Jennifer Geel, Marc Hendricks, Yasmin Goga, Beverley Neethling, Vutshilo Netshituni, Rema Mathew, Johani Vermeulen, Anel van Zyl, Fareed Omar, Jan du Plessis, Liezl du Plessis, Elelwani Madzhia, Thandeka Ngcana, Thanushree Naidoo, Lizette Louw, Daynia E Ballot, Monika L Metzger
Introduction: Collaborative studies have contributed to improved survival of pediatric Hodgkin lymphoma in well-resourced settings, but few are documented in resource-constrained countries. The South Africa Children's Cancer Study Group initiated harmonization of management protocols in 2015. This article analyzes barriers and enablers of the process. Methods: Clinician-researchers at 11 state-funded pediatric oncology units completed preparatory questionnaires in June 2018. Parameters included infrastructure, access to therapeutic modalities and clinician numbers...
January 20, 2023: Pediatric Hematology and Oncology
Natasha Bala, Joseph Stanek, Vilmarie Rodriguez, Anthony Villella
Patients with sickle cell disease (SCD) have a high risk for venous thromboembolism which is associated with increased risk of mortality. Studies examining risk of pulmonary embolism (PE) in children with SCD are lacking. This study was conducted in children with SCD between 0-21 years of age using a nationwide administrative database in the United States- Pediatric Health Information System (PHIS) from January 2010 to June 2021. Diagnostic codes and imaging, procedure, and pharmaceutical billing codes were used to identify PE and potential clinical, demographic, and utilization risk factors...
January 16, 2023: Pediatric Hematology and Oncology
Alison M R Castle, Brianna Empringham, Lisa M Pinto, Anita Villani, Nisha Kanwar, Lesleigh S Abbott, Sarah L Sawyer
Neurofibromatosis Type 1 (NF1) is a neurocutaneous syndrome characterized by multiple café-au-lait macules, neurofibromas, and predisposition to malignancies, including rhabdomyosarcomas (RMS). Somatic NF1 mutations occur in RMS and other cancers, and ∼1% of patients with RMS have NF1. We describe three patients who presented prior to one year of age with RMS and were subsequently diagnosed with NF1. Compared to sporadic RMS, patients with this cancer predisposition syndrome are diagnosed younger, genitourinary sites are more common, and tumors are almost exclusively the embryonal subtype...
January 10, 2023: Pediatric Hematology and Oncology
Olive S Eckstein, M Brooke Bernhardt, Chelsey G Hood, Vivekanudeep Karri, Stephen F Kralik, Kenneth L McClain
Patients with Langerhans cell histiocytosis (LCH) have been effectively treated with intravenous cytarabine. Intravenous or subcutaneous cytarabine infusions have been effective for leukemia patients, and pharmacokinetic studies have shown very similar blood levels of the drug with either route. We present three LCH patients treated with subcutaneous cytarabine either because intravenous access could not be maintained or due to patient refusal. One patient with pulmonary and skin LCH had a complete response...
January 10, 2023: Pediatric Hematology and Oncology
Ai Yamada, Mariko Kinoshita, Sachiyo Kamimura, Takashi Jinnouchi, Minako Azuma, Shinji Yamashita, Kiyotaka Yokogami, Hideo Takeshima, Hiroshi Moritake
Atypical teratoid/rhabdoid tumor (AT/RT) is a rare aggressive central nervous system tumor that typically affects children under three years old and has poor survival with a high risk for neurologic deficits. The primary purpose of this study was to successfully treat the disease and delay or avoid whole-brain radiotherapy for children with AT/RT. A retrospective analysis was performed for six children diagnosed with AT/RT and treated with multimodal treatment at a single institute between 2014 and 2020. Furthermore, germline SMARCB1 aberrations and MGMT methylation status of the tumors were analyzed...
2023: Pediatric Hematology and Oncology
Richa Sharon Angel Korrapolu, Deepthi Boddu, Rikki John, Nikita Antonisamy, Tulasi Geevar, Arun Kumar Arunachalam, Leenu Lizbeth Joseph, Hema Nalapullu Srinivasan, Leni Grace Mathew, Sidharth Totadri
Managing a child with acute lymphoblastic leukemia (ALL) after relapse is arduous in low- and middle-income countries. A file review of children aged ≤15 years diagnosed with relapsed ALL from 2010 to 2019 was performed. Classification of relapse followed the Berlin-Frankfurt-Münster (BFM) scheme. The majority of patients were treated with a modified ALL-REZ-BFM protocol. Of 764 children treated for ALL in the study period, 163 (21.3%) relapsed. The median age at relapse was 101 months (range: 8-297)...
