Simrandip K Gill, Heather E L Rose, Martin Wilson, Daniel Rodriguez Gutierrez, Lara Worthington, Nigel P Davies, Lesley MacPherson, Darren R Hargrave, Dawn E Saunders, Christopher A Clark, Geoffrey S Payne, Martin O Leach, Franklyn A Howe, Dorothee P Auer, Tim Jaspan, Paul S Morgan, Richard G Grundy, Shivaram Avula, Barry Pizer, Theodoros N Arvanitis, Andrew C Peet
1 H-magnetic resonance spectroscopy (MRS) has the potential to improve the noninvasive diagnostic accuracy for paediatric brain tumours. However, studies analysing large, comprehensive, multicentre datasets are lacking, hindering translation to widespread clinical practice. Single-voxel MRS (point-resolved single-voxel spectroscopy sequence, 1.5 T: echo time [TE] 23-37 ms/135-144 ms, repetition time [TR] 1500 ms; 3 T: TE 37-41 ms/135-144 ms, TR 2000 ms) was performed from 2003 to 2012 during routine magnetic resonance imaging for a suspected brain tumour on 340 children from five hospitals with 464 spectra being available for analysis and 281 meeting quality control...
February 1, 2024: NMR in Biomedicine