journal
https://read.qxmd.com/read/38677773/re-consideration-of-lymph-node-metastasis-in-pancreatic-cancer-patients-following-radical-resection-a-retrospective-study
#1
JOURNAL ARTICLE
Ryo Saito, Hiromichi Kawaida, Wataru Izumo, Yuuki Nakata, Hidetake Amemiya, Takaomi Ozawa, Yudai Higuchi, Takashi Nakayama, Suguru Maruyama, Koichi Takiguchi, Katsutoshi Shoda, Naoki Ashizawa, Yuko Nakayama, Kensuke Shiraishi, Shinji Furuya, Hidenori Akaike, Yoshihiko Kawaguchi, Daisuke Ichikawa
BACKGROUND/AIM: Perioperative chemotherapy has become more common in patients with pancreatic cancer (PC), and the significance of lymph node (LN) metastasis and the role of surgical resection in PC have gradually evolved. In the present study, we reconsidered the significance of LN metastasis for patients with PC. PATIENTS AND METHODS: We analyzed 142 PC patients who underwent radical resection at our hospital between September 2012 and December 2021. Patients were divided into three groups based on the performance of preoperative chemotherapy, as follows: up-front surgery (US, n=109), neoadjuvant chemotherapy (NAC, n=22), and conversion surgery (CS, n=11)...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677772/curcumin-alone-and-combined-with-pi3k-inhibitors-elicits-positive-effects-on-oropharyngeal-cancer-cell-lines-regardless-of-hpv-status
#2
JOURNAL ARTICLE
Monika Lukoceviciute, Mark Zupancic, Ourania N Kostopoulou, Stefan Holzhauser, Tina Dalianis
BACKGROUND/AIM: Human papillomavirus positive (HPV+ ) oropharyngeal squamous cell carcinoma (OPSCC) is rising in incidence. Compared to HPV-negative (HPV- ) OPSCC, HPV+ cases have a better 5-year survival. With its severe side-effects, today's chemoradiotherapy has not improved outcome compared to radiotherapy alone, so new therapies are needed. Mutations in phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), fibroblast growth factor receptor 3 (FGFR3) and cell division cycle 27 (CDC27) are found in HPV+ OPSCC, and in vitro targeted therapy combining PI3K and FGFR inhibitors showed synergistic effects...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677771/design-and-evaluation-of-a-humanized-anti-egfr-huscfv-antibody-fragment-in-combination-with-metformin-in-a549-cells-in-vitro
#3
JOURNAL ARTICLE
Jorge Solis-Estrada, Eder Arredondo-Espinoza, Elizeth Pioquinto-Ávila, Aldo O González-Cruz, Xristo Zarate, Isaías Balderas-Rentería
BACKGROUND/AIM: The epidermal growth factor receptor (EGFR) is over-expressed in several types of cancer, and monoclonal antibody therapy has been the strategy that has shown the best results. This study focused on the construction of a humanized single chain antibody (huscFv) directed against EGFR (HER1). MATERIALS AND METHODS: The CDR grafting method was used to incorporate murine complementarity determining regions (CDRs) of cetuximab into human sequences. A dot blot assay was used to examine the affinity of the huscFv secreted by HEK293T for EGFR...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677770/association-of-matrix-metalloproteinase-9-genotypes-with-lung-cancer-risk-in-taiwan
#4
JOURNAL ARTICLE
Li-Hsiou Chen, Yuh-Feng Tsai, Wen-Tzu Wu, Kuo-Liang Chiu, Chia-Wen Tsai, Wen-Shin Chang, Chia-Hsiang Li, Jai-Sing Yang, Mei-Chin Mong, Te-Chun Hsia, DA-Tian Bau
BACKGROUND/AIM: Matrix metalloproteinase-9 (MMP-9) expression is upregulated in various diseases, including lung cancer. However, the role of MMP-9 genotype in lung cancer susceptibility remains uncertain. This study aimed to clarify the contribution of MMP-9 promoter rs3918242 genotypes to the risk of lung cancer in Taiwan. MATERIALS AND METHODS: The MMP-9 rs3918242 genotypes of 358 lung cancer patients and 716 healthy controls were determined using polymerase chain reaction-restriction fragment length polymorphism methodology...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677769/taurine-rescues-cancer-induced-atrophy-in-human-skeletal-muscle-cells-via-ameliorating-the-inflammatory-tumor-microenvironment
