journal
https://read.qxmd.com/read/38760504/nutritional-status-as-independent-prognostic-factor-of-outcome-and-mortality-until-five-years-after-hip-fracture-a-comprehensive-prospective-study
#1
JOURNAL ARTICLE
P C Dagnelie, P C Willems, N R Jørgensen
UNLABELLED: We determined the prognostic value of nutritional status for outcome after hip fracture. Nutritional status was a strong independent prognostic factor for clinical outcome and 5-year mortality. Physical function showed incomplete recovery. Elderly care should focus on prevention already before hip fracture. PURPOSE: To determine the prognostic value of nutritional status in hip fracture patients for multiple clinical and functional outcomes over 6 months, and for new fractures and survival over 5 years post-fracture...
May 17, 2024: Osteoporosis International
https://read.qxmd.com/read/38760503/osteoporosis-management-in-adults-with-schizophrenia-following-index-hip-fracture-event-a-10-year-population-based-retrospective-cohort-study-ontario-canada
#2
JOURNAL ARTICLE
H Ansari, S Jaglal, A M Cheung, R Jain, J Weldon, P Kurdyak
UNLABELLED: Little is known about the incidence of osteoporosis testing and treatment in individuals with schizophrenia, who may be more likely to fracture. Using competing risk models, we found that schizophrenia was associated with lower incidence of testing or treatment. Implications are for understanding barriers and solutions for this disadvantaged group. PURPOSE: Evidence suggests that individuals with schizophrenia may be more likely to experience hip fractures than the general population; however, little is known about osteoporosis management in this disadvantaged subpopulation...
May 17, 2024: Osteoporosis International
https://read.qxmd.com/read/38750265/comment-on-byun-et-al-the-effect-of-teriparatide-on-fracture-healing-after-atypical-femoral-fracture-a-systematic-review-and-meta-analysis
#3
LETTER
Yuya Takakubo, Takahiro Miyaji, Daichi Ota, Takehiro Takahashi, Hiroharu Oki, Takeshi Sameshima, Takaaki Nagase, Masashi Aso, Juji Ito, Kan Sasaki, Masaji Ishii, Michiaki Takagi
No abstract text is available yet for this article.
May 15, 2024: Osteoporosis International
https://read.qxmd.com/read/38748216/the-association-between-myasthenia-gravis-and-risk-of-fracture-a-systematic-review-and-meta-analysis
#4
REVIEW
Chien-Ju Lin, Yu-Shan Lee, Jiann-Horng Yeh, Shu-Jung Liu, Kuan-Yu Lin
Patients with myasthenia gravis (MG), because of their muscle weakness and exposure to corticosteroids treatment, are generally considered to be at increased risk for osteoporosis or fracture. However, clinical evidence of this issue is lacking. In this review, we systematically searched databases, including Cochrane Library, PubMed, Embase, and Airiti library from inception to the end of November 2023 for cohort studies that compared participants with MG and participants without MG for incidence of osteoporosis or fracture...
May 15, 2024: Osteoporosis International
https://read.qxmd.com/read/38740589/examining-treatment-targets-and-equity-in-bone-active-medication-use-within-secondary-fracture-prevention-a-systematic-review-and-meta-analysis
#5
REVIEW
Anum Ali, Ella Huszti, Shahryar Noordin, Usman Ali, Joanna E M Sale
PURPOSE: This systematic review seeks to evaluate the proportion of fragility fracture patients screened in secondary fracture prevention programs who were indicated for pharmacological treatment, received prescriptions for bone-active medications, and initiated the prescribed medication. Additionally, the study aims to analyze equity in pharmacological treatment by examining equity-related variables including age, sex, gender, race, education, income, and geographic location. METHODS: We conducted a systematic review to ascertain the proportion of fragility fracture patients indicated for treatment who received prescriptions and/or initiated bone-active medication through secondary fracture prevention programs...
May 14, 2024: Osteoporosis International
https://read.qxmd.com/read/38733394/denosumab-vs-bisphosphonates-in-primary-osteoporosis-a-meta-analysis-of-comparative-safety-in-randomized-controlled-trials
#6
REVIEW
Takaomi Kobayashi, Tadatsugu Morimoto, Koji Ito, Masaaki Mawatari, Takafumi Shimazaki
Denosumab and bisphosphonates for primary osteoporosis are generally well-tolerated, but their comparative safety remains unclear. We aimed to explore the comparative safety of denosumab and bisphosphonates in primary osteoporosis. Databases such as PubMed and Google Scholar were searched for relevant peer-reviewed randomized controlled trials published in English (as of December 2023). Trials comparing adverse events (AE) between denosumab and bisphosphonates in patients with primary osteoporosis were investigated...
