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Breast Cancer Research and Treatment

Kadri Altundag
No abstract text is available yet for this article.
April 23, 2019: Breast Cancer Research and Treatment
George Boundouki, Joseph Ryan Wong Sik Hee, Natalie Croghan, Katie Stocking, Andrew Pieri, Adam Critchley, Cliona C Kirwan, James R Harvey
PURPOSE: While it is known that histologically involved margins lead to a higher local recurrence rate, re-excision of anterior margins is less common than that of radial margins. However, there are minimal long-term data on the oncological safety of non-surgical management of anterior margins. PATIENTS AND METHODS: A retrospective study was performed of all patients who underwent breast conserving surgery for breast cancer between 2000 and 2008 at two tertiary referral centres...
April 22, 2019: Breast Cancer Research and Treatment
Catherine Schairer, Ahmed Hablas, Ibrahim AbdelBar Seif Eldein, Rabab Gaafar, Henda Rais, Amel Mezlini, Farhat Ben Ayed, Wided Ben Ayoub, Abdellatif Benider, Ali Tahri, Mouna Khouchani, Dalia Aboulazm, Mehdi Karkouri, Saad Eissa, Ruth M Pfeiffer, Shahinaz M Gadalla, Sandra M Swain, Sofia D Merajver, Linda Morris Brown, Amr S Soliman
PURPOSE: We describe the clinico-pathologic and mammographic characteristics of inflammatory breast cancer (IBC) and non-IBC cases enrolled in a case-control study. Because IBC is a clinico-pathologic entity with rapid appearance of erythema and other signs, its diagnosis is based on clinical observation and thus, by necessity, subjective. Therefore, we evaluate our cases by photographic review by outside expert clinicians and by degree of adherence to the two most recent definitions of IBC: the international expert panel consensus statement and American Joint Committee on Cancer (AJCC) 8th edition (we used the slightly less restrictive 7th edition definition for our study)...
April 22, 2019: Breast Cancer Research and Treatment
Hálio Rodrigues-Duarte, Thiemo J A van Nijnatten, Tatiana Khoury, Hiram Cody, Stefanie Jacobs, Maxine S Jochelson
PURPOSE: Successful breast-conserving surgery (BCS) followed by radiation therapy (XRT) is dependent on complete removal of the cancer with clear surgical margins, providing survival rates equivalent to those observed following mastectomy. In patients who have cancers presenting with microcalcifications, post lumpectomy mammograms (PLM) prior to radiation (XRT) can be performed to ensure that no cancer has been left behind. The purpose of this study was to assess the benefit of PLM in patients with malignant breast tumors presenting with microcalcifications...
April 20, 2019: Breast Cancer Research and Treatment
S Speransky, P Serafini, J Caroli, S Bicciato, M E Lippman, N H Bishopric
PURPOSE: Primary breast and prostate cancers can be cured, but metastatic disease cannot. Identifying cell factors that predict metastatic potential could guide both prognosis and treatment. METHODS: We used Cell-SELEX to screen an RNA aptamer library for differential binding to prostate cancer cell lines with high vs. low metastatic potential. Mass spectroscopy, immunoblot, and immunohistochemistry were used to identify and validate aptamer targets. Aptamer properties were tested in vitro, in xenograft models, and in clinical biopsies...
April 20, 2019: Breast Cancer Research and Treatment
Chunyi Gao, Xiaoyu Yuan, Zhenglin Jiang, Deqiang Gan, Lingzhi Ding, Yechao Sun, Jiamin Zhou, Lihua Xu, Yifei Liu, Guohua Wang
BACKGROUND: Phosphorylated AKT is highly expressed or overexpressed in chemoresistant tumor samples. However, the precise molecular mechanism involved in AKT phosphorylation-related chemoresistance in breast cancer is still elusive. The present research was designed to estimate the effect of AKT phosphorylation on cell viability and chemoresistance in breast cancer. METHODS: We utilized MCF-7 and MDA-MB468 human breast cancer cell lines and developed multidrug-resistant MCF-7/MDR and cisplatin-resistant MDA-MB-468 cells...
April 20, 2019: Breast Cancer Research and Treatment
Jennifer R Bellon, Hao Guo, William T Barry, Chau T Dang, Denise A Yardley, Beverly Moy, P Kelly Marcom, Kathy S Albain, Hope S Rugo, Matthew Ellis, Antonio C Wolff, Lisa A Carey, Beth A Overmoyer, Ann H Partridge, Clifford A Hudis, Ian Krop, Harold J Burstein, Eric P Winer, Sara M Tolaney
PURPOSE: Women with HER2-positive breast cancer treated prior to effective anti-HER2 therapy have higher rates of local-regional recurrence (LRR) than those with HER2-negative disease. Effective systemic therapy, however, has been shown to decrease LRR. This study examines LRR in women with HER2-positive breast cancer treated on a single-arm prospective multicenter trial of adjuvant trastuzumab (H) and paclitaxel (T). METHODS: Patients with HER2-positive tumors ≤ 3...
