journal
https://read.qxmd.com/read/38040857/geographic-variation-in-bone-mineral-density-and-prevalent-fractures-in-the-canadian-longitudinal-study-on-aging
#1
JOURNAL ARTICLE
N Hassanabadi, C Berger, A Papaioannou, A M Cheung, E Rahme, W D Leslie, D Goltzman, S N Morin
UNLABELLED: Awareness of the prevalence of osteoporosis and fractures across jurisdictions can guide the development of local preventive programs and healthcare policies. We observed geographical variations in total hip bone mineral density and in the prevalence of major osteoporotic fractures across Canadian provinces, which persisted after adjusting for important covariates. PURPOSE: We aimed to describe sex-specific total hip bone mineral density (aBMD) and prevalent major osteoporotic fractures (MOF) variation between Canadian provinces...
December 2, 2023: Osteoporosis International
https://read.qxmd.com/read/38032495/correction-to-secular-trends-of-incidence-and-hospitalization-cost-of-hip-fracture-in-tangshan-china
#2
X-L Hou, J-Y Liu, X-H Fan, N Zhang, G-L Cao, Z-B Guo, Y-Y Zhang, Y-H Yu, Y-Q Tian, X-X Sun, F-M Tian
No abstract text is available yet for this article.
November 30, 2023: Osteoporosis International
https://read.qxmd.com/read/38030857/effect-of-gender-on-the-evolution-of-pain-and-quality-of-life-after-treatment-of-symptomatic-vertebral-fragility-fractures
#3
JOURNAL ARTICLE
Pilar Peris, Jordi Blasco, Ana Monegal, Helena Florez, Núria Guañabens, Josep Lluis Carrasco
UNLABELLED: The evolution of pain and quality of life after a symptomatic vertebral fracture differs according to patient gender, with a worse evolution in women independently of the treatment received. PURPOSE: In a previous randomized clinical study comparing the effect of vertebroplasty (VP) vs. conservative therapy (CT) on pain evolution and quality of life (QoL) of patients with symptomatic vertebral fractures (VF), we observed the development of chronic back pain in 23% of subjects, independently of the therapy received...
November 30, 2023: Osteoporosis International
https://read.qxmd.com/read/37996546/systematic-review-and-meta-analysis-of-preoperative-predictors-for-early-mortality-following-hip-fracture-surgery
#4
REVIEW
Michael Bui, Wieke S Nijmeijer, Johannes H Hegeman, Annemieke Witteveen, Catharina G M Groothuis-Oudshoorn
Hip fractures are a global health problem with a high postoperative mortality rate. Preoperative predictors for early mortality could be used to optimise and personalise healthcare strategies. This study aimed to identify predictors for early mortality following hip fracture surgery. Cohort studies examining independent preoperative predictors for mortality following hip fracture surgery were identified through a systematic search on Scopus and PubMed. Predictors for 30-day mortality were the primary outcome, and predictors for mortality within 1 year were secondary outcomes...
November 24, 2023: Osteoporosis International
https://read.qxmd.com/read/37993691/hypophosphatasia-presentation-and-response-to-asfotase-alfa
#5
JOURNAL ARTICLE
F Alsarraf, D S Ali, K Almonaei, H Al-Alwani, A A Khan, M L Brandi
UNLABELLED: Hypophosphatasia (HPP) is a rare bone disease with limited scientific evidence on the tolerability and safety of its novel treatment, Asfotase Alfa (AA). We report 7 HPP patients' heterogenous presentations and the significant improvement in various clinical outcomes attained with AA shedding light on this highly effective and safe therapy. INTRODUCTION: Hypophosphatasia (HPP) is a rare inherited metabolic bone disorder characterized by a deficiency in the tissue non-specific alkaline phosphatase (TNSALP) due to loss of function mutation in the ALPL gene...
