journal
https://read.qxmd.com/read/37629793/specific-learning-disorders-variation-analysis-of-15-candidate-genes-in-9-multiplex-families
#1
JOURNAL ARTICLE
Francesco Calì, Francesco Domenico Di Blasi, Emanuela Avola, Mirella Vinci, Antonino Musumeci, Angelo Gloria, Donatella Greco, Daniela Rita Raciti, Alessandro Zagami, Biagio Rizzo, Santina Città, Concetta Federico, Luigi Vetri, Salvatore Saccone, Serafino Buono
Background and Objectives : Specific Learning Disorder (SLD) is a complex neurobiological disorder characterized by a persistent difficult in reading (dyslexia), written expression (dysgraphia), and mathematics (dyscalculia). The hereditary and genetic component is one of the underlying causes of SLD, but the relationship between genes and the environment should be considered. Several genetic studies were performed in different populations to identify causative genes. Materials and Methods : Here, we show the analysis of 9 multiplex families with at least 2 individuals diagnosed with SLD per family, with a total of 37 persons, 21 of whom are young subjects with SLD, by means of Next-Generation Sequencing (NGS) to identify possible causative mutations in a panel of 15 candidate genes: CCPG1 , CYP19A1 , DCDC2 , DGKI , DIP2A , DYM , GCFC2 , KIAA0319 , MC5R , MRPL19 , NEDD4L , PCNT , PRMT2 , ROBO1 , and S100B ...
August 21, 2023: Medicina
https://read.qxmd.com/read/37629792/doppler-indices-of-the-uterine-umbilical-and-fetal-middle-cerebral-artery-in-diabetic-versus-non-diabetic-pregnancy-systematic-review-and-meta-analysis
#2
REVIEW
Sonja Perkovic-Kepeci, Andja Cirkovic, Natasa Milic, Stefan Dugalic, Dejana Stanisavljevic, Milos Milincic, Konstantin Kostic, Nikola Milic, Jovana Todorovic, Ksenija Markovic, Natasa Aleksic Grozdic, Miroslava Gojnic Dugalic
Background and Objectives : The aim of this study was to assess the differences in Doppler indices of the uterine (Ut), umbilical (UA), and middle cerebral artery (MCA) in diabetic versus non-diabetic pregnancies by conducting a comprehensive systematic review of the literature with a meta-analysis. Materials and Methods : PubMed, Web of Science, and SCOPUS were searched for studies that measured the pulsatility index (PI), resistance index (RI), and systolic/diastolic ratio index (S/D ratio) of the umbilical artery, middle cerebral artery, and uterine artery in diabetic versus non-diabetic pregnancies...
August 21, 2023: Medicina
https://read.qxmd.com/read/37629791/is-there-an-association-between-increased-stress-and-smartphone-addiction-insights-from-a-study-on-medical-students-from-saudi-arabia-during-the-covid-19-pandemic
#3
JOURNAL ARTICLE
Haytham I AlSaif, Zeyad A Alhozaimi, Alhanouf S Alrashed, Kholoud S Alanazi, Mohammed G Alshibani, Turky H Almigbal, Saad M Alsaad, Abdullah A Alrasheed, Fahad D Alosaimi
Purpose: Smartphone addiction is prevalent among medical students, and there is a concern that the coronavirus disease 2019 (COVID-19) pandemic fueled a rise in smartphone addiction. Earlier studies suggest a link between excessive smartphone usage and negative outcomes such as depression, stress, and reduced academic achievement. However, there is a dearth of both local studies in Saudi Arabia and studies conducted during the COVID-19 pandemic exploring the prevalence of smartphone addiction and its association with academic performance, depression, and perceived stress, which is the purpose of the current study...
