journal
https://read.qxmd.com/read/38902928/effects-of-stress-related-neuromodulators-on-amygdala-and-hippocampus-resting-state-functional-connectivity
#1
JOURNAL ARTICLE
Catarina Rosada, Renée Lipka, Sophie Metz, Christian Otte, Hauke Heekeren, Katja Wingenfeld
BACKGROUND: The human stress response is characterized by increases in neuromodulators, including norepinephrine (NE) and cortisol. Both neuromodulators can enter the brain and affect neurofunctional responses. Two brain areas associated with stress are the amygdala and the hippocampus. The precise influence of NE and cortisol on the amygdala and hippocampal resting state functional connectivity (RSFC) is poorly understood. AIMS: To investigate the influence of NE and cortisol on the amygdala and hippocampal RSFC...
June 20, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38888164/developing-the-open-psychedelic-evaluation-nexus-consensus-measures-for-assessment-of-supervised-psilocybin-services-an-e-delphi-study
#2
JOURNAL ARTICLE
Philip Todd Korthuis, Kim Hoffman, Adrianne R Wilson-Poe, Jason B Luoma, Alissa Bazinet, Kellie Pertl, David L Morgan, Ryan R Cook, Sarann Bielavitz, Renae Myers, Robert Cameron Wolf, Dennis McCarty, Christopher S Stauffer
BACKGROUND: Voter initiatives in Oregon and Colorado authorize legal frameworks for supervised psilocybin services, but no measures monitor safety or outcomes. AIMS: To develop core measures of best practices. METHODS: A three-phase e-Delphi process recruited 36 experts with 5 or more years' experience facilitating psilocybin experiences in various contexts (e.g., ceremonial settings, indigenous practices, clinical trials), or other pertinent psilocybin expertise...
June 18, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38888086/pivotal-role-of-orexin-signaling-in-the-posterior-paraventricular-nucleus-of-the-thalamus-during-the-stress-induced-reinstatement-of-oxycodone-seeking-behavior
#3
JOURNAL ARTICLE
Jessica M Illenberger, Francisco J Flores-Ramirez, Glenn Pascasio, Marissa Franco, Brandon Mendonsa, Rémi Martin-Fardon
BACKGROUND: The orexin (OX) system has received increasing interest as a potential target for treating substance use disorder. OX transmission in the posterior paraventricular nucleus of the thalamus (pPVT), an area activated by highly salient stimuli that are both reinforcing and aversive, mediates cue- and stress-induced reinstatement of reward-seeking behavior. Oral administration of suvorexant (SUV), a dual OX receptor (OXR) antagonist (DORA), selectively reduced conditioned reinstatement of oxycodone-seeking behavior and stress-induced reinstatement of alcohol-seeking behavior in dependent rats...
June 18, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38877715/is-microdosing-a-placebo-a-rapid-review-of-low-dose-lsd-and-psilocybin-research
#4
REVIEW
Vince Polito, Paul Liknaitzky
Some recent research and commentary have suggested that most or all the effects reported by people who microdose psychedelics may be explained by expectations or placebo effects. In this rapid review, we aimed to evaluate the strength of evidence for a placebo explanation of the reported effects of microdosing. We conducted a PubMed search for all studies investigating psychedelic microdosing with controlled doses and a placebo comparator. We identified 19 placebo-controlled microdosing studies and summarised all positive and null findings across this literature...
June 14, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38863399/the-pseudoscience-of-lithium-and-suicide-reanalysis-of-a-misleading-meta-analysis
#5
JOURNAL ARTICLE
Seyyed Nassir Ghaemi
By manipulating inclusion criteria, one can prove whatever point one wishes in meta-analysis. This critique examines a recent meta-analysis claiming lithium ineffectiveness for suicidality, based on three biased features: inclusion of many large studies specifically designed to exclude suicidality, producing zero suicide outcomes in all groups ( n  = 1856), thereby artificially decreasing statistical significance; arbitrary exclusion of all trials prior to the year 2000, thereby excluding two randomized clinical trials which demonstrated benefit for lithium; and underreporting of placebo suicide events in a recent randomized trial...
