Maria Spiliotopoulou, Nikolaos Papathanasiou, Łukasz Łabieniec, Evangelos Papachristou, Eleftherios Fokaefs, Trifon Spyridonidis, Andreas Fotopoulos, Dimitrios J Apostolopoulos
OBJECTIVE: The objective of this study is to investigate the feasibility and potential advantages of 99mTc-DTPA dynamic single photon emission computed tomography/computed tomography (SPECT/CT) renogram in adults. METHODS: Fifty-five patients aged 19-80 years (mean 56.3) were enrolled. The imaging protocol included: day 1: 99mTc-DTPA planar renogram, followed by planar 99mTc-DMSA scan. Day 3: attenuation-corrected dynamic 99mTc-DTPA SPECT renogram [DSPECT(AC)] and Cr-51 ethylenediamine tetraacetic acid (EDTA) glomerular filtration rate (GFR) calculation...
May 23, 2024: Nuclear Medicine Communications
Raluca Mititelu, Alexandru Mitoi, Catalin Mazilu, Mariana Jinga, Florentina Ionita Radu, Ana Bucurica, Teodora Mititelu, Sandica Bucurica
Portal vein thrombosis, a relatively frequent complication associated with hepatocellular carcinoma (HCC) and liver cirrhosis, is recognized as a significant global health concern. This is mainly due to these conditions' high prevalence and potentially severe outcomes. The aim of our study was to conduct a comprehensive literature review to evaluate the efficacy, accuracy, and clinical implications of 18F-FDG PET-CT in diagnosing and managing portal vein tumor thrombosis (PVTT) in patients with HCC. HCC, which accounts for 80% of liver malignancies, ranks as the fourth most prevalent cancer globally and is a significant contributor to cancer-related mortality...
May 17, 2024: Nuclear Medicine Communications
Qingqing Pan, Xinxin Cao, Jian Li, Fang Li, Yaping Luo
INTRODUCTION: It is important to distinguish Waldenström macroglobulinemia from smoldering Waldenström macroglobulinemia (sWM), because only patients with Waldenström macroglobulinemia require treatment, however the distinction can be clinically complex. The aim of this study is to investigate whether [68Ga]Ga-pentixafor PET/CT shows different characteristics in sWM and Waldenström macroglobulinemia patients and therefore can help to differentiate Waldenström macroglobulinemia and sWM...
May 15, 2024: Nuclear Medicine Communications
Nuh Filizoglu, Salih Ozguven, Tugba Akin Telli, Tunc Ones, Fuat Dede, Halil T Turoglu, Tanju Y Erdil
OBJECTIVE: We aimed to compare different segmentation methods used to calculate prognostically valuable volumetric parameters, somatostatin receptor expressing tumor volume (SRETV), and total lesion somatostatin receptor expression (TLSRE), measured by 68Ga-DOTATATE PET/CT and to find the optimal segmentation method to predict prognosis. PATIENTS AND METHODS: Images of 34 patients diagnosed with gastroenteropancreatic neuroendocrine tumor (GEPNET) who underwent 68Ga-DOTATATE PET/CT imaging were reanalyzed...
May 15, 2024: Nuclear Medicine Communications
Amalia Peix, Amelia Jimenez-Heffernan, Niveditha Devasenapathy, Dragana Sobic-Saranovic, Joao Vitola, Raffaele Giubbini, Carlo Rodella, Saif-Ul Haque, Erick Alexanderson Rosas, Elgin Ozkan, Yung Jih Felix Keng, Maurizio Dondi, Diana Paez, Ganesan Karthikeyan
BACKGROUND: In this substudy of the Value of Gated-SPECT MPI for Ischemia- Guided PCI of non-culprit vessels in STEMI Patients with Multi vessel Disease after primary PCI trial on the value of myocardial perfusion imaging (MPI) for ischemia-guided percutaneous coronary intervention (PCI) of nonculprit vessels in patients with ST-segment-elevation myocardial infarction (STEMI) and multivessel disease after primary PCI we aim to assess if infarct size affects conventional measures of dyssynchrony at rest...
May 15, 2024: Nuclear Medicine Communications
Linlin Guo, Rang Wang, Guohua Shen
PURPOSE: The aim of this study was to evaluate metabolism change in reference organs (liver and mediastinum) and lymphoid cell-rich organs (spleen and bone marrow) during programmed cell death-1 immunotherapy in relapsed or refractory lymphoma patients. METHODS: A total of 66 patients with baseline and serial monitoring fluorodeoxyglucose (FDG) PET/computed tomography scans were retrospectively enrolled. Mean standardized uptake value (SUV) and maximum SUV of evaluated organs were obtained by two reviewers, and their association with tumor burden and clinical response were evaluated...
May 10, 2024: Nuclear Medicine Communications
Jeremy Hugh Yen-Hey Lau, Koon Kiu Ng, Wai Chung Wong, Kwok Sing Ng, King Sun Chu, Ting Kun Au-Yong, Boom Ting Kung
OBJECTIVES: The study aimed to evaluate the frequency of incidental suspicious lesions detected by flourine-18 fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) scans done for staging or restaging in adult cancer patients. We further determined the detection rate of synchronous and metachronous malignancies in these suspicious lesions after further investigations. MATERIALS AND METHODS: This retrospective analysis evaluated the consecutive patients with 18F-FDG PET/CT scans done in Queen Elizabeth Hospital (QEH), Hong Kong between July 2021 and June 2022...