2023: Pediatric Hematology and Oncology
Maharshi Trivedi, Priyakumari Thankamony, Manjusha Nair, Binitha Rajeswari, C S Guruprasad, V R Prasanth, Rekha A Nair, K M Jagathnath Krishna
Anaplastic large-cell lymphoma (ALCL) constitutes 10-15% of non-Hodgkin lymphoma in children. With short-course chemotherapy, outcome has improved up-to 90% in developed-countries. There is limited-data on outcome of pediatric ALCL treated with ALCL99 protocol from low-middle income countries. Children ≤14 years, diagnosed with ALCL between 1st January 2007 and 31st December 2016 were analyzed. Details regarding clinical-presentation and treatment were recorded and outcome was analyzed. Fourteen-children were diagnosed...
2023: Pediatric Hematology and Oncology
Alice Mochon, Sarah Lippé, Maja Krajinovic, Caroline Laverdière, Stacey Marjerrison, Bruno Michon, Philippe Robaey, Émélie Rondeau, Daniel Sinnett, Serge Sultan
Late effects such as neurocognitive issues and fatigue have been reported in childhood acute lymphoblastic leukemia (cALL) survivors. Yet, their association is often poorly understood. In this study, we wished to (1) describe neurocognitive difficulties and fatigue in a well-characterized cohort of long-term cALL survivors and (2) explore the risk of having neurocognitive deficits as a function of fatigue. Childhood ALL survivors ( N  = 285) from three Canadian treatment centers completed the DIVERGT battery of cognitive tests and the PedsQL Multidimensional Fatigue Scale...
2023: Pediatric Hematology and Oncology
Neysimelia Costa Villela, Adriana Seber, Carla Renata Pacheco Donato Macedo, Victor Gottardello Zecchin, Renata Fittipaldi da Costa Guimarães, Thaíssa Maria Veiga Faria, Daniel Onofre Vidal, Gisele Eiras Martins Jorge, George Navarro, Luiz Fernando Lopes
Malignant extracranial germ cell tumors (GCTs) are rare in pediatric patients and are usually extremely sensitive to chemotherapy. Relapsed or refractory tumors, although rare, established the need for second-line therapies, including high-dose chemotherapy with autologous stem cell transplantation (HDCT/ASCT). However, there are few data on its use in children with GCTs. We present a retrospective analysis of all patients diagnosed with extracranial GCTs who received HDCT/ASCT at two Brazilian pediatric cancer centers from May 1999 to December 2019...
2023: Pediatric Hematology and Oncology
Irene Nanyanga, Gideon Kurigamba Kwikiriza, Barnabas Atwiine, Ruth Namazzi, Victor Musiime, Joyce Balagadde Kambugu, Jaques van Heerden
Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. The complete burden and outcomes in Uganda are unknown. The study was a multicenter retrospective chart review of children aged between 0 to 15 years diagnosed with NB from 2010 to 2020. Demographic, clinical and tumor-related characteristics were extracted for analysis. Kaplan-Meier survival curves and Cox regression models were used to determine the one-year overall survival (OS) and identify prognostic factors. Seventy-five patients were evaluated, with a median age at diagnosis of 48 months (IQR 26-108 months)...
December 23, 2022: Pediatric Hematology and Oncology
Sinta Prastiana Dewi, Soehartati A Gondhowiardjo, Irawan Mangunatmadja, Renindra A Aman, Henry Kodrat, T B Mayang Permata, Handoko
Indonesia is a rapidly growing lower-middle-income country (LMIC) located in Southeast Asia. It has 267.3 million inhabitants, with 31.6% (84.4 million) children. According to GLOBOCAN 2020, Indonesia had the highest prevalence of pediatric cancer cases in Southeast Asia (43.5%), and brain tumors had the third-highest incidence in Indonesia. Treating children with brain tumors with radiotherapy is challenging, especially the late treatment effects that can affect their quality of life (QoL). This study aimed to show the QoL in children with brain tumors after radiotherapy in Dr...
November 29, 2022: Pediatric Hematology and Oncology
Marie-Claude Pelland-Marcotte, Soumitra Tole, Eve Bouhelier, Susan Lee, Jessica Halparin, Cherry Mammen, Karen Lyons, Ali Amid
No abstract text is available yet for this article.
November 25, 2022: Pediatric Hematology and Oncology
Maria Aline Ferreira de Cerqueira, Luciana Maria Fortes Magalhães Castelo Branco Couto, Mírian Perpétua Palha Dias Parente, Juan Clinton Llerena
Strokes affect up to 10% of children with sickle-cell disease (SCD). The most commonly used strategy to prevent a first-time stroke or its recurrence is to perform periodic red blood cell transfusions. This article aims to evaluate the quality of life (QoL) of children and adolescents with SCD undergoing a chronic transfusion regimen (CTR) for stroke prophylaxis, according to their caregivers' perception. A cross-sectional study was conducted using a sociodemographic interview with an application of a validated instrument (Pediatric Quality of Life Inventory) involving 16 caregivers of patients with SCD aged <18 years undergoing CTR in a reference center...
