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Nuclear Medicine Communications

Egesta Lopci, Angelo Castello, Emanuela Morenghi, Dario Tanzi, Silvio Cavuto, Fabio Lutman, Giuseppe Chiesa, Elena Vanni, Marco Alloisio, Maurizio Infante
AIM: The aim of this study was to analyze the economic efficiency of second-line diagnostic investigations in patients with undetermined lung nodules. PARTICIPANTS AND METHODS: A retrospective review of all surgical cases included in the DANTE trial from 2001 to 2006 for lung cancer screening was performed. Overall, 217 patients and 261 lung nodules were analyzed. The cohort was divided into patients investigated with PET and/or computed tomography (CT)-guided biopsy (PET-CTB protocol; N=100), compared with those assessed with serial low-dose CT scans (standard protocol; N=161)...
March 11, 2019: Nuclear Medicine Communications
Wenchong Xin, Xiaoyu Yang, Jianfeng Wang, Xiaoliang Shao, Feifei Zhang, Yunmei Shi, Bao Liu, Wenji Yu, Haipeng Tang, Zhifang Wu, Yuetao Wang, Weihua Zhou
BACKGROUND: In single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) studies, attenuation artifacts frequently cause false positives, which can be partially overcome by computed tomography attenuation correction (CT-AC) or gated acquisition [gated myocardial perfusion imaging (GMPI)]. The purpose of this study is to evaluate their relative diagnostic performances for coronary artery disease (CAD). PATIENTS AND METHODS: We enrolled 181 patients who underwent gated SPECT with CT-AC in this study...
March 7, 2019: Nuclear Medicine Communications
Neeraj Khiyani, Simin Dadparvar, Aaron Gish, Charles M Intenzo, Leon S Malmud
BACKGROUND: Radioactive iodine-131 (RAI) is an established treatment for patients with Graves' hyperthyroidism. RAI is reported to be associated with a 20-30% incidence of development or exacerbation of Graves' ophthalmopathy (GO). This study compares the progression of GO in patients who had evidence or no evidence of GO before RAI therapy. PATIENTS AND METHODS: Forty-eight patients were studied. One group had no evidence whereas the other group had evidence of GO before RAI treatment...
March 6, 2019: Nuclear Medicine Communications
Maurits Wondergem, Friso M van der Zant, Ladan Rafimanesh-Sadr, Remco J J Knol
Forced diuresis may improve readability of 2-(3-(1-carboxy-5-[(6-[F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid (F-DCFPyL) PET/computed tomography (CT) by reducing focal ureteral activity. A total of 40 patients received furosemide simultaneously with F-DCFPyL (cohort 1) and 40 patients received furosemide 85 min after F-DCFPyL administration (cohort 2). The frequency of occurrence of activity depositions in ureters and halo artefacts near the kidneys and bladder was measured, as well as intensity of F-DCFPyL uptake in kidneys and bladder...
March 5, 2019: Nuclear Medicine Communications
Xi Sun, Shengxiang Liang, Ting Feng, Panlong Li, Tianhao Zhang, Qi Huang, Hua Liu, Shujun Zhao, Binbin Nie, Baoci Shan
OBJECTIVE: Motor network plays an important role in people's daily lives. However, until now, the energy consumption mechanism of motor network remains unclear. In this study, we aimed to investigate the energy consumption of motor network. MATERIALS AND METHODS: Fluorine-18-fluorodeoxyglucose PET ([F]FDG PET) data of 81 healthy male Sprague-Dawley rats were included in this study. Metabolic motor network was constructed on the basis of group independent component analysis...
February 22, 2019: Nuclear Medicine Communications
Siavash Mehdizadeh Seraj, Abdullah Al-Zaghal, Mahdi Z Zadeh, Pegah Jahangiri, Kamyar Pournazari, William Y Raynor, Thomas J Werner, Poul F Høilund-Carlsen, Abass Alavi, Stephen J Hunt
PURPOSE: The aim of this study was to explore the rate of elimination of fluorine-18-fluorodeoxyglucose (F-FDG) from the liver and assess the impact of hepatic fat and obesity on F-FDG clearance in early and delayed PET scans. We hypothesized that an increase in liver fat may cause a decline in hepatic F-FDG elimination with potential consequences as measured by dual time-point F-FDG PET/CT imaging. PATIENTS AND METHODS: A total of 32 patients from the Cardiovascular Molecular Calcification Assessed by F-NaF PET/CT (CAMONA) clinical trial (17 males, 15 females; mean age: 47...
