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JOURNAL ARTICLE
M R Schene, H C Willems, J H M Driessen, L Vranken, F O Lambers Heersprink, H M J Janzing, R Y van der Velde, J P van den Bergh, C E Wyers
UNLABELLED: Impaired physical performance is associated with increased fracture risk. Performance on four physical functioning tests and prevalence of sarcopenia were assessed for 1789 fracture patients and compared to reference data. Performance was low on all tests, especially for patients with a hip, major or ≥ 1 prevalent vertebral fracture. PURPOSE INTRODUCTION: Impaired physical performance and sarcopenia are associated with increased fracture risk...
February 13, 2024: Osteoporosis International
#42
JOURNAL ARTICLE
Kristen J Koltun, Nicole C A Strock, Connie Weaver, Hang Lee, Nancy I Williams, Connie J Rogers, Janhavi Damani, Mario G Ferruzzi, Cindy H Nakatsu, Mary Jane De Souza
UNLABELLED: Non-pharmacological therapies, such as whole-food interventions, are gaining interest as potential approaches to prevent and/or treat low bone mineral density (BMD) in postmenopausal women. Previously, prune consumption preserved two-dimensional BMD at the total hip. Here we demonstrate that prune consumption preserved three-dimensional BMD and estimated strength at the tibia. PURPOSE: Dietary consumption of prunes has favorable impacts on areal bone mineral density (aBMD); however, more research is necessary to understand the influence on volumetric BMD (vBMD), bone geometry, and estimated bone strength...
February 13, 2024: Osteoporosis International
#43
Linyuhan Zhou, Hui Zhou, Huayan Xu, Xiaomei Sun, Xiaoyong Chen, Peicong Fan, Xiaotang Cai, Qiu Wang
No abstract text is available yet for this article.
February 6, 2024: Osteoporosis International
#44
REVIEW
L Xu, T Zhao, L Perry, S A Frost, G L Di Tanna, S Wang, M Chen, G S Kolt, S Jan, L Si
Fracture liaison services (FLS) have been proven clinically effective and cost-effective in preventing subsequent fractures among patients with an existing fragility fracture. Little is known about their monetary benefits such as their return on investment (ROI). This systematic review aimed to investigate the ROI of FLS and identify the FLS characteristics with better ROI. Studies on the cost-effectiveness of FLS published between January 2000 and December 2022 were searched from MEDLINE, EMBASE, PubMed, and Cochrane Central...
February 1, 2024: Osteoporosis International
#45
REVIEW
Michael Bui, Wieke S Nijmeijer, Johannes H Hegeman, Annemieke Witteveen, Catharina G M Groothuis-Oudshoorn
Hip fractures are a global health problem with a high postoperative mortality rate. Preoperative predictors for early mortality could be used to optimise and personalise healthcare strategies. This study aimed to identify predictors for early mortality following hip fracture surgery. Cohort studies examining independent preoperative predictors for mortality following hip fracture surgery were identified through a systematic search on Scopus and PubMed. Predictors for 30-day mortality were the primary outcome, and predictors for mortality within 1 year were secondary outcomes...
April 2024: Osteoporosis International
#46
JOURNAL ARTICLE
Michael J Bennett, Jacqueline R Center, Lin Perry
UNLABELLED: Coordinating healthcare activities between fracture liaison services (FLS) and primary care is challenging. Using a Delphi technique, we developed 34 consensus statements to support improved care coordination across this healthcare transition. PURPOSE: Evidence supporting an optimal coordination strategy between fracture liaison services (FLS) and primary care is lacking. This study aimed to develop consensus statements to support consistency and benchmarking of clinical practice to improve coordination of care for patients transitioning from FLS to primary care following an osteoporotic fracture...
