journal
https://read.qxmd.com/read/38030214/corrigenda
#1
JOURNAL ARTICLE
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December 2023: Anticancer Research
https://read.qxmd.com/read/38030213/laparoscopic-surgery-for-elderly-colorectal-cancer-patients-with-high-american-society-of-anesthesiologists-scores
#2
JOURNAL ARTICLE
Daiki Matsubara, Koji Soga, Jun Ikeda, Tomoki Konishi, Yusuke Uozumi, Ryo Takeda, Hiroaki Kanazawa, Shuhei Komatsu, Katsumi Shimomura, Fumihiro Taniguchi, Yasuhiro Shioaki, Eigo Otsuji
BACKGROUND/AIM: To evaluate the safety of colorectomy in elderly colorectal cancer patients with high American Society of Anesthesiologists (ASA) scores compared to those with low scores. PATIENTS AND METHODS: Two hundred patients with stage I-IV colorectal cancer aged ≥80 years were retrospectively analyzed. Short- and long-term outcomes were compared between 136 patients with ASA scores ≤2 (low ASA group) and 64 patients with scores ≥3 (high ASA group)...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030212/histological-assessment-of-synovial-sarcoma-before-and-after-tcr-t-cell-therapy-and-cryoablation-a-case-report
#3
JOURNAL ARTICLE
Kunihiro Asanuma, Mikiya Ishihara, Tomoki Nakamura, Katsunori Uchida, Tomohito Hagi, Shinichi Kageyama, Hiroshi Shiku, Akihiro Sudo
BACKGROUND/AIM: Cancer/testis antigens (CTAs) are well-known molecular targets with expression restricted to testicular germ cells and malignant tumors. T-cell receptor (TCR)-engineered T-cell (TCR-T) therapy against CTAs in patients with sarcoma has shown substantial progress, but resistance to TCR-T therapy remains a critical problem. In this report, we present a case of synovial sarcoma treated with TCR-T therapy targeting the New York-esophageal squamous cell carcinoma (NY-ESO)-1 protein...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030211/dosimetric-parameters-after-vmat-adaptive-radiotherapy-in-patients-with-locally-advanced-nsclc-undergoing-4dct
#4
JOURNAL ARTICLE
Linda Agolli, Zeliha Eroglu, Luca Nicosia, Daniel Habermehl
BACKGROUND/AIM: To investigate dosimetric differences in organs at risk (OARs) and cardiac substructures in patients with locally advanced non-small cell lung cancer (NSCLC) between the adaptive radiotherapy (ART) and non-ART groups. PATIENTS AND METHODS: Thirty patients were treated with definitive radiotherapy +/- chemotherapy. Cardiac substructures including the left anterior descending coronary artery (LAD) and large vessels, were contoured. Eight patients experienced tumor shrinkage and were replanned (ART)...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030210/oxidative-stress-regulating-enzymes-and-endometrial-cancer-survival-in-relation-to-metformin-intake-in-diabetic-patients
#5
JOURNAL ARTICLE
Ewelina Kuusiniemi, Peeter Karihtala, Ulla Puistola, Anne Ahtikoski, Elina Urpilainen
BACKGROUND/AIM: Metformin inhibits tumorigenesis in endometrial carcinoma and interferes with the expression of oxidative stress-regulating proteins, such as nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1). Although manganese superoxide dismutase (MnSOD) is vital for withstanding mitochondrial oxidative stress, it has also been linked with chemoresistance and poorer outcomes in several cancer types. However, data on endometrial cancers are limited...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030209/genistein-induces-antiproliferative-activity-and-apoptosis-in-human-osteosarcoma-saos-2-cells
#6
JOURNAL ARTICLE
Hiromi Hagiwara, Hana Wako, Kyoko Nakata, Rieko Aida
BACKGROUND/AIM: Genistein (4', 5, 7-trihydroxyisoflavone) and daidzein (4', 7-dihydroxyisoflavone) are isoflavones derived from soybean and have anti-cancer effects in various cells. However, the effects of genistein and daidzein on the human osteosarcoma cell line Saos-2 has not been investigated before. MATERIALS AND METHODS: Human osteosarcoma Saos-2 cells were treated with genistein for 24 and 48 hours. Cytotoxicity and apoptosis were measured. RESULTS: Genistein significantly inhibited proliferation of Saos-2 cells stronger than daidzein in a dose-dependent manner (0 to 80 μM)...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030208/triage-process-at-endoscopy-with-colonview-fecal-immunochemical-test-fit-will-enhance-diagnostic-accuracy-da-of-colorectal-cancer-screening