February 21, 2019: Nuclear Medicine Communications
Herman P Kaldeway, Evert-Jan Ter Borg, Ewoudt M W van de Garde, Jan B A Habraken, Monique M C van Buul
PURPOSE: The aim of this retrospective study was to evaluate the diagnostic value of semiquantitative parameters in salivary gland scintigraphy (SGS) in the diagnostic work-up of primary Sjögren's Syndrome (SS) using the American-European consensus criteria (AECC) as the gold standard. PATIENTS AND METHODS: 99mTc-pertechnetate-SGS was performed in 110 patients with suspected primary SS. Uptake ratios (URs) and excretion fractions (EFs) for all parotid and submandibular salivary glands were calculated...
February 21, 2019: Nuclear Medicine Communications
Amit Bhoil, Sobhan Vinjamuri
Infections involving cardiovascular implantable electronic devices are becoming increasingly common, and increasingly complex to manage. Advances in technology have made implantable electronic devices smaller, and easier to implant, and patients are now also more likely to be older, with more complex comorbidities. Infections related to these devices are, however, not decreasing, and in some settings, these are rising. There is a clinical need for more accurate tests for confirming or ruling out infected devices...
February 21, 2019: Nuclear Medicine Communications
Rexhep Durmo, Marco Lechiara, Diego Benetti, Carlo Rodella, Luca Camoni, Domenico Albano, Francesco Bertagna, Raffaele Giubbini
PURPOSE: The purpose was to report our experience in the use of radiotracer localization and resection of small, indistinct, or nonpalpable pulmonary lesions. We developed an innovative technique implementing a fluoroscopy system on a single-photon emission computed tomography/computed tomography (SPECT/CT) scan that allowed to perform CT-guided injection of radiotracer directly on SPECT/CT. PATIENTS AND METHODS: Patients were selected for the radiotracer procedure in presence of difficulties in locating nodules with video-assisted thoracoscopic surgery (VATS)...
February 15, 2019: Nuclear Medicine Communications
Philippe Robin, Ran Klein, Jeremy Gardner, Blair Ziebarth, Sadri Bazarjani, Simin Razavi, Lionel S Zuckier, Wanzhen Zeng
PURPOSE: Proposed mechanisms of parathyroid localization in 'dual-phase' technetium-99m-sestamibi imaging include increased presence of mitochondria leading to greater uptake and slower washout compared with thyroid tissues owing to reduced expression of P-glycoprotein. Using new techniques of quantitative single-photon emission computed tomography (SPECT)/computed tomography (CT), we have measured MIBI uptake and washout to better understand factors related to conspicuity. PATIENTS AND METHODS: We retrospectively reviewed 125 consecutive patients...
February 12, 2019: Nuclear Medicine Communications
Blandine Truffault, Philippe Robin, Cecile Tromeur, Alexandra Le Duc Pennec, Ronan Abgral, David Bourhis, Francis Couturaud, Gregoire Le Gal, Pierre-Yves Salaun, Pierre-Yves Le Roux
OBJECTIVE: Following the implementation of single-photon emission computed tomography ventilation/perfusion (SPECT V/Q) in our department, we previously carried out an observational study over the period 2011-2013 that showed the safety of SPECT V/Q to rule out pulmonary embolism (PE). However, PE prevalence (28%) was high compared with some studies. Our hypothesis was that the use of SPECT V/Q may be responsible for an overdiagnosis of PE, especially at the implementation phase of the test...
February 7, 2019: Nuclear Medicine Communications
Nese Torun, Ayse Aktas, Mehmet Reyhan, A Fuat Yapar, G Nihal Nursal
OBJECTIVES: Direct radionuclide cystography (DRC) with cyclic imaging is a sensitive method used for the detection of vesicoureteral reflux (VUR). Radionuclide cystography is generally recommended for follow-up evaluation of VUR. The aim of this study was to evaluate cyclic DRC with DMSA scan results during the follow-up period in children with a prior diagnosis of VUR. PATIENTS AND METHODS: DRC findings of 85 children with VUR were evaluated together with DMSA findings during follow-up...
February 7, 2019: Nuclear Medicine Communications
Laura Galland, Claire Bolot, Sylvain Rosinski, Aurélie Bruno, Sandra Forel, Valentine Bréant, Elise Levigoureux
Despite a mistake during the preparation of technetium-99m (Tc)-nanocolloid rhenium sulphide (Nanocis) because of lack of heating, the apparent radiochemical purity (RCP) of this product was correct. The objectives of this study were to evaluate the impact of absence of heating on the RCP of Tc-nanocolloid rhenium sulphide and the effect of heating on particle size. Five Tc-Nanocis were prepared according to the manufacturer's instructions and five others were realized without any heating step. Quality controls were performed for each preparation...