April 19, 2019: Breast Cancer Research and Treatment
Narjes Bahri, Tahereh Fathi Najafi, Fatemeh Homaei Shandiz, Hamid Reza Tohidinik, Abdoljavad Khajavi
PURPOSE: Breast cancer is the most common cancer among women with high rate of mortality. This systematic review and meta-analysis was conducted to investigate the relation between stressful life events and breast cancer. METHODS: We searched PubMed, Scopus, ScienceDirect, and Google scholar databases from their inception until June 2018. The keywords and phrases we used in the search were (life events AND stress AND breast cancer OR neoplasm) to identify potentially relevant cohort studies that reported relative risk estimates and confidence intervals of this association...
April 19, 2019: Breast Cancer Research and Treatment
I Noordhoek, A F de Groot, D Cohen, G J Liefers, J E A Portielje, J R Kroep
PURPOSE: In breast cancer, hormone receptor (HR) status is generally a qualitative measure; positive or negative. Quantitatively measured oestrogen and progesterone receptors (ER and PR) are frequently proposed prognostic and predictive markers, some guidelines even provide different treatment options for patients with strong versus weak expression. AIM: To evaluate quantitative HR load assessed by immunohistochemistry as a prognostic and predictive measure in stage 1-3 breast cancer...
April 17, 2019: Breast Cancer Research and Treatment
Kamran Ahmad Khan, Bruno Mazuquin, Alastair Canaway, Stavros Petrou, Julie Bruce
PURPOSE: Treatments for breast cancer can lead to chronic musculoskeletal problems. This study aimed to systematically review the evidence surrounding the cost-effectiveness of exercise and physiotherapy interventions aimed at reducing the risk of physical symptoms and functional limitations due to breast cancer treatment. METHODS: A systematic review of the cost-effectiveness of exercise and physiotherapy interventions during and following treatment for breast cancer was undertaken according to PRISMA guidelines...
April 17, 2019: Breast Cancer Research and Treatment
Diana Flores-Díaz, Claudia Arce, Lourdes Flores-Luna, Nancy Reynoso-Noveron, Fernando Lara-Medina, Juan Antonio Matus, Enrique Bargallo-Rocha, Víctor Pérez, Cynthia Villarreal-Garza, Paula Cabrera-Galeana, Alejandro Mohar
PURPOSE: The aim of this study was to compare the difference in disease-free survival (DFS) and overall survival (OS) between invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) in our Hispanic population with breast cancer (BC). METHODS: We retrospectively analyzed a database of 4533 non-metastatic BC patients treated for BC at the National Cancer Institute in Mexico (INCan) between 2006 and 2016. We compared clinical characteristics, treatment and survival between women with invasive ductal and invasive lobular BC...
April 17, 2019: Breast Cancer Research and Treatment
Peng Meng, Marica Vaapil, Abderrahmane Tagmount, Alex Loguinov, Chris Vulpe, Paul Yaswen
PURPOSE: Understanding how differentiation, microenvironment, and hormonal milieu influence human breast cell susceptibility to malignant transformation will require the use of physiologically relevant in vitro systems. We sought to develop a 3D culture model that enables the propagation of normal estrogen receptor alpha (ER) + cells. METHODS: We tested soluble factors and protocols for the ability to maintain progenitor and ER + cells in cultures established from primary cells...
April 16, 2019: Breast Cancer Research and Treatment
Xiaobin Ma, Chengxue Dang, Weili Min, Yan Diao, Wentao Hui, Xiaolong Wang, Zhijun Dai, Xijing Wang, Huafeng Kang
PURPOSE: Targeting DNA repair mechanisms to induce apoptosis may be a promising strategy for breast cancer treatment. Olaparib is proved to have anticancer effect by inhibiting DNA repairing protein poly (ADP-ribose) polymerase (PARP). However, the cytotoxicity of olaparib is very limited to homologous recombination-proficient cells. This study aims to examine the effect and mechanism of olaparib treatment in breast cancer cell lines. METHODS: We investigated the cytotoxic effect of various doses of olaparib treatment to MCF-7 and ZR-75-1 cells in vitro...
April 15, 2019: Breast Cancer Research and Treatment
Jieun Lee, Hee Eun Kim, Young-Seok Song, Eun Yoon Cho, Ahwon Lee
PURPOSE: Ductal carcinoma in situ (DCIS) is well-known precursor of invasive ductal carcinoma (IDC). Parts of patients show recurrence as DCIS or IDC after local treatment, but there are no established markers predicting relapse. We analyzed changes in miRNA and oncogene expression during DCIS progression/evolution to identify potential markers predicting recurrence. METHODS: Forty archival tissues diagnosed as primary or recurrent DCIS and DCIS adjacent to IDC were analyzed...
