Chaochao Gong, Sailing Chen, Yunbing Tang, Huiqian Chen, Jianghuan Xie, Yanning Lv, Zhefan Shen, Yang Zhu, Shaowei Wang, Ren-Shan Ge, Junzhao Zhao
The objective of this study was to examine the effect of 11 organochlorine pesticides on human and rat 17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) in human placental and rat ovarian microsome and on estradiol production in BeWo cells. The results showed that the IC50 values for endosulfan, fenhexamid, chlordecone, and rhothane on human 17β-HSD1 were 21.37, 73.25, 92.80, and 117.69μM. Kinetic analysis revealed that endosulfan acts as a competitive inhibitor, fenhexamid as a mixed/competitive inhibitor, chlordecone and rhothane as a mixed/uncompetitive inhibitor...
March 18, 2024: Journal of Steroid Biochemistry and Molecular Biology