June 12, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38853592/cognitive-impairment-in-schizophrenia-is-associated-with-prefrontal-striatal-functional-hypoconnectivity-and-striatal-dopaminergic-abnormalities
#6
JOURNAL ARTICLE
Kai-Chun Yang, Bang-Hung Yang, Mu-N Liu, Ying-Jay Liou, Yuan-Hwa Chou
BACKGROUND: A better understanding of the mechanisms underlying cognitive impairment in schizophrenia is imperative, as it causes poor functional outcomes and a lack of effective treatments. AIMS: This study aimed to investigate the relationships of two proposed main pathophysiology of schizophrenia, altered prefrontal-striatal connectivity and the dopamine system, with cognitive impairment and their interactions. METHODS: Thirty-three patients with schizophrenia and 27 healthy controls (HCs) who are right-handed and matched for age and sex were recruited...
June 10, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38825869/the-5-ht1a-receptor-biased-agonists-nlx-204-and-nlx-101-like-ketamine-elicit-rapid-acting-antidepressant-activity-in-the-rat-chronic-mild-stress-model-via-cortical-mechanisms
#7
JOURNAL ARTICLE
Mariusz Papp, Piotr Gruca, Ewa Litwa, Magdalena Lason, Adrian Newman-Tancredi, Ronan Depoortère
BACKGROUND: The highly selective 5-HT1A serotonin receptor "biased" agonists NLX-101 and NLX-204 display, like ketamine, potent and efficacious rapid-acting antidepressant (RAAD) activity in the rat chronic mild stress (CMS) model with systemic (i.p.) administration. They rapidly (within 1 day) reverse anhedonia (i.e., CMS-induced sucrose consumption deficit), attenuate working memory deficit (novel object recognition: NOR), and decrease anxiety behavior in the elevated-plus maze (EPM)...
June 2, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38804547/changes-in-processing-speed-during-early-abstinence-from-alcohol-dependence
#8
JOURNAL ARTICLE
Anna Powell, Harry Sumnall, Cecil Kullu, Lynn Owens, Catharine Montgomery
BACKGROUND: Processing speed is a task-independent construct underpinning more complex goal-related abilities. Processing speed is impaired in alcohol dependence (AD) and is linked to relapse, as are the functions it underpins. Reliable measurement of processing speed may allow tracking of AD recovery trajectories and identify patients requiring additional support. AIMS: To assess changes in reaction time (RT) from baseline (at the start of a detoxification programme) across early abstinence...
May 28, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38804544/tripping-into-the-unknown-exploring-the-experiences-of-first-time-lsd-users-through-global-drug-survey-insights
#9
JOURNAL ARTICLE
Luke Baxter, Cheneal Puljević, Tim Piatkowski, Jason Ferris, Emma L Davies, Monica J Barratt, Adam Winstock
BACKGROUND: The recreational use of LSD, a synthetic psychedelic drug, has surged in recent years, coinciding with a renewed research focus on its potential psychotherapeutic properties. AIM: This study aims to describe the experiences and perceptions of individuals engaging in LSD use for the first time, derived from a large international sample. METHODS: This study utilised 2018 Global Drug Survey data collected from 6 November 2017 to 10 January 2018...
May 28, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38742761/measuring-psychotherapeutic-processes-in-the-context-of-psychedelic-experiences-validation-of-the-general-change-mechanisms-questionnaire-gcmq
#10
JOURNAL ARTICLE
Max Wolff, Ricarda Evens, Lea J Mertens, Christopher Schmidt, Jessica Beck, Hans Rutrecht, Aaron D Cherniak, Gerhard Gründer, Henrik Jungaberle
BACKGROUND: Therapeutic and salutogenic effects of psychedelic drugs have been attributed to psychotherapeutic or psychotherapy-like processes that can unfold during the acute psychedelic experience and beyond. Currently, there are no psychometric instruments available to comprehensively assess psychotherapeutic processes (as conceptualized by empirical psychotherapy research) in the context of psychedelic experiences. AIMS: We report the initial validation of the General Change Mechanisms Questionnaire (GCMQ), a self-report instrument designed to measure five empirically established general change mechanisms (GCMs) of psychotherapy-(1) resource activation, (2) therapeutic relationship, (3) problem actuation, (4) clarification, and (5) mastery-in the context of psychedelic experiences...
