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Cytopathology: Official Journal of the British Society for Clinical Cytology

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https://read.qxmd.com/read/30712289/plasmacytoid-morphology-of-poorly-differentiated-thyroid-carcinoma-diagnostic-approach-with-brief-review-of-literature
#1
Debasis Gochhait, Praveena Edura, Rajesh Nachiappa Ganesh, Neelaiah Siddaraju, Vidhyalakshmi Rangarajan, Thara Keloth
Poorly differentiated thyroid carcinoma (PDTC) is an uncommon neoplasm of thyroid accounting for 4-7% of all thyroid neoplasm's (1) that are rarely diagnosed accurately on cytology. Medullary thyroid carcinoma (MTC) is the most frequent primary thyroid neoplasm manifesting with plasmacytoid morphology possibly followed by Hürthle neoplasm (HCN) because of their high incidence compared to other subtypes of malignancy. The plasmacytoid morphology in other primary thyroid neoplasms is uncommon and distinguishing such neoplasm's from MTC is crucial for the clinical management of patients presenting with neoplastic thyroid nodules...
February 3, 2019: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30681764/cytotechnologists-education-and-work-in-finland
#2
Eeva Liikanen
OBJECTIVE: The aim of this study was to survey the work that cytotechnologists carry out in Finland. METHODS: An electronic questionnaire was planned with the Board of the Finnish Association of Cytotechnologists and an email containing the link was sent to all 107 of its members in January 2018. It included 17 questions on their age and work experience, education and work. There was also space for them to add others comments. RESULTS: Just under half (45%) replied...
January 25, 2019: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30657615/ensuring-quality-in-cervical-screening-programmes-based-on-molecular-hpv-testing
#3
REVIEW
Kate Cuschieri, Rob Schuurman, Suzie Coughlan
The increased use of HPV testing within cervical screening programmes necessarily brings about changes to the laboratory services which are required to support them. A crucial element of such services is to demonstrate initial and ongoing quality of the test (and associated processes). In this review we outline some of the quality-considerations and challenges with an emphasis on the laboratory including assay and platform validation, internal quality control selection and strengths and weaknesses of external quality assurance schemes...
January 18, 2019: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30628128/a-practical-cytological-approach-to-the-diagnosis-of-breast-implant-associated-anaplastic-large-cell-lymphoma
#4
REVIEW
Ellis Barbé, Mintsje de Boer, Daphne de Jong
The role of cytopathology in malignant lymphoma is largely restricted to primary screening in patients with lymphadenopathy of unknown causes and evaluation of relapse and transformation during follow-up of patients with known and fully classified malignant lymphoma. Few lymphoma diagnoses fully rely on cytology, however, of which breast-implant associated anaplastic large cell lymphoma (BIA-ALCL) is currently in the center of clinical attention. Due to the major attention both in the medical and lay media for the recently substantiated high lymphoma risk in women with breast implants, cytopathology departments now frequently receive seroma fluid aspirates with this specific differential diagnostic consideration...
January 9, 2019: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30614088/imp3-immunocytochemical-expression-in-direct-endometrial-brushings-a-possible-diagnostic-help-in-endometrial-cytology
#5
Y Norimatsu, K Yanoh, Y Maeda, S Irino, Y Hirai, F Fulciniti, T K Kobayashi
INTRODUCTION: This study evaluated the immunocytochemical (ICC) expression of IMP3 in direct endometrial brushings processed as Liquid-Based Cytology (LBC) samples of endometrioid adenocarcinoma (EAC), serous carcinoma (ESC) and surface papillary syncytial change (SPSC) with endometrial glandular and stromal breakdown (EGBD) to exploit its possible differential diagnostic aid. METHODS: Total 333 samples of LBC samples were obtained from selected outpatients in parallel with Pipelle endometrial sampling...
January 6, 2019: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30570774/cytopathological-results-of-initial-endoscopic-ultrasound-guided-fine-needle-aspiration-for-primary-mass-and-prognosis-in-pancreatic-cancer-patients
#6
Jung Hwan Lee, Sang Myung Woo, Eun Kyung Hong, Sang-Jae Park, Sung-Sik Han, Tae Hyun Kim, Ju Hee Lee, Woo Jin Lee
OBJECTIVES: Clinical outcomes remain unclear in patients suspected of having pancreatic cancer with indeterminate endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) results. This work aimed to investigate the prognosis of pancreatic cancer patients with indeterminate findings at initial EUS-FNA. METHODS: Findings in all patients who underwent EUS-FNA for suspected pancreatic cancer between 2008 and 2015 at the National Cancer Center, Korea, were retrospectively reviewed...