August 21, 2023: Medicina
https://read.qxmd.com/read/37629790/the-prevalence-of-gastrointestinal-bleeding-in-covid-19-patients-a-systematic-review-and-meta-analysis
#4
REVIEW
Eleni Karlafti, Dimitrios Tsavdaris, Evangelia Kotzakioulafi, Adonis A Protopapas, Georgia Kaiafa, Smaro Netta, Christos Savopoulos, Antonios Michalopoulos, Daniel Paramythiotis
Introduction : Severe acute respiratory syndrome coronavirus 2 caused the coronavirus disease of 2019 (COVID-19), which rapidly became a pandemic, claiming millions of lives. Apart from the main manifestations of this infection concerning the respiratory tract, such as pneumonia, there are also many manifestations from the gastrointestinal tract. Of these, bleeding from the gastrointestinal tract is a significant complication quite dangerous for life. This bleeding is divided into upper and lower, and the primary pathophysiological mechanism is the entering of the virus into the host cells through the Angiotensin-converting enzyme 2 receptors...
August 21, 2023: Medicina
https://read.qxmd.com/read/37629789/development-and-validation-of-a-novel-risk-score-for-all-cause-mortality-risk-stratification-prior-to-permanent-pacemaker-implantation-in-octogenarians-or-older
#5
JOURNAL ARTICLE
Hsuan-Ching Lin, Ming-Jui Hung, Chao-Hung Wang, Tien-Hsing Chen, Wei-Siang Chen, Chi-Wen Cheng
Background and Objectives : The demand for permanent pacemaker (PPM) implantation for extremely old patients is increasing. Prior to implanting PPMs, life expectancy evaluation is essential but difficult. We aimed to develop and validate a scoring system for all-cause mortality risk stratification prior to PPM implantation in patients aged ≥80. Materials and Methods : A total of 210 patients aged ≥80 who received PPM implantation were included. Multivariable analysis was performed to assess the effects of different variables on all-cause mortality in a derivation cohort ( n = 100)...
August 21, 2023: Medicina
https://read.qxmd.com/read/37629788/total-talar-prosthesis-learning-from-experience-two-reports-of-total-talar-prosthesis-after-talar-extrusion-and-literature-review
#6
REVIEW
Danilo Leonetti, Giorgio Carmelo Basile, Gabriele Giuca, Elena Corso, Domenico Fenga, Ilaria Sanzarello
Recently, total talar prosthesis has been proposed to substitute the talus during the management of complex talar lesions such as talar extrusion, comminuted talar fractures, or avascular necrosis. Herein, we report two cases of talar extrusion treated with total talar replacement after a high-intensity trauma. Both cases subsequently required revision surgery due to degenerative changes of the tibial plafond (arthrodesis in the first case, conversion to a total ankle prosthesis in the latter). We report and analyze the literature concerning total talar replacement to discuss strategies that could help improve prosthesis survival and reduce the incidence of osteoarthritis...
August 21, 2023: Medicina
https://read.qxmd.com/read/37629787/using-single-peroneal-longus-tendon-graft-for-segmental-meniscus-transplantation-and-revision-anterior-cruciate-ligament-combined-anterolateral-reconstruction
#7
Ling Yang, Chih-Hao Chiu, Kuo-Yao Hsu, Chieh-An Chuang, Alvin Chao-Yu Chen, Yi-Sheng Chan, Cheng-Pang Yang
This case report describes a new approach to segmental meniscal reconstruction using a peroneal longus autograft in a patient with recurrent traumatic medial meniscus tear and anterior cruciate ligament reconstruction (ACLR) failure. While allograft meniscal transplantation is the preferred method for treating meniscal deficiency, its high cost and various legal regulations have limited its widespread use. Autologous tendon grafts have been proposed as a substitute for allograft meniscus transplantation, but their initial results were poor, leading to little progress in this area...
August 21, 2023: Medicina
https://read.qxmd.com/read/37629786/feasibility-and-efficacy-of-the-newly-developed-robotic-hybrid-assistive-limb-shoulder-exercises-in-patients-with-c5-palsy-during-the-acute-postoperative-phase
#8
JOURNAL ARTICLE
Shigeki Kubota, Hideki Kadone, Yukiyo Shimizu, Hiroki Watanabe, Masao Koda, Yoshiyuki Sankai, Masashi Yamazaki
Background and Objectives : Although postoperative C5 palsy is a frequent complication of cervical spine surgery, no effective therapeutic rehabilitation approach has been established for postoperative C5 palsy. The purpose of this study was to find evidence confirming the effectiveness and feasibility of robotic Hybrid Assistive Limb (HAL) shoulder exercises for C5 palsy. Materials and Methods : In this before-after, uncontrolled case series clinical study, we performed a mean of 11.7 shoulder training sessions using a shoulder HAL immediately after the onset of C5 palsy in seven shoulders of six patients who developed postoperative C5 palsy and had difficulty raising their shoulder during the acute postoperative phase of cervical spine surgery...