#5
JOURNAL ARTICLE
Chung-Hsien Chen, Yu-Chi Chen, Yun-Ching Chang, Chih-Hsin Hung, Ching-Yu Huang, Chia-Lung Tsai, Cheuk-Kwan Sun, Hung-Yu Lin
BACKGROUND/AIM: Cancer cachexia is a wasting syndrome that has a devastating impact on the prognosis of patients with cancer. It is well-documented that pro-inflammatory cytokines are involved in the progression of this disorder. Therefore, this study was conducted to investigate the protective effect of taurine, an essential nonprotein amino acid with great anti-inflammatory properties, in attenuating muscle atrophy induced by cancer. MATERIALS AND METHODS: Conditioned media (CM) derived from T24 human bladder carcinoma cells with or without 5 mM taurine were incubated with human skeletal muscle cells (HSkMCs) and their differentiation was examined...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677768/dna-checkpoint-gene-mutation-as-a-biomarker-for-immune-checkpoint-inhibitor-therapy-in-advanced-biliary-tract-cancer
#6
JOURNAL ARTICLE
Ji Eun Shin, Seung Tae Kim
BACKGROUND/AIM: The DNA checkpoint (DNACHK) pathway is engaged in signaling the need for cell cycle arrest. This pathway is being actively researched to assess its role in cancer immunotherapy. PATIENTS AND METHODS: A total of 62 patients participated in this study. These patients were treated with immune checkpoint inhibitors (ICIs) for advanced biliary tract cancers (BTCs) from March 2020 to August 2022 at Samsung Medical Center. DNACHK mutated were defined as genomic alterations, such as single nucleotide variants, multi-nucleotide variants, and short insertion and deletions in seven genes; checkpoint kinase 1 (CHEK1), checkpoint kinase 2 (CHEK2), BRCA1, DNA repair-associated (BRCA1), the serine/threonine kinase ATM, the serine/threonine kinase ATR, mediator of DNA damage checkpoint 1 (MDC1) and tumor protein p53 binding protein 1 (TP53BP1)...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677767/sarcopenic-obesity-promotes-recurrence-in-patients-undergoing-resection-for-colorectal-liver-metastases-crlm
#7
JOURNAL ARTICLE
Doris Wagner, Robert Karitnig, Valerie Wienerroither, Hans Michael Hau, Andri Lederer, Robert Sucher, Peter Kornprat
BACKGROUND/AIM: Sarcopenia, is predictive of a worse outcome after resection for colorectal liver metastases (CRLM). Obesity leads to a metabolic double burden if sarcopenia is as present, prompting malignancy progression, known as sarcopenic obesity (SO). This study aimed to compare sarcopenia and SO in patients undergoing CRLM resection, to prognostic parameters. PATIENTS AND METHODS: The skeletal muscle index (SMI) defined sarcopenia using sex specific cut off values (48...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677766/associations-between-mean-lung-dose-and-prevalence-of-radiation-pneumonitis-in-elderly-lung-cancer-patients
#8
JOURNAL ARTICLE
Dirk Rades, Florian Cremers, Stefan Janssen, Tobias Bartscht, Charlotte Kristiansen, Carmen Timke, Marciana N Duma, Nathan Y Yu, Sabine Bohnet
BACKGROUND/AIM: Pneumonitis is a serious radiotherapy complication. This study, which is a prerequisite for a prospective trial, aimed to identify the prevalence of pneumonitis and risk factors in elderly patients with lung cancer. PATIENTS AND METHODS: Ninety-eight lung cancer patients aged ≥65 years were included. Seventeen factors were investigated regarding grade ≥2 pneumonitis at 24 weeks following radiotherapy. RESULTS: The prevalence of grade ≥2 pneumonitis at 24 weeks was 27...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677765/contrast-enhanced-ultrasound-using-intradermal-microbubble-sulfur-hexafluoride-in-non-invasive-axillary-staging-in-breast-cancer-are-we-missing-a-chance
