journal
Journals Surgical Oncology Clinics of N...

Surgical Oncology Clinics of North America

https://read.qxmd.com/read/38789203/the-contemporary-management-of-esophageal-and-gastric-cancer
#1
EDITORIAL
Smita Sihag, Robert E Merritt
No abstract text is available yet for this article.
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38789202/the-contemporary-management-of-esophageal-and-gastric-cancer
#2
EDITORIAL
Timothy M Pawlik
No abstract text is available yet for this article.
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38789201/the-impact-of-racial-disparities-and-the-social-determinants-of-health-on-esophageal-and-gastric-cancer-outcomes
#3
REVIEW
Sidra N Bonner, Melanie A Edwards
Reducing long-standing inequities in gastric and esophageal cancers is a priority of patients, providers, and policy makers. Many social determinants of health influence risk factors for disease development, incidence, treatment, and outcomes of gastric and esophageal cancers.
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38789200/immune-checkpoint-inhibitors-in-esophageal-carcinoma-assessment-of-efficacy-predictors-of-response-in-clinical-trials
#4
REVIEW
Hassan Abushukair, Aya Abushukair, Meghana Singh, Anwaar Saeed
Esophageal carcinoma (EC) is among the most common causes of cancer-related deaths worldwide. Even with the improvement of multidisciplinary treatment modalities, advanced unresectable EC patients had limited systemic therapeutic options for an extended period. Recently, immune checkpoint inhibitors (ICIs) have been introduced to advanced EC management in both first-line and second-line options, as well as in postoperative settings in resectable EC after preoperative chemoradiation. Herein, the authors present a comprehensive review of clinical trials on administering ICIs in EC patients while discussing reported clinical, molecular, and immune biomarkers and their predictive value for treatment efficacy...
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38789199/updates-in-translational-science-for-esophageal-and-gastric-cancers
#5
REVIEW
Eliza D Hompe, Uma M Sachdeva
In this article, the authors summarize the current state of translational science for esophageal and gastric cancers. The available targeted therapies, immunotherapies, and recently discovered molecular targets are reviewed. The authors introduce circulating tumor deoxyribonucleic acid and its promise as a biomarker to detect disease recurrence. The authors present patient-derived organoids as a new model for studying carcinogenesis and treatment responses. Finally, we discuss the implications of organoid models for precision oncology and describe exciting new work applying gene editing technology to organoids and studying tumor-microenvironment interactions using 3-dimensional co-culture systems...
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38789198/management-of-major-complications-after-esophagectomy
#6
REVIEW
Patrick Bou-Samra, Peter J Kneuertz
Esophagectomy remains a procedure with one of the highest complication rates. Given the advances in medical and surgical management of patients and increased patient survival, the number of complications reported has increased. There are different grading systems for complications which vary based on severity or organ system, with the Esophageal Complications Consensus Group unifying them. Management involves conservative intervention and dietary modification to endoscopic interventions and surgical reintervention...
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38789197/conduit-selection-for-reconstruction-after-esophagectomy-for-esophageal-cancer
#7
REVIEW
Robert E Merritt
The reconstruction of the esophagus after esophagectomy presents many technical and management challenges to surgeons. An effective gastrointestinal conduit that replaces the resected esophagus must have adequate length to reach the upper thoracic space or the neck, have robust vascular perfusion, and provide sufficient function for an adequate swallowing mechanism. The stomach is currently the preferred conduit for esophageal reconstruction after esophagectomy. However, there are circumstances, where the stomach cannot be utilized as a conduit...
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38789196/minimally-invasive-techniques-for-gastrectomy
#8
REVIEW
Samantha M Ruff, Mary E Dillhoff
Gastric adenocarcinoma is an aggressive disease and a leading cause of cancer-related deaths worldwide. Surgery entails either a total or a subtotal gastrectomy. These complex operations carry elevated morbidity and mortality with an extended recovery time. As such, research has focused on minimizing these risks and enhancing postoperative care. Robotic surgery is a newer platform that helps overcome some of the limitations of laparoscopy through three-dimensional vision, better mobility, and improved surgeon dexterity...
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38789195/minimally-invasive-ivor-lewis-esophagectomy
#9
REVIEW
Katherine D Gray, Daniela Molena
Minimally invasive Ivor Lewis esophagectomy is a technically demanding operation that requires an experienced surgeon, assistant, and anesthesiologist. The preoperative workup should focus on the extent of disease and extent of resection required, as well as the cardiopulmonary fitness of the patient. Surgical outcomes show decreased postoperative pain, decreased morbidity largely due to a reduction in respiratory complications, and decreased length of stay. Quality metrics and 5-year overall survival are equivalent to traditional open esophagectomy...
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38789194/robotic-assisted-ivor-lewis-esophagectomy
#10
REVIEW
Cameron Stock, Ammara Watkins, Susan Moffatt-Bruce, Elliot Servais
Robotic-assisted surgery is a safe and effective approach to minimally invasive Ivor Lewis esophagectomy. Outcomes are optimized when surgeons are familiar with the fundamentals of minimally invasive surgery of the esophagus and after gaining sufficient experience with robotic surgical techniques.
