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Journal of Trace Elements in Medicine and Biology

Jun Chen, Fangting Zhang, Wutai Guan, Hanqing Song, Min Tian, Lin Cheng, Kui Shi, Junshuai Song, Fang Chen, Shihai Zhang, Fei Yang, Chunxiao Ren, Yinzhi Zhang
This study aimed to evaluate the effects of increasing selenium (Se) supply for heat-stressed or actively cooled sows on sow productivity, colostrum and milk composition, as well as the selenium and antioxidant status and immunoglobulin levels of sows and nursing piglets. The study was a 2 × 2 factorial design, where the first factor was farrowing environment [heat stress vs. actively cooling, temperature: 29.61 ± 0.19 ℃ (27.70-31.60 ℃) vs. 27.90 ± 0.15 ℃ (26.90-30.20 ℃); temperature-humidity index: 72...
March 2019: Journal of Trace Elements in Medicine and Biology
Shinje Moon, Hye Soo Chung, Jae Myung Yu, Hyung Joon Yoo, Jung Hwan Park, Dong Sun Kim, Yoo-Kyung Park, Sang Nam Yoon
OBJECTIVE: Selenium seems to be a risk factor for diabetes mellitus (DM) in recent studies, opposite to the previous expectation that it may contribute to prevent DM. The authors aimed to ascertain the relationship between selenium and DM. METHODS: Data were collected from the National Health and Nutrition Examination Survey conducted from 2011 to 2014. A multivariate logistic regression analysis with adjustment for age, sex, race/ethnicity, hypertension, dyslipidemia and body mass index was conducted to evaluate the odds ratio for DM...
March 2019: Journal of Trace Elements in Medicine and Biology
Samir A Salama, Hany H Arab, Memy H Hassan, Majed M Al Robaian, Ibrahim A Maghrabi
Cadmium is an extremely toxic pollutant that reaches human body through intake of the industrially polluted food and water as well as through cigarette smoking and exposure to polluted air. Cadmium accumulates in different body organs especially the liver. It induces tissue injury largely through inflammation and oxidative stress-based mechanisms. The aim of the current study was to investigate the ability of γ glutamyl cysteine (γGC) to protect against cadmium-induced hepatocellular injury employing Wistar rats as a mammalian model...
March 2019: Journal of Trace Elements in Medicine and Biology
Ina Gesquiere, Nele Steenackers, Matthias Lannoo, Veerle Foulon, Ann Mertens, Ann Gils, Jan de Hoon, Patrick Augustijns, Christophe Matthys, Bart Van der Schueren
BACKGROUND & AIMS: Oral iron absorption is hampered in obese and bariatric patients, especially after Roux-en-Y gastric bypass (RYGB). As a result, iron deficiency, which is common in both patient groups, can be difficult to treat by oral supplements, often necessitating a switch to parenteral administration. The aim of this study was to find possible predictors of the extent of absorption of an effervescent iron gluconate oral supplement, which enables to pre-emptively identify those patients in which oral supplementation is likely to fail...
March 2019: Journal of Trace Elements in Medicine and Biology
Hamid Reza Shamsollahi, Maryam Nadarloo, Noushin Rastkari, Mika Sillanpää, Mahmood Yousefi, Hasan Pasalari, Ramin Nabizadeh
Iodine deficiency disorders include a wide range of metabolic and nonmetabolic disorders including goiter. To control IDDs, the World Health Organization and responsible agencies in countries established daily iodine uptake. Almost all the countries in the world provide the required iodine through salt iodisation. IDDs are not completely eradicable, so monitoring the salt iodisation programme is necessary for control of IDDs. In Iran, a salt iodisation programme was started in 1996. In this study, we took salt samples from all legally produced salt brands in Iran in 30 provinces and measured iodine concentration...
March 2019: Journal of Trace Elements in Medicine and Biology
K Soukupová, E Rudolf
The specific effects of sodium selenite (selenite) on a chemoresistant human bladder cancer cell line RT-112/D21 were investigated during 72 h. Selenite at low concentration of 2.5 μmol (otherwise tolerated in normal urothelial cells UROtsa) suppressed growth and proliferation of the tested cancer cells via induced oxidative stress. Selenite further altered mitochondrial functions (i.e. decreased mitochondrial membrane potential, increased production of superoxide and reduced ATP synthesis), disrupted lysosomal membranes and activated autophagy...
March 2019: Journal of Trace Elements in Medicine and Biology
Diego Luna, Marta Miranda, Víctor Pereira, Marta López-Alonso
The aim of the present study was to establish the pattern of lobular distribution of trace elements in the liver of cattle. The objective was to determine which part of the liver would provide accurate estimation of the trace element content of the whole organ. Liver samples were obtained from 10 Holstein-Friesian (HF), 10 Galician Blond (GB) and 10 GBxHF crosses (all aged 10 months) at slaughter. Samples were taken from 6 regions of the liver: the internal and external faces of the right lobe (IR and ER respetively); the left lobe (L), caudate lobe (CAU), quadrate lobe (QUA) and the processus papillaris (PP)...
