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Anticancer Research

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https://read.qxmd.com/read/30711999/combination-of-serum-albumin-and-cholinesterase-levels-as-prognostic-indicator-in-patients-ith-colorectal-cancer
#1
Manabu Yamamoto, Hiroaki Saito, Chihiro Uejima, Akimitsu Tanio, Yoichiro Tada, Tomoyuki Matsunaga, Teruhisa Sakamoto, Soichiro Honjo, Keigo Ashida, Yoshiyuki Fujiwara
BACKGROUND/AIM: Nutritional status is strongly associated with cancer prognosis. The aim of this study was to identify the most useful combination of nutrition-related serum markers for predicting prognosis of patients with colorectal cancer (CRC). PATIENTS AND METHODS: A total of 523 patients who underwent proctocolectomies for CRC at our hospital were enrolled in this study. Serum concentrations of albumin, cholinesterase and total cholesterol, and total peripheral lymphocyte count (TLC) were used as nutrition-related markers...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711998/serum-ca-19-9-levels-in-patients-with-benign-and-malignant-disease-correlation-with-the-serum-protein-electrophoretic-pattern
#2
Simon Gundín-Menéndez, Victor Molina Santos, Marina Parra-Robert, Xavier Filella Pla, Josep M Auge Fradera, Rafael Molina Porto
AIM: To confirm that the carbohydrate antigen 19.9 (CA 19.9) protein can be evaluated by determining changes in the β2 zone in protein electrophoresis. MATERIALS AND METHODS: A total of 75 patients (64 with cancer, 11 with benign diseases) with abnormal serum CA 19.9 level were included. RESULTS: Patients with cancer had significantly higher serum CA 19.9 concentrations than those with benign diseases (p<0.001). Similar CA 19.9 levels were observed in patients with normal (median 1129 U/ml), weakly positive (median 699 U/ml) and positive (2333 U/ml) β2 fraction in protein electrophoresis...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711997/influence-of-postoperative-surgical-complications-after-gastrectomy-on-body-weight-and-body-composition-changes-in-patients-with-gastric-cancer
#3
Toru Aoyama, Takaki Yoshikawa, Yukio Maezawa, Kenki Segami, Kazuki Kano, Masakatsu Numata, Takanobu Yamada, Hiroshi Tamagawa, Hirohito Fujikawa, Keisuke Komori, Tsutomu Hayashi, Tsutomu Sato, Norio Yukawa, Yasushi Rino, Munetaka Masuda, Takashi Ogata, Haruhiko Cho, Takashi Oshima
BACKGROUND: Body weight, especially lean body mass, significantly decreases after gastrectomy. Postoperative surgical complications are a major risk factor for changes in body weight and body composition after gastrectomy. However, the influence of postoperative surgical complications after gastrectomy on body weight and body composition changes remains unclear. PATIENTS AND METHODS: This retrospective study examined patients who underwent curative surgery for gastric cancer between May 2010 and February 2017...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711996/clinical-outcomes-of-42-renal-cell-carcinoma-patients-with-metastases-solely-to-the-lung-who-received-sorafenib-as-second-line-systemic-therapy
#4
Hideaki Miyake, Yuto Matsushita, Hiromitsu Watanabe, Keita Tamura, Daisuke Motoyama, Toshiki Ito, Takayuki Sugiyama, Atsushi Otsuka
BACKGROUND/AIM: In renal cell carcinoma (RCC), sorafenib was the first targeted agent demonstrating a definitive benefit in a large phase III clinical trial. The objective of this study was to assess the clinical outcomes of 42 consecutive RCC patients with metastases solely to the lung who received sorafenib as a second-line systemic agent. PATIENTS AND METHODS: Of the 42 patients, 14 (33.3%) and 28 (66.7%) received cytokine therapy and sunitinib, respectively, prior to treatment with sorafenib...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711995/trastuzumab-with-s-1-plus-cisplatin-in-her2-positive-advanced-gastric-cancer-without-measurable-lesions-ogsg-1202
#5
Shunji Endo, Yukinori Kurokawa, Makio Gamoh, Yutaka Kimura, Jin Matsuyama, Hirokazu Taniguchi, Atsushi Takeno, Ryohei Kawabata, Junji Kawada, Toru Masuzawa, Kazuyoshi Yamamoto, Kouji Kobayashi, Daisuke Sakai, Toshio Shimokawa, Taroh Satoh
BACKGROUND/AIM: Trastuzumab with S-1 plus cisplatin was proved to be effective for human epidermal growth factor receptor type 2 (HER2)-positive advanced gastric cancer with measurable lesions. However, the efficacy and safety of this regimen in the absence of measurable lesions are unknown. PATIENTS AND METHODS: Patients with HER2-positive gastric cancer without measurable lesions received cisplatin plus trastuzumab intravenously on day 1 and oral S-1 on days 1-14 of a 21-day cycle...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711994/prognostic-significance-of-the-c-reactive-protein-to-albumin-ratio-in-patients-with-metastatic-colorectal-cancer-treated-with-trifluridine-thymidine-phosphorylase-inhibitor-as-later-line-chemotherapy
#6
Masatsune Shibutani, Hisashi Nagahara, Tatsunari Fukuoka, Yasuhito Iseki, Shinji Matsutani, E N Wang, Kiyoshi Maeda, Kosei Hirakawa, Masaichi Ohira
