Hunter Morera, Palak Dave, Yaroslav Kolinko, Saeed Alahmari, Aidan Anderson, Grant Denham, Chloe Davis, Juan Riano, Dmitry Goldgof, Lawrence O Hall, G Jean Harry, Peter R Mouton
Microglial cells mediate diverse homeostatic, inflammatory, and immune processes during normal development and in response to cytotoxic challenges. During these functional activities, microglial cells undergo distinct numerical and morphological changes in different tissue volumes in both rodent and human brains. However, it remains unclear how these cytostructural changes in microglia correlate with region-specific neurochemical functions. To better understand these relationships, neuroscientists need accurate, reproducible, and efficient methods for quantifying microglial cell number and morphologies in histological sections...
February 23, 2024: Neurotoxicology and Teratology