journal
https://read.qxmd.com/read/38936933/survival-and-risk-factors-for-mortality-in-infants-with-congenital-heart-disease-in-south-korea
#21
JOURNAL ARTICLE
Jue Seong Lee, Jeha Kwon, Hannah Cho, Ju Sun Heo, Kee Soo Ha, Gi Young Jang, O Kyu Noh, Jun Eun Park
BACKGROUND/AIM: The survival of patients with congenital heart disease (CHD) has dramatically improved over recent decades. However, a disparity exists depending on the country and medical system. This study aimed to analyze the survival of infants with CHD until the age of 18 years using large-scale population data in South Korea and investigate the effect of neonatal conditions at birth. PATIENTS AND METHODS: We retrospectively extracted the Korean National Health Insurance Service claims data from January 2002 to December 2020...
2024: In Vivo
https://read.qxmd.com/read/38936932/paclitaxel-ifosfamide-based-therapy-as-salvage-treatment-in-platinum-resistant-recurrent-metastatic-head-and-neck-cancer
#22
JOURNAL ARTICLE
Ming-Yu Chou, Wen-Chi Wu, Pen-Yuan Chu, Shyh-Kuan Tai, Peter Mu-Hsin Chang, Tsung-Lun Lee, Tien-Hua Chen, Muh-Hwa Yang
BACKGROUND: Treatment options are limited, and the prognosis is poor for patients with platinum-resistant recurrent metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). This study evaluated the efficacy and safety of a paclitaxel and ifosfamide (TI) regimen in patients with R/M HNSCC whose disease had progressed following platinum-based therapy. PATIENTS AND METHODS: In this retrospective study, we included 53 patients with R/M HNSCC who underwent at least one cycle of TI-based therapy, post platinum failure, between February 2020 and August 2023...
2024: In Vivo
https://read.qxmd.com/read/38936931/fibula-grafting-for-oromandibular-reconstruction-and-its-effect-on-patient-quality-of-life-a-scoping-review
#23
REVIEW
Marcel Ebeling, Alexander Hagmann, Spyridoula Derka, Alexander Schramm, Frank Wilde, Mario Scheurer, Sebastian Pietzka, Andreas Sakkas
Fibula osteoseptocutaneous flap has been widely used for oncologic bony reconstruction of both the mandible and maxilla. Early and late morbidities of the donor side such as leg weakness, ankle instability, limited ankle mobility, tibial stress fractures or incision area pain are well documented; however, there is a lack of information about the effects of fibula grafting on patient quality of life. To address this issue, a scoping literature search in the PubMed electronic database was performed to identify all relevant studies and reviews in the period between 2010 and 2022...
2024: In Vivo
https://read.qxmd.com/read/38936930/enhancing-the-contouring-efficiency-for-head-and-neck-cancer-radiotherapy-using-atlas-based-auto-segmentation-and-scripting
#24
JOURNAL ARTICLE
Yukari Nagayasu, Shingo Ohira, Toshiki Ikawa, Akira Masaoka, Naoyuki Kanayama, Takahisa Nishi, Tanaka Kazunori, Yutaro Yoshino, Masayoshi Miyazaki, Yoshihiro Ueda, Koji Konishi
BACKGROUND/AIM: Intensity-modulated radiation therapy can deliver a highly conformal dose to a target while minimizing the dose to the organs at risk (OARs). Delineating the contours of OARs is time-consuming, and various automatic contouring software programs have been employed to reduce the delineation time. However, some software operations are manual, and further reduction in time is possible. This study aimed to automate running atlas-based auto-segmentation (ABAS) and software operations using a scripting function, thereby reducing work time...
2024: In Vivo
https://read.qxmd.com/read/38936929/clinicopathologic-significance-of-quaking-expression-in-hepatocellular-carcinoma
#25
JOURNAL ARTICLE
Sung-Eun Kim, Cheol Keun Park, Ji Won Park, Jung Woo Lee, Ji-Young Choe, Yoon Ah Cho
BACKGROUND/AIM: The RNA binding protein quaking (QKI) is associated with the development and progression of tumor suppressors in various cancers. However, the clinical implications of QKI expression have not yet been fully elucidated. In this study, we aimed to investigate the clinicopathological and prognostic significance of QKI expression in hepatocellular carcinoma (HCC). MATERIALS AND METHODS: We performed QKI, Zinc finger E-box-binding homeobox 1 (ZEB1), E-cadherin, and glutathione peroxidase 4 (GPX4) immunohistochemical staining on 166 HCC patient tissue samples...
2024: In Vivo
https://read.qxmd.com/read/38936928/proton-beam-therapy-for-locally-advanced-hepatocellular-carcinoma-with-inferior-vena-cava-tumor-thrombus-case-report
#26
JOURNAL ARTICLE
Shintaro Shiba, Sachika Shiraishi, Koichi Tokuuye, Ryosuke Shirata, Motoko Omura
BACKGROUND/AIM: We report on a case of locally advanced hepatocellular carcinoma (HCC) accompanied by an inferior vena cava tumor thrombus (IVCTT), treated successfully with proton-beam therapy (PBT). CASE REPORT: A 63-year-old male presented with a primary, single HCC with IVCTT, without metastasis to the intrahepatic region, lymph nodes, or distant organs. The clinical staging was identified as T4N0M0 Stage IIIB. The patient's liver function was classified as Child-Pugh class A (score: 6), with a modified albumin-bilirubin (mALBI) grade of 2a...
2024: In Vivo
https://read.qxmd.com/read/38936927/effects-of-statin-and-annatto-extracted-tocotrienol-supplementation-on-glucose-homeostasis-bone-microstructure-and-gut-microbiota-composition-in-obese-mice
#27
JOURNAL ARTICLE
Chwan-Li Shen, Umesh D Wankhade, Kartik Shankar, Rami S Najjar, Rafaela G Feresin, Moamen M Elmassry, Jannette M Dufour, Gurvinder Kaur, Sree V Chintapalli, Brian D Piccolo, Dale M Dunn, Jay J Cao
BACKGROUND/AIM: This study examined the effects of tocotrienols (TT) in conjunction with statin on glucose homeostasis, bone microstructure, gut microbiome, and systemic and liver inflammatory markers in obese C57BL/6J mice. MATERIALS AND METHODS: Forty male C57BL/6J mice were fed a high-fat diet (HFD) and assigned into four groups in a 2 (no statin vs. 120 mg statin/kg diet)×2 (no TT vs. 400 mg TT/kg diet) factorial design for 14 weeks. RESULTS: Statin and TT improved glucose tolerance only when each was given alone, and only statin supplementation decreased insulin resistance...
2024: In Vivo
https://read.qxmd.com/read/38936926/robotic-versus-laparoscopic-abdominoperineal-resection-for-locally-advanced-rectal-cancer-following-preoperative-chemoradiotherapy
#28
COMPARATIVE STUDY
Tatsuki Watanabe, Kazuhito Sasaki, Hiroaki Nozawa, Koji Murono, Shigenobu Emoto, Hiroyuki Matsuzaki, Yuichiro Yokoyama, Shinya Abe, Yuzo Nagai, Takahide Shinagawa, Hirofumi Sonoda, Lim Sukchol, Soichiro Ishihara
BACKGROUND/AIM: The usefulness of robotic surgery compared to laparoscopic surgery for rectal cancer has been reported; however, few reports exist on robotic abdominoperineal resection (APR). The aim of this study was to compare the outcomes of robotic and laparoscopic surgery to determine their usefulness in patients with locally advanced rectal cancer who had undergone preoperative chemoradiotherapy (CRT). PATIENTS AND METHODS: This retrospective study included 43 patients with locally advanced rectal cancer who underwent preoperative CRT and robotic (22 patients) or laparoscopic APR (21 patients) between December 2012 and September 2022...
