Wei Peng, Chao Tong, Lei Li, Chengyu Huang, Yuxin Ran, Xuehai Chen, Yuxiang Bai, Yamin Liu, Jianlin Zhao, Bin Tan, Xiaofang Luo, Hao Wang, Li Wen, Chen Zhang, Hua Zhang, Yubin Ding, Hongbo Qi, Philip N Baker
Successful pregnancy requires normal placentation, which largely depends on the tight regulation of proliferation, invasion, and migration of trophoblast cells. Abnormal functioning of trophoblast cells may cause failure of uterine spiral artery remodeling, which may be related to pregnancy-related disorders, such as preeclampsia. Here, we reported that an actin-binding protein, α-actinin (ACTN)4, was dysregulated in placentas from early onset preeclampsia. Moreover, knockdown of ACTN4 markedly inhibited trophoblast cell proliferation by reducing AKT membrane translocation...
February 18, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology