Nicole E Kendel, Joseph R Stanek, Faye K Willen, Anthony N Audino
Current studies describing younger children with Hodgkin lymphoma are limited by geographical region, small sample sizes and variable age groups. Although published data is lacking, there appears to be a trend toward a higher male to female ratio and a higher proportion of mixed cellularity subtype when compared to older cohorts. We performed a retrospective multicenter study utilizing the Pediatric Health Information System® database to evaluate patients aged 0-39 years with Hodgkin lymphoma. We identified 3,034 unique patients who met inclusion criteria...
April 8, 2024: Pediatric Hematology and Oncology
(no author information available yet)
No abstract text is available yet for this article.
March 10, 2024: Pediatric Hematology and Oncology
Jamie M Brown, Sherry Mathew, Maria Luisa Sulis, L Lee Dupuis, Jennifer Thackray
Due to an evidence gap, the emetogenicity of intravenous (IV) pegaspargase was unable to be included in the clinical practice guideline classifying chemotherapy emetogenicity in pediatric patients. This single-center, retrospective chart review describes the proportion of pediatric patients who did not vomit during the acute phase (complete response; CR) after receiving IV pegaspargase and provides an emetogenicity classification using a preexisting framework. Of 44 patients who received IV pegaspargase between 2011 and 2020, 13 received a serotonin receptor antagonist plus dexamethasone or palonosetron alone and all experienced a CR...
March 7, 2024: Pediatric Hematology and Oncology
Fangfang Yuan, Minghui Li, Xudong Wei, Yuewen Fu
To evaluate the co-transplantation efficacy of umbilical cord mesenchymal stem cells (UC-MSCs) and peripheral blood stem cells (PBSCs) as a novel approach for refractory or relapsed severe aplastic anemia (R/R SAA) in children and adolescents, thirty-two children and adolescents diagnosed with R/R SAA underwent a retrospective chart review. The patients were categorized into two groups based on the source of PBSCs: the matched sibling donor (MSD) group and the unrelated donor (UD) group. No adverse events related to UC-MSC infusion occurred in any of the patients...
March 4, 2024: Pediatric Hematology and Oncology
Dea Aprilianti Permana, Susi Susanah, Riyadi Adrizain, Sri Endah Rahayuningsih, Meita Dhamayanti, Lulu Eva Rakhmilla
Objective: Increased survival rate of patients with Transfusion-dependent Thalassemia (TDT) should be in line with their good quality of life (QoL). The study aimed to analyze the relationship between sociodemographic factors and clinical characteristics with the QoL of children with TDT. Methods: A cross-sectional study was conducted at Hasan Sadikin General Hospital from December 2022 to February 2023. A total of 158 eligible subjects aged 5-18 years with TDT were included in the analysis. QoL assessment was performed using child self-report and parent-proxy report questionnaires, along with physical examination findings...
February 29, 2024: Pediatric Hematology and Oncology
Carol Rossetto, Kent Sepkowitz, Jill Ackerman, Rachel Corke, Nina J Pickett, Wini Cudjoe, Janet Eagan, Mini Kamboj, Richard J O'Reilly, Farid Boulad
Management of the exposure of pediatric oncology patients to varicella zoster virus (VZV) is controversial. We report the exposure of 56 patients to a single child with chicken pox at a pediatric cancer housing facility and describe our strategic approach for their management. We reviewed the immune and clinical status of 56 children with cancer receiving ongoing treatment at Memorial Sloan Kettering Cancer Center (MSK) who, while living at a pediatric cancer housing facility, were exposed to the index patient...
February 20, 2024: Pediatric Hematology and Oncology
Scott Greve Brekke, Arne Lucke, Henrik Hasle, Thomas Baad-Hansen
Primary bone tumors in children and adolescents, while rare, pose significant challenges in diagnosis and management. Children treated for Ewing sarcoma and osteosarcoma are offered a 5-year follow-up program after end of treatment, including radiological surveillance of primary location of tumor and the lungs. There is no consensus regarding how often and how the children should be followed with radiological imaging. This retrospective descriptive study of 69 patients (34 with Ewing sarcoma and 35 with osteosarcoma) investigated the consequences of abnormal findings in 1279 follow-up images...
