journal
https://read.qxmd.com/read/37728607/the-tyrosine-kinase-inhibitor-nintedanib-enhances-the-efficacy-of-90y-labeled-b5209b-radioimmunotherapy-targeting-robo1-without-increased-toxicity-in-small-cell-lung-cancer-xenograft-mice
#1
JOURNAL ARTICLE
Kentaro Fujiwara, Atsushi B Tsuji, Hitomi Sudo, Aya Sugyo, Takao Hamakubo, Tatsuya Higashi
BACKGROUND: Small cell lung cancer (SCLC) has a poor prognosis, and Roundabout homolog 1 (ROBO1) is frequently expressed in SCLC. ROBO1-targeted radioimmunotherapy (RIT) previously showed tumor shrinkage, but regrowth with fibroblast infiltration was observed. The fibroblasts would support tumor survival by secreting growth factors and cytokines. Inhibition of fibroblasts offers a candidate strategy for increasing RIT efficacy. Here, we evaluated the efficacy of combination therapy with 90Y-labeled anti-ROBO1 antibody B5209B (90Y-B5209B) and the tyrosine kinase inhibitor nintedanib in SCLC xenograft mice...
September 21, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37728592/a-comparison-of-18f-fdg-pet-based-radiomics-and-deep-learning-in-predicting-regional-lymph-node-metastasis-in-patients-with-resectable-lung-adenocarcinoma-a-cross-scanner-and-temporal-validation-study
#2
JOURNAL ARTICLE
Kun-Han Lue, Yu-Hung Chen, Sung-Chao Chu, Bee-Song Chang, Chih-Bin Lin, Yen-Chang Chen, Hsin-Hon Lin, Shu-Hsin Liu
OBJECTIVE: The performance of 18F-FDG PET-based radiomics and deep learning in detecting pathological regional nodal metastasis (pN+) in resectable lung adenocarcinoma varies, and their use across different generations of PET machines has not been thoroughly investigated. We compared handcrafted radiomics and deep learning using different PET scanners to predict pN+ in resectable lung adenocarcinoma. METHODS: We retrospectively analyzed pretreatment 18F-FDG PET from 148 lung adenocarcinoma patients who underwent curative surgery...
September 21, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37711080/development-and-validation-of-a-python-3-based-software-to-calculate-mean-platelet-survival-time-by-multiple-hit-method
#3
JOURNAL ARTICLE
Elena Miñana Olmo, Tomás Chivato Martín-Falquina
Platelet kinetic parameters predict the efficiency of splenectomy in patients with immune thrombocytopenia. The multiple hit model is recommended to calculate the mean platelet survival time. This method involves complex formulae and iterative calculations that need specialized software, but currently available programs present some drawbacks. A new optimized solution is proposed. A Python 3 based computer program was developed in order to perform the multiple-hit model calculations. Validation was done by comparing its results to two additional programs, one using the Microsoft Excel solver add-in and the other fitting the curve by brute force...
September 15, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37706268/pet-ct-in-treatment-response-assessment-in-lung-cancer-when-should-it-be-recommended
#4
JOURNAL ARTICLE
Noora Bin Essa, Zoltan Kaplar, Nikita Balaji, Alaa Alduraibi, Jamshed Bomanji, Ashley M Groves, David M L Lilburn, Neal Navani, Francesco Fraioli
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Different treatment options are now possible both for surgical candidates and for those NSCLC patients deemed not suitable for surgery. Despite the treatments available, only a limited number of less advanced stages are potentially curable, with many patients suffering local recurrence or distant metastases. FDG-PET/CT is commonly used in many centers for post-treatment evaluation, follow-up, or surveillance; Nonetheless, there is no clear consensus regarding the indications in these cases...
September 14, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37706262/potential-of-preoperative-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-to-diagnose-contralateral-lymph-node-metastases-in-patients-with-oral-cancer
#5
JOURNAL ARTICLE
Natnicha Wamasing, Shin Nakamura, Hiroshi Watanabe, Ami Kuribayashi, Masahiko Miura
OBJECTIVE: To establish a decision tree using preoperative PET/computed tomography (CT) parameters for detecting contralateral lymph node metastasis (CLNM) in oral cancer patients. METHODS: In total, 140 patients with a confirmed histopathological diagnosis of oral carcinoma showed fluorodeoxyglucose accumulation of contralateral lymph nodes in PET images. Of 260 lymph nodes, eight were metastatic. We compared metastatic and non-metastatic nodes using Fisher-Freeman-Halton exact and Fisher's exact and Mann-Whitney U tests...
