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Microcirculation: the Official Journal of the Microcirculatory Society, Inc

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https://read.qxmd.com/read/30887637/prediction-of-renal-allograft-chronic-rejection-using-a-model-based-on-contrast-enhanced-ultrasonography
#1
Cheng Yang, Shengdi Wu, Ping Yang, Guoguo Shang, Ruochen Qi, Ming Xu, Ruiming Rong, Tongyu Zhu, Wanyuan He
OBJECTIVE: To evaluate the application of contrast-enhanced ultrasonography (CEUS) for the diagnosis of renal allograft chronic rejection (CR). METHOD: A total of 104 patients who were suspected to have acute rejection (AR) or CR were enrolled in this study (derivation group, n = 66; validation group, n = 38). Before biopsy, all patients received an ultrasound examination. RESULTS: In the CR group, rising time (RT) and time to peak (TTP) of medulla (RTm and TTPm, respectively) were significantly longer compared to those in the AR group...
March 18, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30854714/localised-pressure-stimulation-using-turf-like-structures-can-improve-skin-perfusion-in-the-foot
#2
Sara Behforootan, Panagiotis E Chatzistergos, Nachiappan Chockalingam, Aoife Healy, Roozbeh Naemi
OBJECTIVE: Improving perfusion under the skin can potentially reduce ulceration and amputation risk in people with diabetic foot. Localised pressure stimulation has been proven capable of improving skin perfusion in the scalp but its effectiveness for the foot has not been tested. In this study, localised pressure stimulation was realised using flexible turf-like structures with dense vertical fibres and their ability to increase perfusion was assessed. METHODS: The skin in the rear-foot, mid-foot and forefoot of nine healthy volunteers was stimulated using two turf-like structures with different stiffness and one wound filler material that generated a uniform compression...
March 10, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30834638/reconstruction-of-coronary-circulation-networks-a-review-of-methods
#3
Vigneshwaran Vibujithan, Gregory B Sands, Ian J LeGrice, Bruce H Smaill, Nicolas P Smith
Building anatomically-accurate models of the coronary vascular system enables potentially deeper understandings of coronary circulation. To achieve this, (1) images at different levels of vascular network - arteries, arterioles, capillaries, venules, and veins - need to be obtained through suitable imaging modalities, (2) from images, morphological and topological information need to be extracted using image-processing techniques. While there are several modalities that enable the imaging of large vessels, microcirculation imaging- capturing vessels having diameter lesser than 100 μm - has to date been typically confined to small regions of the heart...
March 4, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30828931/heat-shock-protein-90-does-not-contribute-to-cutaneous-vasodilatation-in-older-adults-during-heat-stress
#4
Naoto Fujii, Gregory W McGarr, Kion Hatam, Nithila Chandran, Caroline M Muia, Takeshi Nishiyasu, Pierre Boulay, Reem Ghassa, Glen P Kenny
OBJECTIVES: Heat shock protein 90 (HSP90) contributes to cutaneous vasodilatation during exercise in the heat through nitric oxide synthase (NOS)-dependent mechanisms in young adults. We hypothesized that similar responses would be observed in older middle-aged adults. METHODS: In nineteen habitually-active older middle-aged (56±5 years) men (n=9) and women (n=10), cutaneous vascular conductance (CVC) was measured at four forearm skin sites continuously treated with 1) lactated Ringers solution (Control), 2) 10 mM L-NAME (NOS inhibitor), 3) 178 μM geldanamycin (HSP90 inhibitor), or 4) 10 mM L-NAME and 178 μM geldanamycin combined...
March 4, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30825241/deletion-of-robo4-prevents-high-fat-diet-induced-adipose-artery-and-systemic-metabolic-dysfunction
#5
Tam T T Phuong, Ashley E Walker, Grant D Henson, Daniel R Machin, Dean Y Li, Anthony J Donato, Lisa A Lesniewski
OBJECTIVE: Accumulating evidence suggests the vascular endothelium plays a fundamental role in the pathophysiology of obesity by regulating the functional status of white adipose and systemic metabolism. Roundabout guidance 4 (Robo4) is expressed specifically in endothelial cells and increases vascular stability and inhibits angiogenesis. We sought to determine the role of Robo4 in modulating cardio-metabolic function in response to high fat feeding. METHODS: We examined exercise capacity, glucose tolerance, and white adipose tissue artery gene expression, endothelium-dependent dilation and angiogenesis in wild type and Robo4 knockout mice fed normal chow or a high fat diet (HFD)...