#7
JOURNAL ARTICLE
Maaret Eskelinen, Jannica Meklin, Denise Peixoto Guimaraes, Tuomas Selander, Kari Syrjänen, Matti Eskelinen
BACKGROUND/AIM: This study assessed the diagnostic accuracy (DA) of the predictive features of colorectal cancer (CRC, predictCRC), triage process (triage), and ColonView (CV) fecal immunochemical test (FIT) in a CRC screening setting. The diagnostic score models (DMs) including predictCRC with triage and CV test were also calculated. PATIENTS AND METHODS: The study cohort of 544 patients included 58 CRC patients and 486 non-CRC patients who submitted three consecutive fecal samples for analysis, by two fecal occult blood (FOB) assays (CV FIT test, HemoccultSENSA test)...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030207/three-dimensional-computed-tomography-evaluation-of-the-vasculature-of-right-side-colon-cancer
#8
JOURNAL ARTICLE
Y U Kuboyama, Tetsuo Ishizaki, Junichi Mazaki, Kenta Kasahara, Tomoya Tago, Ryutaro Udo, Yuichi Nagakawa
BACKGROUND/AIM: From an oncological perspective, central ligation of the feeding vessel is an important approach to consider when performing colon cancer surgery. This study aimed to use three-dimensional computed tomography (3D-CT) to clarify the vascular anatomy for performing central vascular ligation to improve the accuracy of minimally invasive surgery (MIS) performed to treat advanced right-side colon cancer. PATIENTS AND METHODS: This descriptive study was conducted at one institution and targeted 92 patients with right-side colon cancer whose vascular anatomy was evaluated with 3D-CT before surgery between January 2014 and December 2020 at Tokyo Medical University Hospital...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030206/8-chloroadenosine-induces-er-stress-and-apoptotic-cell-death-in-cholangiocarcinoma-cells
#9
JOURNAL ARTICLE
Jomnarong Lertsuwan, Jisnuson Svasti, Jutamaad Satayavivad
BACKGROUND/AIM: Cholangiocarcinoma is a lethal cancer, and current chemotherapeutic drugs are not very effective. Recent studies reported that cholangiocarcinoma cells were sensitive to adenosine. One adenosine analog, 8-chloroadenosine (8-CA), was shown to be more potent than adenosine and induced apoptosis in leukemia cells. This study examined effects of 8-CA in cholangiocarcinoma cells and immortalized cholangiocytes. MATERIALS AND METHODS: Cell growth was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030205/proton-pump-inhibitors-ameliorate-oxaliplatin-induced-peripheral-neuropathy-retrospective-analysis-of-two-real-world-clinical-databases
#10
JOURNAL ARTICLE
Akihide Kobayashi, Kenji Ikemura, Eri Wakai, Masayoshi Kondo, Masahiro Okuda
BACKGROUND/AIM: Chemotherapy-induced peripheral neuropathy (CIPN) due to oxaliplatin (L-OHP) is a major clinical problem. Effective and safe preventive strategies for CIPN are urgently needed. Although proton pump inhibitors (PPIs) have various off-target effects, their clinical impact on L-OHP-induced CIPN remains unclear. In the present study, we investigated the effects of PPIs on L-OHP-induced CIPN in patients using two real-world clinical databases. PATIENTS AND METHODS: We retrospectively analyzed the electronic medical records of Osaka University Hospital to examine the effect of PPIs on CIPN development in 217 patients who received XELOX (L-OHP plus capecitabine) therapy for colorectal cancer...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030204/laparoscopic-anatomical-liver-resection-using-liver-mapping-of-incidental-indocyanine-green-fluorescence-due-to-cholestasis
#11
JOURNAL ARTICLE
Kodai Tomioka, Takeshi Aoki, Yoshihiko Tashiro, Tomokazu Kusano, Kazuhiro Matsuda, Kosuke Yamada, Koji Nogaki, Yusuke Wada, Hideki Shibata, Takahito Hirai, Tatsuya Yamazaki, Kazuhiko Saito, Marie Uchida, Shodai Nagaishi, Akira Fujimori, Yuta Enami