March 2024: Osteoporosis International
#47
REVIEW
Aliya A Khan, Maria Luisa Brandi, Eric T Rush, Dalal S Ali, Hatim Al-Alwani, Khulod Almonaei, Farah Alsarraf, Severine Bacrot, Kathryn M Dahir, Karel Dandurand, Chad Deal, Serge Livio Ferrari, Francesca Giusti, Gordon Guyatt, Erin Hatcher, Steven W Ing, Muhammad Kassim Javaid, Sarah Khan, Roland Kocijan, Agnes Linglart, Iman M'Hiri, Francesca Marini, Mark E Nunes, Cheryl Rockman-Greenberg, Christian Roux, Lothar Seefried, Jill H Simmons, Susan R Starling, Leanne M Ward, Liang Yao, Romina Brignardello-Petersen, E Michael Lewiecki
BACKGROUND: This manuscript provides a summary of the current evidence to support the criteria for diagnosing a child or adult with hypophosphatasia (HPP). The diagnosis of HPP is made on the basis of integrating clinical features, laboratory profile, radiographic features of the condition, and DNA analysis identifying the presence of a pathogenic variant of the tissue nonspecific alkaline phosphatase gene (ALPL). Often, the diagnosis of HPP is significantly delayed in both adults and children, and updated diagnostic criteria are required to keep pace with our evolving understanding regarding the relationship between ALPL genotype and associated HPP clinical features...
March 2024: Osteoporosis International
#48
JOURNAL ARTICLE
Kevin Reiland, Burkhard Haastert, Werner Arend, Birgit Klüppelholz, Joachim Windolf, Andrea Icks, Simon Thelen, Silke Andrich
UNLABELLED: We examined incidence rates (IR) for all distal radius fracture (DRF) events based on inpatient and outpatient data from a large statutory health insurance in Germany. Of all DRF, 56% were treated as inpatients, and thus, 44% treated as outpatients. IR were higher in women than in men. PURPOSE: Although a distal radius fracture (DRF) is one of the most common fractures in the elderly population, epidemiological data are limited. Many studies examine only hospitalized patients, do not analyze time trends, or include only small populations...
February 2024: Osteoporosis International
#49
JOURNAL ARTICLE
Kosuke Ebina, Yoshio Nagayama, Masafumi Kashii, Hideki Tsuboi, Gensuke Okamura, Akira Miyama, Yuki Etani, Takaaki Noguchi, Makoto Hirao, Taihei Miura, Yuji Fukuda, Takuya Kurihara, Ken Nakata, Seiji Okada
UNLABELLED: The impact of ROMO on the width of anabolic windows and the increase in BMD was reduced in the RA group compared to the non-RA group, and this reduction was associated with correlations to RA-related factors. PURPOSE: To investigate the effects of romosozumab (ROMO) in postmenopausal osteoporosis, with and without comorbid rheumatoid arthritis (RA). METHODS: In this retrospective, case-controlled, multicenter study, 171 postmenopausal patients who did not receive oral glucocorticoid, comprising 59 in the RA group and 121 in the non-RA group, received uninterrupted ROMO treatment for 12 months...
January 31, 2024: Osteoporosis International
#50
JOURNAL ARTICLE
W Yu, W-M Guan, D Hayashi, Q Lin, M-M Du, W-B Xia, Y-X J Wang, A Guermazi
UNLABELLED: We developed a new tool to assess the severity of osteoporotic vertebral fracture using radiographs of the spine. Our technique can be used in patient care by helping to stratify patients with osteoporotic vertebral fractures into appropriate treatment pathways. It can also be used for research purposes. PURPOSE: The aim of our study was to propose a semi-quantitative (SQ) grading scheme for osteoporotic vertebral fracture (OVF) on anteroposterior (AP) radiographs...
January 31, 2024: Osteoporosis International
#51
LETTER
F Cunha-Santos, D Augusto, A S Pinto, S P Dinis, N Madeira, C Vaz, J F Ferreira
No abstract text is available yet for this article.
January 29, 2024: Osteoporosis International
#52
REVIEW
Toby O Smith, Oliver Brown, Mark A Baxter
PURPOSE: This systematic review aimed to understand older people's perspectives of associated fear-avoidant beliefs following upper limb fracture. METHODS: Published and unpublished literature databases were systematically searched from inception to 1st April 2023. Qualitative studies reporting the perspectives of fear-avoidant beliefs or behaviours in people who had sustained an upper limb fracture were eligible. Data extracted included characteristics of people interviewed, experiences and perceptions of fear, fear of falling, and fear-avoidant beliefs and behaviours...