February 12, 2024: Pediatric Hematology and Oncology
Angela Zanfardino, Patrizia Bruzzi, Michela Trada, Novella Rapini, Emanuela Laudani, Gianluca Tornese, Federica Ortolani, Gianluca Piccolo, Lorena Matonti, Maria Alessandra Saltarelli, Tiziana Timpanaro, Giuseppe D'Annunzio, Barbara Predieri, Francesca Rossi, Rossella Mura, Veronica Barat, Arcangelo Prete, Riccardo Schiaffini, Stefano Zucchini
Glycemic abnormalities are a frequent finding in pediatric oncological patients, both during treatment and after its discontinuation. Moreover, impaired glucose tolerance (IGT), impaired fasting glycemia (IFG) and diabetes mellitus (DM) are not rarely diagnosed in non-oncological hematological diseases. To explore the current pediatric Italian approach to the diagnosis and the management of the glycemic alterations in this clinical setting and, thus, to identify and enforce current clinical needs, we submitted an online 23-items survey to all the Italian Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) centers, and surveys were descriptively analyzed...
January 25, 2024: Pediatric Hematology and Oncology
Chanikarn Tongruang, Siriwan Wananukul, Susheera Chatproedprai, Nattee Narkbunnam, Rattanavalai Nitiyarom, Nongnuch Sirachainan, Rungrote Natesirinilkul, Phumin Chaweephisal, Darintr Sosothikul
The conventional treatment of Kasabach-Merritt Phenomenon (KMP) consists of corticosteroids with vincristine/vinblastine or others. The aim of the study is to compare the first-year direct costs and effectiveness between sirolimus and conventional treatment. A retrospective case-control study of KMP patients was conducted at a mean age of 9 months ( 1 day to 12 years) between 2000 and 2022 from four tertiary centers in Thailand. The direct costs, hematologic and clinical complete response (HCR, CCR), hospitalization, length of stay, and complications were compared...
April 2024: Pediatric Hematology and Oncology
Nirmalya Roy Moulik, Arlene Harriss-Buchan, Giuseppe Saglio, Meinolf Suttorp
Despite being a rare disease, high-income countries (HICs) have formulated guidelines for management of pediatric CML (pCML). We conducted a survey amongst 24 physicians from 22 Low-Middle Income Countries (LMICs) to gather information regarding their practice and experience in treating children with pCML. Rarity of pCML, lack of adequate expertise, and setting-adapted guidelines along with limitations in diagnostic infrastructure as well as challenges in accessing tyrosine kinase inhibitors (TKIs) were identified as major barriers in optimum management of patients...
January 16, 2024: Pediatric Hematology and Oncology
Archana Sasi, Sindhura Chitikela, Shuvadeep Ganguly, Bivas Biswas, Deepam Pushpam, Akash Kumar, Shah Alam Khan, Venkatesan Sampath Kumar, Shashank Sharad Kale, Ahitagni Biswas, Adarsh Barwad, Asit Ranjan Mridha, Sanjay Thulkar, Sameer Bakhshi
Ewing sarcoma (ES) of the spine is a rare childhood cancer with sparse literature on treatment outcomes. We aimed to describe survival outcomes and prognostic factors in patients with spinal ES treated at a single institute in a resource-challenged setting. We conducted a retrospective analysis of patients with spinal ES registered at a tertiary care oncology center between 2003-2019. Clinical patient data was retrieved from hospital records. Cox regression analysis was used to identify the association of baseline clinical parameters with event free survival (EFS) and overall survival (OS)...
January 8, 2024: Pediatric Hematology and Oncology
Hyun Jin Kim, Yeon Jung Lim
Iron deficiency anemia (IDA) can be caused by occult gastrointestinal (GI) blood loss; however, the endoscopic findings in children with anemia are unclear. The study aimed to determine the frequency and factors related to lesions in children with IDA undergoing endoscopy. We retrospectively analyzed the clinical and endoscopic findings of children with a laboratory-based diagnosis of IDA. Of 58 patients, 36 (62.1%) had upper GI tract lesions, with erosive gastritis being the most common lesion. Further, 26 patients underwent concomitant colonoscopy, and 12 (46...