2024: In Vivo
https://read.qxmd.com/read/38936925/body-composition-in-patients-with-metabolic-dysfunction-associated-steatotic-liver-disease-impact-of-body-surface-area
#29
JOURNAL ARTICLE
Saori Onishi, Akira Fukuda, Masahiro Matsui, Kosuke Ushiro, Tomohiro Nishikawa, Akira Asai, Soo Ki Kim, Hiroki Nishikawa
BACKGROUND/AIM: To examine the relationship between the body surface area (BSA) and body composition in patients with metabolic dysfunction-associated steatotic liver disease (MASLD, 2,141 men and 986 women). MATERIALS AND METHODS: BSA and body composition parameters were examined. RESULTS: The median body mass index (BMI) was 25.0 kg/m2 for both men and women (p=0.7754). The median body surface area (BSA) was 1.854 m2 for men and 1.618 m2 for women (p<0...
2024: In Vivo
https://read.qxmd.com/read/38936924/combination-of-autophagy-and-stem-cell-enhancing-properties-of-natural-product-extracts-in-human-dermal-papilla-stem-cells
#30
JOURNAL ARTICLE
Zin Zin Ei, Supalerk Kowinthanaphat, Pilaiwanwadee Hutamekalin, Verisa Chowjarean, Pithi Chanvorachote
BACKGROUND/AIM: Dermal papilla (DP) stem cells are known for their remarkable regenerative capacity, making them a valuable model for assessing the effects of natural products on cellular processes, including stemness, and autophagy. MATERIALS AND METHODS: Autophagy and stemness characteristics were assessed using real-time RT-PCR to analyze mRNA levels, along with immunofluorescence and western blot techniques for protein level evaluation. RESULTS: Butterfly Pea, Emblica Fruits, Kaffir Lime, and Thunbergia Laurifolia extracts induced autophagy in DP cells...
2024: In Vivo
https://read.qxmd.com/read/38936923/c-reactive-protein-is-a-prognostic-factor-for-survival-in-metastatic-upper-tract-urothelial-carcinoma-patients-receiving-pembrolizumab
#31
JOURNAL ARTICLE
Hirotaka Nagasaka, Shotaro Yamamoto, Atsuto Suzuki, Kimitsugu Usui, Hideyuki Terao, Noboru Nakaigawa, Takeshi Kishida
BACKGROUND/AIM: The number of available treatment options for urothelial carcinoma has increased recently. Upper tract urothelial carcinoma (UTUC) is relatively rare compared with bladder cancer. There are few reports on the efficacy of immune checkpoint inhibitors (ICIs) for metastatic UTUC, and ICIs may occasionally show less efficacy and cause severe side effects. Therefore, it is important to predict the treatment response and change the treatment strategy as appropriate. We investigated the prognostic factors for treatment response in patients with metastatic UTUC treated with pembrolizumab at our hospital...
2024: In Vivo
https://read.qxmd.com/read/38936922/similar-efficacy-between-atezolizumab-plus-bevacizumab-versus-hepatic-arterial-infusion-chemotherapy-for-unresectable-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus-a-retrospective-cohort-study
#32
JOURNAL ARTICLE
Akifumi Kuwano, Masayoshi Yada, Kosuke Tanaka, Yuta Koga, Shigehiro Nagasawa, Akihide Masumoto, Kenta Motomura
BACKGROUND/AIM: The landscape of treatments for hepatocellular carcinoma (HCC), including immune checkpoint inhibitors, has expanded significantly. However, unresectable HCC patients with portal vein tumor thrombus (PVTT) continue to face a poor prognosis. This investigation examined the survival outcomes and determinants influencing survival rates in advanced HCC patients with PVTT undergoing treatment with atezolizumab plus bevacizumab (ATZ+BEV) or hepatic arterial infusion chemotherapy (HAIC)...