March 1, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30821858/differential-impact-of-severe-familial-hypercholesterolemia-on-regional-skeletal-muscle-and-organ-blood-flows-during-exercise-effects-of-pde5-inhibition
#6
Christian G Aragonez, Vincent J de Beer, Darla L Tharp, Douglas K Bowles, M Harold Laughlin, Daphne Merkus, Dirk J Duncker, Shawn B Bender
OBJECTIVE: Swine with familial hypercholesterolemia (FH) exhibit attenuated exercise-induced systemic vasodilation that is restored by phosphodiesterase 5 (PDE5) inhibition. Whether the impacts of FH and PDE5 inhibition to impair and restore, respectively, exercise-induced vasodilation results from tissue-specific or generalized effects remains unclear. Thus, we hypothesized that FH induces generalized impairment of skeletal muscle vasodilation that would be alleviated by PDE5 inhibition...
March 1, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30803094/multi-domain-analysis-of-microvascular-flow-motion-dynamics
#7
Andrew J Chipperfield, Marjola Thanaj, Eleonora Scorletti, Christopher D Byrne, Geraldine F Clough
OBJECTIVE: To determine whether analysis of microvascular network perfusion using complexity-based methods can discriminate between groups of individuals at an increased risk of developing CVD. METHODS: Data were obtained from laser Doppler recordings of skin blood flux at the forearm in 50 participants with non-alcoholic fatty liver disease grouped for absence (n=28) or presence (n=14) of type 2 diabetes and use of calcium channel blocker medication (n=8). Power spectral density was evaluated and Lempel-Ziv complexity determined to quantify signal information content at single and multiple time-scales to account for the different processes modulating network perfusion...
February 25, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30801897/effect-of-mild-hypothermia-on-cerebral-microcirculation-in-a-murine-cardiopulmonary-resuscitation-model
#8
HaiFang Yu, Lin Wang, HaiHong Zhang, Wei Wei, Yao Chen, WanChun Tang, Zhi Wan
BACKGROUND: We hypothesized that mild hypothermia may improve brain microcirculation by reducing cerebral microvascular endothelial cells apoptosis, and this effect may be maximized by moving up the initiation of mild hypothermia from after return of spontaneous circulation (ROSC) to the start of cardiopulmonary resuscitation (CPR). METHODS: 35 rats were randomized into the intra-arrest hypothermia group (IAH), post-resuscitation hypothermia group (PRH), normothermia group (NT) or the sham control group...
February 23, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30758094/retinal-microvascular-changes-in-microvascular-angina-findings-from-the-australian-heart-eye-study
#9
Gerald Liew, Paul Mitchell, Joseph Chiha, Adam Jh Plant, Andrew White, Nichole Joachim, Sarah Wang, George Burlutsky, Pramesh Kovoor, Aravinda Thiagalingam, Bamini Gopinath
OBJECTIVE: Microvascular changes in microvascular angina are poorly understood due to difficulties in imaging the coronary microcirculation in vivo. The retinal microvasculature may reflect changes in coronary microcirculation. We assessed microvascular changes in the retina in patients with microvascular angina and compared them with patients with angiographically proven coronary artery disease. METHODS: We performed retinal photography and coronary angiography on 915 patients...
February 13, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30721555/transient-receptor-potential-vanilloid-4-channels-are-important-regulators-of-parenchymal-arteriole-dilation-and-cognitive-function
#10
Janice M Diaz-Otero, Ting-Chieh Yen, Amna Ahmad, Erinn Laimon-Thomson, Bana Abolibdeh, Kara Kelly, Matthew T Lewis, Robert W Wiseman, William F Jackson, Anne M Dorrance
OBJECTIVE: Hypertension-associated parenchymal arteriole (PA) dysfunction reduces cerebral perfusion and impairs cognition. This is associated with impaired TRPV4-mediated PA dilation; therefore, we tested the hypothesis that TRPV4 channels are important regulators of cerebral perfusion, PA structure and dilation, and cognition. METHODS: 10-12-month-old male TRPV4 knockout (WKY-Trpv4em4Mcwi ) and age-matched control WKY rats were studied. Cerebral perfusion was measured by MRI with arterial spin labeling...
