journal
https://read.qxmd.com/read/38537985/impact-of-arteriosclerosis-on-reconstruction-related-complications-after-esophagectomy-and-usefulness-of-tailor-made-reconstruction-technique
#21
JOURNAL ARTICLE
Takahisa Yamaguchi, Koichi Okamoto, Hiroto Saito, Mari Shimada, Toshikatsu Tsuji, Hideki Moriyama, Jun Kinoshita, Itasu Ninomiya, Noriyuki Inaki
BACKGROUND/AIM: Anastomotic leakage is one of the most common and serious postoperative complications following esophagectomy. This study analyzed the effect of risk factors, such as the degree of arteriosclerosis, comorbidities, and patient characteristics on the incidence of reconstruction-related complications including anastomotic leakage. Furthermore, the usefulness of tailor-made reconstruction methods was clarified using wide gastric conduit. PATIENTS AND METHODS: Patients who underwent esophagectomy with a gastric conduit for esophageal cancer between 2011 and 2018 were enrolled...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537984/association-of-preoperative-and-postoperative-plasma-syndecan-1-and-colorectal-cancer-outcome
#22
JOURNAL ARTICLE
Hidenori Tanaka, Hirokatsu Hayashi, Hiroyuki Tomita, Yoshihisa Tokumaru, Masahiro Fukada, Jesse Yu Tajima, Ryoma Yokoi, Hiroshi Tsuchiya, Masashi Kuno, Yuta Sato, Itaru Yasufuku, Ryuichi Asai, Ryutaro Mori, Yoshihiro Tanaka, Naoki Okumura, Manabu Futamura, Nobuhisa Matsuhashi
BACKGROUND/AIM: A three-dimensional network constructed using glycocalyx (GCX) extends throughout the cancer cell nest in human colorectal cancer (CRC). GCX was found to be closely related to cancer. We examined the prognostic correlation and potential of syndecan-1 (SDC1), a representative proteoglycan of GCX, as a biomarker. PATIENTS AND METHODS: We analyzed SDC1 in the transcriptomic profiles of a major publicly available CRC cohort from The Cancer Genome Atlas (TCGA) using a computational algorithm...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537983/novel-insights-in-genetic-variant-classification
#23
LETTER
Anthoula Chatzikyriakidou
No abstract text is available yet for this article.
April 2024: Anticancer Research
https://read.qxmd.com/read/38537982/effectiveness-of-carbon-ion-radiotherapy-for-bone-and-soft-tissue-sarcoma-in-older-patients
#24
JOURNAL ARTICLE
Hideyuki Kinoshita, Tsukasa Yonemoto, Shigeru Yamada, Reiko Imai
BACKGROUND/AIM: The aging population is expected to increase the occurrences of bone sarcoma (BS) and soft tissue sarcoma (STS). Carbon ion radiotherapy (CIRT) is reported to be effective for BS and several STSs. However, the effect of CIRT on clinical outcomes, functional prognoses, and quality of life (QOL) in older patients who underwent CIRT has not been reported. Therefore, we aimed to evaluate the effect of CIRT on clinical outcomes, functional prognoses and QOL in older patients with BS or STS...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537981/clinically-significant-dermatitis-during-adjuvant-radiotherapy-for-invasive-breast-cancer
#25
JOURNAL ARTICLE
Dirk Rades, Charlotte Kristiansen, Carmen Timke, Marciana N Duma, Nathan Y Yu, Tobias Bartscht, Stefan Janssen
BACKGROUND/AIM: Patients with breast cancer receiving adjuvant radiotherapy may experience grade ≥2 dermatitis. In the Interreg-project HeAT, a mobile application (app) reminding patients to perform skin care will be prospectively tested with the goal of decreasing clinically significant radiation dermatitis. This study aimed to identify the prevalence of grade ≥2 dermatitis and risk factors, required for designing the prospective trial. PATIENTS AND METHODS: In a retrospective study of 327 patients with breast cancer irradiated during 2022-2023, the prevalence of grade ≥2 dermatitis and 23 potential risk factors were investigated...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537980/different-influence-pattern-of-conventional-and-alternative-sources-of-smoking-on-adhesion-molecules-and-cytokine-secretion-in-thp-1-monocytes