2024: In Vivo
https://read.qxmd.com/read/38936921/efficacy-of-mirogabalin-for-taxane-associated-chemotherapy-induced-peripheral-neuropathy-in-perioperative-chemotherapy-for-early-breast-cancer
#33
JOURNAL ARTICLE
Takaaki Fujii, Chikako Honda, Keiko Tanabe, Misato Ogino, Sayaka Obayashi, Ken Shirabe
BACKGROUND/AIM: Treatment with taxanes can result in chemotherapy-induced peripheral neuropathy (CIPN). We investigated the efficacy and safety of mirogabalin for the treatment of CIPN in patients who had been administered perioperative chemotherapy including taxane-based agents for breast cancer. PATIENTS AND METHODS: We retrospectively analyzed the case of 43 patients with early breast cancer who received a taxane as perioperative chemotherapy and were administered mirogabalin at the diagnosis of CIPN...
2024: In Vivo
https://read.qxmd.com/read/38936920/association-of-matrix-metalloproteinase-9-genotypes-with-nasopharyngeal-carcinoma-risk
#34
JOURNAL ARTICLE
Chao-Hsuan Chen, Liang-Chun Shih, Shih-Wei Hsu, Hui-Chi Tien, Yen-Fang Liu, Yun-Chi Wang, Chia-Wen Tsai, DA-Tian Bau, Wen-Shin Chang
BACKGROUND/AIM: The up-regulation of matrix metalloproteinase-9 (MMP-9) expression is a characteristic feature observed across various malignancies, including nasopharyngeal carcinoma (NPC). Nevertheless, the influence of MMP-9 genotype in the context of NPC remains underexplored. This study examined the implications of MMP-9 promoter rs3918242 genotypes on the susceptibility to NPC in Taiwan. MATERIALS AND METHODS: In a cohort comprising 208 NPC cases and 416 healthy controls, genotyping of MMP-9 rs3918242 was conducted utilizing polymerase chain reaction-restriction fragment length polymorphism methodology...
2024: In Vivo
https://read.qxmd.com/read/38936919/clinical-aspects-of-chronic-idiopathic-postnasal-drip-an-entity-not-to-be-overlooked
#35
JOURNAL ARTICLE
Taek Yoon Cheong, Ick Soo Choi
BACKGROUND/AIM: Postnasal drip may be related to several diseases, but not all patients are clearly diagnosed. Patients with chronic, idiopathic postnasal drip symptoms are easily overlooked, and their clinical features are yet to be identified. This study aimed to analyze the clinical features and response to first generation antihistamine-decongestant therapy in patients with chronic idiopathic postnasal drip, suggesting it as a distinct entity. PATIENTS AND METHODS: A retrospective cohort study involving 157 chronic idiopathic postnasal drip patients was conducted, analyzing demographics, symptoms, and treatment response to first-generation antihistamines and nasal decongestants...
2024: In Vivo
https://read.qxmd.com/read/38936918/correlation-between-ct-density-incidence-mortality-and-mortality-to-incidence-ratio-in-central-nervous-system-cancers-an-exploratory-analysis-of-global-data
#36
JOURNAL ARTICLE
Tsung-Hsi Yang, Ya-Chuan Chang, Chia-Ying Yu, Wen-Wei Sung, Tsung-Hsien Lee
BACKGROUND/AIM: Cancers of the central nervous system (CNS) pose a significant burden, despite their relatively low incidence compared to other types of cancers. The mortality-to-incidence ratio (MIR) is a crucial indicator of long-term survival and healthcare system performance. Computed tomography (CT) plays a crucial role in the screening, diagnosis, and monitoring of brain tumors, enabling early intervention and treatment. This study aimed to explore the relationship between CT density, CNS cancer incidence, mortality, and MIR to investigate regional variations in CT utilization and their impact on CNS cancer mortality rates...