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38789193/minimally-invasive-modified-mckeown-esophagectomy
#11
REVIEW
Ealaf Shemmeri, Jon O Wee
McKeown esophagectomy is a transthoracic esophagectomy with a cervical anastomosis that is an established mainstay for the management of benign and malignant esophageal pathology. It has gone through multiple modifications. The most current version utilizes robotic or minimally invasive ports through both the right chest and abdominal portions. There is decreased pain and hospital length of stay compared to the open technique. However, anastomotic leak and recurrent laryngeal nerve injury continue to occur...
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38789192/robot-assisted-minimally-invasive-transhiatal-esophagectomy-rami-the
#12
REVIEW
Joshua Watson, Rishindra M Reddy
The authors review the development and steps of the robotic-assisted minimally invasive transhiatal esophagectomy. Key goals of the robot-assisted approach have been to address some of the concerns raised about the technical challenges with the traditional open transhiatal esophagectomy while keeping most of the steps consistent with the open approach.
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38789191/endoscopic-therapies-for-early-stage-esophageal-and-gastric-cancers
#13
REVIEW
Tarek Nammour, Pari M Shah
Early detection of esophageal and gastric cancers offers the possibility of curative treatments with less-invasive interventions than traditional surgical approaches. This review highlights the main endoscopic therapeutic modalities used for early esophageal and gastric malignancies. Endoscopic resection techniques include endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD). EMR is beneficial for smaller, well-defined lesions and involves resecting the superficial layer of the mucosa...
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38789190/advances-in-diagnostic-staging-and-restaging-evaluation-of-esophageal-and-gastric-cancer
#14
REVIEW
Tamar Nobel, Smita Sihag
The initial endoscopic and staging evaluation of esophagogastric cancers must be accurate and comprehensive in order to select the optimal therapeutic plan for the patient. Esophageal and gastric cancers (and treatment paradigms) are delineated by their proximity to the cardia (within 2 cm). The most frequent and important symptom that informs the initial staging evaluation is dysphagia, which is associated with at least cT3 or locally advanced disease. Endoscopic ultrasound is often needed if earlier stage disease is suspected, preferably in combination with endoscopic mucosal or submucosal resection or fine-needle aspiration of suspicious lymph nodes to enhance staging accuracy...
July 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38401920/precision-oncology-and-cancer-surgery
#15
EDITORIAL
Jason K Sicklick
No abstract text is available yet for this article.
April 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38401919/precision-oncology-and-cancer-surgery
#16
EDITORIAL
Timothy M Pawlik
No abstract text is available yet for this article.
April 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38401918/current-multidisciplinary-lymphoma-and-myeloma-management-for-surgeons
#17
REVIEW
William B Pearse, Erin G Reid
Although there are more than 100 clinically distinct lymphoid neoplasms with varied prognoses and treatment approaches, they generally share high sensitivity to glucocorticoids, cytotoxic chemotherapy, and radiation. The disease control rates for lymphoid malignancies are higher than many solid tumors, and many are curable even when presenting with extensive involvement. Novel targeted therapies have improved disease control and cure rates for nearly all subtypes of lymphoid neoplasms. Surgical oncologists will primarily be involved in obtaining biopsies of sufficient quality to allow accurate diagnosis...
April 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38401917/precision-oncology-in-pediatric-cancer-surgery
#18
REVIEW
William G Lee, Eugene S Kim
Pediatric precision oncology has provided a greater understanding of the wide range of molecular alterations in difficult-to-treat or rare tumors with the aims of increasing survival as well as decreasing toxicity and morbidity from current cytotoxic therapies. In this article, the authors discuss the current state of pediatric precision oncology which has increased access to novel targeted therapies while also providing a framework for clinical implementation in this unique population. The authors evaluate the targetable mutations currently under investigation-with a focus on pediatric solid tumors-and discuss the key surgical implications associated with novel targeted therapies...
April 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38401916/precision-oncology-in-soft-tissue-sarcomas-and-gastrointestinal-stromal-tumors
#19
REVIEW
Adam M Fontebasso, Jeffrey D Rytlewski, Jean-Yves Blay, Rebecca A Gladdy, Breelyn A Wilky
Soft tissue sarcomas (STSs), including gastrointestinal stromal tumors (GISTs), are mesenchymal neoplasms with heterogeneous clinical behavior and represent broad categories comprising multiple distinct biologic entities. Multidisciplinary management of these rare tumors is critical. To date, multiple studies have outlined the importance of biological characterization of mesenchymal tumors and have identified key molecular alterations which drive tumor biology. GIST has represented a flagship for targeted therapy in solid tumors with the advent of imatinib which has revolutionized the way we treat this malignancy...
April 2024: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/38401915/precision-oncology-in-melanoma-and-skin-cancer-surgery
#20
REVIEW
Shoshana Levi, Hannah Bank, John Mullinax, Genevieve Boland
There has been perhaps no greater advance in the prognosis of solid tumors in the last decade than for patients with metastatic melanoma. This is due to significant improvements in treatment based on two key components of melanoma tumor biology (1) the identification of driver mutations with therapeutic potential and (2) the mechanistic understanding of a tumor-specific immune response. With breakthrough findings in such a relatively short period of time, the treatment of patients with metastatic melanoma has become intensely personalized...
April 2024: Surgical Oncology Clinics of North America
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