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Experimental and Clinical Endocrinology & Diabetes

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https://read.qxmd.com/read/30991419/short-term-resistance-training-increases-appl1-content-in-the-liver-and-the-insulin-sensitivity-of-mice-fed-a-long-term-high-fat-diet
#1
Luciele Guerra Minuzzi, Gabriel Keine Kuga, Leonardo Breda, Rafael Calais Gaspar, Vitor Rosetto Muñoz, Rodrigo Martins Pereira, José Diego Botezelli, Adelino S R da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Eduardo Rochete Ropelle, José Rodrigo Pauli
BACKGROUND: APPL1, an adapter protein, interact directly with adiponectin receptors mediating adiponectin signaling and acting as a critical regulator of the crosstalk between adiponectin and insulin signaling pathway. The inadequate level of physical activity, high-calorie intake, or both lead to adverse consequences on health, like insulin resistance. On the order hand, physical exercise acts positively in the insulin action. PURPOSE: Here, we investigated the effects of short-term resistance training (RT) on APPL1 content and adiponectin pathway in the liver of mice fed a long-term high-fat diet...
April 16, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30986882/the-predictive-low-glucose-management-system-in-prevention-of-clinically-significant-hypoglycemia-in-type-1-diabetes-a-preliminary-study-identifying-the-most-common-events-leading-up-to-hypoglycemia-during-insulin-pump-therapy
#2
Petros Thomakos, Asimina Mitrakou, Olga Kepaptsoglou, Ibrahim Taraoune, Carol Barreto, Christos Sp Zoupas
BACKGROUND/AIM: Prevention of hypoglycemia remains a major challenge in diabetic management, despite the introduction of modern insulin pumps in daily clinical practice. The Low Glucose Suspend (LGS) and the newer Predictive Low Glucose Management (PLGM) systems incorporated in the Medtronic insulin pumps have shown promising results in prevention of hypoglycemia. Our aim was to evaluate the effect of the 2 systems relative to the frequency of clinically significant hypoglycemia in Type 1 diabetes (T1DM)...
April 15, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30986881/glucose-responsiveness-of-%C3%AE-cells-depends-on-fatty-acids
#3
Felicia Gerst, Christine Singer, Katja Noack, Dunia Graf, Gabriele Kaiser, Madhura Panse, Marketa Kovarova, Erwin Schleicher, Hans-Ulrich Häring, Gisela Drews, Susanne Ullrich
Glucose-stimulated insulin secretion (GSIS) is the gold standard for β-cell function. Both experimental and clinical diabetology, i. e., preceding transplantation of isolated human islets, depend on functional testing. However, multiple factors influence GSIS rendering the comparison of different in vitro tests of glucose responsiveness difficult. This study examined the influence of bovine serum albumin (BSA)-coupled fatty acids on GSIS. Isolated islet preparations of human donors and of 12-months old mice displayed impaired GSIS in the presence of 0...
April 15, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30986880/the-mitochondrial-dna-control-region-might-have-useful-diagnostic-and-prognostic-biomarkers-for-thyroid-tumors
#4
Rıfat Bircan, Hülya Ilıksu Gözü, Esra Ulu, Şükran Sarıkaya, Aylin Ege Gül, Duygu Yaşar Şirin, Serhat Özçelik, Cenk Aral
The literature suggests that mitochondrial DNA (mtDNA) defects are associated with a large number of diseases including cancers. The role of mtDNA variations in thyroid cancer is a highly controversial topic. Therefore, we investigated the role of mt-DNA control region (CR) variations in thyroid tumor progression and the influence of mtDNA haplogroups on susceptibility to thyroid tumors. For this purpose, in total, 108 hot thyroid nodules (HTNs), 95 cold thyroid nodules (CTNs), 48 papillary thyroid carcinoma (PTC) samples with their surrounding tissues and 104 healthy control subjects' blood samples were screened for all mtDNA CR variations using Sanger sequencing...
April 15, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30978727/the-case-for-an-estrogen-iron-axis-in-health-and-disease
#5
Mawieh Hamad, Khuloud Bajbouj, Jalal Taneera
Clinical and experimental evidence suggest that estrogen manipulates intracellular iron metabolism and that elevated levels of estrogen associate with increased systemic iron availability. This has been attributed to the ability of estrogen to suppress hepcidin synthesis, maintain ferroportin integrity and enhance iron release from iron-absorbing duodenal enterocytes and iron-storing macrophages and hepatocytes. These observations speak of a potential "estrogen-iron" axis that manipulates iron metabolism in response to hematologic (erythropoiesis) and non-hematologic (uterine growth, pregnancy, lactation) needs for iron...