2024: In Vivo
https://read.qxmd.com/read/38936917/personalizing-prophylactic-radiotherapy-for-hip-heterotopic-ossification-an-amstar-2-compliant-review-of-meta-analyses
#37
REVIEW
Erika Galietta, Luca Gaiani, Claudio Giannini, Andrea Sambri, Milly Buwenge, Gabriella Macchia, Francesco Deodato, Savino Cilla, Lidia Strigari, Alessandra Arcelli, Michele Fiore, Silvia Cammelli, Massimiliano DE Paolis, Alessio Giuseppe Morganti
BACKGROUND/AIM: Heterotopic ossification (HO) is a common complication following total hip arthroplasty. Various prophylactic treatments have been proposed, including radiotherapy (RT). This review summarizes the evidence from meta-analyses on the efficacy of RT in preventing hip HO. MATERIALS AND METHODS: A literature search was conducted on PubMed. The quality of the meta-analyses was assessed using the AMSTAR-2 tool. RESULTS: Seven meta-analyses were included...
2024: In Vivo
https://read.qxmd.com/read/38936916/effects-of-laurus-nobilis-leaf-extract-lauresh-%C3%A2-on-oral-and-gut-microbiota-diversity-in-mice
#38
JOURNAL ARTICLE
Tetsuro Morikawa, Durga Paudel, Osamu Uehara, Dedy Ariwansa, Yukiko Kobayashi, Jinwei Yang, Koki Yoshida, Yoshihiro Abiko
BACKGROUND/AIM: The leaves of Laurus nobilis have been used for culinary purposes for many years and have recently been shown to have beneficial effects on human health by altering microbiota composition. However, the effects of L. nobilis on the diversity of microbiomes in the oral cavity and gut remain unknown. Therefore, in this study, we examined the effects of an extract of L. nobilis on the diversity of microbiomes in the oral cavity and gut in mice. MATERIALS AND METHODS: C57BL/6J mice were randomly divided into two groups and fed a standard diet (SD) and a standard diet containing 5% LAURESH® , a laurel extract (SDL)...
2024: In Vivo
https://read.qxmd.com/read/38936915/cold-physical-plasma-reduces-motility-of-various-bone-sarcoma-cells-while-remodeling-the-cytoskeleton
#39
JOURNAL ARTICLE
Andreas Nitsch, Pauline Marthaler, Sara Qarqash, Maximilian Bemmann, Sander Bekeschus, Georgi I Wassilew, Lyubomir Haralambiev
BACKGROUND/AIM: Cold physical plasma (CPP) has emerged as an effective therapy in oncology by inducing cytotoxic effects in various cancer cells, including chondrosarcoma (CS), Ewing's sarcoma (ES), and osteosarcoma (OS). The current study investigated the impact of CPP on cell motility in CS (CAL-78), ES (A673), and OS (U2-OS) cell lines, focusing on the actin cytoskeleton. MATERIALS AND METHODS: The CASY Cell Counter and Analyzer was used to study cell proliferation and determine the optimal concentrations of fetal calf serum to maintain viability without stimulation of cell proliferation...
2024: In Vivo
https://read.qxmd.com/read/38936914/preoperative-and-postoperative-platelet-lymphocyte-ratio-is-a-prognostic-marker-for-patients-with-soft-tissue-sarcoma-treated-with-curative-resection
#40
JOURNAL ARTICLE
In Hee Lee, Jihyun Na, Soo Jung Lee
BACKGROUND/AIM: Systemic inflammation has been implicated in the development and progression of cancer. Inflammatory markers have been identified as prognostic indicators in numerous malignancies. This study explored the prognostic relevance of the initial and postoperative neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) on relapse-free survival (RFS) and overall survival (OS) in patients with soft-tissue sarcoma (STS) who underwent curative resection. PATIENTS AND METHODS: We included 89 patients with STS who underwent extensive and radical resection at the Kyungpook National University Chilgok Hospital between 2004 and 2018...
2024: In Vivo
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