January 31, 2019: Nuclear Medicine Communications
Ming-Hsien Wu, Feng-Hsuan Liu, Kun-Ju Lin, Jui-Hung Sun, Szu-Tah Chen
BACKGROUND: Primary aldosteronism (PA) is a common cause of secondary hypertension. Among the many leading causes of PA, the two most frequent are, bilateral adrenal hyperplasia (BAH) and aldosterone-producing adenomas (APA). Since a solitary APA may be cured surgically, but BAH needs lifelong pharmacologic therapy, confirmation is mandatory before surgery. We herein sought to determine the diagnostic value of iodine-131 6-beta-iodomethyl-19-norcholesterol (NP-59) adrenal scintigraphy to distinguish BAH from APA...
January 28, 2019: Nuclear Medicine Communications
Halil Komek, Canan Can, Zuhat Urakçi, Ferat Kepenek
OBJECTIVE: This study was designed to compare the 18-Fluorodeoxyglucose positron emission tomography/computed tomography [(F)FDG PET/CT] and 1,4,7,10-tetraazacyclododecane-NI,NII,NIII,NIIII-tetraacetic acid (D)-Phe1-thy3-octreotate [(Ga)DOTATATE PET/CT) findings in patients with pulmonary carcinoid (PC) tumors. MATERIALS AND METHODS: A total of 20 patients [mean (SD) age: 52.2 (12.9) years, 60% women] with PC tumors and available records on digital images of (F)FDG PET/CT and (Ga)DOTATATE PET/CT and histopathological analysis were included in this retrospective single-center study...
January 28, 2019: Nuclear Medicine Communications
Dong Dai, Hubert H Chuang, Homer A Macapinlac, Tengfei Li, Tinsu Pan
BACKGROUND: Fluorine-18-labeled sodium fluoride (F-NaF) uptake measured with PET in the vessel walls can indicate active microcalcification, a potential biomarker of higher-risk plaques, which are not indicated by macrocalcification measured with computed tomography (CT). The aim of this study was to determine the extent to which F-NaF uptake is correlated with calcification at arterial plaques in cancer patients undergoing whole-body PET/CT imaging. PATIENTS AND METHODS: Image data from 179 patients who underwent F-NaF PET/CT were evaluated retrospectively...
January 25, 2019: Nuclear Medicine Communications
Fadi Rassam, Kasia P Cieslak, Ulrich H W Beuers, Thomas M van Gulik, Roel J Bennink
Technetium-99m (Tc) mebrofenin hepatobiliary scintigraphy (HBS) enables a quantitative assessment of liver function. This is normally performed in a fasting state and might therefore reflect the resting liver function. We evaluated the change in liver function using HBS after stimulation with an oral metabolic challenge. Healthy volunteers aged 50-60 (n=12) or older than or equal to 75 (n=12) years underwent two sequential HBS. The first scan was performed after an overnight fast and the second scan was performed after the administration of chocolate milk...
January 22, 2019: Nuclear Medicine Communications
Yatin Arora, Rana S Singh, Santhosh Sampath, Ashwani Sood, Parminder Singh, Harkant Singh, Anand K Mishra, Madan Parmar
OBJECTIVES: The association between the extent and degree of perfusion-metabolism mismatch and improvement in perfusion and left ventricular ejection fraction (LVEF) after revascularization was assessed. The secondary aim was to identify the best precoronary artery bypass graft surgery (pre-CABG) PET parameter, if any, to predict the improvement in the perfusion and LVEF after CABG. METHODS AND RESULTS: Overal, 31 patients (mean age: 58+8.3 years) with ischemic left ventricle dysfunction underwent NH3 and F-FDG PET for the assessment of myocardial viability...
January 22, 2019: Nuclear Medicine Communications
Lawrence G Hutton, Charlotte A Porter, Andrew J Morgan, Kevin M Bradley, Daniel R McGowan
OBJECTIVES: The aim of the study was to identify a threshold value of the estimated glomerular filtration rate (eGFR) that would predict a measured glomerular filtration rate (mGFR) of ≤25 ml/min/1.73 m. This is to guide use of the new British Nuclear Medicine Society guidelines, which specifies a 24 h sample for patients with a GFR of ≤25 ml/min/1.73 m, when using the single-sample (SS) method. PATIENTS AND METHODS: Data from 1956 patient studies were used to calculate values for the GFR using the slope intercept (SI) method and SS , which was taken 210 min after injection...
January 21, 2019: Nuclear Medicine Communications
Peter G Maliha, Marie Hudson, Gad Abikhzer, Julia Singerman, Stephan Probst
BACKGROUND: To compare the performance of fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) and conventional tests for cancer screening in autoimmune inflammatory myopathy (AIM) patients. PATIENTS AND METHODS: We carried out a retrospective cohort study of AIM patients from one academic center in Montreal, Canada, classified using myositis-specific antibodies, who underwent F-FDG PET/CT between April 2005 and February 2018 and were followed up on average 3...
January 18, 2019: Nuclear Medicine Communications
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