Quitterie Fontanges, Paul Dubos, Tom Lesluyes, Yec'han Laizet, Valérie Velasco, Bárbara Meléndez, Nicky D'Haene, Esther Oliva, Robert H Young, Laetitia Mayeur, Flora Rebier, Mélissa Alamé, Claire Larmonier, Mojgan Devouassoux-Shisheboran, Laurent Arnould, Isabelle Soubeyran, Camille Chakiba, Anne Floquet, Guillaume Babin, Frédéric Guyon, Eliane Mery, Sophie Le Guellec, Jean-Christophe Noël, Sabrina Croce, Frédéric Chibon
A close relationship has been demonstrated between genomic complexity and clinical outcome in uterine smooth muscle tumors. We studied the genomic profiles by array-CGH of 28 fumarate hydratase deficient leiomyomas and 37 leiomyomas with bizarre nuclei (LMBN) from 64 patients. Follow-up was available for 46 patients (from three to 249 months, mean 87.3 months). All patients were alive without evidence of disease. For 51 array-CGH interpretable tumors the mean Genomic Index (GI) was 16.4 (median: 9...
March 2024: Genes, Chromosomes & Cancer