November 24, 2022: Pediatric Hematology and Oncology
Richelle C Waldner, Gregory M T Guilcher, Dania A Monagel, Josephine Ho, Sunil Desai, Elizabeth T Rosolowsky
No abstract text is available yet for this article.
November 16, 2022: Pediatric Hematology and Oncology
Chalinee Monsereenusorn, Wanwipha Malaithong, Nawachai Lertvivatpong, Apichat Photia, Piya Rujkijyanont, Chanchai Traivaree
Children with cancer often require sedation before undergoing invasive procedures. Fentanyl, ketamine, and midazolam are effective drugs widely used for procedural sedation. This study aimed to investigate the efficacy and safety of midazolam-fentanyl (M-F) compared with midazolam-ketamine (M-K) for bedside procedural sedation among pediatric oncology patients. A randomized, double-blinded, crossover trial was conducted among children with cancer requiring procedural sedation for invasive procedures. Patients were randomly assigned either intravenous M-F or M-K and subsequently received the alternate regimens following the crossover design of the study...
November 2022: Pediatric Hematology and Oncology
Harri Sievänen, Päivi Lähteenmäki, Juho Kari, Sanna Halonen, Hanna Soukka, Vesa Eskola, Sauli Palmu
Successful first diagnostic lumbar puncture (LP) is crucial because intrathecal chemotherapy has not yet protected the central nervous system against cancer cells. If blood contaminates the cerebrospinal fluid (CSF) with blasts, they may enter the central neural system and compromise the patient's health. We retrospectively determined the incidence of traumatic lumbar punctures (TLP) in 2,507 LPs of 250 pediatric hemato-oncology patients aged from one to 18 years, including both diagnostic and intrathecal treatment procedures, and 2,617 LPs of 1,525 other age-matched pediatric patients...
November 2022: Pediatric Hematology and Oncology
Kristen J Kurtz, Eran Tallis, Andrea N Marcogliese, Rao H Pulivarthi, Lorraine Potocki, Alexandra M Stevens
Rubinstein-Taybi syndrome (RSTS) is a rare disorder characterized by developmental delay, short stature, dysmorphic facies and skeletal abnormalities. RSTS has been linked to a variety of malignant and benign tumors, but the frequency and characteristics of RSTS-related neoplasms remain unclear. We describe a unique case of near haploid B-cell lymphoblastic leukemia (B-ALL) in a 6-year-old girl with RSTS who harbors a likely pathogenic variant in CREBBP . Somatic CREBBP variants are enriched in some subsets of ALL; however, germline variants have not been previously described in childhood leukemia and may represent an underrecognized predisposition to malignancy...
November 2022: Pediatric Hematology and Oncology
Richard Nyeko, Joyce Balagadde Kambugu, Racheal Angom, Hussein Senyonjo, Solomon Kibudde, Fadhil Geriga, Jaques van Heerden
Brain tumors are the most common solid tumors in children and a leading cause of cancer-related mortality in children worldwide. Data on the epidemiology and management of pediatric brain tumors in Uganda are limited. We aimed to assess the clinicopathological profile and management of pediatric brain tumors at the national oncology center in Uganda since the inception of weekly multidisciplinary meetings. Records of children younger than19 years diagnosed with primary brain tumors at Uganda Cancer Institute between 2017 and 2021 were retrospectively reviewed...
October 31, 2022: Pediatric Hematology and Oncology
Veysel Gok, Alper Ozcan, Sinem Ozer, Filiz Karaman, Esra Aykutlu, Ebru Yilmaz, Musa Karakukcu, Atil Bisgin, Ekrem Unal
Aceruloplasminemia inherited autosomal recessively in the ceruloplasmin gene is a progressive disease with iron accumulation in various organs such as the brain, liver, pancreas, and retina. Ceruloplasmin gene encodes ceruloplasmin protein, which has ferroxidase activity and is involved in copper and iron metabolism. Progressive neurotoxicity, retinopathy, and diabetes may develop in about 40-60 decades. In addition, microcytic anemia accompanied by high ferritin and low ceruloplasmin level that develop at earlier ages can be first manifestation...
October 29, 2022: Pediatric Hematology and Oncology
Atalay Mulu Fentie, Zelalem Tilahun Mekonen, Zelalem Gizachew, Mahlet Hailemariam, Stephen M Clark, Jaime Richardson, Benyam Muluneh
Optimal chemotherapy management is substandard in low and middle-income countries. We aimed to identify major gaps to design interventional strategies for improved chemotherapy management at Tikur Anbessa Specialized Hospital (TASH), Ethiopia. This study was conducted using an observational checklist, open-ended questions, record review, and key informant interviews of department heads and focal persons at TASH. Findings were categorized into specific themes that developed. Chemotherapy represented 60.2% of the hospital medication budget...
October 29, 2022: Pediatric Hematology and Oncology
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