May 11, 2024: Osteoporosis International
https://read.qxmd.com/read/38733393/association-of-depressive-symptoms-with-incident-fractures-the-japan-public-health-center-based-prospective-study-for-the-next-generation-jphc-next
#7
JOURNAL ARTICLE
Yayoi Funakoshi, Koutatsu Maruyama, Tadahiro Kato, Isao Saito, Nobuyuki Takanashi, Kozo Tanno, Kazumasa Yamagishi, Isao Muraki, Nobufumi Yasuda, Kazuhiko Arima, Hiroki Nakashima, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane, Norie Sawada
UNLABELLED: This 5-year longitudinal study investigated the relationship between depressive symptoms and fracture risk in a large Japanese cohort. Depressive symptoms were a significant risk factor for hip fractures in women. PURPOSE: A relationship between depressive symptoms and fractures has not been clearly demonstrated. We aimed to investigate the relationship between depressive symptoms and 5-year fracture risk in the Japan Public Health Center-based Prospective Study for the Next Generation...
May 11, 2024: Osteoporosis International
https://read.qxmd.com/read/38717498/beneficial-effects-of-romosozumab-on-bone-mineral-density-and-trabecular-bone-score-assessed-by-dual-energy-x-ray-absorptiometry-in-a-family-with-osteogenesis-imperfecta
#8
LETTER
Toru Kusakabe, Yuki Ishihara, Takuya Kitamura, Akihiro Yasoda, Kazutaka Nanba, Mika Tsuiki, Noriko Satoh-Asahara, Tetsuya Tagami
No abstract text is available yet for this article.
May 8, 2024: Osteoporosis International
https://read.qxmd.com/read/38713246/enhanced-fracture-risk-prediction-a-novel-multi-trait-genetic-approach-integrating-polygenic-scores-of-fracture-related-traits
#9
JOURNAL ARTICLE
Xiangxue Xiao, Qing Wu
UNLABELLED: The novel metaPGS, integrating multiple fracture-related genetic traits, surpasses traditional polygenic scores in predicting fracture risk. Demonstrating a robust association with incident fractures, this metaPGS offers significant potential for enhancing clinical fracture risk assessment and tailoring prevention strategies. INTRODUCTION: Current polygenic scores (PGS) have limited predictive power for fracture risk. To improve genetic prediction, we developed and evaluated a novel metaPGS combining genetic information from multiple fracture-related traits...
May 7, 2024: Osteoporosis International
https://read.qxmd.com/read/38703219/osteoporosis-and-fracture-risk-assessment-in-adults-with-ischaemic-stroke
#10
JOURNAL ARTICLE
Basil Liu, Chrislyn Yan Ng, Paul Bao Duy La, Phillip Wong, Peter R Ebeling, Shaloo Singhal, Thanh Phan, Anne Trinh, Frances Milat
PURPOSE: To study the prevalence of osteoporosis, falls and fractures in adults with ischaemic stroke. METHODS: Observational cohort study of adults aged ≥ 50 years admitted with ischaemic stroke over a 12-month period were invited to participate in a telephone interview one-year post-stroke to ascertain falls and fracture. A Fracture Risk After Ischaemic Stroke (FRAC-stroke) score was calculated. RESULTS: Of the 1267 patients admitted to the stroke unit between 1 January 2020 and 31 December 2020, 624 had a modified Rankin Score documented...
May 4, 2024: Osteoporosis International
https://read.qxmd.com/read/38658459/refracture-and-mortality-risk-in-the-elderly-with-osteoporotic-fractures-the-ages-reykjavik-study
#11
JOURNAL ARTICLE
Anitha D Praveen, Thor Aspelund, Stephen J Ferguson, Sigurður Sigurðsson, Vilmundur Guðnason, Halldór Pálsson, David Matchar, Benedikt Helgason
UNLABELLED: There is imminent refracture risk in elderly individuals for up to six years, with a decline thereafter except in women below 75 who face a constant elevated risk. Elderly men with fractures face the highest mortality risk, particularly those with hip and vertebral fractures. Targeted monitoring and treatment strategies are recommended. PURPOSE: Current management and interventions for osteoporotic fractures typically focus on bone mineral density loss, resulting in suboptimal evaluation of fracture risk...
