Oscar Illescas, Giulio Ferrero, Antonino Belfiore, Barbara Pardini, Sonia Tarallo, Chiara M Ciniselli, Sara Noci, Elena Daveri, Stefano Signoroni, Laura Cattaneo, Andrea Mancini, Daniele Morelli, Massimo Milione, Francesca Cordero, Licia Rivoltini, Paolo Verderio, Patrizia Pasanisi, Marco Vitellaro, Alessio Naccarati, Manuela Gariboldi
BACKGROUND: Dietary interventions have been proposed as therapeutic approaches for several diseases, including cancer. A low-inflammatory Mediterranean dietary intervention, conducted as a pilot study in subjects with Familial Adenomatous Polyposis (FAP), reduced markers of local and systemic inflammation. We aim to determine whether this diet may modulate faecal microRNA (miRNA) and gene expression in the gut. METHODS: Changes in the faecal miRNome were evaluated by small RNA sequencing at baseline (T0), after the three-month intervention (T1), and after an additional three months (T2)...
February 26, 2024: Clinical Nutrition