journal
https://read.qxmd.com/read/37728411/delayed-skin-grafting-protocol-following-integra%C3%A2-application-for-non-radiated-scalp-reconstruction-for-decreased-wound-depth-and-improved-contour
#1
JOURNAL ARTICLE
Mac Kenzie Reece, Hannah Walker, Isabella Benintendi, Stacey Ward, Ashley Thatcher, R Michael Johnson, Sameep P Kadakia
The clinical use of Integra™ has expanded to include scalp reconstruction since its FDA approval in 1996. Integra™, or dermal regeneration template, can be utilized in patients who are elderly with multiple medical comorbidities. Well-established Integra™ techniques utilize skin grafting 1-2 weeks following evidence of template vascularity. Most studies show the time to graft placement as <30 days, with almost all <52 days. No single article proposes a time frame for applying STSG after neodermis regeneration...
September 20, 2023: Head & Neck
https://read.qxmd.com/read/37727894/compartmental-tongue-surgery-for-intermediate-advanced-squamous-cell-carcinoma-a-multicentric-study
#2
JOURNAL ARTICLE
Luca Calabrese, Marta Tagliabue, Alberto Grammatica, Rita De Berardinis, Federica Corso, Luca Gazzini, Monir Abousiam, Enrico Fazio, Davide Mattavelli, Walter Fontanella, Lorenzo Giannini, Lorenzo Bresciani, Roberto Bruschini, Sara Gandini, Cesare Piazza, Mohssen Ansarin
BACKGROUND: A multicentric study was conducted on technical reproducibility of compartmental tongue surgery (CTS) in advanced tongue cancers (OTSCC) and comparison to standard wide margin surgery (SWMS). METHODS: We studied 551 patients with OTSCC treated by CTS and 50 by SWMS. Oncological outcomes were analyzed. A propensity score was performed to compare survival endpoints for the two cohorts. RESULTS: In the CTS group, survival and prognosis were significantly associated with positive lymph-nodes, extranodal extension, depth of invasion and involvement of the soft tissue connecting the tongue primary tumor to neck lymph nodes (T-N tract), independently from the center performing the surgery...
September 20, 2023: Head & Neck
https://read.qxmd.com/read/37715656/it-is-time-to-improve-the-diagnostic-workup-of-oropharyngeal-cancer-with-circulating-tumor-hpv-dna-systematic-review-and-meta-analysis
#3
REVIEW
Francesca Paolini, Flaminia Campo, Oreste Iocca, Valentina Manciocco, Armando De Virgilio, Valentina De Pascale, Silvia Moretto, Giuanluca Dalfino, Antonello Vidiri, Giovanni Blandino, Fulvia Pimpinelli, Aldo Venuti, Raul Pellini
The possibility of detecting circulating tumor HPV DNA (ctHPVDNA) in plasma in patients with oropharyngeal cancer has been demonstrated in several reports. However, these data are from small cohorts and available tests for detection of ctHPVDNA are not fully validated. The aim is to evaluate sensitivity, specificity, and accuracy of ctHPVDNA by ddPCR to define its efficacy in the clinical setting for the diagnosis of HPV + OPSCC. A comprehensive search of three different databases: MEDLINE, Embase, and Cochrane Library databases...
September 16, 2023: Head & Neck
https://read.qxmd.com/read/37698539/evaluating-depth-of-invasion-across-oral-cavity-subsites-as-part-of-the-ajcc-8th-edition-t-staging-criteria-for-oral-cavity-squamous-cell-carcinoma
#4
JOURNAL ARTICLE
Shivee Gilja, Joshua Barlow, Arvind Kumar, Michael H Berger, Mohemmed N Khan, Diana N Kirke, Scott A Roof
BACKGROUND: The prognostic impact of depth of invasion (DOI) in American Joint Committee on Cancer 8th edition TNM staging for oral cavity squamous cell carcinoma (OCSCCa) across oral cavity subsites is unknown. METHODS: Overall survival of patients with pT1-4a OCSCCa in the National Cancer Database (2010-2017), stratified by tumor size and DOI across eight oral cavity subsites, was evaluated using multivariable-adjusted Cox proportional hazards modeling. RESULTS: When stratified by tumor size ≤2 cm and >2 cm, DOI >5 mm and DOI >10 mm were only associated with worse overall survival, respectively, for tumors of the oral tongue (Tumor size ≤2 cm, DOI >5 mm v DOI ≤5 mm: HR: 1...