April 24, 2024: Osteoporosis International
https://read.qxmd.com/read/38653862/treatment-patterns-in-women-with-postmenopausal-osteoporosis-using-abaloparatide-a-real-world-observational-study
#12
JOURNAL ARTICLE
Deborah T Gold, Tammy Beckett, Chad Deal, Andrew L James, Mahshid Mohseni, Abigail McMillan, Tom Bailey, Leny Pearman, John Caminis, Yamei Wang, Setareh A Williams, Jacqueline M Kernaghan
UNLABELLED: Review of medical records from 173 women with osteoporosis who received abaloparatide treatment revealed that 96.0% had at least one visit for osteoporosis management and 55.5% had medication support group access. The most common reasons for discontinuing treatment were financial (31.2%) and tolerability (22.8%). Most patients (64.8%) completed treatment as prescribed. PURPOSE: Abaloparatide is approved for the treatment of women with postmenopausal osteoporosis at high risk for fracture...
April 24, 2024: Osteoporosis International
https://read.qxmd.com/read/38652313/secondary-fracture-prevention-in-primary-care-a-narrative-review
#13
REVIEW
Mawson Wang, Markus J Seibel
The global burden of osteoporosis continues to rise with an ageing population. Untreated osteoporotic fractures not only heighten the risk of subsequent fractures but are associated with excess mortality. Although primary care guidelines consistently stress the importance of secondary fracture prevention, fewer than 20% of patients are appropriately treated for osteoporosis following an initial osteoporotic fracture. This worldwide phenomenon is known as the osteoporosis care gap. This literature review examines the barriers to secondary fracture prevention in primary care and evaluates the effectiveness of targeted primary care interventions...
April 23, 2024: Osteoporosis International
https://read.qxmd.com/read/38625381/clinical-features-treatment-and-follow-up-of-oppg-and-high-bone-mass-disorders-lrp5-is-a-key-regulator-of-bone-mass
#14
JOURNAL ARTICLE
Na Ren, Shanshan Lv, Xiang Li, Chong Shao, Ziyuan Wang, Yazhao Mei, Wendi Yang, Wenzhen Fu, Yunqiu Hu, Ling Sha, Weiwei Hu, Zhenlin Zhang, Chun Wang
UNLABELLED: Osteoporosis-pseudoglioma syndrome (OPPG) and LRP5 high bone mass (LRP5-HBM) are two rare bone diseases with opposite clinical symptoms caused by loss-of-function and gain-of-function mutations in LRP5. Bisphosphonates are an effective treatment for OPPG patients. LRP5-HBM has a benign course, and age-related bone loss is found in one LRP5-HBM patient. PURPOSE: Low-density lipoprotein receptor-related protein 5 (LRP5) is involved in the canonical Wnt signaling pathway...
April 16, 2024: Osteoporosis International
https://read.qxmd.com/read/38622263/family-caregiver-influence-on-osteoporosis-management-for-older-people-an-integrative-review
#15
REVIEW
Paula Zubick, Sherry Dahlke
An integrative literature review was conducted to understand family/caregiver influence on osteoporosis management for older people. Findings include caregivers' overprotection, caregivers' risks for fragility fractures due to caregiving role, poor bone health in caregivers, and caregivers' burden and facilitators. Caregivers should be included in bone health and discharge planning. Literature on family/caregiver influence on osteoporosis management for older people is sparse. Older people are prone to osteoporosis and fragility fractures due to their age, often triggering the need for a caregiver after experiencing a fragility fracture...