#9
JOURNAL ARTICLE
Gianluca Vanni, Marco Materazzo, Nicola DI Lorenzo, Federico Tacconi, Marco Pellicciaro, Massimiliano Berretta, Giordana DI Mauro, Chiara Adriana Pistolese, Annalisa Noce, Benedetto Longo, Valerio Cervelli, Oreste Claudio Buonomo
BACKGROUND/AIM: In the context of surgical de-escalation in early breast cancer (EBC), this study aimed to evaluate the contrast enhancement ultrasound (CEUS) sentinel lymph node (SLN) procedure as a non-invasive axillary staging procedure in EBC in comparison with standard SLN biopsy (SLNB). PATIENTS AND METHODS: A subanalysis of the AX-CES study, a prospective single-arm, monocentric phase 3 study was performed (EudraCT: 2020-000393-20). The study included patients with EBC undergoing upfront surgery and SLN resection, with no prior history of locoregional treatment, and weighing between 40-85 kg...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677764/sh003-enhances-the-anti-cancer-effects-of-dabrafenib-on-lung-cancer-harboring-braf-g469a-mutation-by-inhibiting-the-mapk-signaling-pathway
#10
JOURNAL ARTICLE
Yu-Jeong Choi, Yoon Hey Chung, Kangwook Lee, Miso Jeong, Seong-Gyu Ko
BACKGROUND/AIM: BRAF mutations are relatively uncommon in lung cancer. However, the majority of therapies targeting BRAF mutations have been developed exclusively for lung cancer patients with V600E mutations, limiting their effectiveness in treating tumors with the non-V600E BRAF mutations. As a result, there is a need to explore effective therapeutic strategies for patients with lung cancer carrying non-V600 BRAF mutations. Therefore, this study aims to identify a combination treatment approach that effectively targets lung cancer with G469A non-V600 BRAF alteration...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677763/cx-4945-silmitasertib-induces-cell-death-by-impairing-lysosomal-utilization-in-kras-mutant-cholangiocarcinoma-cell-lines
#11
JOURNAL ARTICLE
DA Sol Lee, Min Woo Han, Yonghyun Kang, Chorong Kim, Seonmin Lee, Kyu-Pyo Kim, Changhoon Yoo
BACKGROUND/AIM: Macropinocytosis is a non-selective form of endocytosis that facilitates the uptake of extracellular substances, such as nutrients and macromolecules, into the cells. In KRAS-driven cancers, including pancreatic ductal adenocarcinoma, macropinocytosis and subsequent lysosomal utilization are known to be enhanced to overcome metabolic stress. In this study, we investigated the role of Casein Kinase 2 (CK2) inhibition in macropinocytosis and subsequent metabolic processes in KRAS mutant cholangiocarcinoma (CCA) cell lines...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677762/genetic-and-immunological-characterization-of-brain-metastases-from-solid-cancers
#12
JOURNAL ARTICLE
Shoichi Deguchi, Yasuto Akiyama, Koichi Mitsuya, Tomoatsu Ikeya, Chikako Hozumi, Akira Iizuka, Haruo Miyata, Chie Maeda, Tadashi Ashizawa, Takeshi Nagashima, Kenichi Urakami, Keiichi Ohshima, Koji Muramatsu, Takashi Sugino, Yasuhisa Ohde, Yasuhiro Tsubosa, Seiichiro Nishimura, Ken Yamaguchi
BACKGROUND/AIM: Brain metastasis, a leading cause of cancer death, is a clinical challenge. Recently, genetic characterization of brain metastatic lesions based on next generation sequencing-based advanced technologies, such as single-cell RNA sequencing, has been performed to develop novel efficient therapies. The present study aimed to investigate brain-metastasis-specific biomarkers as well as relevant prognostic factors. PATIENTS AND METHODS: The genetic profiles and expression levels of immune response-associated genes and 820 cancer-associated genes were compared between primary cancer lesions and metastatic cancer lesions obtained from nine cancer patients at the Shizuoka Cancer Center...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677761/transhepatic-bromelain-and-acetylcysteine-for-treatment-of-posterior-gastric-pseudomyxoma-peritonei-a-case-report
