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Journals FASEB Journal : Official Publi...

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology

https://read.qxmd.com/read/38837260/skeletal-muscle-metabolic-dysfunction-with-circulating-carboxymethyl-lysine-in-dietary-food-additive-induced-leaky-gut
#21
JOURNAL ARTICLE
Hinako Kodani, Wataru Aoi, Mikiko Hirata, Maki Takami, Yukiko Kobayashi, Masashi Kuwahata
Impaired intestinal permeability induces systemic inflammation and metabolic disturbance. The effect of a leaky gut on metabolism in skeletal muscle, a major nutrient consumer, remains unclear. In this study, we aimed to investigate the glucose metabolic function of the whole body and skeletal muscles in a mouse model of diet-induced intestinal barrier dysfunction. At Week 2, we observed higher intestinal permeability in mice fed a titanium dioxide (TiO2 )-containing diet than that of mice fed a normal control diet...
June 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38822676/unraveling-the-role-of-lipid-droplets-and-perilipin-2-in-bovine-luteal-cells
#22
JOURNAL ARTICLE
Michele R Plewes, Heather A Talbott, Micah B Schott, Jennifer R Wood, Andrea S Cupp, John S Davis
Steroidogenic tissues contain cytosolic lipid droplets that are important for steroidogenesis. Perilipin 2 (PLIN2), a structural coat protein located on the surface of lipid droplets in mammalian cells, plays a crucial role in regulating lipid droplet formation and contributing to various cellular processes such as lipid storage and energy homeostasis. Herein, we examine the role that PLIN2 plays in regulating progesterone synthesis in the bovine corpus luteum. Utilizing gene array databases and Western blotting, we have delineated the expression pattern of PLIN2 throughout the follicular to luteal transition...
June 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38822662/an-insight-into-the-gut-microbiota-after-schistosoma-japonicum-eggs-immunization-in-an-experimental-ulcerative-colitis-model
#23
JOURNAL ARTICLE
Peng Wu, Wenhao Li, Yiting Xie, Wei Guan, Shuguo Yang, Jian Li, Yanqing Zhao
Schistosome infection and schistosome-derived products have been implicated in the prevention and alleviation of inflammatory bowel disease by manipulating the host immune response, whereas the role of gut microbiota in this protective effect remains poorly understood. In this study, we found that the intraperitoneal immunization with Schistosoma japonicum eggs prior to dextran sulfate sodium (DSS) application significantly ameliorated the symptoms of DSS-induced acute colitis, which was characterized by higher body weight, lower disease activity index score and macroscopic inflammatory scores...
June 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38822661/microbiota-influence-on-behavior-integrative-analysis-of-serotonin-metabolism-and-behavioral-profile-in-germ-free-mice
#24
JOURNAL ARTICLE
Léa Roussin, Elisa Gry, Mira Macaron, Sandy Ribes, Magali Monnoye, Véronique Douard, Laurent Naudon, Sylvie Rabot
Previous studies on germ-free (GF) animals have described altered anxiety-like and social behaviors together with dysregulations in brain serotonin (5-HT) metabolism. Alterations in circulating 5-HT levels and gut 5-HT metabolism have also been reported in GF mice. In this study, we conducted an integrative analysis of various behaviors as well as markers of 5-HT metabolism in the brain and along the GI tract of GF male mice compared with conventional (CV) ones. We found a strong decrease in locomotor activity, accompanied by some signs of increased anxiety-like behavior in GF mice compared with CV mice...
June 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38819021/correction-to-intradiscal-inflammatory-stimulation-induces-spinal-pain-behavior-and-intervertebral-disc-degeneration-in%C3%A2-vivo
#25
(no author information available yet)
No abstract text is available yet for this article.
June 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38818939/retraction-5-lipoxygenase-antagonizes-genotoxic-stress-induced-apoptosis-by-altering-p53-nuclear-trafficking
#26
(no author information available yet)
A. Catalano, P. Caprari, S. Soddu, A. Procopio, and M. Romano, "5-Lipoxygenase antagonizes genotoxic stress-induced apoptosis by altering p53 nuclear trafficking," FASEB Journal 18, no. 14 (2004): 1740-1742, https://doi.org/10.1096/fj.04-2258fje. The above article, published online on September 16, 2004 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Dr. Loren E. Wold; the Federation of American Societies for Experimental Biology; and Wiley Periodicals LLC...