December 20, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30556219/extra-gastrointestinal-stromal-tumors-egist-displaying-pure-epithelioid-cytomorphology-are-a-diagnostic-challenge-on-cytology-smears
#7
Bharat Rekhi
Gastrointestinal stromal tumor (GIST) constitutes the commonest mesenchymal tumor of the gastrointestinal tract, invariably immunoreactive for CD117(KIT); originates from the interstitial cells of Cajal; mostly driven by KIT or PDGFRA-activating mutations and is histopathologically characterized by spindle, cell, epithelioid, and rarely pleomorphic morphology.1 Discovered on GIST-1 (DOG1) is another useful immunohistochemical marker for diagnosing GISTs, including those lacking CD117 immunoexpression, characterized by PDGFRA mutation and epithelioid cytomorphology...
December 17, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30556204/broncho-alveolar-lavage-in-a-retro-positive-male
#8
Ariba Zaidi, Parikshaa Gupta, Ritesh Agarwal, Arvind Rajwanshi
Leishmania is a protozoan parasite that can cause cutaneous as well as visceral disease in humans. Leishmaniasis is a vector-borne disease and is transmitted by the bite of infected sandflies. A definitive diagnosis of visceral leishmaniasis can be obtained by microscopic identification of the organisms in smears or tissue sections, culture of the parasite or by DNA detection methods. Leishmania has been rarely demonstrated in broncho-alveolar lavage (BAL), there being only a few case reports in the literature...
December 17, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30556192/cytomorphological-features-of-atypical-polypoid-adenomyoma-of-the-endometrium
#9
Tomoko Arimoto, Mitsuaki Ishida, Yusuke Ebisu, Kaori Sandoh, Kimiaki Okano, Tomomi Mizokami, Masato Kit, Hidetaka Okada, Koji Tsuta
Atypical polypoid adenomyoma (APAM) is a rare mixed epithelial and mesenchymal tumor, which is characterized histopathologically by the presence of disorganized hyperplastic glands showing cytological atypia embedded in intersecting fascicles of fibromuscular stromal cells. 1 Although the utility of endometrial cytological examination in malignant and various benign conditions has been documented, 2-4 little attention has been paid to the cytomorphological features of APAM because of the rarity of this tumor...
December 17, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30554449/enigma-portal-case-phaeohyphomycosis-by-fine-needle-aspiration
#10
Rachel Jug, Trisha Miller Shattuck, Xiaoyin Sara Jiang
48-year-old male History of multiple myeloma, clinically stable Now presenting with subcutaneous nodule near the left lateral epicondyle which had been present for "years" but had recently enlarged. The patient noted a possible remote minor trauma to the area. This article is protected by copyright. All rights reserved.
December 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30549348/mammary-carcinoma-with-osteoclast-like-giant-cell-fine-needle-aspiration-and-cytological-diagnosis-of-a-rare-and-misleading-subtype-of-invasive-ductal-carcinoma
#11
LETTER
Benjamin Bonsang, Françoise Charles, Virginie Conan-Charlet, Sandrine Guilbert, Pascale Marcorelles, Matthieu Talagas
Mammary carcinoma with osteoclast-like giant cell is a very rare subtype of invasive ductal carcinoma not otherwise specified of the WHO classification of Breast tumors . This tumor has a similar prognosis to other breast carcinomas of identical grade and stage. Nevertheless, its clinical and radiological presentation is falsely reassuring and can lead to a damaging diagnosis delay. Conversely, using fine needle aspiration, the cytological diagnosis is attainable, especially in the context of a Rapid Assessment Breast Clinic (RABC)...
December 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30549342/single-slide-assessment-a-highly-effective-cytological-rose-technique-for-ebus-and-eus-guided-fna
#12
Leonie Glinski, Dushyant Shetty, Stephen Iles, Benjamin Diggins, James Garvican
No standardised, comprehensive approach to Rapid On-Site Evaluation (ROSE) of cytology samples currently exists. Recent meta-analysis indicates variation in the effectiveness of ROSE [1], however, reviews commonly omit the details of how ROSE is conducted. This review demonstrates the clinical effectiveness of Single Slide Assessment (SSA) for ROSE of cytology samples, providing a highly effective, standardised methodology, maximising cell yield and the diagnostic potential of samples obtained via Endobronchial or Endoscopic ultrasound (EBUS/EUS)...
December 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30506595/qualitative-and-quantitative-cytomorphologic-features-of-primary-anaplastic-lymphoma-kinase-positive-lung-cancer
#13
Ryuko Tsukamoto, Hiroyuki Ohsaki, Sho Hosokawa, Yasunori Tokuhara, Shingo Kamoshida, Yoshiko Sakuma, Tomoo Itoh, Chiho Ohbayashi
OBJECTIVE: Anaplastic lymphoma kinase (ALK) positive (+) lung cancers are predictive for response to crizotinib and alectinib. There are many cases of lung cancer in which surgery cannot be performed, and such cases require diagnosis by cytologic specimen or biopsy. Estimating ALK (+) lung cancer from cytomorphology would allow molecular testing to proceed without the waste of a small amount of specimen. The purpose of this study was to assess whether qualitative and quantitative cytomorphologic features are sufficient for distinguishing primary ALK (+) from ALK (-) lung cancer...
