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Acta Oncologica

Kirsi Santti, Annette Beule, Mikko Rönty, Hanna Ihalainen, Maija Tarkkanen, Carl Blomqvist
No abstract text is available yet for this article.
March 25, 2019: Acta Oncologica
Louise Skau Rasmussen, Benny Vittrup, Morten Ladekarl, Per Pfeiffer, Mette Karen Yilmaz, Laurids Østergaard Poulsen, Kell Østerlind, Carsten Palnæs Hansen, Michael Bau Mortensen, Frank Viborg Mortensen, Mogens Sall, Sönke Detlefsen, Martin Bøgsted, Claus Wilki Fristrup
BACKGROUND: Adjuvant chemotherapy following curative resection is the standard treatment for pancreatic adenocarcinoma (PC). Randomized clinical trials using gemcitabine have shown a median overall survival (mOS) of 2 years and a 5-year survival rate of 15-20%. However, the effect of gemcitabine outside these trials is less clear. We examined the effect of postoperative gemcitabine on survival in an unselected cohort of patients receiving curative resection for PC in Denmark during a five-year period...
March 25, 2019: Acta Oncologica
Susanne Oksbjerg Dalton, Maja Halgren Olsen, Ida Rask Moustsen, Carina Wedell Andersen, Jette Vibe-Petersen, Christoffer Johansen
BACKGROUND: Implementation of new cancer services may lead to socioeconomic differences in uptake and despite reports of more unmet needs among patients with low socioeconomic position studies have found that these patients receive less rehabilitation. We aimed to investigate associations between indicators for socioeconomic position and referral as well as attendance to rehabilitation for cancer. METHODS: Through the Danish Cancer Registry, we identified all persons diagnosed with cancer in Copenhagen municipality 2010-2015 and obtained information on referral to and visits at the municipal rehabilitation center from municipal records...
March 25, 2019: Acta Oncologica
Mélanie Machiels, Peng Jin, Jeanin E van Hooft, Oliver J Gurney-Champion, Pouya Jelvehgaran, Elizabeth D Geijsen, Paul M Jeene, M Willemijn Kolff, Vera Oppedijk, Coen R N Rasch, Marcel B van Herk, Tanja Alderliesten, Maarten C C M Hulshof
OBJECTIVE: Delineation variation of esophageal tumors remains a large source of geometric uncertainty. In the present study, we investigated the inter- and intra-observer variation in esophageal gross tumor volume (GTV) delineation and the impact of endoscopically implanted fiducial markers on these variations. MATERIAL/METHODS: Ten esophageal cancer patients with at least two markers endoscopically implanted at the cranial and caudal tumor borders and visible on the planning computed tomography (pCT) were included in this study...
March 25, 2019: Acta Oncologica
Christel C L M Boons, Vashti N M F Tromp, Nienke J M Neppelenbroek, Lonneke Timmers, Natasja M van Schoor, Eleonora L Swart, N Harry Hendrikse, Jeroen J W M Janssen, Jacqueline G Hugtenburg
No abstract text is available yet for this article.
March 25, 2019: Acta Oncologica
Bjørg Y Aksnessæther, Jo-Åsmund Lund, Tor Åge Myklebust, Olbjørn H Klepp, Eva Skovlund, Solveig Roth Hoff, Arne Solberg
INTRODUCTION: The aim of this registry-based cohort study was to estimate second cancer (SC) risk following radical prostate cancer (PC) treatment and evaluate if the risk was influenced by radiotherapy. MATERIALS AND METHODS: We collected data from the Cancer Registry of Norway on all patients with PC as first cancer diagnosis, from 1997 to 2014. Standardized incidence ratios (SIRs) for SC were calculated by comparing our cohort to the standard male population...
March 25, 2019: Acta Oncologica
Maria Magdalena Buijs, Robert James Campbell Steele, Niels Buch, Thomas Kolbro, Erik Zimmermann-Nielsen, Morten Kobaek-Larsen, Gunnar Baatrup
BACKGROUND: Previous studies indicate that visual size estimation (in situ) of polyp size tends to differ from postfixation measurements, which effects allocation to surveillance intervals. Little is known about interobserver variation of in-situ measurements of large polyps. The primary objective was to assess interobserver variation of in situ measurements of large colorectal polyps. Secondary objectives were the agreement of in situ measurements with postfixation measurements, and the agreement on detection of ≥20 mm polyps between these measurements...
March 21, 2019: Acta Oncologica
Lena Brandefors, Jack Lindh, Klaus-Dieter Preuss, Natalie Fadle, Michael Pfreundschuh, Eva Kimby
No abstract text is available yet for this article.
March 19, 2019: Acta Oncologica
(no author information available yet)
No abstract text is available yet for this article.
March 18, 2019: Acta Oncologica
Almut Dutz, Linda Agolli, Michael Baumann, Esther G C Troost, Mechthild Krause, Tobias Hölscher, Steffen Löck
PURPOSE: To compare early and late toxicities, dosimetric parameters and quality of life (QoL) between conventionally fractionated proton beam therapy (PBT) and intensity-modulated radiation therapy (IMRT) in prostate cancer (PCA) patients. METHODS: Eighty-eight patients with localized PCA treated between 2013 and 2017 with either definitive PBT (31) or IMRT (57) were matched using propensity score matching on PCA risk group, transurethral resection of the prostate, prostate volume, diabetes mellitus and administration of anticoagulants resulting in 29 matched pairs...