February 5, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30703289/matrix-metalloproteinase-9-mediated-shedding-of-syndecan-4-in-glomerular-endothelial-cells
#11
Trine M Reine, Francesca Lanzalaco, Oddrun Kristiansen, Anne Randi Enget, Simon Satchell, Trond G Jenssen, Svein O Kolset
BACKGROUND: Diabetic nephropathy is the most common cause of end-stage renal failure in the western world and Asia. The mechanisms are not fully elucidated, but disruption of glomerular endothelial glycocalyx and shedding of its components including syndecans has been implicated. AIMS: We hypothesize that reduced glomerular filtration in diabetes is caused by disruption of endothelial glycocalyx in glomeruli, including increased shedding of syndecan-4. The aim of this study was to determine the effects of experimental diabetic conditions by means of hyperglycemia and IL-1β exposure on syndecan-4 shedding in glomerular endothelial cells (GEnC), and to investigate regulation of shedding by sheddases...
January 31, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30703277/microcirculation-at-mooloolaba
#12
Marianne Tare
This special issue of Microcirculation consists of a unique compilation of review and original articles encompassing a diverse range of current and trending topics in microcirculation. These articles were borne out of a joint meeting between the Australian and New Zealand Microcirculation and the Australian Vascular Biology Societies at Mooloolaba, Queensland, Australia. The articles in this issue encompass circulatory and microcirculatory issues from across the spectrum of life, mechanisms in health, in disease and in aging, and consider cell-based therapies, models of disease and state-of-the art technologies...
January 31, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30681226/a-streak-length-based-method-for-quantifying-red-blood-cell-flow-in-skeletal-muscle-arteriolar-networks
#13
Daniel Goldman, Zahra Farid, Dwayne N Jackson
OBJECTIVE: To develop an experimental method to quantify red blood cell flow throughout skeletal muscle arteriolar networks. METHODS: Data on arteriolar geometry was obtained using intravital videomicroscopy of the rat gluteus maximus muscle. RBC velocities and number densities were also obtained during these experiments using fluorescently labeled RBCs. Arteriolar and RBC data were combined to estimate blood volume flow rates, tube (HT ) and discharge hematocrits, and RBC volume flow rates...
January 25, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30659745/fractal-characterization-of-retinal-microvascular-network-morphology-during-diabetic-retinopathy-progression
#14
Natasa Popovic, Mirko Lipovac, Miroslav Radunovic, Jurgi Ugarte, Erik Isusquiza, Andoni Beristain, Ramón Moreno, Nerea Aranjuelo, Tomo Popovic
OBJECTIVE: The study aimed to characterize morphological changes of the retinal microvascular network during the progression of diabetic retinopathy. METHODS: Publicly available retinal images captured by a digital fundus camera from DIARETDB1 and STARE databases were used. The retinal microvessels were segmented using the automatic method and vascular network morphology was analyzed by fractal parametrization such as box-counting dimension, lacunarity, and multifractals...
January 19, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30659710/the-presence-of-cerebral-white-matter-lesions-and-lower-skin-microvascular-perfusion-predict-lower-cognitive-performance-in-type-1-diabetes-patients-with-retinopathy-but-not-in-healthy-controls-a-longitudinal-study
#15
Anna L Emanuel, Eelco van Duinkerken, Mike P Wattjes, Martin Klein, Frederik Barkhof, Frank J Snoek, Michaela Diamant, Etto C Eringa, Richard G IJzerman, Erik H Serné
OBJECTIVE: Cognitive impairments in type 1 diabetes may result from hyperglycemia-associated cerebral microangiopathy. We aimed to identify cerebral microangiopathy and skin microvascular dysfunction - as surrogate marker for generalized microvascular function - as predictors of cognitive performance over time. METHODS: In this prospective cohort study, 25 type 1 diabetes patients with proliferative retinopathy and 25 matched healthy controls underwent neurocognitive testing at baseline and after follow-up (3...
