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Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research

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https://read.qxmd.com/read/30765502/targeting-cholesterol-metabolism-in-glioblastoma-a-new-therapeutic-approach-in-cancer-therapy
#1
Leila Pirmoradi, Nayer Seyfizadeh, Saeid Ghavami, Amir A Zeki, Shahla Shojaei
Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor known with a poor survival rate despite current advances in the field of cancer. Additional research into the pathophysiology of GBM is urgently needed given the devastating nature of this disease. Recent studies have revealed the unique cellular physiology of GBM cells as compared with healthy astrocytes. Intriguingly, GBM cells are incapable of de novo cholesterol synthesis via the mevalonate pathway. Thus, the survival of GBM cells depends on cholesterol uptake via low-density lipoprotein receptors (LDLRs) in the form of apolipoprotein-E-containing lipoproteins and ATP-binding cassette transporter A1 (ABCA1) that efflux surplus cholesterol out of cells...
February 14, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30765501/atrial-dysplasia-in-the-atria-of-humans-without-cardiovascular-disease
#2
Guo-Liang Li, Guy Fontaine, Jine Wu, Shuanliang Fan, Chaofeng Sun, Ardan M Saguner
Research on atrial histology of humans without cardiovascular disease is scarce. Therefore, our aim was to study human atrial histology in subjects without cardiovascular disease. Histology of the right atrium, left atrium or atrial septum was studied in eight patients (one newborn infant and seven adults) who died of a non-cardiac cause and who were not known to suffer from any cardiovascular pathology. Staining with hematoxylin phloxine saffron or Masson's trichrome was performed to have a better identification of fibrosis and H&E for better identification of lymphocytes...
February 14, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30755495/therapeutic-targets-for-the-anemia-of-predialysis-chronic-kidney-disease-a-meta-analysis-of-randomized-controlled-trials
#3
Hongyong Liu, Yuqiu Ye, Yanbing Chen, Yunqiang Zhang, Shaomin Li, Wentao Hu, Rongqian Yang, Zhesi Zhang, Hongquan Peng, Linsheng Lv, Xun Liu
Anemia is one of the major complications in predialysis patients with chronic kidney disease (CKD). A clearer cognition of the prognostic impact of hemoglobin (Hb) or hematocrit (Hct) target on the outcomes of predialysis patients with CKD is significant. This article aims to establish the suitable hemoglobin target to provide clinical guidance. MEDLINE, EmBase, the Cochrane Library and other databases were searched with both MeSH terms and keywords to gather researches that assessed all-cause mortality, stroke, treatment of renal replacement, and transfusion...
February 11, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30728175/development-of-a-prediction-model-for-1-year-poor-prognosis-in-patients-with-acute-ischemic-stroke
#4
Xia Ling, Bo Shen, Kangzhi Li, Lihong Si, Xu Yang
The goals of this study were to develop a new prediction model to predict 1-year poor prognosis (death or modified Rankin scale score of ≥3) in patients with acute ischemic stroke (AIS) and to compare the performance of the new prediction model with other prediction scales. Baseline data of 772 patients with AIS were collected, and univariate and multivariate logistic regression analyses were performed to identify independent risk factors for 1-year poor prognosis in patients with AIS. The area under the receiver operating characteristics curve (AUC) value of the new prediction model and the THRIVE, iScore and ASTRAL scores was compared...
February 6, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30723121/suboptimal-osteoporosis-evaluation-and-treatment-in-older-men-with-and-without-additional-high-risk-factors-for-fractures
#5
Radhika Rao Narla, Lianne A Hirano, Serena H Y Lo, Bradley D Anawalt, Elizabeth A Phelan, Alvin M Matsumoto
We compared osteoporosis case-finding, evaluation and treatment in groups of Older Men and Older Women with age alone as a significant risk for fracture and Older Men with Higher Risk (older men additionally having previous hip fracture, corticosteroid use or androgen deprivation therapy). We studied 13,704 older men and women (≥70 years old) receiving care at a Veterans Affairs medical center from January 2000 to August 2010 whose 10-year hip fracture risk was assessed by limited FRAX score. The main outcome measures were the proportion of patients who had bone mineral density (by dual-energy X-ray absorptiometry [DXA]) and serum 25-hydroxy vitamin D (25-OH D) measurements performed, and calcium/vitamin D or bisphosphonates prescribed...