April 12, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30978726/mirabegron-a-selective-%C3%AE-3-adrenoceptor-agonist-causes-an-improvement-in-erectile-dysfunction-in-diabetic-rats
#6
Didem Yilmaz-Oral, Ecem Kaya-Sezginer, Dilan Askin, Yesim Hamurtekin, Serap Gur
AIM: To investigate the possible beneficial effect of mirabegron [a selective β3 -adrenoceptor (AR) agonist] treatment on erectile dysfunction (ED) in streptozotocin-induced diabetic rats. METHODS: Sprague-Dawley rats (n=20) were divided into two groups: control group and streptozotocin-induced diabetic group. In vivo erectile responses were evaluated after intracavernosal injection of mirabegron (0.4 mg/kg) in rats. The relaxation responses to electrical field stimulation (EFS, 10 Hz), sodium nitroprusside (SNP, 10 nM) and sildenafil (1 μM) of corpus cavernosum (CC) strips were examined after the incubation with mirabegron (10 μM)...
April 12, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30974473/periodontal-disease-may-be-associated-with-the-occurrence-of-diabetic-retinopathy-a-subgroup-analysis-of-the-survey-of-the-diabetes-coordination-notebook-in-gifu
#7
Yukio Horikawa, Akio Suzuki, Mayumi Enya, Ken-Ichi Hashimoto, Shohei Nishida, Ryo Kobayashi, Tetsuya Ohashi, Futoshi Yamazaki, Rieko Totani, Hiroshi Kobayashi, Mayumi Yamamoto, Yoshinori Itoh, Jun Takeda
AIMS: A questionnaire survey of the prevalence of diabetic retinopathy was recently conducted in Japan. A subgroup analysis to examine the association of periodontal disease with diabetic retinopathy in subjects with diabetes and prediabetes was conducted. METHODS: The association of the presence of periodontal disease with the occurrence of diabetic retinopathy was examined using multivariate logistic regression analysis. RESULTS: Of 27 016 subjects who completed a survey at 217 community pharmacies, 5 572 had diabetes or prediabetes, among whom 522 and 1 421 had retinopathy or periodontal disease, respectively...
April 11, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30965364/related-risk-factors-between-subclinical-carotid-atherosclerosis-and-diabetic-retinopathy-in-newly-diagnosed-type-2-diabetes-mellitus-in-china
#8
Fengqi Guo, Ting Zhou, Juan Tang, Mingxia Dong, Qianping Wei
PURPOSE: To analyze the clinical features and related risk factors in diabetic retinopathy (DR) and subclinical atherosclerosis, the micro- and macro-vascular diseases in newly diagnosed type 2 diabetes mellitus (T2DM). METHODS: A retrospective study of 435 cases of inpatients with newly diagnosed T2DM from 2013-2017, and compare the 2 types of T2DM related vascular complications. RESULTS: The macro- and microvascular complications are not rare at this stage...
April 9, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30959531/effects-of-insulin-therapy-and-oral-hypoglycemic-agents-on-glycemic-control-for-type-2-diabetes-mellitus-patients-in-china-a-case-control-study
#9
PanPan Zuo, JianFeng Shi, Juan Yan, LiHong Yang, Chao Liu, Li Yuan, QingQing Lou
OBJECTIVE: The purpose of the study was to compare glycemic control in patients with type 2 diabetes (T2DM) receiving insulin therapy (IT) or oral hypoglycemic agents (OHA), and explore associations between treatment modality and pancreatic beta-cell function. METHODS: A matched, case-control study was conducted from April, 2016 to November, 2016. 2 272 patients with T2DM were identified from electronic medical records at four academic hospitals in China. Based on 1 136 eligible patients using IT, eligible 1 136 OHA patients were matched by age and duration at a ratio of 1:1...
April 8, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30959530/elevated-c-reactive-protein-levels-independently-predict-the-development-of-prediabetes-markers-in-subjects-with-normal-glucose-regulation
#10
Katsuhito Kato, Toshiaki Otsuka, Yoshiyuki Saiki, Nobuyuki Kobayashi, Takayuki Nakamura, Yoichi Kon, Tomoyuki Kawada
AIMS: Prediabetes is a precursor of diabetes and increases the risk of cardiovascular disease. Individuals with prediabetes reportedly have higher C-reactive protein levels, which is a risk factor for diabetes, relative to individuals with normal glucose regulation. Inflammation may play a role in the very early-phase deterioration of glucose metabolism, although there is insufficient knowledge regarding this relationship. Thus, we examined the association between serum C-reactive protein level and the development of three prediabetes markers...
