Xuheng Sun, Nannan Wang, Hongjing Jiang, Qing Liu, Cong Xiao, Jianyi Xu, Yindi Wu, Jingyi Mei, Shuting Wu, Zhanyi Lin
To create tissue-engineered vascular grafts (TEVGs) in vitro, vascular smooth muscle cells (VSMCs) must function effectively and produce sufficient extracellular matrix (ECM) in a three-dimensional space. In this study, we investigated whether the addition of insulin-transferrin-selenium (ITS), a medium supplement, could enhance TEVG formation. PGA fabric was used as the scaffold, and 1% ITS was added to the medium. After two weeks, the tissues were examined using electron microscopy and staining. The ITS group exhibited a denser structure and increased collagen production...
March 28, 2024: Preparative Biochemistry & Biotechnology