#26
JOURNAL ARTICLE
Theresa Mohr, Eva Probst, Christian Idel, Kirstin Plötze-Martin, Jonas Fleckner, Dirk Rades, Daniel Drömann, Sabine Bohnet, Karl-Ludwig Bruchhage, Klaas F Franzen, Ralph Pries
BACKGROUND/AIM: Tobacco is a carcinogen that is closely associated with the occurrence of lung cancer and head and neck squamous cell carcinoma (HNSCC). The consumption of tobacco is also leading to alterations in different immune cell subtypes. However, the impact of different conventional and alternative smoking sources on human monocytes remains elusive. MATERIALS AND METHODS: In this study, we investigated the influence of aqueous extracts of different sources of smoking (cigarettes; heated tobacco product IQOS; e-cigarettes with and without nicotine; nicotine pouches) on different monocytic adhesion molecules, chemokine receptors and checkpoint molecule PD-L1 by flow cytometry...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537979/gastric-cancer-with-the-increased-nicotinamide-n-methyltransferase-positive-stromal-cells-includes-unfavorable-prognosis-related-cancer-associated-fibroblasts
#27
JOURNAL ARTICLE
Satoe Numakura, Hiroshi Uozaki
BACKGROUND/AIM: "Stromal high expression" of Nicotinamide N-methyltransferase (NNMT), previously reported as a poor prognostic factor of gastric cancer, was based on immunohistochemical H-score. However, this could simply indicate an increase in cancer-associated fibroblasts (CAFs) because NNMT is positive for fibroblasts. To verify this, the proportion and staining intensity of stromal NNMT-positive stellate/spindle cells were evaluated separately and examined for its association with related proteins (H3K4me3, H3K27me3, and LOXL2)...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537978/tailoring-radiation-therapy-for-patients-with-limited-cutaneous-t-cell-lymphoma-preliminary-clinical-experience-with-subtotal-skin-electron-therapy
#28
JOURNAL ARTICLE
Brady S Laughlin, Isabella Zaniletti, Madeline G Foster, John Lucido, Aaron R Mangold, Allison C Rosenthal, Charles VAN DER Walt, William Breen, Scott Lester, Bradford Hoppe, Jennifer Petersen, Michael D Armstrong, Aaron Bogan, William G Rule
BACKGROUND/AIM: Total skin electron beam therapy (TSEBT) is an effective treatment for managing cutaneous T-cell lymphoma (CTCL), but may result in unnecessary toxicity. With the production of a custom rolling shield holding a configurable stack of plastic slats to block uninvolved skin, we implemented a program for subtotal skin electron beam therapy (STSEBT). We report our preliminary experience with STSEBT vs. TSEBT to manage CTCL. PATIENTS AND METHODS: A retrospective review of 32 CTCL patients who were treated at a single institution between February 28th, 2017, and May 25th, 2022, was completed...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537977/short-and-long-term-outcomes-after-colonic-stent-insertion-as-a-bridge-to-surgery-in-elderly-colorectal-cancer-patients
#29
JOURNAL ARTICLE
Toshio Shiraishi, Tetsuro Tominaga, Rika Ono, Keisuke Noda, Shintaro Hashimoto, Kaido Oishi, Yuma Takamura, Takashi Nonaka, Makoto Hisanaga, Mitsutoshi Ishii, Hiroaki Takeshita, Kazuo To, Kazuhide Ishimaru, Terumitsu Sawai, Takeshi Nagayasu