August 21, 2023: Medicina
https://read.qxmd.com/read/37629785/sarcoidosis-associated-sensory-ganglionopathy-and-harlequin-syndrome-a-case-report
#9
Ieva Navickaitė, Miglė Ališauskienė, Sandra Petrauskienė, Gintarė Žemgulytė
Background and Objectives : Sensory ganglionopathy is a rare neurological disorder caused by degeneration of the neurons composing the dorsal root ganglia. It manifests as various sensory disturbances in the trunk, proximal limbs, face, or mouth in a patchy and asymmetrical pattern. Harlequin syndrome is characterized by unilateral flushing and sweating of the face, neck, and upper chest, concurrent with contralateral anhidrosis. Here, we present and discuss a clinical case of sarcoidosis-associated ganglionopathy and Harlequin syndrome...
August 20, 2023: Medicina
https://read.qxmd.com/read/37629784/the-carotid-hyoid-topography-is-variable
#10
JOURNAL ARTICLE
Mihaela Daniela Manta, Mugurel Constantin Rusu, Sorin Hostiuc, Alexandra Diana Vrapciu, Bogdan Adrian Manta, Adelina Maria Jianu
Background and Objectives : The carotid bifurcation (CB) is presented in most anatomy textbooks as having a unique location at the upper margin of the thyroid cartilage. Although a number of case reports have provided evidence of the possibility of carotid artery location either lateral or medial to the greater hyoid horn, these reports have not established specific anatomic possibilities and prevalences. Materials and Methods : We retrospectively analysed a batch of 147 CT angiograms for 12 types of carotid-hyoid relationships and classified the bilateral combination possibilities of these types...
August 19, 2023: Medicina
https://read.qxmd.com/read/37629783/promoting-self-management-and-independent-living-of-older-individuals-with-chronic-diseases-through-technology-a-study-of-self-reported-needs-priorities-and-preferences
#11
JOURNAL ARTICLE
Argyroula Kalaitzaki, Michael Rovithis, Alexios Dimitropoulos, Sofia Koukouli, Manolis Linardakis, Elli Katsiri, Nikos Rikos, George Vasilopoulos, George Tsolas, Aikaterini Papachristou, Anastasia Dimitrantzou, Dimitrios Katsiris, Areti Stavropoulou
Background and Objectives : Older patients' needs are rarely examined beforehand, and thus, although technology-based tools can enhance self-management, acceptability rates are still low. This study aimed to examine and compare self-reported needs, priorities, and preferences of older patients with heart failure (HF), diabetes mellitus type II (DM2), and chronic obstructive pulmonary disease (COPD) toward technology use to enhance self-management. Materials and Methods : A convenience sample of 473 participants over 60 s (60...
August 19, 2023: Medicina
https://read.qxmd.com/read/37629782/nonselective-versus-selective-angioembolization-for-trauma-patients-with-pelvic-injuries-accompanied-by-hemorrhage-a-meta-analysis
#12
JOURNAL ARTICLE
Hyunseok Jang, Soon Tak Jeong, Yun Chul Park, Wu Seong Kang
Background and Objectives : Angioembolization has emerged as an effective therapeutic approach for pelvic hemorrhages; however, its exact effect size concerning the level of embolized artery remains uncertain. Therefore, we conducted this systematic review and meta-analysis to investigate the effect size of embolization-related pelvic complications after nonselective angioembolization compared to that after selective angioembolization in patients with pelvic injury accompanying hemorrhage. Materials and Methods : Relevant articles were collected by searching the PubMed, EMBASE, and Cochrane databases until 24 June 2023...