September 12, 2023: Head & Neck
https://read.qxmd.com/read/37698535/prognostic-utility-of-neutrophil-to-albumin-ratio-in-surgically-treated-oral-squamous-cell-carcinoma
#5
JOURNAL ARTICLE
Ya-Yun Yu, Yu-Tsai Lin, Hui-Ching Chuang, Chih-Yen Chien, Tai-Lin Huang, Fu-Min Fang, Yao-Te Tsai, Hui Lu, Ming-Hsien Tsai
BACKGROUND: We aimed to evaluate the prognostic significance of preoperative neutrophil-to-albumin ratio (NAR) in oral squamous cell carcinoma (OSCC). METHODS: A total of 622 patients with surgically treated OSCC were enrolled. NAR was defined as the absolute neutrophil count divided by the serum albumin level in peripheral blood before the radical surgery. Cox proportional hazards model were used to discover survival outcome-associated factors. RESULTS: The optimal cut-off of NAR to predict overall survival (OS) was determined to be 0...
September 12, 2023: Head & Neck
https://read.qxmd.com/read/37695059/transnasal-negative-pressure-therapy-for-accelerating-healing-and-improving-the-prognosis-of-pharyngocutaneous-fistula
#6
JOURNAL ARTICLE
Zhangwei Hu, Xueqin Guo, Lin Chen, Wenbin Lei
BACKGROUND: Pharyngocutaneous fistula (PCF) is one of the most common complications of total laryngectomy. This study is to investigate the efficacy of a novel platform called transnasal negative pressure therapy (TNPT) in the management of PCF. METHODS: We retrospectively reviewed 47 patients who underwent total laryngectomy between April 2015 and February 2021 and developed PCF in our hospital. We focused on the healing rate, dressing change frequency, and healing time between the TNPT and non-TNPT groups...
September 11, 2023: Head & Neck
https://read.qxmd.com/read/37695029/is-it-challenging-to-comply-with-the-guidelines-on-the-timely-initiation-of-port
#7
LETTER
Mranalini Verma, Divya Kukreja, Sanjay Singhal
No abstract text is available yet for this article.
September 11, 2023: Head & Neck
https://read.qxmd.com/read/37682116/impact-of-comorbidities-on-outcomes-in-patients-with-advanced-head-and-neck-cancer-undergoing-immunotherapy
#8
JOURNAL ARTICLE
Meytal Guller, Dylan J Cooper, Hosam Alkhatib, Aditya Suru, Angelo Blancaflor, Christopher A Maroun, Tristan Tham, Hailey Allen, Eden Mazzara, Jerin Thomas, Neha Amin, Evan Wu, David W Eisele, Carole Fakhry, Drew Pardoll, Tanguy Y Seiwert, Gangcai Zhu, Rajarsi Mandal
OBJECTIVES: To explore the impact of pre-existing comorbidities on immunotherapy response, overall and progression-free survival, and immune-related adverse events (irAEs) of patients with advanced head and neck cancer (HNC) treated with immunotherapy. PATIENTS AND METHODS: Ninety-three patients treated with immunotherapy were identified and stratified into comorbidity absent or present (CCI < 1 and CCI ≥ 1, respectively) cohorts, and clinical outcomes were compared between these two groups...
September 8, 2023: Head & Neck
https://read.qxmd.com/read/37682073/transcriptional-subtypes-of-glottic-cancer-characterized-by-differential-activation-of-canonical-oncogenic-programming
#9
JOURNAL ARTICLE
Bharat A Panuganti, Christine Carico, Harishanker Jeyarajan, Mitchell Flagg, Pablo Tamayo
BACKGROUND: There is a paucity of data concerning molecular heterogeneity among glottic squamous cell carcinoma, and the clinical implications thereof. METHODS: Data corresponding to glottic squamous cell carcinoma were derived from The Cancer Genome Atlas. The Onco-GPS computational methodology was levied to derive four patterns of transcriptional activity and three functional subtypes of glottic cancer. RESULTS: Thirty glottic cancer samples stratified to three distinct oncogenic states (S0-S2) based on a Onco-GPS model containing four transcriptional components (F0-F3)...