2024: Pediatric Hematology and Oncology
Luisanna M Sánchez, Anil George, Brian D Friend, Saleh Bhar, Ghadir Sasa, Erin E Doherty, John Craddock, David Steffin, Baheyeldin Salem, Khaled Yassine, Bilal Omer, Caridad Martinez, Kathryn Leung, Robert A Krance, Tami D John
While matched related donor (MRD) allogeneic hematopoietic stem cell transplantation (HSCT) is a curative option for transfusion-dependent beta-thalassemia (TDT), the use of alternative sources has increased, resulting in the exploration of novel transplant-conditioning regimens to reduce the contribution of graft-versus-host disease (GVHD) and graft failure (GF) to transplant-related morbidity and mortality. Alemtuzumab is a CD52 monoclonal antibody that has been successfully incorporated into myeloablative conditioning regimens for other hematologic conditions, yet there have been limited studies regarding the use of alemtuzumab in HSCT for TDT...
December 22, 2023: Pediatric Hematology and Oncology
Gholamreza Bahoush, Mahdi Rahab, Parnian Ahmadvand
Patients with beta-thalassemia major require lifelong and frequent red blood cell transfusions for survival, impacting their quality of life and life expectancy. This treatment approach poses risks of organ damage, iron overload, and increased transfusion-transmitted diseases. N-acetylcysteine (NAC) has been studied for its potential antioxidant effects on hemoglobin stability, aiming to reduce the burden of red blood cell transfusions. To explore this possibility further, we conducted a quasi-experimental study involving 35 individuals with thalassemia major over six months All subjects were already receiving iron chelators and blood transfusions...
December 13, 2023: Pediatric Hematology and Oncology
Firat Ozcelik, Kubra Aslan, Veysel Gok, Mucahit Bilgehan Ari, Alper Ozcan, Ahmet Eken, Ekrem Ünal, Yusuf Ozkul, Munis Dundar
No abstract text is available yet for this article.
December 4, 2023: Pediatric Hematology and Oncology
Satya Prakash Yadav, Revathi Raj, Ramya Uppuluri, Dharma Choudhary, Divya Doval, Vikas Dua, Sunil Bhat, Gaurav Kharya, Rajesh Patil, Shweta Bansal, Deendayalan M, Intezar Mehdi, Vikram Mathews, Aby Abraham, Biju George
No abstract text is available yet for this article.
November 27, 2023: Pediatric Hematology and Oncology
Natsaruth Songthawee, Pornpun Sripornsawan, Shevachut Chavananon, Sirinthip Kittivisuit, Edward B McNeil, Thirachit Chotsampancharoen
Few studies have reported the survival outcomes of myeloid leukemia associated with Down syndrome (DS) in resource-limited countries. This study aimed to compare characteristics and survival outcomes of children with acute myeloid leukemia (AML) between those with and without DS in Thailand. The medical records of AML patients aged 0-15 years treated in a major tertiary center in Southern Thailand between October 1978 and December 2019 were reviewed retrospectively. The overall (OS) and event-free survivals (EFS) rates were calculated using the Kaplan-Meier method...
November 27, 2023: Pediatric Hematology and Oncology
Chia Huan Ng, Juliana P Roden, Jefferson Terry, Kirk R Schultz
Chronic GvHD of the penile tract in male pediatric patients has not been described well in the literature and is often under-diagnosed. We report three cases of penile chronic GvHD in adolescent male patients who received HSCT before the onset of puberty. Their penile cGvHD became symptomatic upon the onset of penile growth associated with puberty in combination with the fibrotic changes in the foreskin. Symptoms did not respond to systemic chronic GvHD medication but require circumcision for alleviation of symptoms...
November 7, 2023: Pediatric Hematology and Oncology
Saori Yamada, Yuta Maruyama, Shoji Saito, Kazutoshi Komori, Hirokazu Morokawa, Eri Okura, Koichi Hirabayashi, Yu Furui, Takashi Kurata, Makoto Nishioka, Tetsuhiro Fukuyama, Kazuo Sakashita, Yozo Nakazawa
No abstract text is available yet for this article.
October 31, 2023: Pediatric Hematology and Oncology
Symbat Saliyeva, Riza Boranbayeva, Minira Bulegenova, Vyacheslav Beloussov
GCT is characterized by specific biochemical markers expression, such as human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP), which are the main tools in the diagnosis and monitoring of GCT treatment. They are expressed in 15-20% of cases of seminoma and in 60-80% of cases of non-seminoma. MicroRNA profiling allows to identify a number of microRNAs that are superior to classical serum tumor markers in the diagnosis of primary tumors, as well as in subsequent monitoring and prediction of recurrence...
October 29, 2023: Pediatric Hematology and Oncology
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