journal
https://read.qxmd.com/read/38661244/masseter-muscle-thickness-is-predictive-of-cancer-cachexia-in-patients-with-head-and-neck-cancer
#21
JOURNAL ARTICLE
Julián Balanta-Melo, Alexander J Jones, Leah J Novinger, Michael G Moore, Andrea Bonetto
BACKGROUND: Cancer cachexia is prevalent in head and neck cancer patients. The L3 skeletal muscle index (SMI) is often used to assess sarcopenia and cachexia but is infrequently able to be measured in this population. Masseter muscle thickness (MT) may serve as an alternative predictor of cachexia. METHODS: SMI and MT were calculated from 20 trauma (CTRL) and 40 cachectic (CA-CX) and non-cachectic (CA-NCX) head and neck cancer patients. Area Under the Curve of the Receiver Operating Characteristics (AUC-ROC) analysis was performed for SMI and MT...
April 25, 2024: Head & Neck
https://read.qxmd.com/read/38660928/evaluating-the-impact-of-the-degree-of-extranodal-extension-on-outcomes-in-locally-advanced-oral-cavity-cancer
#22
JOURNAL ARTICLE
Anirudh Yalamanchali, Christopher Griffith, Chandana A Reddy, Shlomo A Koyfman, Neil M Woody, Shauna R Campbell, Natalie Silver, Joseph Scharpf, Robert R Lorenz, Brandon Prendes, Jamie A Ku, Eric Lamarre, Jessica L Geiger
BACKGROUND: Evaluate whether extranodal extension (ENE) extent impacts outcomes in patients with oral cavity squamous cell carcinoma (OCSCC). METHODS: From an institutional database, patients with OCSCC and pathologic ENE who received adjuvant treatment were included. Surgical slides were reviewed to confirm ENE extent. Multivariable Cox regression was used to relate patient/treatment characteristics with disease-free survival (DFS) and overall survival (OS). ENE was analyzed as both a dichotomous and continuous variable...
April 25, 2024: Head & Neck
https://read.qxmd.com/read/38655707/primary-fit-tracheoesophageal-puncture-in-primary-versus-salvage-laryngectomy-short-term-and-long-term-complications-and-functional-outcomes
#23
JOURNAL ARTICLE
Emese C Kanyo, Shannon S Wu, Chandana A Reddy, Natalie L Silver, Eric D Lamarre, Brian B Burkey, Brandon L Prendes, Joseph Scharpf, Robert R Lorenz, Joann Kmiecik, Jamie A Ku
BACKGROUND: Primary fit tracheoesophageal puncture (TEP) is widely preferred for individuals who have not undergone prior radiation. However, there is no consensus on the relative utility of primary-fit TEP in the setting of salvage laryngectomy. METHODS: A retrospective, single-center review was conducted of individuals undergoing laryngectomy with primary fit TEP between 2012 and 2018. Multivariable analysis was conducted to compare short-term and long-term complications, as well as speech and swallowing outcomes, of those who underwent primary versus salvage laryngectomy...
April 24, 2024: Head & Neck
https://read.qxmd.com/read/38651501/assessing-social-vulnerabilities-of-salivary-gland-cancer-care-prognosis-and-treatment-in-the-united-states
#24
JOURNAL ARTICLE
Govind S Bindra, David J Fei-Zhang, Atharva Desai, John Maddalozzo, Stephanie S Smith, Urjeet A Patel, Daniel C Chelius, Jill N D'Souza, Jeffrey C Rastatter, M Boyd Gillespie, Anthony M Sheyn
BACKGROUND: Salivary gland cancers (SGC)-social determinants of health (SDoH) investigations are limited by narrow scopes of SGC-types and SDoH. This Social Vulnerability Index (SVI)-study hypothesized that socioeconomic status (SES) most contributed to SDoH-associated SGC-disparities. METHODS: Retrospective cohort of 24 775 SGCs assessed SES, minority-language status (ML), household composition (HH), housing-transportation (HT), and composite-SDoH measured by the SVI via regressions with surveillance and survival length, late-staging presentation, and treatment (surgery, radio-, chemotherapy) receipt...
April 23, 2024: Head & Neck
https://read.qxmd.com/read/38646970/reply-to-letter-to-the-editor-regarding-decreased-utilization-for-postoperative-radiation-therapy-in-locoregionally-advanced-medullary-thyroid-cancer
#25
LETTER
Anastasios Maniakas, Mimi I Hu, G Brandon Gunn, Mark Zafereo
No abstract text is available yet for this article.
April 22, 2024: Head & Neck
https://read.qxmd.com/read/38646954/evidence-for-postoperative-radiotherapy-in-medullary-thyroid-cancer
#26
LETTER
N P Rowell
No abstract text is available yet for this article.
April 22, 2024: Head & Neck
https://read.qxmd.com/read/38646952/predicting-the-overall-survival-and-progression-free-survival-of-nasopharyngeal-carcinoma-patients-based-on-hemoglobin-albumin-and-globulin-ratio-and-classical-clinicopathological-parameters
#27
JOURNAL ARTICLE
Zui Chen, Jie Ling, Sujuan Zhang, Yuhua Feng, Yangchun Xie, Xianling Liu, Tao Hou
BACKGROUND: Serum biomarkers have a significant impact on the prediction of treatment outcomes in patients diagnosed with nasopharyngeal carcinoma (NPC). The primary aim of this study was to develop and validate a nomogram that incorporates hemoglobin, albumin, and globulin ratio (HAGR) and clinical data to accurately forecast treatment outcomes in patients with NPC. METHODS: A total of 796 patients diagnosed with NPC were included in the study. RESULTS: The results of the multivariate Cox analysis revealed that TNM stage and HAGR were found to be significant independent prognostic factors for OS and PFS...
April 22, 2024: Head & Neck
https://read.qxmd.com/read/38622975/heterogeneous-characterization-of-neutrophilic-cells-in-head-and-neck-cancers
#28
JOURNAL ARTICLE
Magdalena Fay, Paul E Clavijo, Clint T Allen
BACKGROUND: Neutrophilic cells are among the most abundant immune populations within the head and neck tumor microenvironment (TME) and harbor multiple mechanisms of immunosuppression. Despite these important features, neutrophilic cells may be underrepresented in contemporary studies that aim to comprehensively characterize the immune landscape of the TME due to discrepancies in tissue processing and analysis techniques. Here, we review the role of pathologically activated neutrophilic cells within the TME and pitfalls of various approaches used to study their frequency and function in clinical samples...
April 15, 2024: Head & Neck
https://read.qxmd.com/read/38622973/innovative-surgical-approach-for-trigeminal-trophic-syndrome-successful-healing-of-facial-ulcers-through-cross-face-nerve-grafts
#29
Qing Sun, Xing Li, Zhihui Zhu, Xiting Xiang, Shu Zhang, Xiaowei Liu, Xiao Long, Tao Zhang
BACKGROUND: Trigeminal trophic syndrome (TTS) is a rare condition caused by damage to the trigeminal nervous system, resulting in sensory disturbances and ulcers on the face. Treating TTS is complex and often requires medical or surgical intervention like flap reconstruction. However, there is limited research on surgical treatments for TTS ulcers. METHODS: We report the case of a 19-year-old man with TTS. We employed an innovative surgical technique involving dual cross-face nerve grafts...
April 15, 2024: Head & Neck
https://read.qxmd.com/read/38622958/a-prospective-health-economic-evaluation-to-determine-the-productivity-loss-due-to-premature-mortality-from-oral-cancer-in-india
#30
JOURNAL ARTICLE
Arjun Singh, Richard Sullivan, Manasi Bavaskar, Rathan Shetty, Poonam Joshi, Sudhir Nair, Sudeep Gupta, Pankaj Chaturvedi, Rajendra Badwe
INTRODUCTION: India contributes two-thirds of the global mortality due to oral cancer and has a younger population at risk. The societal costs of this premature mortality are barely discussed. METHODS: Using the human capital approach, we aimed to estimate the productivity lost due to premature mortality, valued using individual socioeconomic data, related to oral cancer in India. A bottom-up approach was used to prospectively collect data of 100 consecutive patients with oral cancer treated between 2019 and 2020, with a follow-up of 36 months...
April 15, 2024: Head & Neck
https://read.qxmd.com/read/38610123/fenestration-of-the-facial-nerve-by-the-stylomastoid-artery
#31
Allen S Zhou, Elliana K DeVore, Amy F Juliano, Jeremy D Richmon
BACKGROUND: Anatomic landmarks such as the tympanomastoid suture line, posterior belly of the digastric muscle, tragal pointer, and styloid process can assist the parotid surgeon in identifying and preserving the facial nerve. Vascular structures such as the posterior auricular artery and its branch, the stylomastoid artery, lay in close proximity to the facial nerve and have been proposed as landmarks for the identification of the facial nerve. In this case report, we describe an anatomic variation in which the stylomastoid artery has fenestrated the main trunk of the facial nerve, dividing it in two...
April 12, 2024: Head & Neck
https://read.qxmd.com/read/38606699/reverse-flow-anterolateral-thigh-free-flap-in-a-case-with-significant-atherosclerosis-a-viable-alternative-for-arterial-microvascular-anastomosis
#32
Jonathan C Garneau, Rod Rezaee
BACKGROUND: The concept of reserve flow perfusion for free flap reconstruction has been demonstrated in various applications in the literature. As it relates to the anterolateral thigh (ALT) free flap, the reserve flow principle has been primarily described to either augment or "supercharge" a large ALT to optimize skin perforator supply or lengthen the vascular pedicle. METHODS: We report a case of a 77-year old male with chronic renal failure who had extensive atherosclerosis of the proximal descending lateral circumflex femoral artery (LCFA) where arterial anastomosis was unable to be performed...
April 12, 2024: Head & Neck
https://read.qxmd.com/read/38600736/transoral-robotic-surgery-with-free-flap-reconstruction-functional-outcomes-of-241-patients-at-a-single-institution
#33
JOURNAL ARTICLE
Praneet C Kaki, Doreen Lam, Neel R Sangal, Karthik Rajasekaran, Ara C Chalian, Robert M Brody, Gregory S Weinstein, Steven B Cannady
BACKGROUND: Transoral robotic surgery (TORS) for oropharyngeal malignancy optimizes oncologic outcomes while preserving functionality. This study identifies patterns of functional recovery after TORS with free flap reconstruction (FFR). METHODS: Retrospective cohort study at a tertiary care center of patients with primary oropharyngeal tumors treated with TORS with FFR between 2010 and 2022. Patients were categorized into: adjuvant chemoradiation or radiation, or no adjuvant therapy (NAT)...
April 10, 2024: Head & Neck
https://read.qxmd.com/read/38600434/international-guidelines-for-intratumoral-and-intranodal-injection-of-nbtxr3-nanoparticles-in-head-and-neck-cancers
#34
JOURNAL ARTICLE
Xavier Liem, Thierry de Baère, Omar I Vivar, Tanguy Y Seiwert, Colette Shen, Zsuzsanna Pápai, Victor Moreno, Zoltán Takácsi-Nagy, Frigyes Helferich, Juliette Thariat, Zhen Gooi, Sue S Yom, Paolo Bossi, Robert L Ferris, Trevor G Hackman, Christophe Le Tourneau, Joseph Rodriguez, Caroline Hoffmann
BACKGROUND: An international multidisciplinary panel of experts aimed to provide consensus guidelines describing the optimal intratumoral and intranodal injection of NBTXR3 hafnium oxide nanoparticles in head and neck squamous cell carcinoma (HNSCC) of the oral cavity, oropharynx, and cervical lymph nodes and to review data concerning safety, feasibility, and procedural aspects of administration. METHODS: The Delphi method was used to determine consensus. A 4-member steering committee and a 10-member monitoring committee wrote and revised the guidelines, divided into eight sections...
April 10, 2024: Head & Neck
https://read.qxmd.com/read/38597121/quality-of-life-after-surgical-treatments-for-facial-palsy-a-systematic-review-and-meta-analysis
#35
JOURNAL ARTICLE
Johannes N van der Lely, Niek J Nieuwdorp, Ineke C A W Smits, Floris V W J van Zijl, Eveline M L Corten, Marc A M Mureau
BACKGROUND: Facial palsy profoundly affects patients' quality of life (QoL). We evaluated the effect of various surgical procedures on QoL using patient-reported outcome measures (PROMs) to provide evidence-based recommendations for improved care. METHODS: Embase, Medline, Web of Science, Cochrane, and CINAHL were searched for studies on QoL in patients with facial palsy who had undergone reconstructive surgery with preoperative and postoperative data from validated PROMs...