April 8, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30873575/elevated-circulating-levels-of-motilin-are-associated-with-diabetes-in-individuals-after-acute-pancreatitis
#11
Fuchsia D Gold-Smith, Ruma G Singh, Maxim S Petrov
AIM: The study aimed to investigate the associations between glycaemic control after acute pancreatitis and gastrointestinal motility, using plasma motilin concentration and gastroparesis cardinal symptom index score as proxies. METHODS: This cross-sectional study recruited a total of 93 individuals after acute pancreatitis. Gastroparesis cardinal index scores, demographic and anthropometric factors, as well as pancreatitis-related factors were analysed. Fasting venous blood was collected to measure motilin, glycated haemoglobin, and fasting blood glucose...
March 14, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30873574/thermographic-characteristics-of-the-diabetic-foot-with-peripheral-arterial-disease-using-the-angiosome-concept
#12
Matthew Carabott, Cynthia Formosa, Anabelle Mizzi, Nikolaos Papanas, Alfred Gatt
AIM: To compare temperature changes following a challenge of limb elevation, in 3 forefoot angiosomes between type 2 diabetes mellitus patients with and without peripheral arterial disease (PAD). METHODS: Participans were categorized in a no PAD, mild PAD or severe PAD group. All underwent thermal imaging, then successive thermal images were taken at 1 min intervals after the lower limbs were elevated for 5 min. Thereafter, the lower limbs were lowered to the original position and imaged after 1 min...
March 14, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30841005/baseline-leptin-adiponectin-ratio-is-a-significant-predictor-of-bmi-changes-in-children-adolescents-after-intensive-lifestyle-intervention
#13
Hana Pejsova, Jaroslav A Hubacek, Petra Zemankova, Lukas Zlatohlavek
INTRODUCTION: Abdominal obesity is a strong cardiometabolic risk factor that often occurs as early as in childhood. The negative effect of abdominal obesity on the metabolism is partially mediated by changes to the production of the major adipocyte hormones leptin and adiponectin. Leptin/adiponectin imbalance is associated with increased risk of developing obesity and type 2 diabetes mellitus. AIM: To determine whether leptin, adiponectin and the leptin/adiponectin ratio are significant predictors of body weight loss in intensively treated children/adolescents...
March 6, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30802917/progression-of-albuminuria-among-patients-with-type-1-diabetes-mellitus-a-long-term-observational-follow-up-study
#14
Theodora Stratigou, Natalia Vallianou, Stavroula Koutroumpi, Barbara Vlassopoulou, Theofanis Apostolou, Stylianos Tsagarakis, George Ioannidis
BACKGROUND: The purpose of the present study was to determine whether patients with DM1 have shown improvement, stabilization or deterioration of their urine albumin excretion levels during a close follow-up. PATIENTS AND METHODS: A cohort of 84 patients, 18-76 years of age, a median duration of diabetes of 24 years (1-50 years) and a median follow-up duration of 12 years (1-37 years) were included in the study. RESULTS: Among the 84 patients for whom we had UAE levels at the beginning and by the end of the study, mean glycosylated hemoglobin was statistically significantly decreased during the follow-up period, from 8...
February 25, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30786314/acoustic-radiation-force-impulse-elastography-and-ultrasonographic-findings-of-achilles-tendon-in-patients-with-and-without-diabetic-peripheral-neuropathy-a-cross-sectional-study
#15
Özlem Turhan İyidir, Feride Kural Rahatlı, Yusuf Bozkuş, Lala Ramazanova, Hale Turnaoğlu, Aslı Nar, Neslihan Başçıl Tütüncü
AIMS: We aimed to evaluate the elastographic features of Achilles tendon with Acoustic Radiation Force Impulse in patients with and without diabetic neuropathy. METHODS: According to the presence of peripheral neuropathy, 45 patients with type 2 diabetes were divided into 2 subgroups. Those with peripheral neuropathy were defined as group I (22 patients) and those without peripheral neuropathy were defined as group II (23 patients). A total of thirty age-, gender-, and body mass index-matched healthy individuals were selected as controls...
