Laíza Moura Almeida-Terassi, Ana Paula Martins Castanha, Greice Rafaele Alves, Valdir Cechinel-Filho, Rivaldo Niero, Isabel O'Neill de Mascarenhas Gaivão, Liana Martins de Oliveira, Luan Vitor Alves de Lima, Mário Sérgio Mantovani, Edson Luis Maistro
Rubus imperialis Chum. Schl. (Rosaceae) have demonstrated some pharmacological activities, including gastroprotective action. However, genotoxic effects of R. imperialis extract was also reported. Since niga-ichigoside F1 (NIF1) is a major compound of this plant species, and which has proven pharmacological properties, it is essential to investigate whether this compound is responsible for the observed toxicity. Therefore, the objective of this study was to analyze the effects of NIF1 on HepG2/C3A cells for possible cytogenotoxicity, cell cycle and apoptosis influence, and expression of genes linked to the DNA damage, cell cycle, cell death, and xenobiotic metabolism...
April 3, 2024: Journal of Applied Toxicology: JAT