May 10, 2024: Nuclear Medicine Communications
Richard F Liu, Cristiano Ferrario, Parvaneh Fallah, April A N Rose, Soumaya Labidi, Aline Mamo, Stephan M Probst
BACKGROUND: Metastatic castration-resistant prostate cancer (mCRPC) remains uniformly lethal. Prostate specific membrane antigen (PSMA) is a transmembrane glycoprotein overexpressed in prostate cancer. 131I-PSMA-1095 (also known as 131I-MIP-1095) is a PSMA-targeted radioligand which selectively delivers therapeutic radiation to cancer cells and the tumor microenvironment. METHODS: We conducted a single-arm, phase 2 trial to assess efficacy and tolerability of 131I-PSMA-1095 in mCRPC patients who had exhausted all lines of approved therapy...
May 10, 2024: Nuclear Medicine Communications
Yash Jain, Archi Agrawal, Amit Joshi, Santosh Menon, Gagan Prakash, Vedang Murthy, Nilendu Purandare, Sneha Shah, Ameya Puranik, Sayak Choudhury, Varun Shukla, Indraja Dev, Kumar Prabhash, Vanita Noronha, Venkatesh Rangarajan
AIM: To evaluate relationship between metabolic PET metabolic parameters and size of the primary tumor, various histopathological subtypes of renal cell carcinoma (RCC) and Fuhrman grade of the tumors. MATERIAL AND METHODS: Retrospective analysis of 93 biopsy-proven RCC patients who underwent pretreatment flourine 18 flourodeoxyglucose PET/computed tomography (18F FDG PET/CT) was performed. Quantitative PET parameters, size of the primary tumor, histopathological subtypes and Fuhrman grades of the tumor were extracted...
April 30, 2024: Nuclear Medicine Communications
Bin Wang, Xinming Zhao, Yunuan Liu, Zhaoqi Zhang, Xiaoshan Chen, Fenglian Jing, Xiaolin Chen, Yu Hua, Jianqiang Zhao
OBJECTIVE: The objective of this study is to evaluate the effectiveness of 68Ga-FAPI-04 PET/computed tomography (CT) for the diagnosis of primary and metastatic gastric cancer and colorectal cancer lesions as compared with 18F-FDG PET/CT. MATERIALS AND METHODS: Fifty-nine patients who underwent both 18F-FDG and 68Ga-FAPI-04 for initial staging or restaging were enrolled. Histopathological findings and clinical imaging follow-up were used as the reference standard...
April 29, 2024: Nuclear Medicine Communications
Akram Al-Ibraheem, Sudqi Allouzi, Ahmed Saad Abdlkadir, Miriam Mikhail-Lette, Kamal Al-Rabi, Mohammad Ma'koseh, Peter Knoll, Zaid Abdelrhman, Omar Shahin, Malik E Juweid, Diana Paez, Egesta Lopci
2-Deoxy-2-[18F]fluoro-d-glucose PET/computed tomography ([18F]FDG PET/CT) has proven to be a sensitive method for the detection and evaluation of hematologic malignancies, especially lymphoma. The increasing incidence and mortality rates of leukemia have raised significant concerns. Through the utilization of whole-body imaging, [18F]FDG PET/CT provides a thorough assessment of the entire bone marrow, complementing the limited insights provided by biopsy samples. In this regard, [18F]FDG PET/CT has the ability to assess diverse types of leukemia The utilization of [18F]FDG PET/CT has been found to be effective in evaluating leukemia spread beyond the bone marrow, tracking disease relapse, identifying Richter's transformation, and assessing the inflammatory activity associated with acute graft versus host disease...
April 22, 2024: Nuclear Medicine Communications
Alberto Bestetti, Barbara Zangheri, Sara Vincenzina Gabanelli, Vincenzo Parini, Carla Fornara
OBJECTIVE: FDG PET imaging plays a crucial role in the evaluation of demented patients by assessing regional cerebral glucose metabolism. In recent years, both radiomics and deep learning techniques have emerged as powerful tools for extracting valuable information from medical images. This article aims to provide a comparative analysis of radiomics features, 3D-deep learning convolutional neural network (CNN) and the fusion of them, in the evaluation of 18F-FDG PET whole brain images in patients with dementia and normal controls...
April 18, 2024: Nuclear Medicine Communications
Sarah Wicks, Danielle Levart, Lauren Conway, Neil Heraghty, A Michael Peters
AIM: The aim of this study is to develop a noninvasive technique for measuring tissue tracer extraction efficiency ( E ) and illustrate it for Tc-99m-mercaptoacetyltriglycine (MAG3) and kidney. METHODS: E was measured in 10 patients with normal MAG3 renography. E is the ratio of tissue clearance-to-blood flow ( Ki/F ). For single-photon tracers, attenuation constants are unknown, so Ki and F cannot be separately measured. However, by deriving attenuation-uncorrected Ki' and F' from the same regions of interests (ROIs), these constants cancel out, giving E ...
