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Osteoporosis International

D M Borek, R C Smith, C N Gruber, B L Gruber
Persistence rates over 36 months with denosumab in patients diagnosed with osteoporosis in a real-world setting were examined, along with baseline patient characteristics predictive of persistence. This study represents the longest observational period with denosumab persistence and shows higher persistence rates when compared to bisphosphonates. INTRODUCTION: The study objective was to describe long-term persistence with denosumab among patients treated for osteoporosis in a real-world setting...
April 22, 2019: Osteoporosis International
A J Arias-Moreno, H S Hosseini, M Bevers, K Ito, P Zysset, B van Rietbergen
This study developed a well-standardized and reproducible approach for micro-finite element (mFE) and homogenized-FE (hFE) analyses that can accurately predict the distal radius failure load using either mFE or hFE models when using the approaches and parameters developed in this study. INTRODUCTION: Micro-FE analyses based on high-resolution peripheral quantitative CT (HR-pQCT) images are frequently used to predict distal radius failure load. With the introduction of a second-generation HR-pQCT device, however, the default modelling approach no longer provides accurate results...
April 17, 2019: Osteoporosis International
H Taipale, J Rysä, J Hukkanen, M Koponen, A Tanskanen, J Tiihonen, H Kröger, S Hartikainen, A-M Tolppanen
We investigated the association between thiazide use and the risk of low-energy fractures among community dwellers with Alzheimer's disease. Longer use was associated with a decreased risk of low-energy fractures. This study extends the previous knowledge of reduced fracture risk of thiazides to persons with Alzheimer's disease. INTRODUCTION: To investigate the association between thiazide use and the risk of low-energy fractures (LEF), and hip fracture among community dwellers with Alzheimer's disease (AD)...
April 16, 2019: Osteoporosis International
M Ma, D-G Huang, X Liang, L Zhang, S Cheng, B Cheng, X Qi, P Li, Y Du, L Liu, Y Zhao, M Ding, Y Wen, X Guo, F Zhang
To scan novel candidate genes associated with osteoporosis, a two-stage transcriptome-wide association study (TWAS) of bone mineral density (BMD) was conducted. The BMD-associated genes identified by TWAS were then compared with the gene expression profiling of BMD in bone cells, B cells, and mesenchymal stem cells. We identified multiple candidate genes and gene ontology (GO) terms associated with BMD. INTRODUCTION: Osteoporosis (OP) is a metabolic bone disease characterized by decrease in BMD...
April 15, 2019: Osteoporosis International
I Tamimi, B Nicolau, H Eimar, S Arekunnath Madathil, A Kezouh, I Karp, F Tamimi
Please find below the correction for the paragraph under the Heading "Materials and methods - Regulatory approval".
April 15, 2019: Osteoporosis International
C Nypaver, J Bernstein, S Mehta
There have been case reports of proximal femur insufficiency fractures in patients who have previously undergone bariatric surgery. We present a follow-up case of a patient who developed bilateral complete proximal femur insufficiency fractures several years after bariatric surgery. Our patient underwent bilateral intramedullary fixation with a satisfactory postoperative outcome. We review and discuss the definition and pathogenesis of atypical femur fractures (AFFs), which may represent a larger category of insufficiency fractures not exclusive to bisphosphonate use, which includes patients with fractures after bariatric surgery...
April 11, 2019: Osteoporosis International
J Zhang, T Zhang, X Xu, Q Cai, D Zhao
We performed a 1-year prospective study to see whether zoledronic acid infusion combined with percutaneous kyphoplasty could provide more benefits in the treatment of T12 or L1 osteoporotic vertebral compression fracture (OVCF). INTRODUCTION: To investigate and analyze the clinical effects of zoledronic acid (ZOL) in combination with percutaneous kyphoplasty (PKP) in the treatment of OVCF in postmenopausal women. METHODS: Included in this study were 101 postmenopausal women patients with T12 or L1 OVCF who received PKP in our hospital between August 2015 and July 2017...
April 11, 2019: Osteoporosis International
T T Shi, M Min, Y Zhang, C Y Sun, M M Liang, Y H Sun
Recently published studies on the association between depression and hip fracture (HF) are inconsistent. Therefore, we performed this meta-analysis with the main aim to clarify the association between depression and HF, and also to identify possible susceptible groups. Relevant literature published until February 2019 was obtained and screened according to established inclusion criteria. Two researchers independently processed quality assessment and data extraction prior to the meta-analysis. Pooled hazard ratios (HRs) with 95%CI (confidence intervals) were calculated...
April 11, 2019: Osteoporosis International
T Jiang, B J Wei, D X Zhang, L Li, G L Qiao, X A Yao, Z W Chen, X Liu, X Y Du
Diagnosis of parathyroid carcinoma on histological examination is challenging. Thousands of differentially expressed lncRNAs were identified on the microarray data between parathyroid cancer and adenoma samples. Four lncRNAs were significantly dysregulated in further validation. The "lncRNA score" calculated from these lncRNAs differentiated parathyroid carcinomas from adenomas. LncRNAs serve as biomarkers for parathyroid cancer diagnosis. INTRODUCTION: Diagnosis of parathyroid carcinoma (PC) on histological examination is challenging...
April 10, 2019: Osteoporosis International
J -Y Reginster, F Bianic, R Campbell, M Martin, S A Williams, L A Fitzpatrick
This network meta-analysis assessed the efficacy of abaloparatide versus other treatment options to reduce the risk of fractures in women with postmenopausal osteoporosis. The analysis indicates that abaloparatide reduces the risk of fractures in women with postmenopausal osteoporosis versus placebo and compared with other treatment options. INTRODUCTION: This network meta-analysis (NMA) assessed the relative efficacy of abaloparatide versus other treatments to reduce the risk of fractures in women with postmenopausal osteoporosis (PMO)...