September 14, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37706261/optimizing-stress-only-myocardial-perfusion-imaging-a-clinical-prediction-model-to-improve-patient-selection
#6
JOURNAL ARTICLE
Patrick J Martineau, Matthieu Pelletier-Galarneau, Piotr Slomka, Andrew L Goertzen, William D Leslie
BACKGROUND: Stress-only single photon emission computed tomography myocardial perfusion imaging (MPI) offers numerous advantages in terms of improved workflow, cost and radiation reduction but is currently not widely utilized due to challenges in selecting appropriate patients for this technique. METHODS: Data from 5959 individuals were used to derive (N = 4018) and validate (N = 1941) a binomial logistic regression model to predict normal stress MPI studies (stress total perfusion deficit  < 4%, ejection fraction ≥ 50%)...
September 14, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37706260/rabbit-systemic-glucose-metabolism-map-by-total-body-dynamic-pet-ct-technology
#7
JOURNAL ARTICLE
Haochen Wang, Xue Xie, Yanhua Duan, Leiying Chai, Kun Li, Jianfeng Qiu, Zhaoping Cheng
BACKGROUND: This study evaluated total-body glucose metabolism in a preclinical lab animal, the rabbit, by employing a dynamic glucose metabolic image obtained with total-body fluorine-18 fluorodeoxyglucose (18F-FDG) PET/computed tomography (PET/CT). METHODS: The dynamic total-body PET/CT system was used to obtain glucose metabolic imaging from 10 sedated body-matched rabbits. The standard uptake value (SUV) of 18F-FDG was used to evaluate glucose metabolism. In addition, the correlation between glucose metabolism and sexes was assessed, as well as metabolic differences between left- and right sides...
September 14, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37706259/the-role-of-18f-fdg-pet-ct-in-the-management-of-differentiated-thyroid-cancer
#8
JOURNAL ARTICLE
Mohamad Haidar, Mutaz Kassas, Feras Chehade, Rita Chahinian, Jean Abi-Ghosn, Marwan M Haddad
INTRODUCTION: In previous literature, 18F-FDG-PET/ CT imaging significantly impacted differentiated thyroid cancer (DTC) therapy. Low thyroglobulin (Tg) levels and negative Iodine-131 (131I) whole-body scan (WBS), along with negative 18F-FDG-PET/ CT, suggested a lesser likelihood of active illness. Positive 18F-FDG-PET/CT findings, however, were associated with a variety of signs of local recurrence and regional or distant metastases in patients with suspected WBS. We aim to evaluate the utility of 18F-FDG-PET/CT in managing DTC patients with negative 131I post-therapy WBS and elevated Tg...
September 14, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37706257/a-simplified-general-schema-for-rapid-single-time-point-marrow-predictive-dosimetry
#9
JOURNAL ARTICLE
Yung Hsiang Kao
The red marrow is often the dose-limiting organ in systemic radionuclide therapy. However, multi-time-point personalised predictive dosimetry is resource intensive and impractical for routine clinical implementation. Single-time-point methods are a reasonable alternative for streamlining dosimetric workflows. However, there is a lack of single time-point methodology specific for the marrow. A simplified schema for rapid marrow predictive dosimetry is proposed based on direct image quantification of marrow radioconcentration, which may be generalised to most forms of systemic radionuclide therapy...
September 14, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37706256/evaluation-of-post-chemotherapy-residual-seminomatous-masses-by-18f-fluorodeoxyglucose-pet-ct-using-tumor-to-liver-ratio-conundrum-or-solution
#10
JOURNAL ARTICLE
Suchismita Ghosh, Archi Agrawal, Venkatesh Rangarajan, Sayak Choudhury, Priyamvada Maitre, Nilendu Purandare, Sneha Shah, Ameya Puranik, Ganesh Bakshi, Amit Joshi, Gagan Prakash, Santosh Menon, Kumar Prabhash, Vanita Norohna, Mahendra Pal, Vedang Murthy
OBJECTIVE: Assessment of diagnostic accuracy of FDG-PET/CT in the detection of viable disease in post-chemotherapy seminomatous residual masses using visual interpretation, SUVmax, and T/L ratio. METHODS: This is a retrospective study assessing the post-chemotherapy seminomatous residual masses of size >3 cm. The PET/CT scan findings were interpreted visually for presence of residual disease which were validated from histopathology reports or imaging follow-up for a maximum of 3 years...
