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Head & Neck

Chang M Song, Min S Kim, Dong W Lee, Yong B Ji, Jung H Park, Dong S Kim, Kyung Tae
BACKGROUND: The purpose of this study was to determine whether postauricular robotic and conventional hemithyroidectomy result in significantly different voice outcomes. METHODS: We prospectively compared the voice handicap index (VHI)-10 and acoustic parameters of a postauricular facelift robotic group and a conventional group preoperatively, 1 week, 1 month, and 6 months after surgery. RESULTS: Forty-two patients in the postauricular group and 68 patients in the conventional group completed the VHI-10 questionnaire and acoustic analysis...
April 17, 2019: Head & Neck
Van Quang Le, Quoc Duy Ngo, Xuan Quy Ngo
BACKGROUND: The nonrecurrent laryngeal nerve (NRLN) is a rare embryologically derived variant of the RLN. We aimed to identify the proportion of NRLN (during thyroidectomy), classify clinical NRLN types, and recommend some surgical considerations. METHOD: In this prospective study, from May 2017 to September 2018, our hospital carried out 2158 thyroid operations. We reported the NRLN rate and distinguished NRLN into four types. RESULTS: Overall, NRLN had an incidence rate of 0...
April 17, 2019: Head & Neck
Ying-Chyi Song, Kuo-Feng Hung, Kai-Li Liang, Jen-Huai Chiang, Hui-Chi Huang, Hui-Ju Lee, Mei-Yao Wu, Sheng-Jie Yu, Hsin-Yi Lo, Tin-Yun Ho, Hung-Rong Yen
BACKGROUND: To investigate the benefits of adjunctive Chinese herbal medicine (CHM) for patients with nasopharyngeal carcinoma (NPC). METHODS: We included all patients diagnosed with NPC during 1997-2009 and followed until 2011 in Taiwan. We used 1:1 frequency matching by age, sex, comorbidity, conventional treatment, and index year to compare the CHM users and non-CHM users (n = 2542 each). The prescribed CHM was further investigated with regard to its cytotoxicity...
April 15, 2019: Head & Neck
Jamie R Oliver, S Peter Wu, Clifford M Chang, Dylan F Roden, Binhuan Wang, Kenneth S Hu, David Schreiber, Babak Givi
BACKGROUND: Small cohort studies have suggested oral tongue squamous cell carcinoma (OTSCC) could be associated with worse prognosis in individuals younger than 40. METHODS: We compared the survival of all OTSCC cases in the National Cancer Database under 40 years old with those older than 40, excluding patients over 70. Cox regression and propensity score matched (PSM) survival analyses were performed. RESULTS: A total of 22 930 OTSCC patients were identified...
April 15, 2019: Head & Neck
Goretti Duran, Santiago Aguín, Raquel Cruz, Francisco Barros, José María Giráldez, Beatriz Bernárdez, Rafael López-López, Ángel Carracedo, María Jesús Lamas
BACKGROUND: Platinum-based chemoradiotherapy (CRT) is the standard treatment for locally advanced head and neck squamous-cell carcinomas (HNSCC), and most patients experience serious toxicities. The aim of this study was to investigate the association between candidate genes involved in radiation/platinum pathways and acute toxicity of CRT to determine the predictive value of these polymorphisms for toxicity. METHODS: Thirty-six selected single nucleotide polymorphisms (SNPs) in 29 genes were genotyped in 110 patients treated with cisplatin-based CRT...
April 11, 2019: Head & Neck
Willem W B de Kort, Sybren L N Maas, Robert J J Van Es, Stefan M Willems
OBJECTIVE: Literature analysis on the prognostic factor of the nodal yield (NY) in neck dissections (NDs), which in general surgical oncology is a strong prognosticator and quality-of-care marker. METHODS: We performed a systematic review of all PubMed and Embase publications until June 30, 2018 screening for data on NY as prognosticator and overall survival (OS) as outcome in patients with head and neck squamous cell carcinoma (HNSCC). Risk for bias was asserted by application of the Quality In Prognosis Studies tool...
April 10, 2019: Head & Neck
Yoshihiro Miyagawa, Koji Araki, Taku Yamashita, Shingo Tanaka, Yuya Tanaka, Masayuki Tomifuji, Yasuji Ueda, Yoshikazu Yonemitsu, Hideaki Shimada, Akihiro Shiotani
BACKGROUND: This study was designed to assess the therapeutic effect of urokinase-targeted recombinant oncolytic Sendai virus, termed "BioKnife," on anaplastic thyroid carcinoma (ATC). METHODS: Urokinase activity was investigated in human ATC cell lines, and BioKnife cytotoxicity against the cell lines was evaluated in vitro. Orthotopic mouse models of ATC were treated with three intratumoral injections of BioKnife, control virus, or phosphate-buffered saline (PBS) and were observed daily until >20% weight loss occurred...