BACKGROUND/AIM: Colonic stents have been inserted as a bridge to surgery in patients with resectable colorectal cancer, allowing bowel decompression for systemic assessment and better preparation to avoid stoma construction. However, reports of short- and long-term prognoses for elderly patients remain limited. PATIENTS AND METHODS: This retrospective study reviewed 175 consecutive patients who underwent colonic stent insertion for bowel obstruction followed by curative colectomy...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537976/analysis-and-development-of-antigen-specific-t-cells-derived-from-peripheral-blood-mononuclear-cells-of-healthy-donors
#30
JOURNAL ARTICLE
Jihyeong Kim, Sungwook Jung, Byung-Kwan Jeong, Kyung-Ae Kim, Jang Jisu, Won Seon Bang, Baknoon Ham, Joo Young Kim, Young-Ae Kim, Hee Jin Lee
BACKGROUND/AIM: Adoptive cell therapy using antigen-specific T cells is a promising treatment modality for cancer patients. Various methods to isolate specific T cells and identify corresponding T cell receptor (TCR) sequences are known. This study aimed to identify antigen-specific TCR from T cells isolated using carboxyfluorescein succinimidyl ester (CFSE), which marks proliferating activated T cells. MATERIALS AND METHODS: CFSE stained healthy donor peripheral blood mononuclear cells (PBMCs) were treated with cytomegalovirus (CMV) or Epstein-Barr virus (EBV) peptides for seven days...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537975/results-of-definitive-chemo-radiotherapy-using-computed-tomography-based-brachytherapy-for-cervical-cancer
#31
JOURNAL ARTICLE
Tomomi Aoshika, Shin-Ei Noda, Takanori Abe, Y U Kumazaki, Ryuta Hirai, Mitsunobu Igari, Satoshi Saito, Yasuhiro Ryuno, Misaki Iino, Yuga Takeda, Tomohiro Ohta, Jun Watanabe, Keita Tsukahara, Shingo Kato
BACKGROUND/AIM: Concurrent cisplatin-based chemoradiotherapy (CCRT) is the standard treatment for locally advanced cervical cancer. Especially, CCRT with magnetic resonance imaging (MRI) or computed tomography-based image-guided brachytherapy (CT-based 3D-IGBT) for cervical cancer has resulted in good LC rates. However, progression-free survival (PFS) and overall survival (OS) rates for locally advanced cervical cancer are still low and could be improved. The aim of the study was to evaluate treatment efficacy and late toxicity of external beam radiotherapy (EBRT) and CT-based IGBT with or without concurrent chemotherapy in patients with squamous cell carcinoma of the uterine cervix and investigate patterns of failure...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537974/safety-and-limitations-of-laparoscopic-total-gastrectomy-for-gastric-cancer-a-comparative-analysis-of-short-and-long-term-outcomes-with-open-surgery
#32
JOURNAL ARTICLE
Koshiro Morino, Michihiro Yamamoto, Norihiro Shimoike, Yuta Iwasaki, Ryosuke Yamanaka, Nozomu Nakanishi, Ryo Matsusue, Takafumi Machimoto
BACKGROUND/AIM: Laparoscopic gastrectomy is a standard treatment strategy for gastric cancer (GC); however, the clinical impact of laparoscopic total gastrectomy (LTG) on survival outcomes remains unclear. We compared the short- and long-term results of LTG with those of open total gastrectomy (OTG). PATIENTS AND METHODS: Patients undergoing total gastrectomy with lymph node dissection for Stage I/II/III GC between 2010 and 2020 were retrospectively analyzed. Patients were classified into those undergoing LTG (n=143, LTG group) and OTG (n=173, OTG group)...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537973/the-crp-albumin-lymphocyte-cally-index-is-an-independent-prognostic-factor-for-gastric-cancer-patients-who-receive-curative-treatment
#33
JOURNAL ARTICLE
Toru Aoyama, Yukio Maezawa, Itaru Hashimoto, Kentaro Hara, Ayako Tamagawa, Keusike Kazama, Aya Kato, Haruhiko Cho, Masato Nakazono, Masakatsu Numata, Shinnosuke Kawahara, Mie Tanabe, Jyunya Morita, Takashi Oshima, Aya Saito, Norio Yukawa, Yasushi Rino