June 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38814727/dna-methylation-mediated-11%C3%AE-hsd2-downregulation-drives-the-increases-in-angiotensin-converting-enzyme-and-angiotensin-ii-within-preeclamptic-placentas
#27
JOURNAL ARTICLE
Fengying Deng, Jiahui Lei, Jie Chen, Meng Zhao, Chenxuan Zhao, Mengyu Fu, Miao Sun, Meihua Zhang, Junlan Qiu, Qinqin Gao
Preeclampsia (PE) is a complex human-specific complication frequently associated with placental pathology. The local renin-angiotensin system (RAS) in the human placenta, which plays a crucial role in regulating placental function, has been extensively documented. Glucocorticoids (GCs) are a class of steroid hormones. PE cases often have abnormalities in GCs levels and placental GCs barrier. Despite extensive speculation, there is currently no robust evidence indicating that GCs regulate placental RAS. This study aims to investigate these potential relationships...
June 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38809700/ucp1-dependent-brown-adipose-activation-accelerates-cardiac-metabolic-remodeling-and-reduces-initial-hypertrophic-and-fibrotic-responses-to-pathological-stress
#28
JOURNAL ARTICLE
Azariyas A Challa, Pablo Vidal, Santosh K Maurya, Chandan K Maurya, Lisa A Baer, Yang Wang, Natasha Maria James, Parth J Pardeshi, Matthew Fasano, Andrew N Carley, Kristin I Stanford, E Douglas Lewandowski
Brown adipose tissue (BAT) is correlated to cardiovascular health in rodents and humans, but the physiological role of BAT in the initial cardiac remodeling at the onset of stress is unknown. Activation of BAT via 48 h cold (16°C) in mice following transverse aortic constriction (TAC) reduced cardiac gene expression for LCFA uptake and oxidation in male mice and accelerated the onset of cardiac metabolic remodeling, with an early isoform shift of carnitine palmitoyltransferase 1 (CPT1) toward increased CPT1a, reduced entry of long chain fatty acid (LCFA) into oxidative metabolism (0...
June 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38809685/mettl3-s-role-in-cervical-cancer-development-through-m-6-a-modification
#29
JOURNAL ARTICLE
Yuqiu Liu, Changzhong Li, Qianqian Deng, Xingye Ren, Hongqing Wang
N6-methylated adenosine (m6 A) is a crucial RNA modification in eukaryotes, particularly in cancer. However, its role in cervical cancer (CC) is unclear. We aimed to elucidate the part of m6 A in CC by analyzing methyltransferase-like 3 (METTL3) expression, identifying downstream targets, and exploring the underlying mechanism. We assessed METTL3 expression in CC using western blotting, quantitative polymerase chain reaction (qPCR), and immunohistochemistry. In vitro and in vivo experiments examined METTL3's role in CC...
June 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38814725/ghrelin-alleviates-intestinal-ischemia-reperfusion-injury-by-activating-the-ghsr-1%C3%AE-sirt1-foxo1-pathway
#30
JOURNAL ARTICLE
Shi-Shi Liao, Le-le Zhang, Yi-Guo Zhang, Jie Luo, Tulanisa Kadier, Ke Ding, Rong Chen, Qing-Tao Meng
Ischemia-reperfusion (IR) injury is primarily characterized by the restoration of blood flow perfusion and oxygen supply to ischemic tissue and organs, but it paradoxically leads to tissue injury aggravation. IR injury is a challenging pathophysiological process that is difficult to avoid clinically and frequently occurs during organ transplantation, surgery, shock resuscitation, and other processes. The major causes of IR injury include increased levels of free radicals, calcium overload, oxidative stress, and excessive inflammatory response...
June 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38807561/correction-to-heparin-poloxamer-hydrogel-encapsulated-rhfgf21-enhances-wound-healing-in-diabetic-mice
#31
(no author information available yet)
No abstract text is available yet for this article.