February 20, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30754064/association-of-the-pnpla2-scd1-and-leptin-expression-with-fat-distribution-in-liver-and-adipose-tissue-from-obese-subjects
#16
Lucía De la Cruz-Color, Zamira Helena Hernández-Nazará, Montserrat Maldonado-González, Eliseo Navarro-Muñíz, José Alfredo Domínguez-Rosales, José Rodrigo Torres-Baranda, Elizabeth Del Carmen Ruelas-Cinco, Sandra Margarita Ramírez-Meza, Bertha Ruíz-Madrigal
The expansion of adipose tissue is regulated by insulin and leptin through SREBP-1c, up-regulating lipogenesis in tissues by SCD1 enzyme, while ATGL enzyme is key in lipolysis. THE RESEARCH OBJECTIVE WAS TO EVALUATE THE EXPRESSION OF SREBF1, SCD1, PNPLA2, AND LEP GENES IN HEPATIC-ADIPOSE TISSUE, AND RELATED THEM WITH THE INCREMENT AND DISTRIBUTION OF FAT DEPOTS OF INDIVIDUALS WITHOUT INSULIN RESISTANCE.: Thirty-eight subjects undergoing elective cholecystectomy with liver and adipose tissue biopsies (subcutaneous-omental) are included...
February 12, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30754063/step-as-a-useful-tool-to-screen-for-diabetes-specific-health-related-problems-in-community-based-geriatric-patients-an-exploratory-secondary-analysis-of-cross-sectional-data
#17
Solveig Carmienke, Anne-Kathrin Geier, Tobias Deutsch, Franz Maximilian Rasche, Thomas Frese
BACKGROUND AND AIMS: Comprehensive geriatric assessments are established tools for the identification of health problems in the elderly. So far, little is known about tailoring and targeting to facilitate their application. As a starting point for a tailored assessment of patients with diabetes, a highly prevalent health condition, we aimed to assess if the Standardized Assessment of Elderly People (STEP) is able to identify relevant differences in self-reported health problems between diabetic and non-diabetic patients...
February 12, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30743268/determinants-of-awareness-on-diabetes-and-its-complications
#18
Umit Gokhan Sendur, Mine Adas
INTRODUCTION: Diabetes mellitus is a chronic disease that requires continuous medical care. Raising awareness and determining the factors affecting awareness about diabetes and its complications have an important role in achieving glycemic control and preventing complications. OBJECTIVE: In this study, we aimed to determine the sociodemographic properties of participants, the status of patients' awareness, and the factors affecting awareness. We also aimed to determine the relationships between these factors and diabetes regulation...
February 11, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30669168/role-of-vasopressin-receptor-2-and-3-in-acth-secreting-tumors-and-their-potential-therapeutic-implications
#19
Jia Yang, Yehong Yang, Yongfei Wang, Shuo Zhang, Haixia Cheng, Shuyang Wang, Liang Ge, Yiming Li, Hongying Ye
PURPOSE: We investigated the expression of vasopressin receptor 2 and 3 on corticotrophin tumor cells, their role in regulating ACTH secretion, and their potential therapeutic implications. METHODS: We retrospectively assessed 52 hospitalized patients with pathologically confirmed ACTH-secreting tumors. The expression of vasopressin receptor 2 and 3 was explored via qualitative and quantitative immunohistochemistry analyses. The role of vasopressin receptors in regulating ACTH secretion was further studied in the AtT-20 cell line...
January 22, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30669167/real-world-adequacy-of-glycaemic-control-in-treatment-na%C3%A3-ve-greek-patients-with-type-2-diabetes-mellitus-initiating-treatment-with-metformin-monotherapy-at-the-maximum-tolerated-dose-the-reload-study
#20
Vasilis Tsimihodimos, Alexandra Bargiota, Emmanouil M Pagkalos, Christos Manes, Aggelos Papas, Eugenia Karamousouli, Bernd Voss, Moses S Elisaf
BACKGROUND: Metformin, in the absence of contraindications or intolerance, is recommended as first-line treatment for patients with type 2 diabetes mellitus (T2DM). This observational, retrospective study assessed the real-world adequacy of glycaemic control in Greek patients with T2DM initiating metformin monotherapy at maximum tolerated dose. METHODS: Included patients received metformin monotherapy for ≥24 months; relevant patient data were collected immediately prior to metformin initiation (baseline) and at other prespecified time points...
January 22, 2019: Experimental and Clinical Endocrinology & Diabetes
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