April 10, 2019: Head & Neck
Fa Chen, Lingjun Yan, Jing Wang, Lisong Lin, Yu Qiu, Zhijian Hu, Junfeng Wu, Xiaodan Bao, Liangkun Lin, Rui Wang, Lin Cai, Fengqiong Liu, Baochang He
BACKGROUND: The aim of the present study was to assess the long noncoding RNA (lncRNA) expression profile of oral cancer and clarify the biological functions and clinical value of a novel lncRNA ENST00000470447.1. METHOD: Microarray assay was used to explore lncRNA expression profiles in three paired oral cancer and adjacent normal tissue samples. The expression of targeted lncRNA (ENST00000545372.1, ENST00000470447.1, and ENST00000412353.1) was validated by quantitative real-time polymerase chain reaction...
April 10, 2019: Head & Neck
Laura E Henry, Thorsen W Haugen, Christopher H Rassekh, Nithin D Adappa, Gregory S Weinstein, Bert W O'Malley
BACKGROUND: In this paper, we present three cases where a novel transoral robotic surgery (TORS) approach was used to resect clival chordomas extending into the nasopharynx to demonstrate progress in the evolution of robotic surgery of the head and neck. METHODS: The first patient had a history of metastatic chordoma resection and presented with trismus and dysphagia; the second and third patients had first presentation with nasal congestion and facial numbness, respectively...
April 10, 2019: Head & Neck
Gabriela M da Silva, Victoria Saavedra, Renata C F Ianez, Elen A de Sousa, Ágatha N Gomes, Natalie Kelner, Maria A Nagai, Luiz P Kowalski, Fernando A Soares, Silvia V Lourenço, Cláudia M Coutinho-Camillo
BACKGROUND: Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. Apoptosis plays an important role in organogenesis of glandular structures, and aberrations of apoptotic mechanisms is associated with a wide array of pathologic conditions. METHODS: The immunoexpression of proteins associated with apoptosis and proliferation was evaluated in 40 mucoepidermoid carcinoma cases. RESULTS: Par-4, Survivin, MUC1, PHLDA1, Fas, and Ki-67 were predominantly expressed in mucoepidermoid carcinoma...
April 9, 2019: Head & Neck
Giuseppe Di Taranto, Shih-Heng Chen, Rossella Elia, Ngamcherd Sitpahul, Jeffrey C Y Chan, Luigi Losco, Emanuele Cigna, Diego Ribuffo, Hung-Chi Chen
BACKGROUND: Interposition vein grafts (IVG) and vascular bridge flaps (VBF) have been exploited as vascular conduit in challenging head and neck reconstructions. METHODS: A retrospective review was conducted on 6025 flaps. The effect of patients' characteristics and length of IVG on flap compromise and loss were analyzed. Comparison between IVG and VBF was performed. RESULTS: The flap compromise and loss rates for the overall group were 8...
April 9, 2019: Head & Neck
Narek Shaverdian, John V Hegde, Carol Felix, Sophia Hsu, Vincent Basehart, Michael L Steinberg, Allen M Chen
BACKGROUND: We evaluated priorities, expectations, and regret among patients treated on a phase II trial of de-escalated chemoradiation for human papillomavirus (HPV)-positive oropharyngeal cancer. METHODS: Eligibility included stage III/IV squamous cell carcinoma of the oropharynx, p16-positivity, age ≥18 years, and Zubrod score 0-1. Participants were surveyed with validated measures evaluating their treatment experience. RESULTS: Twenty-four of 27 (89%) patients participated with a median follow-up of 24 months...
April 8, 2019: Head & Neck
Mykayla L Sandler, John R Sims, Catherine Sinclair, Kayvon F Sharif, Rebecca Ho, Lauren E Yue, Maria J Téllez, Sedat Ulkatan, Azita S Khorsandi, Margaret Brandwein-Weber, Mark L Urken
BACKGROUND: Schwannomas, benign tumors arising from neurolemmocytes, are the most common type of peripheral nerve tumors. Extracranial schwannomas are most often found in the parapharyngeal space, commonly involving the vagus nerve to cervical sympathetic trunk. Vagal schwannomas present several unique clinical and therapeutic challenges. METHODS: A comprehensive literature review was conducted on 197 articles reporting 235 cases of cervical vagal schwannomas. Presenting symptoms, treatment approach, and postoperative outcomes were recorded and analyzed...