May 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38805171/prolactin-receptor-potentiates-chemotherapy-through-mirnas-induced-g6pd-tkt-inhibition-in-pancreatic-cancer
#32
JOURNAL ARTICLE
Ying-Na Liao, Pei-Qi Huang, Hong Pan, Yan-Zhi Gai, Yun-Fei Zhan, Shu-Xin Li, Hui-Zhen Nie
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, with a notoriously dismal prognosis. As a competitive inhibitor of DNA synthesis, gemcitabine is the cornerstone drug for treating PDAC at all stages. The therapeutic effect of gemcitabine, however, is often hindered by drug resistance, and the underlying mechanisms remain largely unknown. It is unclear whether their response to chemotherapeutics is regulated by endocrine regulators, despite the association between PDAC risk and endocrine deregulation...
May 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38805158/expert-consensus-report-on-lipid-mediators-role-in-resolution-of-inflammation-and-muscle-preservation
#33
JOURNAL ARTICLE
Charles N Serhan, Magnus Bäck, Valerio Chiurchiù, Martin Hersberger, Bettina Mittendorfer, Philip C Calder, Dan L Waitzberg, Christian Stoppe, Stanislaw Klek, Robert G Martindale
This meeting report presents a consensus on the biological aspects of lipid emulsions in parenteral nutrition, emphasizing the unanimous support for the integration of lipid emulsions, particularly those containing fish oil, owing to their many potential benefits beyond caloric provision. Lipid emulsions have evolved from simple energy sources to complex formulations designed to improve safety profiles and offer therapeutic benefits. The consensus highlights the critical role of omega-3 polyunsaturated fatty acids (PUFAs), notably eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), found in fish oil and other marine oils, for their anti-inflammatory properties, muscle mass preservation, and as precursors to the specialized pro-resolving mediators (SPMs)...
May 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38805156/transport-activity-regulates-mitochondrial-bioenergetics-and-biogenesis-in-renal-tubules
#34
JOURNAL ARTICLE
Chih-Jen Cheng, Jonathan M Nizar, Dao-Fu Dai, Chou-Long Huang
Renal tubules are featured with copious mitochondria and robust transport activity. Mutations in mitochondrial genes cause congenital renal tubulopathies, and changes in transport activity affect mitochondrial morphology, suggesting mitochondrial function and transport activity are tightly coupled. Current methods of using bulk kidney tissues or cultured cells to study mitochondrial bioenergetics are limited. Here, we optimized an extracellular flux analysis (EFA) to study mitochondrial respiration and energy metabolism using microdissected mouse renal tubule segments...
May 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38805151/parasite-derived-microrna-let-7-5p-detection-for-metacestodiasis-based-on-rolling-circular-amplification-assisted-crispr-cas9
#35
JOURNAL ARTICLE
Liqun Wang, Guiting Pu, Tingli Liu, Guoliang Chen, Hong Li, Tharheer Oluwashola Amuda, Shanling Cao, Hongbin Yan, Hong Yin, Baoquan Fu, Xuenong Luo
Metacestodiasis is an infectious disease caused by the larval stage of cestode parasites. This disease poses a serious health hazard to wildlife, livestock, and humans, and it incurs substantial economic losses by impacting the safety of the livestock industry, the quality of meat production, and public health security. Unfortunately, there is currently no available molecular diagnostic method capable of distinguishing cysticercus- and Echinococcus-derived microRNAs (miRNAs) from other helminthes and hosts in the plasma of metacestode-infected animals...
May 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38801406/the-endocannabinoid-anandamide-activates-pro-resolving-pathways-in-human-primary-macrophages-by-engaging-both-cb-2-and-gpr18-receptors
#36
JOURNAL ARTICLE
Alessandro Leuti, Marina Fava, Giulia Forte, Niccolò Pellegrini, Sergio Oddi, Lucia Scipioni, Esteban A Gomez, Jesmond Dalli, Mauro Maccarrone
Resolution of inflammation is the cellular and molecular process that protects from widespread and uncontrolled inflammation and restores tissue function in the aftermath of acute immune events. This process is orchestrated by specialized pro-resolving mediators (SPM), a class of bioactive lipids able to reduce immune activation and promote removal of tissue debris and apoptotic cells by macrophages. Although SPMs are the lipid class that has been best studied for its role in facilitating the resolution of self-limited inflammation, a number of other lipid signals, including endocannabinoids, also exert protective immunomodulatory effects on immune cells, including macrophages...