November 23, 2023: Osteoporosis International
https://read.qxmd.com/read/37982857/hypophosphatasia%C3%A2-diagnosis-current-state-of-the-art-and-proposed-diagnostic-criteria-for-children-and-adults
#6
REVIEW
Aliya A Khan, Maria Luisa Brandi, Eric T Rush, Dalal S Ali, Hatim Al-Alwani, Khulod Almonaei, Farah Alsarraf, Severine Bacrot, Kathryn M Dahir, Karel Dandurand, Chad Deal, Serge Livio Ferrari, Francesca Giusti, Gordon Guyatt, Erin Hatcher, Steven W Ing, Muhammad Kassim Javaid, Sarah Khan, Roland Kocijan, Agnes Linglart, Iman M'Hiri, Francesca Marini, Mark E Nunes, Cheryl Rockman-Greenberg, Christian Roux, Lothar Seefried, Jill H Simmons, Susan R Starling, Leanne M Ward, Liang Yao, Romina Brignardello-Petersen, E Michael Lewiecki
BACKGROUND: This manuscript provides a summary of the current evidence to support the criteria for diagnosing a child or adult with hypophosphatasia (HPP). The diagnosis of HPP is made on the basis of integrating clinical features, laboratory profile, radiographic features of the condition, and DNA analysis identifying the presence of a pathogenic variant of the tissue nonspecific alkaline phosphatase gene (ALPL). Often, the diagnosis of HPP is significantly delayed in both adults and children, and updated diagnostic criteria are required to keep pace with our evolving understanding regarding the relationship between ALPL genotype and associated HPP clinical features...
November 20, 2023: Osteoporosis International
https://read.qxmd.com/read/37982856/the-challenge-of-hypophosphatasia-diagnosis-in-adults-results-from-the-hpp-international-working-group-literature-surveillance
#7
REVIEW
Maria Luisa Brandi, Aliya A Khan, Eric T Rush, Dalal S Ali, Hatim Al-Alwani, Khulod Almonaei, Farah Alsarraf, Severine Bacrot, Kathryn M Dahir, Karel Dandurand, Chad Deal, Serge Livio Ferrari, Francesca Giusti, Gordon Guyatt, Erin Hatcher, Steven W Ing, Muhammad Kassim Javaid, Sarah Khan, Roland Kocijan, E Michael Lewiecki, Agnes Linglart, Iman M'Hiri, Francesca Marini, Mark E Nunes, Cheryl Rockman-Greenberg, Lothar Seefried, Jill H Simmons, Susan R Starling, Leanne M Ward, Liang Yao, Romina Brignardello-Petersen, Christian Roux
Hypophosphatasia (HPP) is an inborn error of metabolism caused by reduced or absent activity of the tissue non-specific alkaline phosphatase (TNSALP) enzyme, resulting from pathogenic variants in the ALPL gene. Clinical presentation of HPP is highly variable, including lethal and severe forms in neonates and infants, a benign perinatal form, mild forms manifesting in adulthood, and odonto-HPP. Diagnosis of HPP remains a challenge in adults, as signs and symptoms may be mild and non-specific. Disease presentation varies widely; there are no universal signs or symptoms, and the disease often remains underdiagnosed or misdiagnosed, particularly by clinicians who are not familiar with this rare disorder...
November 20, 2023: Osteoporosis International
https://read.qxmd.com/read/37982855/proposed-diagnostic-criteria-for-the-diagnosis-of-hypophosphatasia-in-children-and-adolescents-results-from-the-hpp-international-working-group
#8
REVIEW
Eric Rush, Maria Luisa Brandi, Aliya Khan, Dalal S Ali, Hatim Al-Alwani, Khulod Almonaei, Farah Alsarraf, Severine Bacrot, Kathryn M Dahir, Karel Dandurand, Chad Deal, Serge Livio Ferrari, Francesca Giusti, Gordon Guyatt, Erin Hatcher, Steven W Ing, Muhammad Kassim Javaid, Sarah Khan, Roland Kocijan, E Michael Lewiecki, Agnes Linglart, Iman M'Hiri, Francesca Marini, Mark E Nunes, Cheryl Rockman-Greenberg, Christian Roux, Lothar Seefried, Susan R Starling, Leanne Ward, Liang Yao, Romina Brignardello-Petersen, Jill H Simmons
Hypophosphatasia (HPP) is a rare inborn error of metabolism that presents variably in both age of onset and severity. HPP is caused by pathogenic variants in the ALPL gene, resulting in low activity of tissue nonspecific alkaline phosphatase (TNSALP). Patients with HPP tend have a similar pattern of elevation of natural substrates that can be used to aid in diagnosis. No formal diagnostic guidelines currently exist for the diagnosis of this condition in children, adolescents, or adults. The International HPP Working Group is a comprised of a multidisciplinary team of experts from Europe and North America who have expertise in the diagnosis and management of patients with HPP...