March 18, 2019: Acta Oncologica
Zandra Nymand Ennis, Sidsel Arnspang Pedersen, Morten Rix Hansen, Anton Pottegård, Thomas Patrick Ahern, Jesper Hallas, Per Damkier
BACKGROUND: Phthalates are used as excipients in some drug products, and up to a 50-fold increased urinary excretion of phthalate metabolites compared to non-users has been demonstrated in users of such products. In vitro studies have demonstrated that phthalates stimulate mechanisms involved in gastric cancer development. We therefore examined the association between cumulative phthalate exposure from drug products and the risk of gastric adenocarcinomas. METHODS: Using the Danish Cancer Registry, we identified all patients with incident gastric adenocarcinoma from 2008 to 2015 (n = 1525)...
March 18, 2019: Acta Oncologica
Bengt Glimelius, Peter Nygren
No abstract text is available yet for this article.
March 18, 2019: Acta Oncologica
Gunhild M Gjerset, Cecilie E Kiserud, Jon H Loge, Sophie D Fosså, Torbjørn Wisløff, Sævar B Gudbergsson, Line M Oldervoll, Lene Thorsen
BACKGROUND: Rehabilitation aims to improve function, but the effects of different programs are not clear. The aims of the present study were to: (1) compare the level of fatigue and health-related quality of life (HRQOL) of cancer survivors admitted to a one-week inpatient educational program (IEP) to the general population (NORMS), (2) examine changes in fatigue, HRQOL and physical activity after the IEP and (3) examine the proportions of survivors for female and male separately with clinically relevant improvement (>10% of maximum scale)...
March 12, 2019: Acta Oncologica
Teresia Svanvik, Janusz Marcickiewicz, Karin Sundfeldt, Erik Holmberg, Ulf Strömberg
BACKGROUND: For a few types of cancer, lower socioeconomic status (SES) is associated with higher incidence, and for even more cancer types it is associated with having a less favorable tumor stage at diagnosis. For endometrial cancer (EC), however, there is no clear evidence of such associations with SES. There is a need for analysis of sociodemographic disparities in EC incidences according to stage at diagnosis, which may provide support for trying to improve early detection of EC...
March 8, 2019: Acta Oncologica
Pasquale Niscola, Nélida Inés Noguera, Gianfranco Catalano, Luca Cupelli, Stefano Fratoni, Marco Giovannini, Carla Mazzone, Benedetta Neri, Laura Scaramucci, Malgorzata Monika Trawinska, Paolo de Fabritiis, Elisabetta Abruzzese
No abstract text is available yet for this article.
March 8, 2019: Acta Oncologica
Ida Hovdenak Jakobsen, Therese Juul, Henriette Vind Thaysen, Christoffer Johansen, Søren Laurberg
BACKGROUND: The ongoing multi-center randomized FURCA-trial investigates the effect of patient-led follow-up after rectal cancer, aiming at improving management of late effects and survivorship care. The purpose of this present sub-study was to identify potential systematic differences between participants and non-participants in the FURCA-trial, in regard to demographic and clinical factors at baseline, and in quality of life (QoL) and fear of cancer recurrence (FCR) after one year. MATERIAL AND METHODS: The population comprised patients invited to the FURCA-trial during the first 13 months' recruitment...
March 5, 2019: Acta Oncologica
Victoria Blanes-Vidal, Gunnar Baatrup, Esmaeil S Nadimi
BACKGROUND: Colorectal capsule endoscopy (CCE) is a potentially valuable patient-friendly technique for colorectal cancer screening in large populations. Before it can be widely applied, significant research priorities need to be addressed. We present two innovative data science algorithms which can considerably improve acquisition and analysis of relevant data on colorectal polyps obtained from capsule endoscopy. MATERIAL AND METHODS: A fully paired study was performed (2015-2016), where 255 participants from the Danish national screening program had CCE, colonoscopy, and histopathology of all detected polyps...
March 5, 2019: Acta Oncologica
Melissa Vos, Stefan Sleijfer, Saskia Litière, Nathan Touati, Florence Duffaud, Winette T van der Graaf, Hans Gelderblom
BACKGROUND: There is an unmet need for markers predicting the outcome of patients with advanced soft tissue sarcoma (STS) treated with pazopanib. Since toxicity might be related to the anti-tumor activity of the drug, the aim of this study was to determine whether pazopanib-induced proteinuria, hypothyroidism and cardiotoxicity grade 3-4 were associated with outcome. METHODS: The combined results of the EORTC 62043 and 62072 trials were retrospectively assessed and used in a landmark analysis to evaluate the effect of the toxicities on progression-free survival (PFS) and overall survival (OS), using the Kaplan-Meier method and Cox regression models...
March 4, 2019: Acta Oncologica
Cecilie D R Buskbjerg, Ali Amidi, Ditte Demontis, Eva R Nissen, Robert Zachariae
BACKGROUND: Cancer-related cognitive impairment (CRCI) is a commonly reported complaint among non-CNS cancer patients. Even subtle CRCI may have detrimental effects on quality of life and identifying patients at increased risk for CRCI to improve survivorship care is important. In the present paper, we systematically reviewed available studies of possible genetic risk factors for developing CRCI. METHODS: Keyword-based systematic searches were undertaken on 24 July 2018 in PubMed, Web of Science, The Cochrane Library, and CINAHL...
March 1, 2019: Acta Oncologica
Marianne K Thygesen, Gunnar Baatrup, Christina Petersen, Niels Qvist, Rasmus Kroijer, Morten Kobaek-Larsen
BACKGROUND: The standard investigation in colorectal cancer screening (optical colonoscopy [OC]) has a less invasive alternative with the colon capsule endoscopy (CCE). The experiences of screening individuals are needed to support a decision aid (DA) and to provide a patient view in future health technology assessments (HTA). We aimed to explore the experiences of CCE at home and OC in an outpatient clinic by screening participants who experienced both investigations on the same bowel preparation...
March 1, 2019: Acta Oncologica
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