BACKGROUND/AIM: The CRP-albumin-lymphocyte (CALLY) index is a promising biomarker. We clarified the clinical impact of the CALLY index in gastric cancer patients who received curative treatment. PATIENTS AND METHODS: Consecutive patients who underwent curative resection for gastric cancer at Yokohama City University from 2005 to 2020 were selected based on medical records. The CALYY index was calculated as follows: serum ALB level (g/dl) × lymphocyte count (cells/μl)/C-reactive protein (mg/dl) ×104 Results: Two hundred fifty-nine patients were included in the present study...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537972/colorectal-cancer-screening-by-fecal-immunochemical-tests-fit-considerations-on-sampling-and-markers-hb-and-hb-hp-complex-of-fecal-occult-blood-fob
#34
JOURNAL ARTICLE
Kari Syrjänen, Maaret Eskelinen, Jannica Meklin, Panu Hendolin, Matti Eskelinen, Osmo Suovaniemi
BACKGROUND/AIM: Formal demonstration of the efficacy of colorectal cancer (CRC) screening by fecal immunochemical tests (FITs) in reducing CRC incidence and mortality is still missing. The aim of this study was to analyze the impact of sampling and FIT marker in the recently implemented CRC screening program in Finland. PATIENTS AND METHODS: Because only the index test [FIT hemoglobin (Hb)]-positive subjects are verified by the reference test (colonoscopy), the new screening program is subject to verification bias that precludes estimating the diagnostic accuracy (DA) indicators...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537971/clinical-impact-of-preoperative-prognostic-nutritional-index-in-surgical-patients-with-pancreatic-cancer-treated-with-perioperative-adjuvant-chemotherapy
#35
JOURNAL ARTICLE
Shinnosuke Kawahara, Toru Aoyama, Masaaki Murakawa, Rei Kanemoto, Daishi Takahashi, Yuto Kamioka, Itaru Hashimoto, Yukio Maezawa, Satoshi Kobayashi, Makoto Ueno, Naoto Yamamoto, Takashi Oshima, Norio Yukawa, Yasushi Rino, Aya Saito, Soichiro Morinaga
BACKGROUND/AIM: The prognostic nutritional index (PNI) is used as a marker to evaluate the nutritional and immunological status of patients with various cancers. This study aimed to investigate whether preoperative PNI is a prognostic factor in patients with pancreatic cancer who underwent perioperative adjuvant chemotherapy and surgical resection. PATIENTS AND METHODS: We retrospectively enrolled 232 pancreatic cancer patients who underwent surgical resection with perioperative adjuvant chemotherapy between January 2013 and December 2022...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537970/high-risk-patients-with-colorectal-liver-metastases-assessed-by-the-beppu-score-can-have-excellent-survival-through-multidisciplinary-treatment-including-local-ablation
#36
JOURNAL ARTICLE
Toru Beppu, Kensuke Yamamura, Toshiro Masuda, Hideaki Miyamoto, Jiro Nasu, Seiya Saito, Koichi Doi, Takashi Katsumori, Tsutomu Oda, Takatoshi Isiko
BACKGROUND/AIM: The Beppu score assessed by the Japanese Society of Hepato-Biliary-Pancreatic Surgery nomogram helps predict postoperative disease-free survival for patients with resectable colorectal liver metastases (CRLM). Using the Beppu score, patients with resectable CRLM were divided into three groups according to recurrence risk: low (≤6 points), moderate (7-10 points), and high-risk (≥11 points). Hepatectomy following preoperative chemotherapy is recommended for high-risk patients...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537969/cd8-positive-t-cell-infiltration-with-human-leukocyte-antigen-class-1-expression-predicts-patients-with-stage-iv-colorectal-cancer-survival
#37
MULTICENTER STUDY
