
February 28, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30822497/functional-multipotency-of-stem-cells-biological-traits-gleaned-from-neural-progeny-studies
#19
REVIEW
Yang D Teng
In this review, a stem cell concept, initially defined by the author more than 10 years ago focusing on neural stem cells, has been systematically refined and updated. Relative to the conventional view which touched principally on the totipotency, pluripotentcy and multipotency of cell lineage differentiation (e.g., the ability of neural stem cells to grow into all three types of neural cells), accumulated data obtained by other researchers and my own team promoted Functional Multipotency; Totipotency; Pluripotency; Induced Pluripotent Stem Cell; Multipotency; Stem Cell; Neural Stem Cell; Neural Progeny; Mesenchymal Stromal Stem Cell; Recovery Neurobiology me and my colleagues to propose and establish a new biological concept: Functional Multipotency of Stem Cells...
February 26, 2019: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/30807819/what-do-plants-really-know
#20
EDITORIAL
Daniel A Chamovitz
No abstract text is available yet for this article.
February 26, 2019: Seminars in Cell & Developmental Biology
journal
journal
32522
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"