April 10, 2024: Head & Neck
https://read.qxmd.com/read/38595113/the-osteocutaneous-radial-forearm-free-flap-a-pictorial-essay
#36
JOURNAL ARTICLE
Hilary C McCrary, Janice L Farlow, John Alexander, Catherine T Haring, Stephen Y Kang, Matthew O Old, Nolan B Seim
The osteocutaneous radial forearm free flap (OCRFFF) is a versatile flap with the ability to reconstruct complex defects. We detail the techniques necessary to harvest an OCRFFF, including an outline on making 90-degree osteotomies to maximize bone harvest. In this pictorial essay, we provide illustrations of the anatomy and surgical techniques necessary for OCRFFF harvest. Detailed discussion is provided on how to protect the perforators to the bone and the approach to making osteotomies in a 90-degree fashion...
April 10, 2024: Head & Neck
https://read.qxmd.com/read/38594829/p16-overexpression-identifies-oncogenic-high-risk-hpv-infection-in-non-oropharyngeal-squamous-cell-carcinoma-of-the-head-and-neck
#37
JOURNAL ARTICLE
Anne-Sophie Becker, Jenny Merkel, Inci Bozkurt, Daniel Fabian Strüder, Claudia Maletzki, Maja Hühns, Annette Helene Zimpfer
BACKGROUND: Human papillomavirus (HPV) is an increasing risk factor for cancer. HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) is associated with a favorable outcome. Blockstaining for p16 is a surrogate marker for HPV+ OPSCC. In oral and laryngeal squamous cell carcinoma (OSCC/LSCC), the relevance of p16 immunohistochemistry, alone or in combination with other cell cycle-related proteins, to identify HPV-driven non-OPSCC is less well understood. METHODS: We stained for p16, pRb, cyclin D1, and p53 in 327 HNSCC...
April 9, 2024: Head & Neck
https://read.qxmd.com/read/38591178/survival-outcomes-and-toxicity-profiles-among-patients-with-nonmetastatic-nasopharyngeal-carcinoma-treated-with-intensity-modulated-radiotherapy-imrt-versus-imrt-carbon-ion-radiotherapy-a-propensity-score-matched-analysis
#38
JOURNAL ARTICLE
Yujiao Li, Xiyin Guan, Xing Xing, Chaosu Hu
OBJECTIVES: To compare survival outcomes and toxic effects among patients with newly diagnosed nonmetastatic nasopharyngeal carcinoma (NPC) when treated with intensity-modulated radiotherapy (IMRT) versus IMRT + carbon-ion radiotherapy (CIRT). METHODS: We performed a retrospective propensity score matching analysis (1:1) of patients treated with IMRT and IMRT + CIRT. Descriptive statistics were used to examine the baseline characteristics of the patients...
April 9, 2024: Head & Neck
https://read.qxmd.com/read/38591104/analysis-of-local-regional-and-distant-recurrence-of-disease-in-mucoepidermoid-tumors-of-larynx-a-systematic-review
#39
REVIEW
Francesco Chiari, Giuseppe Di Martino, Claudio Donadio Caporale, Gabriele Molteni, Livio Presutti, Pierre Guarino
The aim of this systematic review is to analyze epidemiology, clinical presentation, histopathological features, treatment and oncological outcomes in laryngeal mucoepidermoid cancer (MEC) in order to improve the knowledge on the management of such a rare malignant neoplasm. Specifically, authors highlight patients' and tumors' features about local, regional, and distant recurrence of disease. PRISMA 2020 guidelines were applied in this systematic literature review. A computerized search was performed using the Embase/Pubmed, Scopus, and Cochrane databases, for articles published from 1971 to December 2023...
April 9, 2024: Head & Neck
https://read.qxmd.com/read/38587969/free-temporalis-muscle-fascia-graft-in-dural-reconstruction-following-surgical-resection-of-intermediate-and-malignant-skull-base-tumors-a-10-year-experience-from-a-single-center
#40
JOURNAL ARTICLE
Martin Jurlina, Matija Mamic, Jure Pupic-Bakrac, Lovro Matoc, Hrvoje Jednacak, Ivica Luksic, Marica Zizic
BACKGROUND: Data from patients with post-ablative dural defects reconstructed using a free temporalis muscle fascia graft (FTFG) after resection of anterior or central skull base tumors were retrospectively analyzed. METHODS: The primary predictor and outcome variables were the reconstructive methods for dural repair and postoperative cerebrospinal fluid (CSF) leakage rate, respectively. RESULTS: Eighty patients were included, and 94 postoperative dural reconstructions were performed using FTFG...
April 8, 2024: Head & Neck
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