March 2019: Journal of Trace Elements in Medicine and Biology
Per M Roos
The causes of neurodegenerative disorders are largely unknown. Environmental factors seem to contribute to neurodegeneration in genetically susceptible individuals. Increasing evidence point towards a key role for environmental exposure in the causation of neurodegenerative disorders and specifically for metal exposure. Alterations of metalloproteins seem to be a common motif in neurodegeneration and enough evidence has now accumulated to designate these disorders as metallopathies. Paired sampling refers to the simultaneous sampling of CSF and blood and by comparing metal concentrations between CSF and blood conclusions about exposure and barrier properties can be drawn...
March 2019: Journal of Trace Elements in Medicine and Biology
Fazlullah Khan, Saeideh Momtaz, Mohammad Abdollahi
BACKGROUND: Exposure to the environmental toxicants poses a serious threat to human health. The extent of exposure and the development of diseases are interrelated with each other. Chronic exposure to mercury (Hg) increases the risk of developing serious human disorders from embryo to adulthood. OBJECTIVES: The purpose of this review is to highlight the most common human disorders induced by Hg exposure on the basis of epigenetic mechanisms. A growing body of evidence shows that Hg exposure leads to alterations in the epigenetic markers...
March 2019: Journal of Trace Elements in Medicine and Biology
Tommaso Filippini, Stefano Tancredi, Carlotta Malagoli, Silvia Cilloni, Marcella Malavolti, Federica Violi, Luciano Vescovi, Annalisa Bargellini, Marco Vinceti
Aluminum and tin are ubiquitous in the environment. In normal biological systems, however, they are present only in trace amounts and have no recognized biological functions in humans. High exposure to these metals can result in adverse health effects such as neurodegenerative diseases. In non-occupationally exposed subjects, diet is the primary source of exposure. In this study, we aimed at estimating dietary aluminum and tin intake in an Italian adult population. We measured aluminum and tin concentrations through inductively-coupled plasma mass spectrometry in 908 food samples...
March 2019: Journal of Trace Elements in Medicine and Biology
Kateřina Macáková, Maria Carmen Catapano, Václav Tvrdý, Kateřina Klimková, Jana Karlíčková, Přemysl Mladěnka
Some compounds without apparent chelation sites have been shown to chelate cupric ions using the hematoxylin assay. Since these compounds also have reduction potential (direct antioxidant effect), the aim of this study was to determine the possible interference of reducing agents with the hematoxylin assay. Four different known reducing agents (hydroxylamine, vitamin C, trolox - a water-soluble form of vitamin E and reduced glutathione /GSH/) were selected for the study together with oxidized glutathione (GSSG) for comparison...
March 2019: Journal of Trace Elements in Medicine and Biology
Andrew Duncan, Christopher F Harrington, Anthony Catchpole, Andrew Taylor
The determination of copper and iron in liver biopsies have important roles in the diagnosis of Wilson's Disease and haemochromatosis respectively. An external quality assurance scheme is essential for analytical validation of results, however, none was available for these analytes at the time of this investigation. Accordingly a pilot scheme was established. The results of this scheme and of a corresponding questionnaire are recorded. Twenty-nine identical sets of lyophilised certified reference materials or dried aliquots of livers purchased from local stores were distributed to 26 specialist trace element laboratories offering this clinical service...
March 2019: Journal of Trace Elements in Medicine and Biology
Anurag Kumar Srivastav, Nitesh Dhiman, Ratnakar Tiwari, Nidhi Arjaria, Jyoti Prakash, Pankaj Jagdale, Anjaneya Ayanur, Dhirendra Singh, Satyakam Patnaik, Mahadeo Kumar
Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used nanomaterials. Following oral exposure, these NPs can accumulate in various organs and induce the toxicity due to their physiochemical characteristics. In present study to reduce the toxicity, surface engineered ZnO NPs (c-ZnO NPs) were in-situ synthesized by using polyacrylamide grafted guar gum (PAm-g-GG) polymer in alkaline media. Further, the comparative effect of bared ZnO NPs (b-ZnO NPs) and c-ZnO NPs were assessed on secondary target organ liver and kidneys of Swiss mice at doses of 10, 50 and 300 mg/kg following 28 days repeated oral treatment...
March 2019: Journal of Trace Elements in Medicine and Biology
Yuxiao Tang, Ruirui Qi, Huiwen Wu, Wencai Shi, Yan Xu, Min Li
The existence of sports anemia, induced by strenuous or long-term exercise and characterized by decreases of red blood cells (RBCs), hemoglobin and iron content, remains to be doubtful. To observe the effects of endurance exercise on RBCs and explain the underlying reason, we designed this study by observing RBCs parameters and iron metabolism in 8-weeks training rats and effects of iron supplement or protein supplement on RBCs. Results showed that erythrocyte counts, hematocrit, mean corpuscular volume and hemoglobin content decreased while RBC distribution width increased in exercised rats at later stage during 8 weeks training...