January 27, 2024: Osteoporosis International
#53
JOURNAL ARTICLE
Linyuhan Zhou, Hui Zhou, Huayan Xu, Xiaomei Sun, Xiaoyong Chen, Peicong Fan, Xiaotang Cai, Qiu Wang
UNLABELLED: Fractures often cause irreversible harm in Duchenne muscular dystrophy (DMD). This study investigated the trajectory of bone mineral density (BMD) using group-based trajectory modeling and identified that BMD acts as an early-stage indicator of clinically significant bone fragility. The greater the early-stage BMD, the better the 4-year bone health outcome. PURPOSE: Most Duchenne muscular dystrophy (DMD) children suffer bone loss after long-term glucocorticoid (GC) exposure, which induces scoliosis and fragility fractures...
January 26, 2024: Osteoporosis International
#54
JOURNAL ARTICLE
Felipe F Silva, Gisela R Machado, Ana C M Ribeiro, Karina R Bonfiglioli, Andrea Y Shimabuco, Camille P Figueiredo, Liliam M T Guerra, Valéria F Caparbo, Rosa M R Pereira, Diogo S Domiciano
UNLABELLED: We ascertained the fracture risk factors stratified by vertebral and non-vertebral sites in rheumatoid arthritis (RA) females. Bone/muscle features, but not disease activity, were the main markers for fractures in this long-standing RA population: low trabecular bone score (TBS) for vertebral fracture and decreased appendicular muscle mass for non-vertebral fracture. PURPOSE: To assess risk factors for fractures, including clinical, laboratory and dual energy X-ray absorptiometry (DXA) parameters (bone mass, trabecular bone score-TBS, muscle mass) in women with established rheumatoid arthritis (RA)...
January 25, 2024: Osteoporosis International
#55
JOURNAL ARTICLE
Masayuki Iki, Kenji Fujimori, Shinichi Nakatoh, Junko Tamaki, Shigeyuki Ishii, Nobukazu Okimoto, Hironori Imano, Sumito Ogawa
PURPOSE: Fracture risk assessment is recommended at three months after glucocorticoid (GC) therapy initiation. This study aimed to assess whether GC exposure in the initial 90 days of GC therapy is associated with subsequent hip and clinical vertebral fracture risk using the nationwide health insurance claims database of Japan (NDBJ). METHODS: Patients aged [Formula: see text] 50 years who were prescribed GC (≥ 70 mg prednisolone or equivalent; PSL) in the initial 90 days of GC therapy and were followed for hip and clinical vertebral fracture incidences for the subsequent 1080 days were selected from NDBJ...
January 24, 2024: Osteoporosis International
#56
JOURNAL ARTICLE
Seongmin Jeon, Dongwoo Yu, Sungho Kim, Sang Woo Kim, Ikchan Jeon
UNLABELLED: Teriparatide and denosumab, anti-osteoporosis medications with different mechanisms, have been widely used in the patients with osteoporotic vertebral fracture (OVF) considered as advanced osteoporosis. Teriparatide has been shown to enhance bone formation and fracture healing in OVF, but there are still no sufficient evidences discussing about the role of denosumab in newly developed OVF. In this study, we found the similar radiological deformation and functional outcomes of conservative treatment with teriparatide and denosumab in thoracolumbar (TL) OVF, and teriparatide showed a more frequent incidence of fracture union with paravertebral bone bridge formation compared to denosumab...
January 23, 2024: Osteoporosis International
#57
JOURNAL ARTICLE
Xuewei Cao, Joyce H Keyak, Sigurdur Sigurdsson, Chen Zhao, Weihua Zhou, Anqi Liu, Thomas F Lang, Hong-Wen Deng, Vilmundur Gudnason, Qiuying Sha
UNLABELLED: Hip fracture risk assessment is an important but challenging task. Quantitative CT-based patient-specific finite element (FE) analysis (FEA) incorporates bone geometry and bone density in the proximal femur. We developed a global FEA-computed fracture risk index to increase the prediction accuracy of hip fracture incidence. PURPOSE: Quantitative CT-based patient-specific finite element (FE) analysis (FEA) incorporates bone geometry and bone density in the proximal femur to compute the force (fracture load) and energy necessary to break the proximal femur in a particular loading condition...