May 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38795334/dipeptidyl-peptidase-4-disturbs-adipocyte-differentiation-via-the-negative-regulation-of-the-glucagon-like-peptide-1-adiponectin-cathepsin-k-axis-in-mice-under-chronic-stress-conditions
#37
JOURNAL ARTICLE
Meiping Zhang, Xueling Yue, Shengnan Xu, Jinshun Piao, Longguo Zhao, Shangzhi Shu, Masafumi Kuzuya, Ping Li, Lan Hong, Weon Kim, Bin Liu, Xian Wu Cheng
Exposure to chronic psychosocial stress is a risk factor for metabolic disorders. Because dipeptidyl peptidase-4 (DPP4) and cysteinyl cathepsin K (CTSK) play important roles in human pathobiology, we investigated the role(s) of DPP4 in stress-related adipocyte differentiation, with a focus on the glucagon-like peptide-1 (GLP-1)/adiponectin-CTSK axis in vivo and in vitro. Plasma and inguinal adipose tissue from non-stress wild-type (DPP4+/+ ), DPP4-knockout (DPP4-/- ) and CTSK-knockout (CTSK-/- ) mice, and stressed DPP4+/+ , DPP4-/- , CTSK-/- , and DPP4+/+ mice underwent stress exposure plus GLP-1 receptor agonist exenatide loading for 2 weeks and then were analyzed for stress-related biological and/or morphological alterations...
May 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38795328/chaperone-mediated-autophagy-protects-the-bone-formation-from-excessive-inflammation-through-pi3k-akt-gsk3%C3%AE-%C3%AE-catenin-pathway
#38
JOURNAL ARTICLE
Kai Hang, YiBo Wang, JinWu Bai, ZhongXiang Wang, WeiLiang Wu, WeiWei Zhu, ShuangAi Liu, ZhiJun Pan, JianSong Chen, WenHao Chen
Multiple regulatory mechanisms are in place to ensure the normal processes of bone metabolism, encompassing both bone formation and absorption. This study has identified chaperone-mediated autophagy (CMA) as a critical regulator that safeguards bone formation from the detrimental effects of excessive inflammation. By silencing LAMP2A or HSCA8, we observed a hindrance in the osteoblast differentiation of human bone marrow mesenchymal stem cells (hBMSCs) in vitro. To further elucidate the role of LAMP2A, we generated LAMP2A gene knockdown and overexpression of mouse BMSCs (mBMSCs) using adenovirus...
May 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38795327/liver-specific-deletion-of-de-novo-dna-methyltransferases-protects-against-glucose-intolerance-in-high-fat-diet-fed-male-mice
#39
JOURNAL ARTICLE
S Yao, K Prates, A Freydenzon, G Assante, A F McRae, M J Morris, N A Youngson
Alterations to gene transcription and DNA methylation are a feature of many liver diseases including fatty liver disease and liver cancer. However, it is unclear whether the DNA methylation changes are a cause or a consequence of the transcriptional changes. It is even possible that the methylation changes are not required for the transcriptional changes. If DNA methylation is just a minor player in, or a consequence of liver transcriptional change, then future studies in this area should focus on other systems such as histone tail modifications...
May 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38787620/mif-as-a-potential-diagnostic-and-prognostic-biomarker-for-triple-negative-breast-cancer-that-correlates-with-the-polarization-of-m2-macrophages
#40
JOURNAL ARTICLE
Mengting Chen, Hongsen Liu, Bo Hong, Yufei Xiao, Yun Qian
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays a crucial role in antitumor immunity. However, the role of MIF in influencing the tumor microenvironment (TME) and prognosis of triple-negative breast cancer (TNBC) remains to be elucidated. Using R, we analyzed single-cell RNA sequencing (scRNA-seq) data of 41 567 cells from 10 TNBC tumor samples and spatial transcriptomic data from two patients. Relationships between MIF expression and immune cell infiltration, clinicopathological stage, and survival prognosis were determined using samples from The Cancer Genome Atlas (TCGA) and validated in a clinical cohort using immunohistochemistry...
May 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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