December 1, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30506593/mammary-analogue-secretory-carcinoma-of-salivary-gland-diagnosed-on-submandibular-gland-cytology-a-case-report-and-review-of-literature
#14
Ethar Al-Husseinawi, Soheila Hamidpour, Evanthia Omoscharka
Mammary analogue secretory carcinoma (MASC) of the salivary glands morphologic and molecular similarities to secretory carcinoma of the breast(sc). (1) Here, we report a 46 year old female who presented with a right submandibular gland mass. Fine needle aspiration differential diagnosis included oncocytosis, oncocytoma, acinic cell carcinoma and MASC.We also review the current literature regarding clinical presentation, and diagnostic workup of this entity. This article is protected by copyright. All rights reserved...
December 1, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30500092/large-b-cell-lymphoma-concommittant-to-intra-cerebral-hemorrhage
#15
Jean-François Lesesve, Delphine Gérard
A 63-year old man presented with intra-cerebral hemorrhage (ICH) confirmed by tomodensitometry. The cerebrospinal fluid (CSF) examination showed a xanthochromic liquid with 1.537 x 109 /L nucleated cells (Body Fluid mode, Sysmex XN-9000, Roissy, Fr), increased red blood cells (RBCs), loose clusters of leptomeningeal cells (fig 1) macrophages and abnormal lymphocytes (fig 2). Interestingly, fresh phagocytosis of intact RBCs by macrophages ("erythrophages", fig 3) or leptomeningeal cells (fig 4), and dark coarse granules into macrophages was observed (fig 5)...
November 30, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30499622/digital-cytopathology-a-constant-evolution-comments-on-capitanio-a-dina-r-e-and-treanor-d-digital-cytology-a-short-review-of-technical-and-methodological-approaches-and-applications
#16
LETTER
Simone L Van Es, Vanessa White, Jennifer Ross, Janelle Greaves, Stephanie Gay, Derek Holzhauser, Tony Badrick
Capitanio et al provide a succinct review of digital cytopathology technology with particularly good overviews of scanner focusing methodologies as well as explanations of deep focusing techniques. The aim of this letter is to briefly comment and expand on some of the information provided by these authors. This article is protected by copyright. All rights reserved.
November 30, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30499616/answer-to-van-es-et-al-digital-pathology-a-constant-evolution
#17
LETTER
Arrigo Capitanio
The letter from Van Es et al makes useful positive comments about some aspects of our original paper. It is clear that the main technical problem related to digital cytology is the three dimensional distribution of the cells network in the cytological preparation. As Van Es et al say the unpredictable cell distribution in the z-axis does not allow, at the moment, the determination of the ideal number of z-axis scanning levels for each cytological specimen. This article is protected by copyright. All rights reserved...
November 30, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30485558/liquid-biopsy-a-new-avenue-in-pathology
#18
REVIEW
R K Ghosh, T Pandey, P Dey
Liquid biopsy is a relatively new entity. This non-invasive technique provides us real-time information of a tumor. The liquid biopsy contains circulating tumor cells, cell-free DNA and exosomes. The main indications for liquid biopsy include the early diagnosis, screening, detection of minimal residual disease, designing personalized treatment and predicting biological behavior of the tumor. In this review, we have discussed various aspects of liquid biopsy and compared it with the conventional biopsy. This article is protected by copyright...
November 28, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30484917/touch-imprint-cytology-on-endoscopic-ultrasound-fine-needle-biopsy-provides-comparable-sample-quality-and-diagnostic-yield-to-standard-endoscopic-ultrasound-fine-needle-aspiration-specimens-in-the-evaluation-of-solid-pancreatic-lesions
#19
Stefano Francesco Crinò, Alberto Larghi, Laura Bernardoni, Alice Parisi, Luca Frulloni, Armando Gabbrielli, Pietro Parcesepe, Aldo Scarpa, Erminia Manfrin
OBJECTIVES: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the gold standard for the diagnosis of solid pancreatic lesions (SPLs). Cytological samples can also be obtained using touch imprint cytology (TIC) on EUS fine-needle biopsy (FNB) specimens. We aimed to compare sample quality and diagnostic yield of EUS-FNA-standard cytology (EUS-FNA-SC) to that of EUS-FNB-TIC in a series of patients with SPLs. METHODS: Thirty-two consecutive patients referred for EUS-tissue acquisition of SPLs who underwent rapid on-site evaluation of both EUS-FNA-SC and paired EUS-FNB-TIC during the same endoscopic session were retrospectively identified...
November 28, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/30663851/management-of-cytological-material-for-ancillary-studies-still-an-issue-one-decade-later
#20
EDITORIAL
Fernando Schmitt
No abstract text is available yet for this article.
January 2019: Cytopathology: Official Journal of the British Society for Clinical Cytology
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