February 5, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30723120/association-between-trace-element-concentrations-and-anemia-in-patients-with-chronic-kidney-disease-a-cross-sectional-population-based-study
#6
Chi-Feng Pan, Cheng-Jui Lin, Shu-Hua Chen, Chi-Feng Huang, Chun-Chuan Lee
Anemia is common in chronic kidney disease (CKD) and may be affected by trace element concentrations. While the concentrations of trace elements are known to be altered in CKD, the relationship between trace element and hemoglobin concentrations has not been systematically investigated in a large cohort. This study aims to examine associations between trace element concentrations and anemia in patients with CKD. Data from the National Health and Nutrition Examination Survey collected from 2011 to 2014 were used for this analysis...
February 4, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30723119/outcomes-from-an-elective-medical-student-research-scholarly-concentration-program
#7
Laura Radville, Annette Aldous, Jennifer Arnold, Alison K Hall
To examine how to increase research career outcomes among medical graduates, we analyzed the impact of the Research Scholarly Concentration at The George Washington University School of Medicine and Health Sciences. Residency placement, subsequent scholarship, and career outcomes were compared among 670 graduates who participated in the elective Clinical and Translational Research Scholarly Concentration or no Concentration between 2009 and 2018. We conducted a retrospective study of residency match (highly selective vs less selective), job type (academic vs non-academic), and postmedical school publications (any vs none)...
February 4, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30696751/delayed-febrile-response-with-bloodstream-infections-in-patients-with-continuous-flow-left-ventricular-assist-devices
#8
Christopher A Wrobel, Mark H Drazner, Colby R Ayers, David D Pham, Ricardo M La Hoz, Justin L Grodin, Sonia Garg, Pradeep P A Mammen, Robert M Morlend, Faris Araj, Alpesh A Amin, William K Cornwell, Jennifer T Thibodeau
Bloodstream infections (BSIs) are common in patients with continuous-flow left ventricular assist devices (CF-LVADs). Whether CF-LVADs modulate the febrile response to BSIs is unknown. We retrospectively compared the febrile response to BSIs in patients with heart failure (HF) with CF-LVADs versus a control population of patients with HF receiving inotropic infusions. BSIs were adjudicated using the Centers for Disease Control and Prevention and the National Healthcare Safety Network criteria. Febrile status (temperature ≥38°C, 100...
January 29, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30659091/event-dependence-in-the-analysis-of-cardiovascular-readmissions-postpercutaneous-coronary-intervention
#9
Anupama Vasudevan, James W Choi, Georges A Feghali, Stuart R Lander, Li Jialiang, Jeffrey M Schussler, Robert C Stoler, Ravi C Vallabhan, Carlos E Velasco, Peter A McCullough
Recurrent hospitalizations are common in longitudinal studies; however, many forms of cumulative event analyses assume recurrent events are independent. We explore the presence of event dependence when readmissions are spaced apart by at least 30 and 60 days. We set up a comparative framework with the assumption that patients with emergency percutaneous coronary intervention (PCI) will be at higher risk for recurrent cardiovascular readmissions than those with elective procedures. A retrospective study of patients who underwent PCI (January 2008-December 2012) with their follow-up information obtained from a regional database for hospitalization was conducted...
January 18, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30659090/effects-of-different-types-and-frequencies-of-physical-activity-on-the-homeostatic-model-assessment-of-insulin-resistance
#10
Junhyun Kwon, Woorim Kim, Sang Ah Lee, Dongwoo Choi, Eun-Cheol Park
This study analyzed the type and frequency of physical activity that most effectively reduces the homeostatic model assessment of insulin resistance (HOMA2-IR) among adults (≥19 years) in Asia. We used national representative data from 1645 men and 2272 women who participated in the Korea National Health and Nutrition Examination Survey in 2015 were included in the analysis. The effects of different types and frequencies of physical activity on HOMA2-IR were investigated using a multiple regression analysis...