August 19, 2023: Medicina
https://read.qxmd.com/read/37629781/when-critical-view-of-safety-fails-a-practical-perspective-on-difficult-laparoscopic-cholecystectomy
#13
REVIEW
Catalin Alius, Dragos Serban, Dan Georgian Bratu, Laura Carina Tribus, Geta Vancea, Paul Lorin Stoica, Ion Motofei, Corneliu Tudor, Crenguta Serboiu, Daniel Ovidiu Costea, Bogdan Serban, Ana Maria Dascalu, Ciprian Tanasescu, Bogdan Geavlete, Bogdan Mihai Cristea
The incidence of common bile duct injuries following laparoscopic cholecystectomy (LC) remains three times higher than that following open surgery despite numerous attempts to decrease intraoperative incidents by employing better training, superior surgical instruments, imaging techniques, or strategic concepts. This paper is a narrative review which discusses from a contextual point of view the need to standardise the surgical approach in difficult laparoscopic cholecystectomies, the main strategic operative concepts and techniques, complementary visualisation aids for the delineation of anatomical landmarks, and the importance of cognitive maps and algorithms in performing safer LC...
August 19, 2023: Medicina
https://read.qxmd.com/read/37629780/collagen-based-ovule-therapy-reduces-inflammation-and-improve-cervical-epithelialization-in-patients-with-fungal-viral-and-bacterial-cervico-vaginitis
#14
JOURNAL ARTICLE
Nicoletta De Rosa, Fabrizia Santangelo, Celestino Todisco, Fabiana Dequerquis, Claudio Santangelo
Background and Objectives : Vulvovaginal infections pose significant health challenges for women, necessitating effective treatment approaches. This retrospective observational study aimed at investigating the efficacy of collagen-based vaginal ovules therapy, specifically Plurigin Ovules, in restoring cervical epithelialization and reducing inflammation in mycotic, viral, and bacterial cervico-vaginitis. Materials and Methods : A total of 398 women with cervico-vaginitis were included in the study, categorized into three groups: bacterial cervico-vaginitis (Group A), viral cervico-vaginitis (Group B), and fungal cervico-vaginitis (Group C)...
August 18, 2023: Medicina
https://read.qxmd.com/read/37629779/multiple-flap-transfer-for-multiple-local-recurrence-of-soft-tissue-sarcoma
#15
JOURNAL ARTICLE
Ryo Karakawa, Hidehiko Yoshimatsu, Yuma Fuse, Tomoyuki Yano
Background and Objectives : Surgical management of local recurrence of soft tissue sarcomas (STS) is still challenging. In this article, we report on multiple flap reconstructions for multiple local recurrences of STS. Their feasibility will be validated by examining clinical cases. Materials and Methods : Patients who underwent multiple flap reconstructions for multiple local recurrences of STS between April 1997 and October 2021 were included in this retrospective study. Patient demographics, tumor characteristics, surgical characteristics, and postoperative complications were examined...
August 18, 2023: Medicina
https://read.qxmd.com/read/37629778/can-routine-laboratory-tests-be-suggestive-in-determining-suspicions-of-malignancy-in-the-case-of-thyroid-nodules
#16
JOURNAL ARTICLE
Mervat Matei, Mihaela Maria Vlad, Ioana Golu, Cristina Ștefania Dumitru, Graziano De Scisciolo, Sergiu-Ciprian Matei
Background and objectives: Thyroid nodules are a common finding in clinical practice and can be either benign or malignant. The aim of this study was to compare laboratory parameters between patients with malignant thyroid nodules and those with benign thyroid nodules. Materials and methods: A total of 845 patients were included, with 251 in the study group (malignant thyroid nodules) and 594 in the control group (benign thyroid nodules). Results: Our results show that there were statistically significant differences in several laboratory parameters, including FT3, FT4, ESR, fibrinogen, WBC, and lymphocyte percentage, between the two patient groups ( p < 0...