March 2019: Journal of Trace Elements in Medicine and Biology
Aydan Caglayan, Doruk Cevdi Katlan, Zafer Selcuk Tuncer, Kunter Yüce
Epithelial ovarian cancer (EOC) has been associated with oxidative stress (OS) due to epithelial inflammation which makes ovaries more vulnerable to the deleterious effects of reactive oxygen species (ROS). However, antioxidant enzymes (AOEs) such as manganese-superoxide dismutase (Mn-SOD), copper,zinc-superoxide dismutase (Cu,Zn-SOD) and glutathione peroxidase (GPx1) protect cells against the biological damage of ROS-induced OS and support cancer prevention by maintaining normal cell cycle progression, inhibiting proliferation, tumor invasion, angiogenesis, inflammation or inducing apoptosis...
March 2019: Journal of Trace Elements in Medicine and Biology
Eike Christian Kühn, Anna Slagman, Ellen C D Kühn-Heid, Julian Seelig, Christian Schwiebert, Waldemar B Minich, Christian Stoppe, Martin Möckel, Lutz Schomburg
OBJECTIVE: Selenium-binding protein 1 (SELENBP1) is an intracellular protein with variable expression in response to cellular stress. As the selenium (Se) status is affected by inflammation and hypoxia, we hypothesized that SELENBP1 contributes to disease-specific Se metabolism. To test this hypothesis, a quantitative assay was developed and used to monitor SELENBP1 in patients with acute coronary syndrome (ACS). MATERIALS AND METHODS: SELENBP1 was expressed, antibodies were generated and a luminometric immuno assay (LIA) was established and characterized...
March 2019: Journal of Trace Elements in Medicine and Biology
Matías F F Pérez Díaz, Maria G Plateo Pignatari, Verónica P Filippa, Fabián H Mohamed, Eduardo J Marchevsky, María S Gimenez, Dario C Ramirez
Cadmium (Cd) exposure has been associated with an increased risk of cardiovascular diseases. The diet is a modifiable source of protecting or damaging factors that may affect this risk. Herein we tested the hypothesis that a soybean-based diet (SBD) protects the vascular wall of the aorta against Cd-induced pro-inflammatory and pro-apoptotic effects. To test this hypothesis, we fed male Wistar rats for 60 days with a casein-based diet (CBD) or an SBD. These animals were also exposed to tap-water without (CBD-Co/SBD-Co) or with 15(CBD-15Cd/SBD-15Cd) or 100 (CBD-100Cd/SBD-100Cd) ppm of Cd...
March 2019: Journal of Trace Elements in Medicine and Biology
Bin Li, Breno Pannia Espósito, Shunhao Wang, Jie Zhang, Ming Xu, Shuping Zhang, Zhihong Zhang, Sijin Liu
Iron chelation has already been proposed to be a feasible strategy for cancer therapeutics in that reinforced iron demand is demonstrated in cancer cells, and quite a few iron chelators have been developed for this purpose. Desferrioxamine (DFO), an iron chelator approved by the U.S. Food and Drug Administration (FDA), has been extensively examined to remove extra iron. However, DFO has been found to harbor limited efficacies in combating cancer cells due to poor cellular permeability. In the current study, we synthesized the DFO derivative, named as desferrioxamine-caffeine dimer (DFCAF) by linking DFO to caffeine with high purity and excellent stability...
March 2019: Journal of Trace Elements in Medicine and Biology
Irena Baranowska-Bosiacka, Tomasz Olszowski, Izabela Gutowska, Jan Korbecki, Ewa Rębacz-Maron, Katarzyna Barczak, Anna Lubkowska, Dariusz Chlubek
OBJECTIVE: As cardiovascular events are one of the main causes of death in developed countries, each factor potentially increasing the risk of cardiovascular disease deserves special attention. One such factor is the potentially atherogenic effect of lead (Pb) on lipid metabolism, and is significant in view of the still considerable Pb environmental pollution and the non-degradability of Pb compounds. METHODS: Analysis of saturated fatty acids (SFA) (caprylic acid (C8:0), decanoic acid (C10:0), lauric acid (C12:0), tridecanoic acid (C13:0), myristic acid (C14:0), pentadecanoic acid (C15:0), palmitic acid (C16:0), heptadecanoic acid (C17:0), stearic acid (C18:0), and behenic acid (C22:0)), monounsaturated fatty acid (MUFA) (palmitoleic acid (C16:1), oleic acid (18:1w9), trans-vaccenic acid (C18:1 trans11)), and polyunsaturated fatty acid (PUFA) (linoleic acid (C18:2n6), gamma-linolenic acid (C18:3n6), arachidonic acid (C20:4n6)), was conducted by gas chromatography...
March 2019: Journal of Trace Elements in Medicine and Biology
Karlee N Dyck, Shabina Bashir, Graham W Horgan, Alan A Sneddon
Cadmium (Cd) is a toxic metal that can be relatively high in brown meat from crab and there is concern that it may accumulate in long-term crabmeat consumers posing a health risk. Sixteen healthy habitual crabmeat consumers and twenty five healthy non-crabmeat consumers were recruited through completion of a seafood frequency questionnaire. Whole blood and urine samples were analysed for Cd levels and urinary beta-2-microglobulin, an established marker of Cd-induced kidney toxicity, to determine levels in crabmeat consumers...
March 2019: Journal of Trace Elements in Medicine and Biology
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