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In Vivo

Jun Yamamura, Shunji Kamigaki, Masaki Tsujie, Junya Fujita, Hiroki Osato, Chihiro Higashi, Hirofumi Kanaizumi, Yumiko Tanaka, Mika Hamada, Wataru Shinzaki, Yukihiko Hashimoto, Yoshifumi Komoike
BACKGROUND/AIM: Little evidence is currently available on significant determinants of post-recurrence survival for patients with hormone receptor-positive (HR+), HER2-negative (HER2-) breast cancer. The objective of this study was to evaluate factors influencing post-recurrence survival in HR+/HER2-breast cancer. PATIENTS AND METHODS: A cohort of 236 patients with recurrent HR+/HER2- breast cancer was retrospectively analyzed to identify significant factors correlating with prognosis after recurrence...
January 2019: In Vivo
Talyta Ellen DE Jesus Dos Santos, Fernando Barroso Duarte, Maritza Cavalcante Barbosa, Anna Thawanny Gadelha Moura, João Paulo Leitão DE Vasconcelos, Francisco Dário Rocha-Filho, Diego F Coutinho, Ilana Zalcberg, Paulo R L Vasconcelos, Yhasmine Delles Oliverira Garcia, Romélia Pinheiro Gonçalves Lemes
BACKGROUND/AIM: Although risk stratification using the Prognostic Scores Systems (IPSS, WPSS and IPSS-R) incorporate key information about prognosis of patients with Myelodysplastic syndromes (MDS), patients classified as low-risk may evolve rapidly and aggressively, despite a "favorable" prognostic stratification. The aim of this study was to identify biomarkers for predicting prognosis, and for better stratification and management of these patients. MATERIALS AND METHODS: Expression of CD34 and p53 in megakaryocytes was examined by immunohistochemistry in 71 MDS patients classified as low-risk...
January 2019: In Vivo
Takashi Sasaki, Ryo Kanata, Ikuhiro Yamada, Masato Matsuyama, Masato Ozaka, Naoki Sasahira
BACKGROUND/AIM: FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, oxaliplatin) and gemcitabine plus nab-paclitaxel therapy have recently been introduced for the treatment of metastatic pancreatic cancer. Herein, overall treatment outcomes of metastatic pancreatic cancer after introduction of FOLFIRINOX and gemcitabine plus nab-paclitaxel therapy were evaluated, in daily practice. PATIENTS AND METHODS: Metastatic pancreatic cancer patients (n=321) who started systemic chemotherapy between January 2011 and December 2016 were included and were divided into two groups: group A (2011-2013) and group B (2014-2016)...
January 2019: In Vivo
Hae Jin Park, Han Suk Ryu, Kyubo Kim, Kyung Hwan Shin, Wonshik Han, Dong-Young Noh
BACKGROUND/AIM: In this study, the treatment outcome and risk factors for recurrence in patients undergoing surgery with or without adjuvant radiotherapy (RT) for malignant phyllodes tumors of the breast (MPTB) were analyzed. PATIENTS AND METHODS: Forty-three patients (61.4%) underwent breast-conserving surgery (BCS) and 27 (38.6%) underwent mastectomy. Fifteen patients (21.4%) received adjuvant RT. RESULTS: With a median follow-up of 76 months, the 7-year local control (LC), distant metastasis-free survival (DMFS), disease-free survival (DFS), and cause-specific survival (CSS) rates were 90...
January 2019: In Vivo
Michael B J Kohake, Ulrich Wiebking, Padhraig F O'Loughlin, Christian Krettek, Ralph Gaulke
BACKGROUND/AIM: The aim of the present study was to assess the impact of syndesmotic screw fixation on overall clinical outcomes following Weber B-type ankle fractures. MATERIALS AND METHODS: A total of 21 patients with syndesmotic rupture requiring screw fixation were compared to 40 patients with an intact syndesmosis. Olerud-Molander-Ankle-Score, American Orthopedic Foot & Ankle Society ankle hindfoot score, and the Short Form Health Survey-36 were recorded...
January 2019: In Vivo
Dongwei Zhang, Sarah C Glover, Weidong Liu, Xiuli Liu, Jinping Lai
Pyogenic granuloma (PG) represents a lobular capillary proliferation commonly seen in the skin or oral mucosa. They are rarely reported in the gastrointestinal tract. The mechanism underlying PG pathogenesis is not well understood. Only one case of cutaneous PG associated with cytomegalovirus (CMV) infection has been reported in the English literature. Here, we report such a unique case of PG arising from the small bowel. A 67-year-old male, status post ileocolic resection, presented for follow-up colonoscopy because of Crohn's disease of the terminal ileum and the colon...