April 7, 2019: Head & Neck
Anna See, Amy E L Lim, Jiunn Wong, Hui Lin Choong, N Gopalakrishna Iyer, Hiang Khoon Tan, Ngian Chye Tan, Jeremy C F Ng
BACKGROUND: The efficacy of parathyroidectomy for primary and secondary hyperparathyroidism is well-established but evidence in tertiary hyperparathyroidism is lacking. We examined parathyroidectomy's effect in tertiary hyperparathyroidism. METHODS: Patients with tertiary hyperparathyroidism who underwent parathyroidectomy were followed up for 12 months. A modification of the 13-item parathyroid symptoms list developed by Pasieka was administered at 0, 1, 3, 6, and 12 months post-surgery...
April 7, 2019: Head & Neck
Smriti Panda, Alok Thakar, Kapil Sikka, Suresh C Sharma
BACKGROUND: To report the experience with sternomastoid (SM) myofascial flap for reconstruction/buttressing of lateral pharyngeal wall and floor of mouth defects following transoral onco-surgery. METHODS: Prospectively collected data from February 2012-January 2018. SM flap harvested as a superiorly based flap supplied by the occipital artery and consisting of only the anterior SM head. RESULTS: A total of 42 patients were included (TORS, n = 40; TOUSS, n = 2)...
April 4, 2019: Head & Neck
Paul Tabet, Nadim Saydy, Laurent Letourneau-Guillon, Olga Gologan, Éric Bissada, Tareck Ayad, Jean-Claude Tabet, Louis Guertin, Phuc Félix Nguyen-Tan, Apostolos Christopoulos
BACKGROUND: The usefulness of fine-needle aspiration (FNA), core-needle biopsy (CNB), and frozen section (FS) for assessing lateral cystic neck masses (LCNM) remains unclear. METHODS: A retrospective review of patients presenting with a LCNM was undertaken. RESULTS: In total, 135 patients were included. FNA had a lower sensitivity then CNB (59% vs 83%; P = .036) and FS (59% vs 93%; P = .01). FS had a better negative predictive value (NPV) when compared to FNA (92% vs 40%; P < ...
April 4, 2019: Head & Neck
Marta Tagliabue, Sara Gandini, Fausto Maffini, Valeria Navach, Roberto Bruschini, Gioacchino Giugliano, Francesca Lombardi, Susanna Chiocca, Elisabetta Rebecchi, Eleonora Sica, Massimo Tommasino, Luca Calabrese, Mohssen Ansarin
BACKGROUND: We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the "T-N tract," in patients with tongue squamous cell carcinoma at an advanced stage. METHODS: We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T-N tract...
April 3, 2019: Head & Neck
Scott R Hall, Gregory S Neel, Brent A Chang, Brittany E Howard, Thomas H Nagel, David G Lott, Richard E Hayden, Nan Zhang, Michael L Hinni
BACKGROUND: The American Joint Committee on Cancer (AJCC) eighth edition introduces a staging system specific for human papilloma virus positive oropharyngeal cancer with separate clinical (AJCC 8c) and pathological (AJCC 8p) criteria. METHODS: In this retrospective cohort study, preoperative imaging and pathology reports were used to stage patients based on the AJCC 8c and AJCC 8p criteria, respectively. The primary endpoint was agreement between AJCC 8c and AJCC 8p...
April 2, 2019: Head & Neck
Shaohua Zhan, Dan Luo, Wei Ge, Bin Zhang, Tianxiao Wang
BACKGROUND: This meta-analysis aimed to identify the clinicopathological factors that could predict the risk of occult lateral neck lymph node metastasis (OLLNM) in N0/N1a papillary thyroid cancer (PTC). METHODS: A literature search of PubMed, Web of Science, OvidSP, and Chinese National Knowledge Infrastructure databases was performed using relevant keywords. Specific odds ratios and confidence intervals were calculated. RESULTS: The final analysis included 15 studies with a total of 5342 patients...
April 2, 2019: Head & Neck
Ximena Mimica, Yao Yu, Marlena McGill, Christopher A Barker, Sean McBride, Ian Ganly, Jennifer R Cracchiolo, Lara A Dunn, Nora Katabi, Kevin Sine, Dennis Mah, Anna Lee, Nancy Lee, Marc A Cohen
BACKGROUND: Standard treatment of squamous cell carcinoma (SCC) of the anterior nasal mucosa is surgical resection with or without postoperative radiation. METHODS: Retrospective review of patients diagnosed with SCC of the nasal cavity between January 2000 and July 2018 who refused total rhinectomy and who were treated with radiation with or without chemotherapy with curative intent. RESULTS: Eleven patients were identified, 73% had stage III or stage IV disease...
April 1, 2019: Head & Neck
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