November 20, 2023: Osteoporosis International
https://read.qxmd.com/read/37980284/deprescribing-bisphosphonates-for-older-adults-with-dementia-perspectives-of-caregivers
#9
JOURNAL ARTICLE
Joshua D Niznik, Casey J Kelley, Lauren Fasth, Cathleen Colón-Emeric, Carolyn T Thorpe, Meredith A Gilliam, Jennifer L Lund, Laura C Hanson
UNLABELLED: Little is known about caregivers' perspectives on deprescribing bisphosphonates for older adults with dementia. Caregivers agreed that fracture prevention was important for maintaining functional independence but acknowledged that changing goals of care may justify deprescribing. Conversations grounded in "what matters most" can align fracture prevention treatment with goals of care. PURPOSE: The long-term fracture prevention benefits of bisphosphonates may begin to be overshadowed by the potential burden of adverse effects and polypharmacy for older adults living with dementia as the disease progresses...
November 18, 2023: Osteoporosis International
https://read.qxmd.com/read/37955683/patients-preferences-for-fracture-risk-communication-the-risk-communication-in-osteoporosis-rico-study
#10
JOURNAL ARTICLE
Charlotte Beaudart, Mitali Sharma, Patricia Clark, Saeko Fujiwara, Jonathan D Adachi, Osvaldo D Messina, Suzanne N Morin, Lynn A Kohlmeier, Caroline B Sangan, Xavier Nogues, Griselda Adriana Cruz-Priego, Andrea Cavallo, Fiona Cooper, Jamie Grier, Carolyn Leckie, Diana Montiel-Ojeda, Alexandra Papaioannou, Nele Raskin, Leonardo Yurquina, Michelle Wall, Olivier Bruyère, Annelies Boonen, Elaine Dennison, Nicholas C Harvey, John A Kanis, Jean-François Kaux, E Michael Lewiecki, Oscar Lopez-Borbon, Zoé Paskins, Jean-Yves Reginster, Stuart Silverman, Mickaël Hiligsmann
UNLABELLED: The RICO study indicated that most patients would like to receive information regarding their fracture risk but that only a small majority have actually received it. Patients globally preferred a visual presentation of fracture risk and were interested in an online tool showing the risk. PURPOSE: The aim of the Risk Communication in Osteoporosis (RICO) study was to assess patients' preferences regarding fracture risk communication. METHODS: To assess patients' preferences for fracture risk communication, structured interviews with women with osteoporosis or who were at risk for fracture were conducted in 11 sites around the world, namely in Argentina, Belgium, Canada at Hamilton and with participants from the Osteoporosis Canada Canadian Osteoporosis Patient Network (COPN), Japan, Mexico, Spain, the Netherlands, the UK, and the USA in California and Washington state...
November 13, 2023: Osteoporosis International
https://read.qxmd.com/read/37947843/the-joint-effects-of-physical-activity-and-sleep-duration-on-risk-of-osteoporosis-in-taiwanese-adult-population-the-taiwan-biobank-study
#11
JOURNAL ARTICLE
Kun-Hui Chen, Chen-Ming Su, Wei-Ju Liu, Huey-En Tzeng, Chia-Lin Lee, Chun-Hao Tsai
UNLABELLED: Most studies investigating the association between physical activity and osteoporosis prevention only focused on specific types of physical activity. This study's evidence regarding the combined effects or interaction of sleep duration and physical activity. The findings emphasize the role of sleep duration and physical activity in association with osteoporosis. PURPOSE: The associations between physical activity, sleep duration, and prevalent osteoporosis in Taiwanese adults were studied in this cross-sectional study...