May 14, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38680011/psilocybin-promotes-neuroplasticity-and-induces-rapid-and-sustained-antidepressant-like-effects-in-mice
#11
JOURNAL ARTICLE
Xiangting Zhao, Yingjie Du, Yishan Yao, Wei Dai, Yongyu Yin, Guyan Wang, Yunfeng Li, Liming Zhang
BACKGROUND: Psilocybin offers new hope for treating mood disorders due to its rapid and sustained antidepressant effects, as standard medications require weeks or months to exert their effects. However, the mechanisms underlying this action of psilocybin have not been identified. AIMS: To investigate whether psilocybin has rapid and sustained antidepressant-like effects in mice and investigate whether its potential mechanisms of action are related to promoted neuroplasticity...
April 28, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38654554/exploring-psychedelic-assisted-therapy-in-the-treatment-of-functional-seizures-a-review-of-underlying-mechanisms-and-associated-brain-networks
#12
REVIEW
Evan Cole Lewis, Alexandria Jaeger, Manesh Girn, Egiroh Omene, Madeline Brendle, Elena Argento
Functional seizures (FS), the most common subtype of functional neurological disorder (FND), cause serious neurological disability and significantly impact quality of life. Characterized by episodic disturbances of functioning that resemble epileptic seizures, FS coincide with multiple comorbidities and are treated poorly by existing approaches. Novel treatment approaches are sorely needed. Notably, mounting evidence supports the safety and efficacy of psychedelic-assisted therapy (PAT) for several psychiatric conditions, motivating investigations into whether this efficacy also extends to neurological disorders...
April 23, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38654553/the-trace-amine-associated-receptor-1-agonists-non-dopaminergic-antipsychotics-or-covert-modulators-of-d2-receptors
#13
JOURNAL ARTICLE
Gavin P Reynolds
A major effort of the pharmaceutical industry has been to identify and market drug treatments that are effective in ameliorating the symptoms of psychotic illness but without the limitations of the current treatments acting at dopamine D2 receptors. These limitations include the induction of a range of adverse effects, the inadequate treatment response of a substantial proportion of people with schizophrenia, and the generally poor response to negative and cognitive features of the disease. Recently introduced drug treatments have gone some way to avoiding the first of these, with a reduced propensity for weight gain, cardiovascular risk and extrapyramidal motor effects...
April 23, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38647196/influence-of-gaba-a-and-gaba-b-receptor-activation-on-auditory-sensory-gating-and-its-association-with-anxiety-in-healthy-volunteers
#14
JOURNAL ARTICLE
Sara de la Salle, Justin Piche, Brittany Duncan, Joëlle Choueiry, Molly Hyde, Robert Aidelbaum, Ashley Baddeley, Danielle Impey, Noreen Rahmani, Vadim Ilivitsky, Verner Knott
BACKGROUND: Dysfunctional sensory gating in anxiety disorders, indexed by the failure to inhibit the P50 event-related potential (ERP) to repeated stimuli, has been linked to deficits in the major inhibitory neurotransmitter γ-aminobutyric acid (GABA). AIMS/METHODS: This study, conducted in 30 healthy volunteers, examined the acute effects of GABAA (lorazepam: 1 mg) and GABAB receptor (baclofen: 10 mg) agonists on P50 measures of auditory sensory gating within a paired-stimulus (S1-S2) paradigm and assessed changes in gating in relation to self-ratings of anxiety...
April 22, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38863284/esketamine-combined-with-a-mindfulness-based-intervention-for-individuals-with-alcohol-problems
#15
RANDOMIZED CONTROLLED TRIAL
Emily M Gent, Joshua W Bryan, Maisy A Cleary, Tegan I Clarke, Harry D Holmwood, Rania O Nassereddine, Chris Salway, Simon Depla, Sarah Statton, Joy Krecké, Celia Ja Morgan
BACKGROUND: Alcohol use disorder (AUD) is a major public health issue, posing harmful consequences for individuals and society. Recent advances in addiction research have highlighted the therapeutic potential of ketamine-assisted therapy for AUD. However, the exact mechanisms underlying its effectiveness remain unknown. AIMS: This double-blind, pilot study aimed to investigate esketamine combined with mindfulness-based intervention (MBI) to examine whether esketamine enhances engagement in MBI for individuals with alcohol misuse problems and whether enhanced engagement has any impact on alcohol-related outcomes...