September 8, 2023: Head & Neck
https://read.qxmd.com/read/37676108/incidence-and-risk-factors-of-surgical-site-infection-in-patients-with-head-and-neck-cancer-a-meta-analysis
#10
REVIEW
Yu Wang, Mingyi Wang, Lili Hou, Fuping Xiang, Xiaomei Zhao, Meizhen Qian
We systematically review the incidence and risk factors of surgical site infection (SSI) in patients with head and neck cancer. PubMed, Embase, Cochrane Library, and Web of Science databases were searched to obtain studies on the risk factors for SSI in patients with HNC. The retrieval time was from the establishment of the database to February 2023. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias in included studies. Meta-analysis was performed by using Stata 15...
September 7, 2023: Head & Neck
https://read.qxmd.com/read/37675788/ultrasonographic-features-of-mass-lesions-in-the-oral-submucosal-epithelium-using-intraoral-ultrasonography
#11
JOURNAL ARTICLE
Masaru Konishi, Toshinori Ando, Mutsumi Miyauchi, Naoya Kakimoto
BACKGROUND: Mass lesions occurring under the oral mucosal epithelium are often small and difficult to diagnose; however, intraoral ultrasonography can delineate these lesions. We aimed to investigate the features of submucosal mass lesions in the oral cavity using intraoral ultrasonography. METHODS: Fifty patients with hemangioma, irritation fibroma, mucous cyst, lipoma, and pleomorphic adenoma were included. Age, site, largest diameter, thickness, marginal morphology type, border type, internal echo posterior echo, and internal or peripheral Doppler images of the lesions were recorded...
September 7, 2023: Head & Neck
https://read.qxmd.com/read/37671696/protocolized-awake-secondary-tracheoesophageal-puncture-with-immediate-voicing
#12
JOURNAL ARTICLE
Nicolette Jabbour, Timothy Rodriggs, Meredith O'Dea, Taha Mur, Kailey Vitale, Daniel L Faden
Tracheoesophageal (TE) puncture with voice prosthesis placement is a common method for vocal rehabilitation in patients who have undergone total laryngectomy. Tracheoesophageal voice prosthesis (TEP) placement after laryngectomy, known as secondary TE puncture, is traditionally done in the operating room, using rigid esophagoscopy. Traditional secondary TEP placement carries a number of downsides including risks associated with general anesthesia, high cost, and technical challenges associated with anatomical variables...
September 6, 2023: Head & Neck
https://read.qxmd.com/read/37671689/distal-positioning-of-the-skin-paddle-of-pectoralis-major-myocutaneous-flap-in-head-and-neck-reconstruction
#13
JOURNAL ARTICLE
Muthuswamy Dhiwakar, Jeevithan Shanmugam, Zubair A Khan, Shivprakash Mehta, Konagalla Karthik
BACKGROUND: To assess outcomes of pectoralis major myocutaneous flap (PMF) wherein the skin paddle (SP) was positioned with its distal portion extending beyond the lower border of pectoralis major by ≥2 cm (PMF-d). METHODS: Consecutive head and neck reconstructions with PMF-d (n = 110). SP dimensions l2 (distal extent below the lower border of pectoralis major), l1 (proximal extent above lower border of pectoralis major), and b (breadth) were recorded...
September 6, 2023: Head & Neck
https://read.qxmd.com/read/37671671/successful-surgery-with-preservation-of-laryngeal-function-in-a-patient-with-collision-primary-squamous-cell-carcinoma-and-adenoid-cystic-carcinoma-in-the-hypopharynx-and-synchronous-esophageal-carcinoma-a-case-report
#14
Ziming Fu, Xiaolong Xu, Yangyang Bao, Zhe Chen, Jiangtao Zhong, Shuihong Zhou
BACKGROUND: The definition of "collision tumor" is the coexistence of two histologically and morphologically distinct tumors within the same anatomical area without histological admixture. Collision tumors featuring primary squamous cell and adenoid cystic carcinomas of the hypopharynx, combined with synchronous esophageal carcinoma, are very rare. METHODS: We describe a patient with a collision tumor of the hypopharynx and synchronous esophageal carcinoma who underwent partial laryngectomy, with preservation of laryngeal function, and radical esophageal resection featuring esophageal reconstruction using a gastric tube...
