Eva Morales, María Teresa Prieto-Sánchez, Jaime Mendiola, Ana Cutillas-Tolín, Evdochia Adoamnei, Desirée Valera-Gran, Carmen Martínez-Graciá, Marina Santaella-Pascual, Clara Suárez-Martinez, Jesús Vioque, María Jesús Castaños, Eva Del Castillo, Luis García-Marcos
BACKGROUND & AIMS: Prenatal folate exposure may alter epigenetic marks in the offspring. We aimed to evaluate associations between prenatal exposure to folic acid (FA) in preconception and in utero with cord blood DNA methylation in long interspersed nuclear element 1 (LINE-1) and Alu short interspersed nuclear elements (SINEs) as markers of global DNA methylation levels. METHODS: Data come from 325 mother-child pairs participating in the Nutrition in Early Life and Asthma (NELA) birth cohort (2015-2018)...
April 16, 2024: Clinical Nutrition
Maxim D'heedene, Tim Vanuytsel, Lucas Wauters
BACKGROUND & AIMS: Celiac disease (CD) is a chronic inflammatory disease of the small intestine induced and maintained by gluten ingestion in susceptible individuals. Current treatment consists of strict adherence to a lifelong gluten-free diet (GFD) which is considered safe and effective in the large majority of patients. However, since adherence to a GFD is difficult and has a negative impact on quality of life, an increasing interest in other treatment options has emerged. Moreover, in some individuals a GFD is not sufficiently effective, necessitating alternative treatments...
April 15, 2024: Clinical Nutrition
Yafang Yang, Ligang Yang, Jiale Wu, Jing Hu, Min Wan, Jindi Bie, Jiaxin Li, Da Pan, Guiju Sun, Chao Yang
BACKGROUND: Probiotic administration is a promising therapy for improving conditions in NAFLD patients. This network meta-analysis aimed to compare and estimate the relative effects of probiotic interventions and identify the optimal probiotic species for the treatment of NAFLD (Nonalcoholic fatty liver disease) patients. METHODS: The PubMed, Web of Science, Embase, and Cochrane databases were searched from inception to 29 January 2024 to identify RCTs that were published in English...
April 13, 2024: Clinical Nutrition
Isma'il Kadam, Mudar Dalloul, Jeanette Hausser, Doron Vaday, Ella Gilboa, Liang Wang, Joan Hittelman, Lori Hoepner, Lawrence Fordjour, Pavani Chitamanni, Anjana Saxena, Xinyin Jiang
BACKGROUND & AIMS: Both maternal metabolic dysregulation, e.g., gestational diabetes mellitus (GDM), and maternal supply of nutrients that participate in one-carbon (1C) metabolism, e.g., folate, choline, betaine, and vitamin B12 , have been demonstrated to influence epigenetic modification such as DNA methylation, thereby exerting long-lasting impacts on growth and development of offspring. This study aimed to determine how maternal 1C nutrient intake was associated with DNA methylation and further, development of children, as well as whether maternal GDM status modified the association in a prospective cohort...
April 12, 2024: Clinical Nutrition
Mette Glavind Bülow Pedersen, Esben Søndergaard, Camilla Bak Nielsen, Mogens Johannsen, Lars Christian Gormsen, Niels Møller, Niels Jessen, Nikolaj Rittig
No abstract text is available yet for this article.
April 11, 2024: Clinical Nutrition
Aleksandra Jatkowska, Konstantinos Gkikas, Ben Nichols, Bryn Short, Vasiliki-Konstantina Rizou, Panagiotis Kapranos, Jennifer Klein Gunnewiek, Edelyn Christina, Vaios Svolos, Christopher Quince, Konstantinos Gerasimidis
INTRODUCTION: Enteral nutrition (EN) involves replacing all or part of a person's habitual diet with a nutritional formula. The impact of varying doses of EN on the gut microbiome remains understudied. METHODS: Healthy adults replaced all (100% EN) or part (85% EN, 50% EN and 20% EN) of their energy requirements with EN for 7 days. Faecal samples were collected before and on day 7 of interventions. Faecal pH, short chain fatty acids (SCFAs), branched-chain fatty acids (BCFAs) and 16S rRNA sequencing were performed...
April 9, 2024: Clinical Nutrition
Niamh Hanlon, Natalie Gillan, James Neil, Karin Seidler
BACKGROUND AND AIMS: Dysbiosis is emerging as a potential trigger of systemic lupus erythematosus (SLE). Group 3 innate lymphoid cells (ILC3s) are recognised as key regulators of intestinal homeostasis. The aryl hydrocarbon receptor (AhR) is critical to intestinal ILC3 development and function. This mechanistic review aimed to investigate whether AhR activation of gut ILC3s facilitates IL-22-mediated antimicrobial peptide (AMP) production to enhance colonisation resistance and ameliorate SLE pathology associated with intestinal dysbiosis...