January 22, 2024: Osteoporosis International
#58
JOURNAL ARTICLE
Seong-Eun Byun, Hasung Kim, Seung Yun Lee, Sang-Min Kim
UNLABELLED: With the analysis of nationwide health claim data, treatment with the composite agent of SERMs and vitamin D reduces the risk of osteoporotic fracture and hip fracture better compared to SERMs treatment in women with osteoporosis aged ≥ 50 years. PURPOSE: This study compared the potential of the composite agent of selective estrogen receptor modulators (SERMs) and vitamin D (SERM + VitD) with that of SERMs-only for fracture prevention and mortality reduction in women aged ≥ 50 years...
January 19, 2024: Osteoporosis International
#59
JOURNAL ARTICLE
Michael Kriegbaum Skjødt, Joeri Nicolaes, Christopher Dyer Smith, Kim Rose Olsen, Cesar Libanati, Cyrus Cooper, Bo Abrahamsen
UNLABELLED: In men and women with opportunistically identifiable vertebral fractures (VFs) on routine CT scans including the chest and/or abdomen, the risk of death is 51% higher than in those with no VF on the CT scan, and 325% higher than an age- and sex-matched general population cohort. PURPOSE: There is little knowledge about the risk of death in patients with VFs present on routine radiological imaging. We evaluated the risk of death in men and women aged 50 years or older with opportunistically identifiable VFs on routine CT scans and not treated with osteoporosis medications...
January 18, 2024: Osteoporosis International
#60
JOURNAL ARTICLE
Liesbeth Vandenput, Helena Johansson, Eugene V McCloskey, Enwu Liu, Marian Schini, Kristina E Åkesson, Fred A Anderson, Rafael Azagra, Cecilie L Bager, Charlotte Beaudart, Heike A Bischoff-Ferrari, Emmanuel Biver, Olivier Bruyère, Jane A Cauley, Jacqueline R Center, Roland Chapurlat, Claus Christiansen, Cyrus Cooper, Carolyn J Crandall, Steven R Cummings, José A P da Silva, Bess Dawson-Hughes, Adolfo Diez-Perez, Alyssa B Dufour, John A Eisman, Petra J M Elders, Serge Ferrari, Yuki Fujita, Saeko Fujiwara, Claus-Christian Glüer, Inbal Goldshtein, David Goltzman, Vilmundur Gudnason, Jill Hall, Didier Hans, Mari Hoff, Rosemary J Hollick, Martijn Huisman, Masayuki Iki, Sophia Ish-Shalom, Graeme Jones, Magnus K Karlsson, Sundeep Khosla, Douglas P Kiel, Woon-Puay Koh, Fjorda Koromani, Mark A Kotowicz, Heikki Kröger, Timothy Kwok, Olivier Lamy, Arnulf Langhammer, Bagher Larijani, Kurt Lippuner, Fiona E A McGuigan, Dan Mellström, Thomas Merlijn, Tuan V Nguyen, Anna Nordström, Peter Nordström, Terence W O'Neill, Barbara Obermayer-Pietsch, Claes Ohlsson, Eric S Orwoll, Julie A Pasco, Fernando Rivadeneira, Anne-Marie Schott, Eric J Shiroma, Kristin Siggeirsdottir, Eleanor M Simonsick, Elisabeth Sornay-Rendu, Reijo Sund, Karin M A Swart, Pawel Szulc, Junko Tamaki, David J Torgerson, Natasja M van Schoor, Tjeerd P van Staa, Joan Vila, Nicholas J Wareham, Nicole C Wright, Noriko Yoshimura, MCarola Zillikens, Marta Zwart, Nicholas C Harvey, Mattias Lorentzon, William D Leslie, John A Kanis
UNLABELLED: The relationship between self-reported falls and fracture risk was estimated in an international meta-analysis of individual-level data from 46 prospective cohorts. Previous falls were associated with an increased fracture risk in women and men and should be considered as an additional risk factor in the FRAX® algorithm. INTRODUCTION: Previous falls are a well-documented risk factor for subsequent fracture but have not yet been incorporated into the FRAX algorithm...
January 17, 2024: Osteoporosis International
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