Annalinda Pisano, Loredana Le Pera, Raffaella Carletti, Bruna Cerbelli, Maria Gemma Pignataro, Angelina Pernazza, Fabrizio Ferre, Maria Lombardi, Davide Lazzeroni, Iacopo Olivotto, Ornella E Rimoldi, Chiara Foglieni, Paolo G Camici, Giulia d'Amati
OBJECTIVE: Coronary microvascular dysfunction (CMD) is a key pathophysiological feature of hypertrophic cardiomyopathy (HCM), contributing to myocardial ischemia and representing a critical determinant of patients' adverse outcome. The molecular mechanisms underlying the morphological and functional changes of CMD are still unknown. Aim of this study was to obtain insights on the molecular pathways associated with microvessel remodelling in HCM. METHODS: Interventricular septum myectomies from patients with obstructive HCM (n=20) and donors' hearts (CTR, discarded for technical reasons, n=6) were collected...
October 5, 2022: Microcirculation: the Official Journal of the Microcirculatory Society, Inc