September 6, 2023: Head & Neck
https://read.qxmd.com/read/37667677/bilateral-nodule-radiofrequency-ablation-in-a-single-setting-first-reported-case-series
#15
JOURNAL ARTICLE
Peter P Issa, Brandon M Magazine, Alexandra LaForteza, Mohamed Shama, Emad Kandil
BACKGROUND: Radiofrequency ablation (RFA) is a minimally-invasive ablative technique with an impressive safety profile used to manage thyroid nodules. Current reports with RFA describe the treatment of a single nodule in a single-setting. We describe the first series of bilateral nodule RFA in a single-setting. METHODS: RFA was performed on patients with bilateral thyroid nodules in a single-setting. A cohort of randomly selected patients undergoing RFA for bilateral thyroid nodules in a separate setting was reported as a control cohort...
September 5, 2023: Head & Neck
https://read.qxmd.com/read/37650152/reply-to-letter-to-the-editor-should-there-be-a-definite-place-for-grade-in-the-next-tnm-staging-system-for-major-salivary-gland-malignancies
#16
LETTER
Allen S Ho, Michael Luu, Bonnie L Balzer, Zachary S Zumsteg
No abstract text is available yet for this article.
August 31, 2023: Head & Neck
https://read.qxmd.com/read/37649395/should-there-be-a-definite-place-for-grades-in-the-next-tnm-staging-system-for-major-salivary-gland-malignancies
#17
LETTER
Teja Kantamani, Shivakumar Thiagarajan
No abstract text is available yet for this article.
August 30, 2023: Head & Neck
https://read.qxmd.com/read/37646526/pulse-granuloma-presenting-as-a-lateral-neck-mass-an-unusual-presentation-of-a-fourth-branchial-cleft-fistula
#18
Tiffany Wang, Scott Roof, William H Westra
BACKGROUND: The pulse granuloma (PG) is believed to represent a distinctive foreign body reaction to ingested particles of legumes. Its presentation in the neck is entirely unexpected. METHODS: A woman presented with a mass of the lower neck that recurred following incision and drainage. The recurrent mass was found to be associated with an open sinus tract at the apex of the left pyriform sinus. The opening of the sinus tract was closed and the cyst was removed...
August 30, 2023: Head & Neck
https://read.qxmd.com/read/37646494/patterns-of-alaryngeal-voice-adoption-and-predictive-factors-of-vocal-rehabilitation-failure-following-total-laryngectomy
#19
JOURNAL ARTICLE
Vivianne Landry, Apostolos Christopoulos, Louis Guertin, Eric Bissada, Paul Tabet, Ilyes Berania, Émilie Royal-Lajeunesse, Marie-Jo Olivier, Tareck Ayad
OBJECTIVE: We aimed to determine patterns of alaryngeal voice acquisition and predictive factors of vocal rehabilitation (VR) failure following total laryngectomy (TL) at a large Canadian tertiary care center. METHODS: All consecutive patients having undergone a TL between January 1st, 2011 and December 31st, 2019, at the Centre Hospitalier de l'Université de Montréal were included. RESULTS: One hundred and ninety-seven laryngectomized patients were identified...
August 30, 2023: Head & Neck
https://read.qxmd.com/read/37642334/health-related-quality-of-life-functional-outcomes-and-complications-after-sentinel-lymph-node-biopsy-and-elective-neck-dissection-in-early-oral-cancer-a-systematic-review
#20
JOURNAL ARTICLE
Christopher McDonald, Samuel Kent, Andrew Schache, Simon Rogers, Richard Shaw
BACKGROUND: Elective neck dissection improves survival in early oral cancer. Sentinel lymph node biopsy may also do this with less morbidity. This systematic review compared health-related quality of life, functional outcomes, and complications after sentinel lymph node biopsy and elective neck dissection in early oral cancer. METHODS: PRISMA guidelines were followed. Thirteen studies met inclusion criteria. RESULTS: Results favoring sentinel lymph node biopsy were found in complications, scar length and appearance, length of hospital stay, time to drain removal, and objective shoulder measures at timepoints up to 12 months...
August 29, 2023: Head & Neck
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