November 10, 2023: Osteoporosis International
https://read.qxmd.com/read/37940698/correction-to-the-comparison-of-alendronate-and-raloxifene-after-denosumab-card-study-a-comparative-efficacy-trial
#12
Sabashini K Ramchand, Joy N Tsai, Hang Lee, Grace Sassana-Khadka, Mackenzie Jordan, Savannah Ryan, Benjamin Z Leder
No abstract text is available yet for this article.
November 9, 2023: Osteoporosis International
https://read.qxmd.com/read/37940697/evaluation-of-costs-osteoporosis-treatment-and-re-fractures-in-german-collaborative-orthogeriatric-care-after-fragility-fractures
#13
JOURNAL ARTICLE
Claudia Konnopka, Gisela Büchele, Andrea Jaensch, Dietrich Rothenbacher, Clemens Becker, Kilian Rapp, Espen Henken, Hans-Helmut König
UNLABELLED: Orthogeriatric co-management (OGCM) may provide benefits for geriatric fragility fracture patients in terms of more frequent osteoporosis treatment and fewer re-fractures. Yet, we did not find higher costs in OGCM hospitals for re-fractures or antiosteoporotic medication for most fracture sites within 12 months, although antiosteoporotic medication was more often prescribed. PURPOSE: Evidence suggests benefits of orthogeriatric co-management (OGCM) for hip fracture patients...
November 9, 2023: Osteoporosis International
https://read.qxmd.com/read/37940696/lms-based-continuous-pediatric-reference-values-for-soluble-receptor-activator-of-nuclear-factor-kappa-b-ligand-srankl-and-osteoprotegerin-opg-in-the-harp-cohort
#14
JOURNAL ARTICLE
Helene Tietze, Veronika Pott, Nele Kanzelmeyer, Nima Memaran, Ulrich Baumann, Charlotte Mindermann, Adriana Suhlrie, Jens Drube, Anette Melk, Anibh M Das, Dirk Schnabel, Dieter Haffner, Maren Leifheit-Nestler
UNLABELLED: Soluble RANKL (sRANKL) and osteoprotegerin (OPG) are regulators of osteoclast differentiation and activation, but adequate pediatric reference values are lacking. Here we provide LMS (Lambda-Mu-Sigma)-based continuous pediatric reference percentiles for sRANKL, OPG and sRANKL/OPG ratio that will allow calculation of standardized patient z-scores to assess bone modeling in children. PURPOSE: Soluble receptor activator of nuclear factor kappa B ligand (sRANKL) and osteoprotegerin (OPG) are regulators of osteoclast differentiation and activation and thus bone metabolic turnover in children...
November 9, 2023: Osteoporosis International
https://read.qxmd.com/read/37938406/effect-of-educational-intervention-on-preventing-osteoporosis-in-postmenopausal-women
#15
JOURNAL ARTICLE
S Najafi, F Mohammadkhah, M M Ebrahimi, P A Harsini, A Khani Jeihooni
UNLABELLED: In the experimental group, the average scores of knowledge, constructs of theory of planned behavior, nutrition, and walking had a significant enhancement compared to the control group after the educational intervention. After the intervention, the value of the lumbar spine bone mineral density T-score in the experimental group increased, while in the control group, it decreased. INTRODUCTION: Osteoporosis is a global public health problem currently affecting millions of people worldwide and in Iran...