Tetsuta Satoyoshi, Yoshihiko Hirohashi, Koichi Okuya, Masaaki Miyo, Emi Akizuki, Masayuki Ishii, Ryo Miura, Terufumi Kubo, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Ichiro Takemasa, Toshihiko Torigoe
BACKGROUND/AIM: The immune microenvironment in cancer correlates with cancer progression and patient prognosis. Cancer immune microenvironment evaluation, based on CD3+ and CD8+ T cell infiltration at the center and invasive margin of the tumor, is defined as the immunoscore. An international multicenter analysis revealed that the immunoscore can accurately predict the prognosis of patients with colorectal cancer (CRC) (stage I, II, and III). However, no markers are currently available to predict the prognosis in patients with stage IV CRC...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537968/risk-factors-for-long-term-body-weight-loss-after-proximal-gastrectomy-a-retrospective-analysis
#38
JOURNAL ARTICLE
Yuya Agatsuma, Koki Nakanishi, Chie Tanaka, Mitsuro Kanda, Dai Shimizu, Shinichi Umeda, Keisuke Kurimoto, Yoshikuni Inokawa, Hideki Takami, Norifumi Hattori, Masamichi Hayashi, Goro Nakayama, Michitaka Fujiwara, Yasuhiro Kodera
BACKGROUND/AIM: Proximal gastrectomy (PG) is a therapy for early-stage proximal gastric cancer and offers advantages such as the preservation of food storage capacity and less body weight loss (BWL). Nevertheless, significant BWL following PG may occur, affecting the patient's well-being and survival. In this study, we aimed to identify the relevant factors for BWL following PG by analyzing an institutional database of patients. PATIENTS AND METHODS: We enrolled 58 consecutive patients who underwent PG for gastric or esophagogastric junction cancer at our institution between April 2004 and March 2021...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537967/the-contribution-of-double-strand-break-repair-radiation-sensitive-protein-51-genotypes-to-lung-cancer-in-taiwan
#39
JOURNAL ARTICLE
Kuo-Liang Chiu, Shou-Cheng Wang, Chia-Hsiang Li, Te-Chun Shen, Li-Hsiou Chen, Yi-Cheng Shen, Wen-Shin Chang, Chia-Wen Tsai, Te-Chun Hsia, DA-Tian Bau
BACKGROUND/AIM: Numerous studies have reported the over-expression of the radiation-sensitive protein 51 (RAD51) in various types of cancer. However, the role of RAD51 genotypes in lung cancer remains largely unknown. This study aimed to assess the impact of the common variant RAD51 rs1801320 (G-135C) genotypes on the risk of lung cancer in Taiwan. MATERIALS AND METHODS: The contribution of RAD51 rs1801320 genotypes to lung cancer risk was investigated in a cohort comprising 358 lung cancer patients and 716 age- and sex-matched healthy controls, utilizing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537966/tcr-cdr3-cmv-antigen-chemical-complementaries-are-associated-with-a-worse-outcome-for-renal-cell-carcinoma
#40
JOURNAL ARTICLE
Lila Alkassab, Michael J Diaz, Elizabeth A Fetcher, Taha I Huda, Srijit Paul, Shivanshu Kumar, Andrea Chobrutskiy, Boris I Chobrutskiy, Joanna J Song, George Blanck
BACKGROUND/AIM: Due to still unresolved questions regarding viruses as either a primary cause or a comorbidity in cancer, we examined a potential immune response to cytomegalovirus (CMV) in the renal cell carcinoma (RCC) setting using genomics and bioinformatics approaches. MATERIALS AND METHODS: Specifically, we assessed chemical complementarity scores (CSs) for solid tissue normal resident, T-cell receptor (TCR) complementarity determining region 3 (CDR3s) and CMV antigens and determined whether higher or lower CS groups were associated with a higher or lower survival probability...
April 2024: Anticancer Research
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