Jose E Leon-Rojas, Sabahat Iqbal, Sjoerd B Vos, Roman Rodionov, Anna Miserocchi, Andrew W McEvoy, Vejay N Vakharia, Laura Mancini, Marian Galovic, Rachel E Sparks, Sebastien Ourselin, Jorge M Cardoso, Matthias J Koepp, John S Duncan
BACKGROUND: The piriform cortex (PC) occupies both banks of the endorhinal sulcus and has an important role in the pathophysiology of temporal lobe epilepsy (TLE). A recent study showed that resection of more than 50% of PC increased the odds of becoming seizure free by a factor of 16. OBJECTIVE: We report the feasibility of manual segmentation of PC and application of the Geodesic Information Flows (GIF) algorithm to automated segmentation, to guide resection. METHODS: Manual segmentation of PC was performed by two blinded independent examiners in 60 patients with TLE (55% Left TLE, 52% female) with a median age of 35 years (IQR, 29-47 years) and 20 controls (60% Women) with a median age of 39...
August 18, 2021: British Journal of Neurosurgery