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Cancer Gene Therapy

Sheng-Ze Deng, Min-Fang Lai, You-Ping Li, Chun-Hua Xu, Hao-Ran Zhang, Jian-Guo Kuang
It is well established that human marrow stromal cells (hMSCs) can directly migrate towards tumor microenvironments associated with tumor formation and intracellular communication. Gene regulatory networks in tumors may be targeted by microRNAs (miRNAs), especially those derived in exosomes from hMSCs. However, the potential functional roles of hMSCs in glioma cell growth still remain controversial. Therefore, this study aimed at exploring the regulatory mechanisms of hMSC exosomal microRNA-375 (miR-375) in glioma...
February 7, 2019: Cancer Gene Therapy
Xiaotong Zhang, Xi Liu, Zhifei Jing, Jianbin Bi, Zeliang Li, Xiankui Liu, Jun Li, Zhenhua Li, Zhe Zhang, Chuize Kong
Accumulating evidence shows that circular RNAs (circRNAs) function as microRNA sponges that regulate gene expression in the progression of human cancers. However, the roles of circRNAs and functional miRNA sponges in bladder cancer (BC) remain largely unknown. In the present study, we applied bioinformatics methods and hypothesised that miR-146b may target the 3'-untranslated region (UTR) of CARMA3 mRNA and circINTS4 may serve as a sponge for miR-146b in BC tumorigenesis. Expression of circINTS4 was significantly increased in miR-146b-downregulated BC tissues and cell lines compared to adjacent normal tissues...
February 6, 2019: Cancer Gene Therapy
Zhicheng Yao, Shida Yang, Hongyou Zhao, Huike Yang, Xin Jiang
All animal experiments were approved by the Animal Care and Use Committee (ACUC), Louisiana State University Health Science Center and not The People's Hospital of Liaoning Province as indicated in the original version of the Article. The PDF and HTML versions of the Article have been modified accordingly.
February 1, 2019: Cancer Gene Therapy
Huijuan Wang, Jingjing Hou, Guowei Zhang, Mina Zhang, Peng Li, Xiangtao Yan, Zhiyong Ma
Retrospective analysis of data from 14,528 lung cancer patients with multiple primary malignant neoplasm (MPMN) revealed that 2.5% (364/14,528) were MPMN cases and 96.2% (350/364) were diagnosed with two primary malignancies, 3.6% (13/364) with three primary malignancies, and 0.3% (1/364) with four primary malignancies. Among 350 lung cancer patients diagnosed with two primary malignancies, 26.6% (93/350) had lung cancer diagnosed first (LCF) and 73.4% (257/350) had other cancers diagnosed initially (OCF), whereas synchronous MPMN (SMPMN) accounted for 21...
January 31, 2019: Cancer Gene Therapy
Mien-Chun Lin, Meilin Wang, Ming-Chieh Chou, Chun-Nun Chao, Chiung-Yao Fang, Pei-Lain Chen, Deching Chang, Cheng-Huang Shen
Prostate cancer is the second most common cancer in men globally. Prostate cancer patients at advanced stages are usually treated with androgen deprivation therapy (ADT). However, with disease progression, it often becomes the incurable castration-resistant prostate cancer (CRPC). JC polyomavirus (JCPyV) is a human DNA virus. Its virus-like particles (VLPs) exhibit similar tropism to native virions and they are capable of delivering exogenous genes to the target cells for expression. JCPyV has been detected in prostate cells; therefore, prostate cancer cells may be susceptible to JCPyV infection and JCPyV VLPs may be used as a vector for gene therapy against prostate cancer...
January 29, 2019: Cancer Gene Therapy
Rianna Vandergaast, Sarawut Khongwichit, Huailei Jiang, Timothy R DeGrado, Kah-Whye Peng, Duncan R Smith, Stephen J Russell, Lukkana Suksanpaisan
Noninvasive bioluminescence imaging (BLI) of luciferase-expressing tumor cells has advanced pre-clinical evaluation of cancer therapies. Yet despite its successes, BLI is limited by poor spatial resolution and signal penetration, making it unusable for deep tissue or large animal imaging and preventing precise anatomical localization or signal quantification. To refine pre-clinical BLI methods and circumvent these limitations, we compared and ultimately combined BLI with tomographic, quantitative imaging of the sodium iodide symporter (NIS)...
January 24, 2019: Cancer Gene Therapy
V Konduri, M M Halpert, Y C Baig, R Coronado, J R Rodgers, J M Levitt, B Cerroni, S Piscoya, N Wilson, L DiBernardi, Z Omarbekov, L Seelhoff, V Ravi, L Douglass, W K Decker
Angiosarcoma is a deadly neoplasm of the vascular endothelium. Metastatic disease is often present at diagnosis, and 5-year survival is only 10-35%. Although there exist no immunocompetent mouse models of angiosarcoma with which to study immune-based approaches to therapy, angiosarcoma is a major killer of companion dogs, responsible for up to 2% of all canine deaths in some susceptible breeds or an estimated 120,000 per year in the US. The canine disease (HSA) often presents in the spleen as acute hemoabdomen secondary to splenic rupture...
January 23, 2019: Cancer Gene Therapy
Xiaofeng Xu, Tao Liu, Jun Wu, Yijin Wang, Ying Hong, Huaijun Zhou
Cervical cancer is one of the most prevalent gynecologic malignancies and has remained an intractable cancer over the past decades. We analyzed the aberrant expression patterns of cervical cancer using RNA-Seq data from The Cancer Genome Atlas (TCGA). A total of 3352 differently expressed genes (DEGs) were identified in 306 cervical cancer samples compared with 3 control samples, with 1401 genes upregulated and 1951 downregulated. Under Kaplan-Meier analysis, 76 out of these DEGs with a significantly different survival rate between patients with high and low expression groups were picked out and uploaded to perform Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, which identified a transferrin receptor (TFRC)-involved HIF-1 signaling pathway (p < 0...
January 17, 2019: Cancer Gene Therapy
Weilong Zhang, Ying Song, Xue He, Xiaoni Liu, Ye Zhang, Zuozhen Yang, Ping Yang, Jing Wang, Kai Hu, Weiyou Liu, Xiuru Zhang, Xiaoliang Yuan, Hongmei Jing
Plasma cell myeloma (PCM) secretes monoclonal immunoglobulin (Ig) by clonal plasma cells of abnormal proliferation in the bone marrow. As PCM is incurable, it is necessary to find new biomarkers to predict the prognosis and recurrence of PCM. The relationship between cancer and RBBP8 has not been fully studied. The role of RBBP8 in tumorigenesis remains inconsistent. We described the expression of RBBP8 in the gene expression profile of 1930 PCM samples (1878 PCM patients) from seven independent data sets. We analyzed the relationship between RBBP8 and survival prognosis, recurrence, and treatment response in patients with PCM, and the biological significance of RBBP8 in PCM...
January 9, 2019: Cancer Gene Therapy
Guillermo Garaulet, Gema Pérez-Chacon, Hernan Alarcón, Arantzazu Alfranca, Francisca Mulero, Jorge Martínez-Torrecuadrada, Juan M Zapata, Antonio Rodríguez
Interleukin 12 is a promising anti-cancer agent; however, IL12 systemic administration is hampered by side-effects. Although intratumoral administration of IL12 is giving promising results in clinical trials, only a small percentage of patients show a complete therapeutic response. This outcome could be improved by controlling the IL12 expression window. In this work we have tested the efficacy of a self-processing P2A and codon optimized murine IL12 (mIL12Pop) using inflammation-regulated lentivectors in a syngeneic tumor model...
January 9, 2019: Cancer Gene Therapy
Sherif G Ahmed, Abdelanabi Ahmed, Mohamed Doha, Gary J Brenner
Schwannomas are peripheral nerve sheath tumors associated with three genetically distinct disease entities, namely sporadic schwannoma, neurofibromatosis type-2, and schwannomatosis. Schwannomas are associated with severe disability and in cases lead to death. The primary treatment is operative resection that itself can cause neurologic damage and is at times contra-indicated due to tumor location. Given their homogenous Schwann-lineage cellular composition, schwannomas are appealing targets for gene therapy...
January 9, 2019: Cancer Gene Therapy
Manish R Patel, Alexander Dash, Blake A Jacobson, Yan Ji, Daniel Baumann, Kareem Ismail, Robert A Kratzke
The concept of using viruses to treat cancer has now shown proof of concept in several recent clinical trials, leading to the first FDA approval of virotherapy for melanoma last year. Vesicular stomatitis virus (VSV) is a promising oncolytic virus that has inhibitory effects on a number of cancer types including non-small cell lung cancer. One of the major mechanisms of resistance to VSV infection is the type I interferon (IFN) response, leading to the development of VSV expressing IFNβ which will lead to resistance of viral replication in normal cells which have intact IFN signaling but allow replication in cancer cells with defective IFNβ signaling...
January 9, 2019: Cancer Gene Therapy
Fang Bao, Wei Wan, Ting He, Feifei Qi, Guanghua Liu, Kai Hu, Xin-An Lu, Ping Yang, Fei Dong, Jing Wang, Hongmei Jing
Patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) have a poor prognosis. Chimeric antigen receptor (CAR) modified T cells targeting CD19 hold great promise to improve the complete response rates of DLBCL patients compared with conventional therapies. Here, we conducted a clinical trial to evaluate the efficacy and safety of CAR-T cells. Five patients with relapsed or refractory DLBCL were treated with autologous T cells expressing the 19-41BBz chimeric antigen receptor (CAR) specifically targeted the CD19 antigen (IM19 CAR-T)...
January 9, 2019: Cancer Gene Therapy
Weilong Zhang, Ye Zhang, Zuozhen Yang, Xiaoni Liu, Ping Yang, Jing Wang, Kai Hu, Xue He, Xiuru Zhang, Hongmei Jing
Multiple myeloma (MM) is one of hematological malignancies, characterized by malignant proliferation of plasma cells. Biomarkers play an important role in evaluating the development and prognosis of MM. Ubiquitin-conjugating enzyme E2T (UBE2T) is served to connect with particular E3 ubiquitin ligase to degraded-related substrates, contributing to DNA repair in the Fanconi anemia pathway. Also, numerous evidences reported that UBE2T is closely related to cell proliferation and carcinogenesis. However, the relationship between MM and UBE2T has not been studied...