#13
JOURNAL ARTICLE
Si Louise Sun, Mina Sarofim, David L Morris
BACKGROUND/AIM: Pseudomyxoma peritonei (PMP) is a rare condition characterized by diffuse spread of mucinous tumors within the peritoneal cavity. Traditional treatment modalities, such as cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are challenging in cases of recurrent disease, owing to anatomical complexities and increasing morbidity and mortality risk. BromAc® has emerged as a novel, targeted therapy for PMP with evidence for intra-tumoral administration to break down mucin deposits...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677760/demographic-disparities-in-acute-myeloid-leukemia-mortality-trends-in-the-united-states
#14
JOURNAL ARTICLE
Sishir Doddi, Oscar Salichs, Taryn Hibshman, Peter Alamir, Siddharth Kunte
BACKGROUND/AIM: Acute myeloid leukemia (AML) is a hematological malignancy with an overall poor prognosis; however, survival rates vary widely by clinical and demographic characteristics. This study sought to identify historical trends in AML mortality in the US and to identify any disparities by sex, race or ethnicity. PATIENTS AND METHODS: For each demographic population, the age adjusted mortality rate (AAMR) per 1,000,000 for AML-related deaths from 1999 to 2020 in the United States was accessed from the CDC Wonder Database...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677759/twenty-five-years-overall-survival-prognostic-value-of-the-lymph-node-ratio-in-de-novo-metastatic-breast-cancer
#15
JOURNAL ARTICLE
Olena Gorobets, Bhumsuk Keam, Vincent Vinh-Hung, Nam P Nguyen
BACKGROUND/AIM: The lymph node ratio (LNR) indicates the number of involved lymph nodes divided by the number of lymph nodes found during axillary exploration. This study investigated the prognostic value of the LNR in de novo metastatic breast cancer (dnMBC). We hypothesized that LNR might predict long-term survival even in cases where the disease has already disseminated beyond the regional stage. PATIENTS AND METHODS: Patients with dnMBC were selected from the Surveillance, Epidemiology, and End Results (SEER) 9-registries database 1988-2012...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677758/aldehyde-dehydrogenese-1-high-cancer-stem-like-cells-cancer-initiating-cells-escape-from-cytotoxic-t-lymphocytes-due-to-lower-expression-of-human-leukocyte-antigen-class-1
#16
JOURNAL ARTICLE
Tomohide Shirosaki, Noriko Kawai, Yuma Ebihara, Aiko Murai, Terufumi Kubo, Rena Morita, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Toshiaki Shichinohe, Yoshihiko Hirohashi, Satoshi Hirano, Toshihiko Torigoe
BACKGROUND/AIM: Human gastric cancer stem-like cells (CSCs)/cancer-initiating cells can be identified as aldehyde dehydrogenase-high (ALDHhigh ) cells. Cancer immunotherapy employing immune checkpoint blockade has been approved for advanced gastric cancer cases. However, the effectiveness of cancer immunotherapy against gastric CSCs/CICs remains unclear. This study aimed to investigate the susceptibility of gastric CSCs/CICs to immunotherapy. MATERIALS AND METHODS: Gastric CSCs/CICs were isolated as ALDHhigh cells using the human gastric cancer cell line, MKN-45...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677757/the-albumin-bilirubin-grade-as-prognostic-indicator-for-recurrent-hepatocellular-carcinoma-needing-repeat-liver-resection