April 6, 2019: Osteoporosis International
Y H Roh, E S Lee, J Ahn, H S Kim, H S Gong, K H Baek, H Y Chung
Individuals with poor knowledge of osteoporosis and lower socioeconomic status, including being single and having a lower level of annual income, are less likely to be assessed or treated for osteoporosis. Individuals with particular osteoporosis risk factors such as smokers and heavy drinkers are overlooked for diagnosis. Further study is needed to identify and address the existing barriers and to promote osteoporosis management for women with these risk factors. INTRODUCTION: Despite the negative health consequences of osteoporosis and the availability of effective treatment, a pervasive and persistent prevention care gap for osteoporosis remains present throughout the world...
April 3, 2019: Osteoporosis International
T-C Li, C-C Lin
No abstract text is available yet for this article.
April 2, 2019: Osteoporosis International
K Fischer, M Trombik, G Freystätter, A Egli, R Theiler, H A Bischoff-Ferrari
We investigated the timeline of functional recovery after hip fracture over 12 months in adults age ≥ 65 years using objective lower extremity function tests and subjective physical functioning. Objective functional recovery was largely complete in the first 6 months, whereas subjective recovery improved up to 9 months after hip fracture. INTRODUCTION: Hip fractures are a major cause of loss of function among seniors. We assessed the timeline of objective and subjective functional recovery after hip fracture...
April 2, 2019: Osteoporosis International
B E Keenan, S L Evans
A variety of hip protectors are available, but it is not clear which is the most effective and there is no standard test to evaluate their performance. This is the first study that uses a standard mechanical test on hip protectors. Some protectors perform well but others are almost ineffective, providing little to no protection to the wearer during a fall. INTRODUCTION: Each year, over 70,000 patients are admitted to hospital in the UK with hip fractures. There are a variety of commercial hip protectors currently available...
April 2, 2019: Osteoporosis International
M Nagai, K Dote, M Kato
No abstract text is available yet for this article.
April 1, 2019: Osteoporosis International
L Beaupre, B Sobolev, P Guy, J D Kim, L Kuramoto, K J Sheehan, J M Sutherland, E Harvey, S N Morin
Little is known about post-acute care following hip fracture surgery. We investigated discharge destinations from surgical hospitals for nine Canadian provinces. We identified significant heterogeneity in discharge patterns across provinces suggesting different post-acute recovery pathways. Further work is required to determine the impact on patient outcomes and health system costs. INTRODUCTION: To examine discharge destinations by provinces in Canada, adjusting for patient, injury, and care characteristics...
April 1, 2019: Osteoporosis International
A Salari-Moghaddam, O Sadeghi, A H Keshteli, B Larijani, A Esmaillzadeh
INTRODUCTION: No study is available summarizing earlier publications on the association between metformin use and risk of fracture. This systematic review and meta-analysis were conducted to summarize earlier findings on the association between metformin use and risk of fracture. METHODS: We conducted a systematic search on all published articles up to October 2018 using online databases including PubMed/Medline, ISI Web of Science, and Scopus. Observational studies that considered metformin use as the exposure variable and bone fracture as the main outcome variable or as one of the outcome variables and participants included were 18 years and older were included in the systematic review...
March 29, 2019: Osteoporosis International
A A Khan, R Josse, P Kannu, J Villeneuve, T Paul, S V Uum, C R Greenberg
Hypophosphatasia (HPP) is a rare inherited disorder of bone and mineral metabolism caused by loss of function mutations in the ALPL gene. The presentation in children and adults can be extremely variable and natural history is poorly understood particularly in adults. Careful patient evaluation is required with consideration of pharmacologic intervention in individuals meeting criteria for therapy. INTRODUCTION: The purposes of this review are to present current evidence regarding the diagnosis and management of hypophosphatasia in children and adults and provide evidence-based recommendations for management...
March 26, 2019: Osteoporosis International
M K Kwak, E J Lee, J W Park, S Y Park, B -J Kim, T H Kim, K Suh, J -M Koh, S H Lee, D -W Byun
HIV-infected men under the age of 50 years had a lower bone mass compared to that of HIV-uninfected men. Lower CD4 T cell counts, independent of whether antiretroviral therapy (ART) was used, were associated with lower BMD. HIV-infected patients with low CD4 T cell counts may need follow-up and intervention regarding bone health, including younger patients. INTRODUCTION: HIV-infected patients have a low bone mineral density (BMD) owing to multifactorial interaction between common osteoporosis risk factors and HIV-related factors, including chronic inflammation and ART...
March 26, 2019: Osteoporosis International
M P Høiberg, K H Rubin, T Holmberg, M J Rothmann, S Möller, J Gram, M Bech, K Brixen, A P Hermann
Use of antiosteoporotic medication in the population-based, risk-stratified osteoporosis strategy evaluation (ROSE) screening study, comparing the use of FRAX followed by DXA with usual care, was examined. Screening increased the overall use of medication. Being recommended treatment by the hospital and higher age increased the likelihood of starting medication, but, nevertheless, a large percentage opted not to start treatment. INTRODUCTION: The aim of the study was to examine the impact on medication prescription, adherence, and persistence of osteoporotic medicine in the randomized population-based ROSE screening study for osteoporosis...
March 26, 2019: Osteoporosis International
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