November 8, 2023: Osteoporosis International
https://read.qxmd.com/read/37938405/the-incremental-risk-of-fragility-fractures-in-aging-men
#16
JOURNAL ARTICLE
A R Agarwal, O Tarawneh, J S Cohen, A Gu, K F Moseley, J N DeBritz, G J Golladay, S C Thakkar
INTRODUCTION: While the United States Preventative Services Task Force recommends osteoporosis screening for women 65 years and older, there is no definitive recommendation for routine osteoporosis screening in men. The purpose of this study was to determine the age at which the odds of fragility fractures (FFx) increase in men to help guide future policy discussions evaluating an optimal screening strategy in this population. METHODS: Men older than 49 years were identified in the PearlDiver Patient Records Database...
November 8, 2023: Osteoporosis International
https://read.qxmd.com/read/37932510/pre-operative-bone-quality-deficits-and-risk-of-complications-following-spine-fusion-surgery-among-postmenopausal-women
#17
JOURNAL ARTICLE
Alexander S Dash, Emma Billings, Katelyn Vlastaris, Han Jo Kim, Matthew E Cunningham, Joseph Raphael, Francis Lovecchio, John A Carrino, Darren Lebl, Donald McMahon, Emily M Stein
UNLABELLED: Poor bone quality is a risk factor for complications after spinal fusion surgery. This study investigated pre-operative bone quality in postmenopausal women undergoing spine fusion and found that those with small bones, thinner cortices and surgeries involving more vertebral levels were at highest risk for complications. PURPOSE: Spinal fusion is one of the most common surgeries performed worldwide. While skeletal complications are common, underlying skeletal deficits are often missed by pre-operative DXA due to artifact from spinal pathology...
November 7, 2023: Osteoporosis International
https://read.qxmd.com/read/37921994/forearm-bone-mineral-density-predicts-screw-loosening-after-lumbar-fusion-similar-to-lumbar-hounsfield-unit-value-in-patients-with-lumbar-spondylolisthesis
#18
JOURNAL ARTICLE
Qian Chen, Zhen Tu, Youwei Ai, Wen Li, Jianwen Chen, Junfei Feng, Wei Deng, Ye Wang, Ping Jiang
UNLABELLED: Preoperative bone density assessment is necessary to predict screw loosening. The forearm BMD is a useful predictor of BMD-related complications after lumbar operation. Our results show that the forearm BMD is as effective a predictor of screw loosening as the lumbar average HU value. Measurement of the forearm BMD may be a useful adjunct in predicting screw loosening following lumbar fusion. PURPOSE: To determine the relationship between forearm bone mineral density (BMD) and the risk of pedicle screw loosening in patients with lumbar spondylolisthesis...
November 3, 2023: Osteoporosis International
https://read.qxmd.com/read/37897507/vaccination-against-covid-19-reduced-the-mortality-risk-of-covid-positive-hip-fracture-patients-to-baseline-levels-the-nationwide-data-linked-impact-protect-study
#19
JOURNAL ARTICLE
Andrew J Hall, N D Clement, A M J MacLullich, T O White, A D Duckworth
UNLABELLED: This nationwide study used data-linked records to assess the effect of COVID-19 vaccination among hip fracture patients. Vaccination was associated with a lower risk of contracting COVID-19 and, among COVID-positive patients, it reduced the mortality risk to that of COVID-negative patients. This provides essential data for future communicable disease outbreaks. PURPOSE: COVID-19 confers a three-fold increased mortality risk among hip fracture patients...
October 28, 2023: Osteoporosis International
https://read.qxmd.com/read/37878064/understanding-the-long-term-impact-of-incident-osteoporotic-fractures-on-healthcare-utilization-and-costs-in-korean-postmenopausal-women
#20
JOURNAL ARTICLE
S Han, S Kim, E J Yeh, H S Suh
UNLABELLED: This study provides long-term evidence that healthcare resource utilization and costs of care in women who experienced incident osteoporotic fractures remained higher than those in women without fractures over a span of 5 years. These findings emphasize the importance of early diagnostics and treatment for osteoporosis. PURPOSE: To evaluate healthcare resource utilization (HCRU) and costs of care over 5 years after the incident osteoporotic fractures (OF) in postmenopausal women...
October 25, 2023: Osteoporosis International
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