January 19, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30656790/quantitative-assessment-of-microperfusion-by-indocyanine-green-angiography-in-kidney-transplantation-resembles-chronic-morphological-changes-in-kidney-specimens
#16
Ulrich Rother, Kerstin Amann, Werner Adler, Nina Nawroth, Ioannis Karampinis, Michael Keese, Serhat Manap, Susanne Regus, Alexander Meyer, Stefan Porubsky, Karl Hilgers, Bernhard K Krämer, Werner Lang, Kai Nowak, Andreas L H Gerken
OBJECTIVE: Indocyanine green fluorescence angiography enables a quantitative real-time perfusion assessment in kidney transplantation. The results of intraoperative microperfusion of the kidney allograft were compared to the renal chronicity score in pre-transplantation kidney biopsy specimens. The intrarenal resistance index was calculated by duplex sonography as a method of reference. METHODS: Seventy-seven patients with end stage renal disease undergoing kidney transplantation were prospectively included in two centers...
January 17, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30636088/quantification-of-adherens-junction-disruption-and-contiguous-paracellular-protein-leak-in-human-lung-endothelial-cells-under-septic-conditions
#17
Lefeng Wang, Justin Chung, Sean E Gill, Sanjay Mehta
OBJECTIVE: Sepsis is associated with dysfunction of microvascular endothelial cells (MVEC) resulting in organ edema and inflammation. Vascular endothelial (VE)-cadherin, a component of MVEC adherens junctions, may be disrupted in sepsis. However, the direct connection between individual MVEC VE-cadherin disruption and increased paracellular permeability is uncertain. METHODS: Human pulmonary MVEC were cultured on a biotin matrix and treated with cytomix, as a model of sepsis, vs PBS...
January 12, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30597676/morphological-and-pharmacological-characterization-of-the-porcine-popliteal-artery-a-novel-model-for-study-of-lower-limb-arterial-disease
#18
N E Frederick, R Mitchell, T W Hein, P Bagher
OBJECTIVE: This study was undertaken to characterize structural and pharmacological properties of the pig popliteal artery in order to develop a novel system for the examination of lower limb blood flow regulation in a variety of cardiovascular pathologies, such as diabetes-induced peripheral artery disease. METHODS: Popliteal arteries were isolated from streptozocin-induced diabetic pigs or age-matched saline-injected control pigs for morphological study using transmission electron microscopy and for examination of vasoreactivity to pharmacological agents using wire myography...
December 30, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30597690/developmental-onset-of-cardiovascular-disease-could-the-proof-be-in-the-placenta
#19
J N D'Errico, P A Stapleton
The Barker Hypothesis states change to the maternal environment may have significant impacts on fetal development, setting the stage for adult disease to occur. The development of the materno-fetal vasculature during implantation and maintenance during pregnancy is extremely precise, yet dynamic. Delays or dysfunction in the orchestration of anatomical remodeling, maintenance of blood pressure, or responsiveness to metabolic demand may have severe consequences to the developing fetus. While these intermissions may not be fatal to the developing fetus, an interruption, reduction, or an inability to meet fetal demand of blood flow during crucial stages of development may pre-dispose young to disease later in life...
December 29, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/29908046/sepsis-induced-acute-kidney-injury-a-disease-of-the-microcirculation
#20
REVIEW
Shuai Ma, Roger G Evans, Naoya Iguchi, Marianne Tare, Helena C Parkington, Rinaldo Bellomo, Clive N May, Yugeesh R Lankadeva
AKI is a common complication of sepsis and is significantly associated with mortality. Sepsis accounts for more than 50% of the cases of AKI, with a mortality rate of up to 40%. The pathogenesis of septic AKI is complex, but there is emerging evidence that, at least in the first 48 hours, the defects may be functional rather than structural in nature. For example, septic AKI is associated with an absence of histopathological changes, but with microvascular abnormalities and tubular stress. In this context, renal medullary hypoxia due to redistribution of intra-renal perfusion is emerging as a critical mediator of septic AKI...
February 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
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