June 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38686649/aripiprazole-for-treating-delirium-a-systematic-review-is-it-a-valid-yet-understudied-treatment
#16
REVIEW
Stefano Maddalena, Carlo Magistri, Cristiano Mellini, Giuseppe Sarli
BACKGROUND: Delirium is a neuropsychiatric condition that commonly occurs in medical settings, especially among older individuals. Despite the lack of strong evidence in the literature, haloperidol is considered the first-line pharmacological intervention. Unfortunately, its adverse effects can be severe, and psychiatrists are considering the use of alternative drugs targeting dopamine and serotonin domains (atypical antipsychotics). Among them, aripiprazole is considered to have one of the safest pharmacological profiles...
June 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38678377/unveiling-potential-adverse-events-associated-with-escitalopram-oxalate-a-real-world-analysis-based-fda-adverse-event-reporting-system-database
#17
JOURNAL ARTICLE
Ying Jiang, Yusi Cheng, Zhiqiang Du, Yuan Shen, Qin Zhou, Yingying Ji, Haohao Zhu
OBJECTIVE: The study aimed to conduct a multidimensional evaluation of potential adverse events (AEs) of escitalopram oxalate based on the FDA adverse event reporting system (FAERS) database. METHODS: This study utilized the reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and multi-item gamma-poisson shrinker (MGPS) to mine and analyze data from the FAERS database from the first quarter of 2004 to the second quarter of 2023...
June 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38641957/mining-and-analysis-of-security-alert-signals-of-valbenazine-based-on-the-food-and-drug-administration-adverse-event-reporting-system-database
#18
JOURNAL ARTICLE
Qi Wang, Kankan Qu, Zhiqiang Du, Yuan Shen, Ying Jiang, Haohao Zhu
BACKGROUND: Valbenazine is used for tardive movement disorders in adults. Current studies on its safety are mostly from clinical trials and small case reports, limiting information on rare adverse reactions. This study investigated valbenazine-related adverse event (AE) risk signals using the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database. METHODS: Valbenazine AEs data were collected from the FAERS database from 2017 Q2 to 2023 Q1, employing methods like reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network, and empirical Bayesian geometric mean...
June 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38519421/the-pharmacokinetics-and-pharmacodynamics-of-ibogaine-in-opioid-use-disorder-patients
#19
JOURNAL ARTICLE
Thomas Knuijver, Rob Ter Heine, Arnt F A Schellekens, Paniz Heydari, Luc Lucas, Sjoerd Westra, Maarten Belgers, Toon van Oosteren, Robbert Jan Verkes, Cornelis Kramers
OBJECTIVE: Ibogaine is a hallucinogenic drug that may be used to treat opioid use disorder (OUD). The relationships between pharmacokinetics (PKs) of ibogaine and its metabolites and their clinical effects on side effects and opioid withdrawal severity are unknown. We aimed to study these relationships in patients with OUD undergoing detoxification supported by ibogaine. METHODS: The study was performed in 14 subjects with OUD. They received a single dose of 10mg/kg ibogaine hydrochloride...
May 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38616411/phase-1-placebo-controlled-single-ascending-dose-trial-to-evaluate-the-safety-pharmacokinetics-and-effect-on-altered-states-of-consciousness-of-intranasal-bpl-003-5-methoxy-n-n-dimethyltryptamine-benzoate-in-healthy-participants
#20
JOURNAL ARTICLE
James Jonathan Rucker, Claire Roberts, Mathieu Seynaeve, Allan H Young, Ben Suttle, Takahiro Yamamoto, Anna O Ermakova, Fiona Dunbar, Frank Wiegand
AIMS: To investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BPL-003, a novel intranasal benzoate salt formulation of 5-methoxy- N,N -dimethyltryptamine (5-MeO-DMT), in healthy participants. METHODS: In all, 44 psychedelic-naïve participants enrolled in the double-blind, placebo-controlled single ascending dose study (1-12 mg BPL-003). Concentrations of 5-MeO-DMT and its pharmacologically active metabolite, bufotenine, were determined in plasma and urine...
April 14, 2024: Journal of Psychopharmacology
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