January 2019: In Vivo
Konstantinos A Polyzos, Maria L Karadima, Aikaterini C Kosma, Andreas Lazaris, Nikolaos Kavantzas, Nikolas Tsavaris
BACKGROUND/AIM: The aim of the present study was the evaluation of the influence of cancer stem cells and other parameters in stage IV colorectal cancer patients. MATERIALS AND METHODS: One hundred patients were retrospectively included in the study and 24 variables were examined for their relation with response to treatment and survival. RESULTS: A low ploidy score in the histology of colorectal cancer was associated with improvement of performance status and response to therapy...
January 2019: In Vivo
Hidejiro Kawahara, Yuki Hiramoto, Mitsumasa Takeda, Nori Matsumoto, Takeyuki Misawa, Katsuhiko Yanaga
BACKGROUND: Postoperative changes in patient anthropometric and nutritional statuses after proctocolectomy due to ulcerative colitis (UC) are unclear. PATIENTS AND METHODS: Between January 2015 and December 2017, nine patients who underwent proctocolectomy with temporary ileostomy (PTI) for UC at our hospital were enrolled in this study. For the comparison group, eight patients who underwent low anterior resection (LAR) with temporary ileostomy for rectal cancer in the same period were recruited...
January 2019: In Vivo
Marina Milic, Marcia Hall, Annette Hawkins, Andrew Gogbashian, Gordon Rustin, Anand Sharma
BACKGROUND: Single-agent carboplatin at area under the curve 10 (AUC10) is an effective treatment for metastatic seminoma. As far as we are aware of, there have been no studies reporting its effects on short-term quality of life. The objective was to study the efficacy, safety and tolerability, using health-related quality of life, of carboplatin AUC10 chemotherapy in patients with metastatic seminoma. PATIENTS AND METHODS: Forty-four patients with metastatic seminoma treated at Mount Vernon Cancer Centre with carboplatin AUC10 were included in this study...
January 2019: In Vivo
Carsten Nieder, Astrid Dalhaug, Adam Pawinski
BACKGROUND/AIM: The aim of this study was to analyze the prognostic impact of serum lactate dehydrogenase (LDH) in patients with oligometastatic brain metastases, arbitrarily defined as max. Four brain lesions and 5 metastatic lesions overall. PATIENTS AND METHODS: This was a retrospective single institution analysis. Overall, 42 patients were identified from a prospectively maintained database. RESULTS: Seventeen patients (40%) had extracranial metastases...
January 2019: In Vivo
Toru Aoyama, Yukio Maezawa, Takaki Yoshikawa, Kenki Segami, Kazuki Kano, Tsutomu Hayashi, Takanobu Yamada, Masakatsu Numata, Motohico Goda, Hiroshi Tamagawa, Tsutomu Sato, Norio Yukawa, Yasushi Rino, Munetaka Masuda, Takashi Ogata, Haruhiko Cho, Takashi Oshima
BACKGROUND: Body weight, especially lean body mass, significantly decreases after gastrectomy for gastric cancer due to surgical invasion, reduced food intake, and reduced mobility, which can reduce the quality of life and induce associated toxicity or reduce compliance with adjuvant chemotherapy. Such risks can be particularly high in elderly patients with gastric cancer. However, whether or not changes in the weight and body composition differ between elderly and non-elderly patients remains unclear...
January 2019: In Vivo
Tatsunori Kiriu, Masatsugu Yamamoto, Tatsuya Nagano, Kiyoko Koyama, Masahiro Katsurada, Daisuke Tamura, Kyosuke Nakata, Motoko Tachihara, Kazuyuki Kobayashi, Yoshihiro Nishimura
BACKGROUND/AIM: Red cell distribution width (RDW) has been reported to reflect the inflammation and nutrition status and predict prognosis of non-small cell lung cancer (NSCLC) patients treated with anti-programmed cell death-1 (PD-1) antibody. The aim of this study was to analyze the correlation between RDW and prognosis of NSCLC patients. PATIENTS AND METHODS: We collected retrospective data on consecutive NSCLC patients treated with anti-PD-1 antibody from December 2015 to April 2018 at the Kobe University Hospital, Japan...
January 2019: In Vivo
Yo-Ichi Yamashita, Katsunori Imai, Shigeki Nakagawa, Yosuke Nakao, Toshihiko Yusa, Rumi Itoyama, Hirohisa Okabe, Hiromitsu Hayashi, Akira Chikamoto, Hideo Baba
BACKGROUND: Removal of an isolated portal vein (PV) thrombus is still a difficult problem in liver surgery. In this report, we present technical details of the ultrasonography (US)-guided suction thrombectomy for an isolated PV thrombus in a case with PV tumor thrombus extending into the main PV trunk of a patient undergoing right hemi-hepatectomy and tumor thrombectomy for hepatocellular carcinoma (HCC). PATIENTS AND METHODS: Three cases were treated with US-guided suction thrombectomy for an isolated PV thrombus in liver surgeries...