January 9, 2019: Cancer Gene Therapy
Shangfeng Li, Shengkai Zhang, Jie Chen
Small nucleolar RNA host gene 16 (SNHG16) has been documented to be involved in the pathogenesis of human cancers. Here, we elucidated the biological roles and regulatory mechanism of SNHG16 in the pathogenesis of oral squamous cell carcinoma (OSCC). In this paper, we found that c-Myc and SNHG16 were overexpressed in OSCC tissues and cell lines compared with normal tissues and normal human oral keratinocytes cells. There was a notable positive correlation between SNHG16 and c-Myc expression in OSCC tissues...
January 4, 2019: Cancer Gene Therapy
Tomomi Yoneda, Naoto Kunimura, Koichi Kitagawa, Yuka Fukui, Hiroki Saito, Keita Narikiyo, Motoki Ishiko, Naoki Otsuki, Ken-Ichi Nibu, Masato Fujisawa, Satoshi Serada, Tetsuji Naka, Toshiro Shirakawa
Prostate cancer is one of the most common cancers in men. The overactivation of IL-6/JAK/STAT3 signaling and silencing of SOCS3 are frequently observed in prostate cancer. In the present study we undertook to develop Ad-SOCS3 gene therapy for the treatment of prostate cancer and also investigated whether Ad-SOCS3 increased sensitivity to NK cells. We demonstrated that Ad-SOCS3 could significantly inhibit growth of castration-resistant prostate cancer (CRPC) cell lines expressing pSTAT3, DU-145 (at 10, 20, and 40 MOI), and TRAMP-C2 (at 40 MOI), but not the PC-3 CRPC cell line with the STAT3 gene deleted...
January 4, 2019: Cancer Gene Therapy
Longzhen Cui, Zhiheng Cheng, Yan Liu, Yifeng Dai, Yifan Pang, Yang Jiao, Xiaoyan Ke, Wei Cui, Qingyi Zhang, Jinlong Shi, Lin Fu
Acute myeloid leukemia (AML) is a hematological malignancy characterized by the proliferation of immature myeloid cells, with impaired differentiation and maturation. Pyruvate dehydrogenase kinase (PDK) is a pyruvate dehydrogenase complex (PDC) phosphatase inhibitor that enhances cell glycolysis and facilitates tumor cell proliferation. Inhibition of its activity can induce apoptosis of tumor cells. Currently, little is known about the role of PDKs in AML. Therefore, we screened The Cancer Genome Atlas (TCGA) database for de novo AML patients with complete clinical information and PDK family expression data, and 84 patients were included for the study...
December 22, 2018: Cancer Gene Therapy
Yu Zhong, Chao Yu, Wenyi Qin
Recently, long non-coding RNAs (lncRNAs) are considered as critical regulators in pathogenesis progression of cerebral ischemia. In present study, lncRNA-small nucleolar RNA host gene 14 (SNHG14) was found upregulated in middle cerebral artery occlusion/reperfusion (MCAO/R) treated brain tissues and oxygen-glucose deprivation and reoxygenation (OGD/R) treated PC-12 cells. Interference of SNHG14 by shRNA vector enhanced neuron survival and suppressed inflammation in response to OGD/R insult. SNHG14 positively regulated the expression of Rho-associated coiled-coil-containing protein kinase 1 (ROCK1) via acting as a sponge of microRNA (miR)-136-5p...
December 14, 2018: Cancer Gene Therapy
Shao-Ying Li, Hong Wang, Hui-Fang Mai, Guo-Feng Li, Shao-Jun Chen, Gui-Sen Li, Bi-Chan Liang
Breast cancer is ranked as the second leading cause of cancer-related deaths among women. Accumulating evidences have revealed that long non-coding RNAs (lncRNAs) are involved in human tumorigenesis owing to the regulation of essential pathways for tumor initiation and progression. Herein, the current study aimed to explore the regulatory mechanism of lncRNA ZFHX4-AS1 in breast cancer in relation to the Hippo signaling pathway. Initially, microarray analysis was conducted to screen out differentially expressed lncRNAs related to breast cancer...
December 14, 2018: Cancer Gene Therapy
Tiancheng Zhao, Yahong Chen, Shihou Sheng, Yuanyu Wu, Tao Zhang
This study aimed to analyze the functions of microRNA 498 (miR-498) on gastric cancer (GC) cell proliferation migration and cisplatin chemosensitivity. QTR-PCR found that miR-498 was markedly downregulated in GC cell lines and human GC tumors. It was discover that, lentivirus-mediated miR-498 overexpression inhibited cancer cell proliferations in vitro and in vivo, invasion and cisplatin chemoresistance. Bmi1 was demonstrated to be directly regulated by miR-498 in GC cell lines. Moreover, Bmi1 upregulation was found to reverse the tumor-suppressing functions of miR-498 in GC...
December 5, 2018: Cancer Gene Therapy
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