BACKGROUND/AIM: Indocyanine green (ICG) fluorescence is useful in laparoscopic hepatectomy (LH) for tumor identification and staining, as well as determination of resection margins. At our Institution, patient-specific, three-dimensional simulations and rehearsal of surgical strategies are carried out preoperatively. We describe cases in which ICG administered preoperatively became stagnated and fluoresced in an area similar to the preoperatively established resection area and the pathological findings in these cases...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030203/peptide-receptor-radionuclide-therapy-for-recurrent-olfactory-neuroblastoma-after-cranioplasty-for-surgical-infection-a-case-report
#12
JOURNAL ARTICLE
Hidenori Suzuki, Shoichi Haimoto, Yoshitaka Inaba, Hiroyuki Tachibana, Keisuke Takanari, Masashi Ando, Koichi Yoshizawa, Nobuhiro Hanai
BACKGROUND: Peputide receptor radionuclide therapy with 177Lu for midgut neuroendocrine metastasis has been clinically approved as a safe treatment. Unresectable metastases of olfactory neuroblastoma have shorter survival due to insufficient effective systemic treatment. CASE REPORT: Herein, we report a patient treated with peputide receptor radionuclide therapy for unresectable recurrent olfactory neusroblastoma following a rare cranial metastasectomy infection...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030202/-in-vitro-characterization-of-the-bacteria-derived-hypoxia-selective-cytotoxin-be-43547
#13
JOURNAL ARTICLE
Morten Busk, Peter P Eggertsen, Jens Overgaard, Michael R Horsman, Thomas Tørring, Kristian M Jacobsen, Thomas B Poulsen
BACKGROUND/AIM: Hypoxia-activated pro-drugs, such as TH-302, may kill hypoxic treatment-resistant tumor cells, but have failed in clinical trials. This may be related to variable levels of drug-activating reductases. Compounds such as bacteria-derived BE-43547, which target hypoxic cells independently of reductases, may be beneficial. This study characterized the in vitro potency and hypoxia selectivity of BE-43547 and TH-302. MATERIALS AND METHODS: Tumor cells were exposed to different oxygenation levels in the presence/absence of drug, and survival was quantified using total cell number (BE-43547) or clonogenic survival (BE-43547 and TH-302) assays...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030201/carotid-artery-stenosis-on-panoramic-radiographs-and-ct-scans-in-patients-with-malignancies-after-radiotherapy
#14
JOURNAL ARTICLE
Walla Samara, Omid Moztarzadeh, Jan Pernicky, Nasimeh Baghalipour, Mohammad Najeh Samara, Jiri Gencur, Lukas Hauer
BACKGROUND/AIM: This study aimed to identify the progression of carotid artery stenosis (CAS) in patients with head and neck cancer following radiation therapy (RT) by characterizing associated risk factors. PATIENTS AND METHODS: Panoramic radiographs (OPG), computed tomography (CT) scans, cone-beam CT (CBCT) scans, and ultrasonography (US) of 69 patients with head and neck tumors were selected and analyzed to identify the presence of CAS. Data on tumor location, smoking status, hypertension (HTN), hyperlipidemia (HLD), diabetes mellitus (DM), and treatment were collected from the patients' medical records...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030200/disparities-in-time-to-treatment-for-skin-cancer
#15
JOURNAL ARTICLE
Syeda Hoorulain Ahmed, Harsheen Kaur Manaise, Reed Popp, Seema Sharan, Shivam Bansal, Kulkaew Belle Sukniam, Swathi R Raikot, Gabrielle Kowkabany, Paola Berrios Jimenez, Kyle Popp, Fatima Mubarak, Anthony George, Emmanuel Gabriel
BACKGROUND/AIM: Skin cancer is the most common cancer worldwide. This study aimed to identify factors contributing to the disparities in skin cancer treatment. PATIENTS AND METHODS: Data from The National Cancer Database (NCDB) spanning 2004 to 2019 were utilized. Variables including age, sex, race, Hispanic origin, Charlson-Deyo Comorbidity (CDC) score, geographic location, insurance status, income, grade and stage of cancer, and type of treatment facility impacting the time to treatment, surgery, radiation, and chemotherapy were analyzed...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030199/organ-specific-tumor-response-to-avelumab-maintenance-therapy-for-advanced-urothelial-carcinoma-a-multicenter-retrospective-study
#16
JOURNAL ARTICLE