April 15, 2019: Breast Cancer Research and Treatment
Jangsoon Lee, Bora Lim, Troy Pearson, Kuicheon Choi, Jon A Fuson, Chandra Bartholomeusz, Linda J Paradiso, Thomas Myers, Debu Tripathy, Naoto T Ueno
Unfortunately in the original publication of the article, the author's funding support has been mentioned incorrectly. The correct funding statement should read as "This work was supported by the Morgan Welch Inflammatory Breast Cancer Research Program, the State of Texas Rare and Aggressive Breast Cancer Research Program, MD Anderson's Cancer Center Support Grant (P30CA016672, used the Characterized Cell Line Core Facility and Flow Cytometry and Cellular Imaging Facility), and Spirita Oncology, LLC."The first affiliations was incorrect in the original article...
April 15, 2019: Breast Cancer Research and Treatment
Bihong T Chen, Taihao Jin, Sunita K Patel, Ningrong Ye, Huiyan Ma, Chi Wah Wong, Russell C Rockne, James C Root, Andrew J Saykin, Tim A Ahles, Andrei I Holodny, Neal Prakash, Joanne Mortimer, James Waisman, Yuan Yuan, Daneng Li, Mina S Sedrak, Jessica Vazquez, Vani Katheria, William Dale
PURPOSE: Older cancer patients are at increased risk of cancer-related cognitive impairment. The purpose of this study was to assess the alterations in intrinsic brain activity associated with adjuvant chemotherapy in older women with breast cancer. METHODS: Chemotherapy treatment (CT) group included sixteen women aged ≥ 60 years (range 60-82 years) with stage I-III breast cancers, who underwent both resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing with NIH Toolbox for Cognition before adjuvant chemotherapy, at time point 1 (TP1), and again within 1 month after completing chemotherapy, at time point 2 (TP2)...
April 13, 2019: Breast Cancer Research and Treatment
Maggie L Westfal, Numa P Perez, Ya-Ching Hung, David C Chang, Cassandra M Kelleher
PURPOSE: Breast masses in pediatric patients are often managed similarly to adult breast masses despite significant differences in pathology and natural history. Emerging evidence suggests that clinical observation is safe. The purpose of this study was to quantify the clinical appropriateness of the management of benign breast disease in pediatric patients. METHODS: A multi-institutional retrospective cohort study was completed between 1995 and 2017. Patients were included if they had benign breast disease and were 19 years old or younger...
April 13, 2019: Breast Cancer Research and Treatment
Daniel N Cagney, Nayan Lamba, Sofia Montoya, Puyao Li, Luke Besse, Allison M Martin, Rachel H Brigell, Paul J Catalano, Paul D Brown, Jose P Leone, Shyam K Tanguturi, Daphne A Haas-Kogan, Brian M Alexander, Nancy U Lin, Ayal A Aizer
PURPOSE: Brain metastases from breast cancer are frequently managed with brain-directed radiation but the impact of subtype on intracranial recurrence patterns after radiation has not been well-described. We investigated intracranial recurrence patterns of brain metastases from breast cancer after brain-directed radiation to facilitate subtype-specific management paradigms. METHODS: We retrospectively analyzed 349 patients with newly diagnosed brain metastases from breast cancer treated with brain-directed radiation at Brigham and Women's Hospital/Dana-Farber Cancer Institute between 2000 and 2015...
April 13, 2019: Breast Cancer Research and Treatment
Michael Coory, Kate Thornton
PURPOSE: Uptake of biosimilars depends on clinicians and patients having confidence in the evidential basis of marketing approval. The aim of this systematic review was to assess the evidential role of randomised clinical endpoint studies in the marketing approval of trastuzumab biosimilars. METHODS: We searched PubMed for any published reports of randomised studies associated with the five trastuzumab biosimilars approved by the EMA, as on 31 January 2019. We also searched ClinicalTrials...
April 12, 2019: Breast Cancer Research and Treatment
Rinat Bernstein-Molho, Amihood Singer, Yael Laitman, Iris Netzer, Shelley Zalmanoviz, Eitan Friedman
BACKGROUND: Studies assessing the contribution of non-BRCA1/2 gene mutations to inherited breast cancer (BC) predisposition consistently reported low (up to 4%) yield. The current study aimed at assessing the spectrum of non-BRCA mutations in unselected Israeli BC cases and the utility of BRCAPRO and Penn II models, as tools for prediction of detecting non-BRCA1/2 mutations in Israeli BC patients who tested negative for the predominant Jewish BRCA1/2 mutations. METHODS: All consecutive Jewish Israeli BC patients at the Sheba Medical center who tested negative for the predominant BRCA1/2 mutations and elected to perform multigene panel testing were included...
April 12, 2019: Breast Cancer Research and Treatment
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