April 8, 2024: Clinical Nutrition
Huicong Niu, Min Chu, Ning Yang, Daosheng Wang, Yang Liu, Xueyu Mao, Shiliang Xia, Delong Wang, Xuechun Wu, Jing Zhao
BACKGROUND: The double burden of malnutrition, defined as the coexistence of obesity and malnutrition, is an increasing global health concern and is unclear in patients after ischemic stroke. The current study explored the combined impacts of obesity and malnutrition on patients with ischemic stroke. METHODS: We conducted a single-center prospective cohort study with patients with ischemic stroke enrolled in Minhang Hospital in China between January 2018 and December 2022...
April 5, 2024: Clinical Nutrition
Tiantian Wu, Hongxia Xu, Wei Li, Fuxiang Zhou, Zengqing Guo, Kunhua Wang, Min Weng, Chunling Zhou, Ming Liu, Yuan Lin, Suyi Li, Ying He, Qinghua Yao, Hanping Shi, Chunhua Song
BACKGROUND & AIMS: The key step of the Global Leadership Initiative on Malnutrition (GLIM) is nutritional risk screening, while the most appropriate screening tool for colorectal cancer (CRC) patients is yet unknown. The GLIM diagnosis relies on weight loss information, and bias or even failure to recall patients' historical weight can cause misestimates of malnutrition. We aimed to compare the suitability of several screening tools in GLIM diagnosis, and establish machine learning (ML) models to predict malnutrition in CRC patients without weight loss information...
April 5, 2024: Clinical Nutrition
Inoli Shennon, Brooke C Wilson, Anna H Behling, Theo Portlock, Rashidul Haque, Terrence Forrester, Charles A Nelson, Justin M O'Sullivan
Malnutrition affects 195 million children under the age of five worldwide with long term effects that include impaired cognitive development. Brain development occurs rapidly over the first 36 months of life. Whilst seemingly independent, changes to the brain and gut microbiome are linked by metabolites, hormones, and neurotransmitters as part of the gut-brain axis. In the context of severe malnutrition, the composition of the gut microbiome and the repertoire of biochemicals exchanged via the gut-brain axis vary when compared to healthy individuals...
April 4, 2024: Clinical Nutrition
Susanna Klevebro, Simon Kebede Merid, Ulrika Sjöbom, Wen Zhong, Hanna Danielsson, Dirk Wackernagel, Ingrid Hansen-Pupp, David Ley, Karin Sävman, Mathias Uhlén, Lois E H Smith, Ann Hellström, Anders K Nilsson
BACKGROUND & AIM: Clinical trials supplementing the long-chain polyunsaturated fatty acids (LCPUFAs) docosahexaenoic acid (DHA) and arachidonic acid (AA) to preterm infants have shown positive effects on inflammation-related morbidities, but the molecular mechanisms underlying these effects are not fully elucidated. This study aimed to determine associations between DHA, AA, and inflammation-related proteins during the neonatal period in extremely preterm infants. METHODS: A retrospective exploratory study of infants (n = 183) born below 28 weeks gestation from the Mega Donna Mega trial, a randomized multicenter trial designed to study the effect of DHA and AA on retinopathy of prematurity...
April 3, 2024: Clinical Nutrition
Noushin Sadat Ahanchi, Farnaz Khatami, Erand Llanaj, Hugo G Quezada-Pinedo, Helga Dizdari, Arjola Bano, Marija Glisic, Michele F Eisenga, Pedro-Marques Vidal, Taulant Muka
Biological hormonal changes are frequently cited as an explanatory factor of sex and menopause differences in cardiometabolic diseases (CMD) and its associated risk factors. However, iron metabolism which varies between sexes and among women of different reproductive stages could also play a role. Recent evidence suggest that iron may contribute to CMD risk by modulating oxidative stress pathways and inflammatory responses, offering insights into the mechanistic interplay between iron and CMD development. In the current review, we provide a critical appraisal of the existing evidence on sex and menopausal differences in CMD, discuss the pitfall of current estrogen hypothesis as sole explanation, and the emerging role of iron in CMD as complementary pathway...