Nobuki Furubayashi, Akinori Minato, Toshihisa Tomoda, Yoshifumi Hori, Keijiro Kiyoshima, Takahito Negishi, Yusuke Haraguchi, Toshiki Koga, Kentaro Kuroiwa, Naohiro Fujimoto, Motonobu Nakamura
BACKGROUND/AIM: The organ-specific therapeutic effects of avelumab for the maintenance treatment of advanced urothelial carcinoma (UC) are unclear. PATIENTS AND METHODS: Patients who received avelumab for advanced UC that had not progressed with first-line platinum-based chemotherapy and who had measurable disease were retrospectively analyzed. The organ-specific response was evaluated, and progression-free survival (PFS) and overall survival (OS) were estimated...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030198/simvastatin-induces-autophagy-and-inhibits-proliferation-in-prostate-cancer-cells
#17
JOURNAL ARTICLE
Yoshiyuki Miyazawa, Yoshitaka Sekine, Daisuke Oka, Shun Nakazawa, Yusuke Tsuji, Hiroshi Nakayama, Kazuhiro Suzuki
BACKGROUND/AIM: Statin has recently been studied for its effects on inducing cell death and inhibiting metastasis. Nevertheless, the precise mechanism of its anti-tumor effect is not yet fully understood. We conducted research on statin as a novel treatment for castration-resistant prostate cancer (CRPC). This study focused on autophagy in prostate cancer cells and assessed the effects of simvastatin. MATERIALS AND METHODS: After administering simvastatin to PC-3 cells, we conducted a microarray analysis...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030197/the-clinical-influence-of-geriatric-nutritional-risk-index-in-patients-with-gastric-cancer-who-receive-curative-treatment
#18
JOURNAL ARTICLE
Toru Aoyama, Yukio Maezawa, Itaru Hashimoto, Kentaro Hara, Keisuke Kazama, Masakatsu Numata, Sho Sawazaki, Hiroshi Tamagawa, Ayako Tamagawa, Masato Nakazono, Kenki Segami, Haruhiko Cho, Minori Tateishi, Tomoyuki Minami, Shinsuke Nagasawa, Keisuke Komori, Aya Kato, Kazuki Otani, Shinnosuke Kawahara, Takashi Oshima, Norio Yukawa, Aya Saito, Yasushi Rino
BACKGROUND/AIM: We evaluated the clinical impact of the Geriatric Nutritional Risk Index (GNRI) in patients who received curative treatment and perioperative adjuvant treatment. We also investigated the association between the GNRI and the clinicopathological features of patients with GC. PATIENTS AND METHODS: This study included 280 patients who underwent curative treatment for GC between 2005 and 2020. The prognosis and clinicopathological parameters of the high-GNRI and low-GNRI groups were compared...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030196/lncrna-sema3b-as1-inhibits-mir-513c-5p-to-regulate-the-progression-of-triple-negative-breast-cancer
#19
JOURNAL ARTICLE
Haizhen Yu, Yang Wu, Jianyuan Huang, Shizhen Li
BACKGROUND/AIM: Triple-negative breast cancer (TNBC) is the most malignant breast cancer subtype with a short survival time and high morality. There is an urgent need for effective indicators able to predict tumor progression and provide reference for adjusting the therapeutic strategy of TNBC. lncRNA semaphorin 3B antisense RNA1-AS1 (SEMA3B-AS1) was previously identified to be correlated with the stemness and autophagy of breast cancer. SEMA3B-AS1's role in TNBC was investigated in the present study, aiming to explore a novel biomarker for the development and prognosis of TNBC...
December 2023: Anticancer Research
https://read.qxmd.com/read/38030195/ramucirumab-plus-paclitaxel-as-a-second-line-chemotherapy-in-older-adults-with-advanced-gastric-cancer-ycog1601
#20
JOURNAL ARTICLE
Sho Sato, Chikara Kunisaki, Yuko Tamura, Akikazu Yago, Kohei Kasahara, Tsutomu Sato, Hiroki Kondo, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo
BACKGROUND/AIM: Ramucirumab plus paclitaxel has been widely used as a second-line chemotherapy for treating advanced gastric cancer. However, the real-world data of this regimen for older patients with gastric cancer (GC) remains unrevealed. The aim of this study was to clarify the feasibility and efficacy of this regimen for older patients with GC in a single-arm, phase II study. PATIENTS AND METHODS: Patients aged ≥70 years having unresectable or recurrent GC who met the eligible criteria were enrolled...
December 2023: Anticancer Research
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