September 14, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37706253/scientific-support-for-nuclear-medicine
#11
JOURNAL ARTICLE
Andy G Irwin
This report was prepared on behalf of the British Nuclear Medicine Society (BNMS). Information included builds upon a previous BNMS report and also brings together information from a variety of sources to reflect current good scientific practice in this BNMS guidance. Training and career pathways are defined. Roles and functions provided by physicists are described, and the risks associated with inadequate scientific staffing are explored. Published staffing guidance has been reviewed and a recent publication on provision of Medical Physics Expert (MPE) support has been endorsed...
September 14, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37661788/evaluation-of-treatment-response-by-hopkins-criteria-on18f-fdg-pet-ct-in-patients-of-non-small-cell-lung-cancer-and-its-comparison-with-percist-response-criteria
#12
JOURNAL ARTICLE
Shreya Dang, Divya Shivdasani, Melvika Pereira, Natasha Singh, Rachita Rungta, Debdip Roy, Jugal Kesariya
AIM: To assess treatment response on FDG PET-CT in NSCLC patients by visual Hopkins score compared to PERCIST criteria and its potential for prognostication (or its correlation with survival). METHODS: Forty-four NSCLC patients with baseline and post-treatment FDG PET-CT scans were included, and interpreted using Hopkins and PERCIST criteria classifying patients into responders and non-responders. PERCIST-based CMR and PMR, and Hopkins Scores 1,2,3 were classified responders...
September 4, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37661779/identifying-and-troubleshooting-the-pitfalls-of-ictal-interictal-brain-perfusion-spect-studies
#13
JOURNAL ARTICLE
Antoine Rogeau, David M L Lilburn, Zoltan Kaplar, Cameron Anderson, Catherine J Scott, Fahmida A Chowdhury, Francesco Fraioli, Jamshed B Bomanji
Epilepsy is a prevalent condition, and surgical intervention can benefit patients with refractory seizures. Single photon emission computed tomography (SPECT) using 99mTc-HMPAO or 99mTc-ECD provides assessment of regional cerebral blood flow and is the primary non-invasive approach for imaging brain perfusion in ictal and interictal states. Ictal/interictal SPECT is valuable in localising epileptogenic foci, particularly when MRI and electroencephalography are negative. However, to obtain accurate images reflecting brain perfusion in both states, meticulous preparation of the patient, timely radiotracer injection and close coordination between neurology and nuclear medicine teams are essential...
September 4, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37661777/improving-outcomes-in-carcinoid-heart-disease-learning-from-a-single-centre
#14
JOURNAL ARTICLE
Jack Cope, Rory Maclean, Shweta Hota, John K Ramage, Nicola Mullholland, Dominique Clement, Sarah Brown, Sue Piper, Phil MaCarthy, Olaf Wendler, Raj Srirajaskanthan
INTRODUCTION: A significant proportion of patients with carcinoid syndrome develop carcinoid heart disease (CHD). Valve degeneration can lead to right heart failure, and worsening prognosis. Replacement of affected valves is an effective therapy. We reviewed patients treated with valve replacement to assess prognostic factors. METHODS: CHD patients records who underwent valve replacement from 2003-2019 were reviewed. RESULTS: Twenty-six patients underwent valve replacement...
September 4, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37661775/predictive-value-of-suvmax-in-visceral-pleural-invasive-lung-adenocarcinoma-with-different-diameters
#15
JOURNAL ARTICLE
Xiaoyan Sun, Cheng Chang, Chun Xie, Jiahao Zhu, Xuping Ni, Wenhui Xie, Yuetao Wang
OBJECTIVES: This study aimed to investigate predictive visceral pleural invasion (VPI) occurrence value of the maximum standardized uptake value (SUVmax) in patients with lung adenocarcinoma (LA). PATIENTS AND METHODS: A total of 388 LA patients were divided into D1ab, D1c, D1, D2, D2a, D2b, D3, and all patient groups based on their tumor diameter (D). Patients were also classified into negative VPI (VPI-n) and positive VPI (VPI-p) groups according to VPI presence...