January 18, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30659089/elevated-serum-il-35-levels-in-rheumatoid-arthritis-are-associated-with-disease-activity
#11
Yuxuan Li, Lutian Yao, Siyan Liu, Jisheng Wu, Liping Xia, Hui Shen, Jing Lu
To investigate serum interleukin (IL)- 35 levels in patients with rheumatoid arthritis (RA) and to describe the association between serum IL-35 levels and clinical parameters: erythrocyte sedimentation rate (ESR), C reactive protein (CRP), global health on Visual Analog Scale, Disease Activity Score in 28 joints based on ESR (DAS28-ESR), rheumatoid factor (RF) and anticyclic citrullinated peptide antibodies (ACPAs). The study included 129 patients with RA and 83 healthy controls. Serum IL-35 levels were detected by ELISA...
January 18, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30635363/role-of-ct-guided-transthoracic-biopsy-in-the-diagnosis-of-mycobacterial-infection
#12
Kyongmin Sarah Beck, Dae Hee Han, Kyo Young Lee, Seung Joon Kim
Mycobacterial infection(MI) is sometimes diagnosed using CT-guided transthoracic needle biopsy (TNB). However, the exact role of CT-guided TNB in this diagnostic process is not clearly known. The purpose of this study is to analyze the role of CT-guided TNB in patients with MI who present with a focal lung lesion. Of 1233 patients who underwent CT-guided TNB from January 2010 through February 2016 at our institution, patients with a final diagnosis of MI were included for analysis. Clinical characteristics and biopsy-related factors were compared between patients whose diagnosis could be established using TNB samples alone (group 1) and those whose samples from additional tests were necessary for diagnosis (group 2)...
January 11, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30635362/monoclonal-b-cell-lymphocytosis-and-prostate-cancer-incidence-and-effects-of-radiotherapy
#13
Fiorella D'Auria, Luciana Valvano, Luciana Rago, Teodora Statuto, Giovanni Calice, Giovanni D'Arena, Vincenzo Fusco, Pellegrino Musto
Monoclonal B-cells lymphocytosis (MBL) is a benign condition that may precede chronic lymphocytic leukemia (CLL), not rarely present in peripheral blood of healthy elderly people, among which there is also a male prevalence. Though CLL has been associated with various types of solid tumors, including prostate cancer (PC), no data exist about the relationship between PC and MBL. We studied the frequency of CLL-like MBL clones in a group of 48 patients affected by PC and followed them during and after whole-pelvis radiotherapy (WPRT) treatment...
January 11, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30593542/serum-heart-type-fatty-acid-binding-protein-decreases-and-soluble-isoform-of-suppression-of-tumorigenicity-2-increases-significantly-by-long-term-physical-activity
#14
Michael Sponder, Michael Lichtenauer, Bernhard Wernly, Vera Paar, Uta Hoppe, Michael Emich, Monika Fritzer-Szekeres, Brigitte Litschauer, Jeanette Strametz-Juranek
The aim of this prospective study was to investigate the influence of long-term physical activity on biomarkers for myocyte ischemia (heart-type fatty acid-binding protein, H-FABP), matrix remodelling/vascular stress (soluble isoform of suppression of tumorigenicity 2, sST2) and inflammation (soluble urokinase-type plasminogen activator receptor, suPAR). In this prospective observational study 109 subjects were recruited, 98 completed the study. Subjects were asked to perform exercise within the calculated training pulse for 8 months...