January 2019: In Vivo
Thomas Auer, Isabel Heidegger, Tobias DE Zordo, Daniel Junker, Werner Jaschke, Fabian Steinkohl, Friedrich Aigner
AIM: To evaluate the feasibility of ultrasound (US) computed tomography (CT) or magnetic resonance imaging (MRI) fusion imaging (FI) for localization and assessment of kidney lesions. MATERIALS AND METHODS: Twenty-eight patients with kidney lesions previously detected on CT or MRI were included in this retrospective study. All 28 patients with kidney lesions, which were indefinable (42.9%) or hard to localize (57.1%) on gray-scale US alone, underwent FI of US with CT/MRI datasets...
January 2019: In Vivo
Hiroshi Doi, Kiyoshi Nakamatsu, Shimpei Anami, Kohei Fukuda, Masahiro Inada, Hitoshi Tatebe, Kazuki Ishikawa, Shuichi Kanamori, Hajime Monzen, Yasumasa Nishimura
AIM: This study aimed to identify prognostic factors for response to whole-brain radiotherapy (WBRT) in patients with brain metastases (BMs) from non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: This study retrospectively evaluated 100 patients who underwent WBRT for BMs from NSCLC between December 2012 and October 2017. Clinical factors were tested for associations with overall survival after WBRT. RESULTS: The median follow-up time was 134 days (range=14-1,395 days), the median survival time was 143 days, and the 1-year survival rate was 30...
January 2019: In Vivo
Goro Kawasaki, Naomi Imayama, Izumi Yoshitomi, Kohei Furukawa, Masahiro Umeda
BACKGROUND/AIM: Postresective mandibular reconstruction is common in cases of oral and mandibular tumors. However, complications such as plate fracture and/or plate exposure can occur. The purpose of this study was to analyze complications and survival of reconstructive plates used to correct mandibular defects caused by oral cancer. PATIENTS AND METHODS: Clinical and radiological data from 34 patients were analyzed. Only discontinuous mandibular defect cases were included in this study...
January 2019: In Vivo
Hirofumi Mizuno, Hisataka Miyai, Aya Yokoi, Terumasa Kobayashi, Chiaki Inabu, Takayuki Maruyama, Daisuke Ekuni, Nobuyoshi Mizukawa, Shin Kariya, Kazunori Nishizaki, Yoshihiro Kimata, Manabu Morita
BACKGROUND/AIM: The aim of this retrospective cohort study was to investigate the association between renal dysfunction (RD) and the development of oral mucositis (OM) in patients undergoing concurrent chemoradiotherapy (CCRT) for pharyngeal cancer including radiation to the oral cavity. PATIENTS AND METHODS: Of 130 patients diagnosed as having pharyngeal cancer who received CCRT at the Okayama University Hospital Head and Neck Cancer Center, 44 were finally selected...
January 2019: In Vivo
Antonio Riccardo Buonomo, Riccardo Scotto, Emanuela Zappulo, Mariagiovanna Nerilli, Biagio Pinchera, Giuseppe Perruolo, Pietro Formisano, Salvatore Nappa, Ivan Gentile
BACKGROUND: The aim of this study was to investigate the association between vitamin D deficiency (<10 mg/ml) and mortality in patients with and without hepatocellular carcinoma (HCC) in a cohort of patients with liver cirrhosis. MATERIALS AND METHODS: A prospective study was conducted among 345 patients with liver cirrhosis. RESULTS: At enrolment, 46 (13.3%) patients had HCC. Severe vitamin D deficiency was associated with mortality (p<0...
January 2019: In Vivo
Carsten Nieder, Rosalba Yobuta, Bård Mannsåker
BACKGROUND/AIM: The aim of this study was to analyze the patterns of treatment and outcomes in patients with a large number of brain metastases, arbitrarily defined as 20 or more lesions. These patients are typically excluded from studies of focal brain treatment, e.g., surgery or radiosurgery, and might have a limited prognosis. PATIENTS AND METHODS: This was a retrospective single-institution analysis. Overall, 11 patients were identified from a prospectively maintained database...
January 2019: In Vivo
Kouji Izumi, Hiroaki Iwamoto, Hiroshi Yaegashi, Kazuyoshi Shigehara, Takahiro Nohara, Yoshifumi Kadono, Atsushi Mizokami
BACKGROUND: Combination chemotherapy with gemcitabine and cisplatin is the standard first-line treatment for advanced urinary tract urothelial cancer. Carboplatin is often substituted for cisplatin in patients who are cisplatin-ineligible, such as those with a glomerular filtration rate less than 60 ml/min. However, carboplatin-based chemotherapy has not been not confirmed as meeting the standard of care based on randomized controlled trials, and it is still unclear whether carboplatin can offer prognosis comparable to that with cisplatin...
January 2019: In Vivo
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