April 3, 2024: Clinical Nutrition
André O Werneck, Euridice M Steele, Felipe M Delpino, Melissa M Lane, Wolfgang Marx, Felice N Jacka, Brendon Stubbs, Mathilde Touvier, Bernard Srour, Maria Lc Louzada, Renata B Levy, Carlos A Monteiro
BACKGROUND & AIMS: We aimed to analyze the prospective association between adherence to the ultra-processed dietary pattern and risk of depressive outcomes using original data from the NutriNet Brasil cohort and via a systematic review and meta-analysis of observational studies that have investigated the same association. METHODS: In our original research analysis, we used data from 15,960 adults (≥18 y) participating in the NutriNet Brasil cohort study, free of depression or depressive symptoms during the baseline (77...
April 1, 2024: Clinical Nutrition
Jiangmei Pan, Guoling Xu, Zhenwei Zhai, Jingxia Sun, Qiu Wang, Xiuxian Huang, Yanli Guo, Quan Lu, Jianming Mo, Yuechou Nong, Jianhao Huang, Wensheng Lu
BACKGROUND & AIMS: The elderly are prone to fragility fractures, especially those suffering from type 2 diabetes mellitus (T2DM) combined with osteoporosis. Although studies have confirmed the association between GNRI and the prevalence of osteoporosis, the relationship between GNRI and fragility fracture risk and the individualized 10-year probability of osteoporotic fragility fractures estimated by FRAX remains unclear. This study aims to delve into the association between the GNRI and a fragility fracture and the 10-year probability of hip fracture (HF) and major osteoporotic fracture (MOF) evaluated by FRAX in elderly with T2DM...
April 1, 2024: Clinical Nutrition
Young-Hwan Park, Hye Sun Lee, Juyeon Yang, Li Rang Lim, Yu-Jin Kwon, Ji-Won Lee
BACKGROUND & AIMS: The relationship between diet and health, particularly the role of carbohydrates, has been extensively studied. However, carbohydrate intake based on individual health conditions remains unclear. Here, we aimed to investigate whether the association between carbohydrate intake and all-cause mortality varied between individuals with and without diabetes mellitus (DM). METHODS: This prospective cohort study used data from the Korean Genome and Epidemiology Study (KoGES)...
April 1, 2024: Clinical Nutrition
Mikerenayi Maimaitijiang
No abstract text is available yet for this article.
April 1, 2024: Clinical Nutrition
Elena González Arnáiz, Diana Ariadel Cobo, Brisamar Estébanez, David Barajas Galindo, Begoña Pintor de la Maza, Ana Urioste Fondo, Carmen Dameto Pons, María J Cuevas, María D Ballesteros Pomar
BACKGROUND AND AIMS: Sarcopenic obesity (SO) is defined as a combination of low strength and muscle mass along with excess adiposity. Our study aimed to determine the prevalence of sarcopenic obesity in candidates for bariatric surgery, according to ESPEN/EASO criteria using bioimpedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA). METHODS: Retrospective study of adult patients (18-60 years) candidates for bariatric surgery (BMI ≥40 kg/m2 or ≥35 kg/m2 with associated complications)...
April 1, 2024: Clinical Nutrition
Bahar Atasoy, Serdar Balsak, Alpay Alkan, Ahmet Akcay, Abdusselim Adil Peker, Ozlem Toluk, Naz Atila, Ahmet Kaya, Ozlem Ipar, Pinar Soysal
OBJECTIVES: The purpose of this study to determinate whether there is a relationship between the nutritional status and white matter integrity in older patients by using Diffusion Tensor Imaging (DTI). METHODS: The patients were evaluated by Mini-Nutritional Assessment Scale. The patients are categorized in the groups of well-nourished, risk of malnutrition, or malnourished, depending on the overall score> 23.5, 17-23.5, or 17; respectively. All patients had brain MRI and DTI...
April 1, 2024: Clinical Nutrition
Jingjing Yu, Qiang Hu
No abstract text is available yet for this article.
April 1, 2024: Clinical Nutrition
Michelle E G Weijzen, Maxime Kohlen, Alejandra Monsegue, Dion C J Houtvast, Jean Nyakayiru, Sandra Beijer, Phil Geerlings, Lex B Verdijk, Luc J C van Loon
BACKGROUND & AIM: In hospitalized patients, daily protein intake remains far below WHO requirements for healthy adults (0.8 g·kg-1 ·d-1 ) as well as ESPEN guidelines for patients (1.2-1.5 g·kg-1 ·d-1 ). Providing access to a pre-sleep protein dense snack between dinner and going to bed may serve as a great opportunity to increase daily energy and protein intake in hospitalized patients. However, it remains to be assessed whether protein provision prior to sleep effectively increases protein intake, or may reduce food intake throughout the remainder of the day(s)...
March 28, 2024: Clinical Nutrition
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