September 4, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37661771/pet-ct-imaging-fibroblast-activation-protein-in-initial-colorectal-cancer-compared-to-18f-fdg-pet-ct
#16
JOURNAL ARTICLE
Ye Dong, Penghui Sun, Hubing Wu, Jinmei Zhong, Min Cao, Ganghua Tang, Wenlan Zhou
OBJECTIVE: In this study, the potential advantage of FAPI over 18F-labelled deoxyglucose (18F-FDG) in evaluation of the initial staging colorectal cancer (CRC) was investigated. MATERIALS AND METHODS: Thirty-two patients with histopathologically confirmed primary CRC were included in our study. They all underwent both 18F-FDG and FAPI PET/CT. Lesion detectability and tracer uptakes, mainly quantified by maximum standardized uptake value (SUVmax) and target-to-background ratio (TBR), were compared for paired lesions between both modalities using the Wilcoxon signed-rank test and paired t-test...
September 4, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37642499/a-convolutional-neural-network-based-system-to-estimate-the-arterial-plasma-radioactivity-curve-in-18f-fdg-dynamic-brain-pet-study
#17
JOURNAL ARTICLE
Keisuke Kawauchi, Mui Saito, Kentaro Nishigami, Chietsugu Katoh
PURPOSE: Quantitative images of metabolic activity can be derived through dynamic PET. However, the conventional approach necessitates invasive blood sampling to acquire the input function, thus limiting its noninvasive nature. The aim of this study was to devise a system based on convolutional neural network (CNN) capable of estimating the time-radioactivity curve of arterial plasma and accurately quantify the cerebral metabolic rate of glucose (CMRGlc) directly from PET data, thereby eliminating the requirement for invasive sampling...
August 30, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37615528/monte-carlo-simulation-of-spect-characterization-for-223ra-post-injection-scintigraphy
#18
JOURNAL ARTICLE
Hind Saikouk, Naïma El Khayati, Aboubakr Matrane
OBJECTIVES: 223Ra is a promising α-emitting radionuclide for prostate cancer metastasis palliative treatment. Post-injection scintigraphy is of major importance to verify the concentration of the radiopharmaceutical in the targeted sites. Given the low activity administered to patients, the choice of acquisition parameters, including the collimator type, the energy window's width and the photopeak energy to be used, is primordial for the image quality. The purpose of our work was to select the SPECT configuration suitable for 223Ra post-injection scintigraphy...
August 24, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37615527/revising-and-exploring-the-variations-in-methodologies-for-establishing-the-diagnostic-reference-levels-for-paediatric-pet-ct-imaging
#19
JOURNAL ARTICLE
Qays Alhorani, Essam Alkhybari, Mohammad Rawashdeh, Akmal Sabarudin, Rukiah A Latiff, Akram Al-Ibraheem, Sobhan Vinjamuri, Mazlyfarina Mohamad
PET-computed tomography (PET/CT) is a hybrid imaging technique that combines anatomical and functional information; to investigate primary cancers, stage tumours, and track treatment response in paediatric oncology patients. However, there is debate in the literature about whether PET/CT could increase the risk of cancer in children, as the machine is utilizing two types of radiation, and paediatric patients have faster cell division and longer life expectancy. Therefore, it is essential to minimize radiation exposure by justifying and optimizing PET/CT examinations and ensure an acceptable image quality...
August 24, 2023: Nuclear Medicine Communications
https://read.qxmd.com/read/37615497/histopathology-validated-lesion-detection-rates-of-clinically-significant-prostate-cancer-with-mpmri-68ga-psma-11-pet-and-11c-acetate-pet
#20
JOURNAL ARTICLE
Kristina Sandgren, Sara N Strandberg, Joakim H Jonsson, Josefine Grefve, Angsana Keeratijarut Lindberg, Erik Nilsson, Anders Bergh, Karin Söderkvist, Camilla Thellenberg Karlsson, Bengt Friedrich, Anders Widmark, Lennart Blomqvist, Vibeke Berg Loegager, Jan Axelsson, Mattias Ögren, Margareta Ögren, Tufve Nyholm, Katrine Riklund
OBJECTIVE: PET/CT and multiparametric MRI (mpMRI) are important diagnostic tools in clinically significant prostate cancer (csPC). The aim of this study was to compare csPC detection rates with [68Ga]PSMA-11-PET (PSMA)-PET, [11C]Acetate (ACE)-PET, and mpMRI with histopathology as reference, to identify the most suitable imaging modalities for subsequent hybrid imaging. An additional aim was to compare inter-reader variability to assess reproducibility. METHODS: During 2016-2019, all study participants were examined with PSMA-PET/mpMRI and ACE-PET/CT prior to radical prostatectomy...
August 24, 2023: Nuclear Medicine Communications
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