August 18, 2023: Medicina
https://read.qxmd.com/read/37629777/antibody-kinetics-after-three-doses-of-sars-cov-2-mrna-vaccination-in-patients-with-inflammatory-bowel-disease
#17
JOURNAL ARTICLE
Evangelos Tsipotis, Ankith Maremanda, Laura Bowles Zeiser, Caoilfhionn Connolly, Sowmya Sharma, Sharon Dudley-Brown, Sarah Frey, Mark Lazarev, Joanna M Melia, Alyssa M Parian, Dorry L Segev, Brindusa Truta, Huimin Yu, William A Werbel, Florin M Selaru
Background: The emergence of new SARS-CoV-2 variants calls for more data on SARS-CoV-2 mRNA vaccine response. Aims: We aimed to assess the response to a third mRNA vaccine dose against SARS-CoV-2 in inflammatory bowel disease (IBD) patients. Methods: This was a single-center, observational prospective study of IBD patients who received a third mRNA vaccine dose against SARS-CoV-2. Antibody titers were taken post-third-dose at one and three months using the Roche Elecsys anti-SARS-CoV-2-S enzyme immunoassay...
August 18, 2023: Medicina
https://read.qxmd.com/read/37629776/quality-of-life-predictors-in-a-group-of-informal-caregivers-during-the-covid-19-pandemic
#18
JOURNAL ARTICLE
Ana Claudia Damian, Alexandra Ioana Mihăilescu, Cristina Anghele, Constantin Alexandru Ciobanu, Cristian Petrescu, Sorin Riga, Vlad Dionisie, Adela Magdalena Ciobanu
Background and Objectives : The informal caregiver's contribution to the wellbeing of dementia patients is critical since these individuals become dependent on others for all daily activities. Our goal was to investigate the dynamics of anxiety, depression, burnout, sleep, and their influence on quality of life over a 6-month period in the context of pandemic distress in a sample of informal caregivers of Alzheimer's patients. Materials and Methods : For this prospective, longitudinal study, we conducted a 6-month telephonic survey between 2021 and 2022, administering a series of questionnaires at three timepoints (baseline, 3 months and 6 months) to a group of informal caregivers of patients suffering from dementia due to Alzheimer's disease...
August 18, 2023: Medicina
https://read.qxmd.com/read/37629775/vertigo-associated-with-otosclerosis-and-stapes-surgery-a-narrative-review
#19
REVIEW
Violeta Necula, Alma Aurelia Maniu, László-Péter Ujváry, Maximilian-George Dindelegan, Mara Tănase, Mihai Tănase, Cristina Maria Blebea
Otosclerosis is a pathological condition affecting the temporal bone, and is characterized by remodelling of the labyrinthine bone tissue through a dynamic process of osteolysis and osteogenesis. This condition progressively leads to hearing loss, tinnitus, and vertigo. Stapedotomy, a surgical procedure involving the removal of the stapes superstructure and its replacement with a prosthesis, is the treatment of choice to improve hearing in individuals with otosclerosis. However, vestibular dysfunction is a significant complication associated with this procedure, which can occur intraoperatively or postoperatively, ranging from the immediate postoperative period to weeks, months, or even years after surgery...
August 18, 2023: Medicina
https://read.qxmd.com/read/37629774/the-role-of-critical-ultrasound-reassessment-in-the-decision-making-of-bethesda-iii-thyroid-nodules
#20
JOURNAL ARTICLE
Giuseppina Orlando, Giuseppa Graceffa, Sergio Mazzola, Fabrizio Vassallo, Maria Pia Proclamà, Pierina Richiusa, Stefano Radellini, Nunzia Cinzia Paladino, Giuseppina Melfa, Gregorio Scerrino
Background and Objectives : Bethesda III (BIII) thyroid nodules have an expected malignancy rate of 5-15%. Our purpose was to assess which US criteria are most associated with cancer risk, and the value of critical ultrasound (US) reassessment. Methods : From 2018 to 2022, 298 BIII nodules were enrolled for thyroidectomy (79 malignancies). We evaluated ultrasonographic data: hechogenicity, intralesional vascularization, spiculated margins, micro-calcifications, "taller than wide" shape, extra-thyroidal growth, size increase, as well as their association with histology...
August 17, 2023: Medicina
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