December 27, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30593541/long-term-efficacy-of-rifaximin-to-manage-the-symptomatic-uncomplicated-diverticular-disease-of-the-colon
#15
Francesco Di Mario, Chiara Miraglia, Ginevra Cambiè, Alessandra Violi, Antonio Nouvenne, Marilisa Franceschi, Giovanni Brandimarte, Walter Elisei, Marcello Picchio, Antonio Tursi
Although rifaximin is currently advised in managing symptomatic uncomplicated diverticular disease (SUDD) of the colon, no long-term data are available. This retrospective study assessed the outcome of a large cohort of patients with SUDD, treated with rifaximin, during an 8-year follow-up. The study group (group A) included 346 patients with SUDD (median age 64 years, IQR 58-69, 62.4% females), treated with rifaximin 800 mg/d for 7 days every month. The control group (group B) included 470 patients with SUDD (median age 65 years, IQR 59-74 years, 60...
December 27, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30573494/the-characteristics-and-clinical-significance-of-mucin-levels-in-bronchoalveolar-lavage-fluid-of-patients-with-interstitial-lung-disease
#16
Li Wei, Jing Zhao, Jing Bao, Yanliang Ma, Ying Shang, Zhancheng Gao
To investigate the expression and clinical significance of secretory mucins in patients with interstitial lung disease (ILD). The bronchoalveolar lavage fluid (BALF) concentrations of mucins (MUCs) from 27 patients with ILD, 6 patients with lung cancer, 8 patients with pleural effusion and 9 patients with bronchiectasis were determined by ELISA. The concentration of MUC5AC was significantly increased in patients with ILD (12.84±15.02 ng/mL) compared with patients with pleural effusion (4.33±2.51 ng/mL), lung cancer (8...
December 19, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30559166/copeptin-levels-upon-corticosteroid-treatment-in-acute-community-acquired-pneumonia
#17
Milica Popovic, Claudine Angela Blum, Mirjam Christ-Crain
No abstract text is available yet for this article.
December 16, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30530528/metabolic-syndrome-is-a-sequela-of-radiation-exposure-in-hypothalamic-obesity-among-survivors-of-childhood-brain-tumors
#18
Raven Cooksey, Susan Y Wu, Laura Klesse, Jon D Oden, Ross E Bland, Joseph C Hodges, Lynn Gargan, Gloria Lena Vega, Daniel C Bowers
Survivors of childhood brain tumors may be at risk for early onset of metabolic syndrome, possibly secondary to surgery and/or radiation exposure. This study examines effects of radiation exposure to hypothalamus-pituitary-adrenal axis (HPA) on metabolic risk among survivors of childhood brain tumors. One hundred forty-two met inclusion criteria; 60 had tumor surgery plus radiation exposure (<u>></u>1 Gray (Gy)) to HPA. The second subgroup of 82 subjects had surgery only and were not exposed to radiation...
December 9, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30530527/association-of-triglyceride-to-hdl-cholesterol-ratio-with-cardiometabolic-outcomes
#19
May Yang, Joseph Rigdon, Sandra A Tsai
Electronic medical records (EMRs) offer a potential opportunity to identify patients at high risk for cardiometabolic disease, which encompasses type 2 diabetes and cardiovascular disease (CVD). The objective of this retrospective cohort study is to use information gathered from EMR to investigate the association between triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) and cardiometabolic outcomes in a general population of subjects over 50 years of age during a follow-up period of 8-9 years...
December 9, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30530786/a-novel-scoring-system-for-assessing-the-severity-of-electrolyte-and-acid-base-disorders-and-predicting-outcomes-in-hospitalized-patients
#20
Yimei Wang, Jiachang Hu, Xuemei Geng, Xiaoyan Zhang, Xialian Xu, Jing Lin, Jie Teng, Xiaoqiang Ding
Electrolyte and acid-base disorders are commonly seen in critically ill and other hospitalized patients. A scoring system is needed to assess the severity of electrolyte and acid-base disorders and to predict outcome in hospital patients. Herein, we prospectively enrolled a total of 322,046 patients, including 84,700 patients in the derivation cohort and 237,346 in the validation cohort, in a large, tertiary hospital in East China from 2014 to 2017. A points-scoring system of general electrolyte and acid-base disorders with a sum of 20...
December 6, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
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