April 15, 2024: Osteoporosis International
https://read.qxmd.com/read/38619605/the-cost-effectiveness-of-osteoporosis-medications-for-preventing-periprosthetic-fractures-following-femoral-neck-fracture-indicated-hip-arthroplasty-a-break-even-analysis
#16
JOURNAL ARTICLE
Amil R Agarwal, Matthew J Kinnard, Christopher Murdock, Amy Y Zhao, Uzoma Ahiarakwe, Jordan S Cohen, Kendall F Moseley, Gregory J Golladay, Savyasachi C Thakkar
UNLABELLED: Osteoporosis treatment following arthroplasty for femoral neck fracture (FNF) is associated with lower rates of periprosthetic fracture (PPF). Our study evaluated the economic viability of treatment in patients following arthroplasty and demonstrates that treatment with oral bisphosphonates can be cost-effective in preventing PPF. INTRODUCTION: Osteoporosis treatment following arthroplasty for femoral neck fracture (FNF) is associated with lower rates of periprosthetic fracture (PPF)...
April 15, 2024: Osteoporosis International
https://read.qxmd.com/read/38613637/delayed-and-significant-hypercalcaemia-due-to-teriparatide-therapy-a-case-report-and-review
#17
JOURNAL ARTICLE
K McCarroll, T Carroll, M Neville, D Fitzpatrick, R Lannon
INTRODUCTION: Transient hypercalcaemia due to teriparatide occurs in up to 11% of patients though delayed hypercalcaemia (> 24 h post injection) is rare. We report the case of a female who developed significant delayed hypercalcaemia after teriparatide treatment for osteoporosis and review other cases in the literature to date. CASE REPORT: A 72-year-old female on teriparatide for the treatment of osteoporosis was found to have hypercalcaemia (3.30 mmol/l) on routine testing approximately 3 months after starting therapy...
April 13, 2024: Osteoporosis International
https://read.qxmd.com/read/38607417/higher-prevalence-of-thyroid-specific-autoantibodies-tpoab-and-tgab-is-related-to-a-higher-prevalence-of-fractures-in-females-results-from-nhanes-2007-2010
#18
JOURNAL ARTICLE
Jialu Wu, Jian Li, Zhe Yan, Xijie Yu, Hui Huang
UNLABELLED: A retrospective analysis was conducted using data from the NHANES. Bone mineral density (BMD) was compared in different thyroid-specific autoantibodies groups. Strengths of associations were calculated by using binary logistic regression models. Higher titers of thyroid-specific autoantibodies (TgAb and/or TPOAb) may lead to decreased BMD. Higher prevalence of TgAb and TPOAb significantly associated with fractures in females but not in males. PURPOSE: Hashimoto's thyroiditis is characterized by elevated thyroid-specific autoantibodies...
April 12, 2024: Osteoporosis International
https://read.qxmd.com/read/38587675/association-of-bone-fracture-with-30-year-body-mass-index-bmi-trajectories-findings-from-the-framingham-heart-study-bone-fracture-and-30-year-bmi-trajectories
#19
JOURNAL ARTICLE
Zihao Xin, Hanfei Xu, Xiaoyu Zhang, Elizabeth J Samelson, Douglas P Kiel, Ching-Ti Liu
UNLABELLED: A knowledge gap exists in associating later life's osteoporotic fracture and middle adulthood's BMI trajectories. We observed an association showing those transitioning from overweight to normal weight face a higher fracture risk in late adulthood, emphasizing the potential benefits of maintaining a stable BMI to reduce late-life fractures. PURPOSE: Numerous studies on the relationship between obesity and fractures have relied on body mass index (BMI) at a single time point, yielding inconclusive results...
April 8, 2024: Osteoporosis International
https://read.qxmd.com/read/38587674/impact-of-osteoporosis-and-osteoporosis-medications-on-fracture-healing-a-narrative-review
#20
REVIEW
M Chandran, K E Akesson, M K Javaid, N Harvey, R D Blank, M L Brandi, T Chevalley, P Cinelli, C Cooper, W Lems, G P Lyritis, P Makras, J Paccou, D D Pierroz, M Sosa, T Thomas, S Silverman
UNLABELLED: Antiresorptive medications do not negatively affect fracture healing in humans. Teriparatide may decrease time to fracture healing. Romosozumab has not shown a beneficial effect on human fracture healing. BACKGROUND: Fracture healing is a complex process. Uncertainty exists over the influence of osteoporosis and the medications used to treat it on fracture healing. METHODS: Narrative review authored by the members of the Fracture Working Group of the Committee of Scientific Advisors of the International Osteoporosis Foundation (IOF), on behalf of the IOF and the Société Internationale de Chirurgie Orthopédique et de Traumatologie (SICOT)...
April 8, 2024: Osteoporosis International
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