April 17, 2024: Nuclear Medicine Communications
Shiro Ishii, Shigeyasu Sugawara, Yumi Tanaka, Natsumi Kawamoto, Junko Hara, Ryo Yamakuni, Hiroki Suenaga, Kenji Fukushima, Hiroshi Ito
OBJECTIVE: We aimed to elucidate the factors underlying the difference between estimated glomerular filtration rate (eGFR) calculated from serum creatinine and Gate's GFR (gGFR) measured using technetium-99m diethylene triamine pentaacetic acid ( 99m Tc-DTPA) scintigraphy. METHODS: This study was based on consecutive patients who underwent 99m Tc-DTPA scintigraphy at our hospital between January 2021 and December 2022 and whose blood serum creatinine data were obtained on the same day as the 99m Tc-DTPA scintigraphy...
April 15, 2024: Nuclear Medicine Communications
Fernando Mut, María P Gaudiano, Miguel Kapitán
OBJECTIVES: Transient ischemic dilatation (TID) in myocardial perfusion single photon emission computed tomography (SPECT) is considered a marker of poor prognosis. However, it has been suggested that some cases are due to apparent volumetric changes secondary to differences in heart rate (HR) at the time of acquisition. We assessed the correlation between transient dilatation and HR in low risk patients with no perfusion defects. METHODS: We retrospectively analyzed patients sent for 99mTc-MIBI SPECT using a 2-day protocol...
April 15, 2024: Nuclear Medicine Communications
Awiral Saxena, Padma Subramanyam, Manjit Sarma, Bhagirath Bhad, Renjitha Bhaskaran, Shanmuga Sundaram Palaniswamy
OBJECTIVE: The objective of this study is to evaluate the role of hybrid 18F-FDG PET for treatment response assessment and management guidance in patients with skull base osteomyelitis. MATERIALS AND METHODS: Retrospectively, 33 patients, with at least a baseline and follow-up PET (computed tomography/MRI) scan, were included. Parameters like standardized uptake value (SUV) max, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) (initial, follow-up, percentage change) were analysed and outcomes based on 18F-FDG PET reports were classified into resolution (a), partial response (b), progression (c) and stable disease (d)...
April 15, 2024: Nuclear Medicine Communications
Parmod Kumar, Pulkit Arora, Rajender Kumar, Harmandeep Singh, Atul Parashar, Bhagwant R Mittal, Anish Bhattacharya
OBJECTIVE: Electrical contact burns of the scalp cause serious morbidity and mortality. Early necrotic bone debridement and flap cover are crucial for successful wound closure. 18F Sodium Fluoride (NaF), with high bone-to-soft tissue activity ratio, is useful for bone viability assessment. This study evaluated the role of 18F NaF PET-computed tomography (CT) in objectively defining the extent and depth of nonviable calvarial bone, to guide adequate bone debridement. METHOD: Of 20 patients referred to our institute with electrical contact burns of the scalp during a 2-year period, 15 were enrolled in the study...
April 9, 2024: Nuclear Medicine Communications
Shreya Shalimar Datta Gupta, Shamim A Shamim, Shivanand Gamanagatti, Priyanka Gupta, Maroof A Khan, Madhav B Mallia, Viju Chirayil, Ashutosh Dash, Chandrasekhar Bal
OBJECTIVE: Hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) have limited therapeutic options, Re-188 lipiodol transarterial therapy being one of them. We aimed to assess the safety and efficacy of Re-188 lipiodol exclusively in HCC with PVT as well as to compare two chelating agents for the synthesis of Re-188 lipiodol: novel bis-(diethyldithiocarbamato) nitrido (N-DEDC) with existing acetylated 4-hexadecyl 1-2,9,9-tetramethyl-4,7-diaza-1,10-decanethiol [(A)HDD]. METHODS: Patients with radiological diagnosis of HCC with PVT having Eastern Cooperative Oncology Group (ECOG) performance status ≤2 and Child Pugh score (PS) A or B were recruited...
April 5, 2024: Nuclear Medicine Communications
Stefan Vöö, Valeria Mercadante, Saima Riaz, Sarah Algodayan, Catherine Scott, Dimitris Priftakis, Martina Shephard, Jamshed Bomanji
No abstract text is available yet for this article.
April 5, 2024: Nuclear Medicine Communications
Hemat Abdelsamea Mahmoud, Aya Abdel-Baset Ahmed Ali Alsanory, Hanan Gamal-Eldin Mostafa, Esraa Roshdy Hassan
BACKGROUND: This retrospective study analyzed factors influencing hypothyroidism development after radioactive iodine therapy for Graves' disease. PATIENTS AND METHODS: Three hundred and three patients with Graves' disease treated with radioactive iodine (RAI) from 2013 to 2022 at two Egyptian hospitals were included. Data collected included demographics, lab values, thyroid imaging, RAI doses, and outcomes. Patients were followed for ≥1 year to assess hypothyroidism onset...
April 2, 2024: Nuclear Medicine Communications
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