#17
JOURNAL ARTICLE
Hidetoshi Gon, Shohei Komatsu, Satoshi Omiya, Masahiro Kido, Kenji Fukushima, Takeshi Urade, Toshihiko Yoshida, Keisuke Arai, Jun Ishida, Yoshihide Nanno, Daisuke Tsugawa, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto
BACKGROUND/AIM: This study aimed to evaluate the utility of the albumin-bilirubin grade for predicting the prognosis after repeat liver resection for patients with recurrent hepatocellular carcinoma. PATIENTS AND METHODS: Ninety patients with intrahepatic recurrent hepatocellular carcinoma who underwent repeat liver resection at our institution between 2005 and 2019 were retrospectively analyzed. Cox proportional-hazards regression models evaluated independent preoperative prognostic factors, including the albumin-bilirubin grade...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677756/clinical-significance-of-serum-scc-levels-before-treatment-for-locally-advanced-cervical-squamous-cell-carcinoma
#18
JOURNAL ARTICLE
Yusuke Yamaoka, Saya Tamura, Koji Yamanoi, Mana Taki, Ryusuke Murakami, Ken Yamaguchi, Junzo Hamanishi, Masaki Mandai
BACKGROUND/AIM: Although serum squamous cell carcinoma (SCC) antigen values are known to be useful in predicting the prognosis of cervical SCC, they have only been examined in a cursory manner. This study aimed to meticulously investigate the clinical significance of serum SCC antigen levels in patients with locally advanced cervical squamous cell carcinoma (LACSC). PATIENTS AND METHODS: The study included patients who were diagnosed with local stage (T-stage) 1b3/2/3 LACSC and underwent initial treatment at our institute between January 2006 and December 2016 (T-1b3: n=30; T-2: n=75; T-3: n=34)...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677755/muscle-invasive-bladder-cancer-with-hydronephrosis-exhibits-a-high-frequency-of-mutations-in-fibroblast-growth-factor-receptor-3-gene
#19
JOURNAL ARTICLE
Kohei Kobatake, Kenichiro Ikeda, Yuki Kohada, Ryo Tasaka, Kenshiro Takemoto, Takafumi Fukushima, Shunsuke Miyamoto, Yohei Sekino, Hiroyuki Kitano, Keisuke Goto, Keisuke Hieda, Akihiro Goriki, Tetsutaro Hayashi, Nobuyuki Hinata
BACKGROUND/AIM: Recent studies have reported conflicting findings regarding the significance of hydronephrosis (HN) in muscle-invasive bladder cancer (MIBC). The molecular characteristics of MIBC with HN are unclear, therefore, we aimed to address the gaps in previous research and elucidate HN's molecular significance in patients with MIBC. MATERIALS AND METHODS: Clinical, genetic, and imaging information on bladder cancer patients enrolled in The Cancer Genome Atlas were obtained from public databases to analyze the association between the presence of hydronephrosis and genetic alterations and molecular subtyping...
May 2024: Anticancer Research
https://read.qxmd.com/read/38677754/strategies-to-perform-emergency-laparoscopic-partial-liver-resection-for-ruptured-hepatocellular-carcinoma
#20
JOURNAL ARTICLE
Masashi Tsunematsu, Shinji Onda, Yoshihiro Shirai, Kyohei Abe, Takashi Horiuchi, Koichiro Haruki, Kenei Furukawa, Norimitsu Okui, Tomohiko Taniai, Toru Ikegami
BACKGROUND/AIM: Laparoscopic hepatic resection is currently used for ruptured hepatocellular carcinoma (HCC); however, it is technically challenging. We developed and implemented surgical strategies for emergency laparoscopic partial liver resection in selected patients with peripheral lesions who were hemodynamically stable and without severe liver dysfunction. PATIENTS AND METHODS: The surgical techniques used were as follows. First, the Pringle maneuver was performed to control hepatic blood inflow (step 1)...
May 2024: Anticancer Research
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