Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia.

Cognitive and behavioral phenomena define behavioral variant frontotemporal dementia (bvFTD), but neuropsychiatric symptoms (NPS) outside the core criteria are common throughout the illness. Identifying how NPS cluster in bvFTD may guide development of future therapies.

Psychiatry and Clinical Neurosciences | 2025 April

Atypical tactile preferences in autism spectrum disorder: Reduced pleasantness responses to soft objects resembling human body parts.

Previous studies have reported atypical sensory responses in individuals with autism spectrum disorder (ASD) and their implications for social touch. Although adults with ASD often report discomfort with being touched by others, their preferences for the physical properties of objects are less well understood. In a prior study, we observed that, in typically developed (TD) adults, compliance (a physical correlate of softness) increased tactile pleasantness for deformable surfaces up to levels comparable to those of human body parts. In the present study, we conducted psychophysical experiments to test whether individuals with ASD show atypical affective responses to soft objects resembling human body parts.

Psychiatry and Clinical Neurosciences | 2025 April

Epidemiology of Hikikomori: A systematic review and meta-analysis of 19 studies.

Hikikomori, a severe form of social withdrawal, has been recognized as an important global public health problem. However, estimates of the worldwide Hikikomori prevalence have been inconsistent. This study aimed to provide a comprehensive assessment of the cross-cultural prevalence of Hikikomori through a meta-analysis and systematic review.

Psychiatry and Clinical Neurosciences | 2025 March

Brain iron load and neuroaxonal vulnerability in adult attention-deficit hyperactivity disorder.

Adult attention deficit hyperactivity disorder (ADHD) may be associated with an increased risk of dementia in old age. Here, we investigated the liability for neurodegenerative brain disease in adult ADHD, possibly reflected by increased brain iron content and associated neuroaxonal vulnerability.

Psychiatry and Clinical Neurosciences | 2025 March

Predicting social anxiety disorder based on communication logs and social network data from a massively multiplayer online game: Using a graph neural network.

Social anxiety disorder (SAD) is a mental disorder that requires early detection and treatment. However, some individuals with SAD avoid face-to-face evaluations, which leads to delayed detection. We aim to predict individuals with SAD based on their communication logs and social network data from a massively multiplayer online game (MMOG).

Psychiatry and Clinical Neurosciences | 2025 March

Why physical restraints for fall prevention in psychiatric inpatients are medically unjustifiable.

Psychiatry and Clinical Neurosciences | 2025 March

Increase in luteinizing hormone is linked to reduction in depression in patients with dementia: Secondary analysis of a randomized clinical trial of benzoate.

Psychiatry and Clinical Neurosciences | 2025 March

Long-term outcomes of schizophrenia in relation to course of social recovery and prescribed antipsychotics: A 10-year follow-up study at a single university hospital in Japan.

Psychiatry and Clinical Neurosciences | 2025 March

Focused ultrasound as an emerging therapy for neuropsychiatric disease: Historical perspectives and a review of current clinical data.

Psychiatric disorders are a common source of disease morbidity with high rates of refractoriness to first-line treatments. As such, many have investigated the utility of neurosurgical interventions for treatment-resistant forms of these conditions. More recently among these, functional neurosurgical techniques using high- and low-intensity focused ultrasound (FUS) have emerged as promising options in this arena, largely due to their minimally-invasive nature and encouraging early safety and efficacy data. Existing clinical data have thus far demonstrated FUS to be a potentially useful intervention for treatment-refractory forms of obsessive-compulsive disorder, major depressive disorder, various anxiety disorders, substance-use disorder, and schizophrenia. This report presents a comprehensive review of existing clinical trial data, summarizing key findings, study specifications, and providing critical analysis. In addition to giving the most complete summary of modern clinical research on this topic to date, this report characterizes the current state of this body of literature using bibliometric analysis, succinctly highlighting the most investigated topics and the most promising areas of modern investigation. Based on our review of the literature, current work on this topic is highly heterogeneous with regard to specific treatment protocols and anatomic targets for FUS - targeting multiple nuclei at a wide variety of intensities. We recommend that future studies aim to clarify more precise therapeutic targets and specific treatment protocols which optimize the efficacy of these techniques.

Psychiatry and Clinical Neurosciences | 2025 March

REIMAGINE: A central nervous system basket trial showing safety and efficacy of vafidemstat on aggression in different psychiatric disorders.

Vafidemstat is a brain-penetrant, orally bioavailable, small molecule irreversible inhibitor of the histone lysine-specific demethylase KDM1A (also known as LSD1), which corrects memory deficits and behavior alterations including aggression and social interaction deficits in preclinical models.

Psychiatry and Clinical Neurosciences | 2025 March