BACKGROUND/AIM: New drugs for metastatic colorectal cancer (mCRC) have been recently developed for use in later-line chemotherapy and have contributed to further prolongation of the survival of patients. However, in later-line chemotherapy, treatment failure may lead to discontinuation of chemotherapy and the transition to best supportive care. Therefore, a biomarker able to predict the effects of later-line chemotherapy is required. The C-reactive protein-to-albumin ratio (CAR), which is an inflammatory marker, has been reported to correlate with therapeutic outcome in patients with mCRC who underwent first-line chemotherapy...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711993/uptake-of-18-f-fluorodeoxyglucose-in-major-salivary-gland-cancer-predicts-survival-adjusting-for-pathological-stage
#7
Hidenori Suzuki, Tsuneo Tamaki, Masami Nishio, Hoshino Terada, Daisuke Nishikawa, Yusuke Koide, Shintaro Beppu, Nobuhiro Hanai
AIM: To investigate whether 18 F-fluorodeoxyglucose uptake is associated with overall survival in patients with major salivary gland cancer using univariate and multivariate analyses after adjusting for pathological stage (eighth edition of the International Union Against Cancer). PATIENTS AND METHODS: A total of 32 patients with major salivary gland cancer treated with curative surgery were enrolled. Parameters for 18 F-fluorodeoxyglucose uptake were assessed by positron-emission tomography combined with computed tomography...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711992/leptomeningeal-gliomatosis-a-single-institution-study-of-31-patients
#8
Didier Autran, Maryline Barrie, Mona Matta, Colette Monserrat, Chantal Campello, Gregorio Petrirena, Celine Boucard, Laetitia Padovani, Anderson Loundou, Romain Appay, Thomas Graillon, Henry Dufour, Dominique Figarella-Branger, Olivier Chinot, Emeline Tabouret
BACKGROUND/AIM: Secondary leptomeningeal gliomatosis (LG) is a rare and severe progression pattern of glioma. Our objective was to evaluate the characteristics and outcome of patients with LG. PATIENTS AND METHODS: We retrospectively reviewed 31 patients diagnosed with secondary LG. At the time of LG diagnosis, the median age of patients was 45 years. The histological grade was IV in 20 patients and II to III in 11 patients. As a first-line of therapy for LG, 22 patients received an oncological treatment: i) BCNU-temozolomide (TMZ) (n=15), ii) other type of chemotherapy (n=7), and iii) no treatment (supportive care) (n=9)...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711991/evaluation-of-tolerability-of-trifluridine-tipiracil-combination-tablet-in-patients-with-advanced-recurrent-colorectal-cancer
#9
Michio Kimura, Eiseki Usami, Hitomi Teramachi, Tomoaki Yoshimura
AIM: This study aimed to clarify the tolerability of a trifluridine/tipiracil combination tablet (TAS-102) in patients with advanced or recurrent colorectal cancer over 75 years of age. PATIENTS AND METHODS: Patients were divided into groups under the age of 75 years (n=62), and 75 years and over (n=17). The treatment period with TAS-102 tablet, reasons for discontinuation, adverse events (AEs), and overall survival (OS) were compared between the groups. RESULTS: The incidence of AEs (including neutropenia, anemia, nausea, malaise, and anorexia) was similar for both groups and the treatment enforcement periods for different regimens were not statistically significant between the groups (p=0...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711990/gastric-lavage-malignant-cells-ygl-and-hypohemoglobinemia-yanemia-as-new-systems-of-tumor-regression-grading-and-prognostic-prediction-for-gastric-cancer-after-neoadjuvant-treatment
#10
Edoardo Virgilio, Enrico Giarnieri, Maria Rosaria Giovagnoli, Monica Montagnini, Antonella Proietti, Rosaria D'Urso, Alessandra Fegiz, Paolo Mercantini, Genoveffa Balducci, Marco Cavallini
BACKGROUND/AIM: Although reckoned necessary for survival benefit, neoadjuvant chemotherapy (NAC) of gastric cancer (GC) patients has so far provided questionable results. Consequently, searching for new and clearer systems of response to NAC, post-NAC re-evaluation and prognostic prediction appears essential. The purpose of this study was to examine endogastric cytopathology and hemoglobin level count as new features, potentially useful for GC patients after NAC. PATIENTS AND METHODS: Between April 2012 and October 2018, 21 of 116 patients with resectable GC received NAC and were investigated for the presence of free-floating malignant cells in their gastric lavage (yGL1) and the development of hypohemoglobinia (yAnemia)...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711989/use-of-a-reinforced-triple-row-stapler-following-distal-pancreatectomy-reduces-the-incidence-of-postoperative-pancreatic-fistula-in-patients-with-a-high-bmi
#11
Hiromichi Kawaida, Hiroshi Kono, Hidetake Amemiya, Naohiro Hosomura, Ryo Saito, Kazunori Takahashi, Atsushi Yamamoto, Mitsuaki Watanabe, Shinji Furuya, Hiroki Shimizu, Hidenori Akaike, Yoshihiko Kawaguchi, Makoto Sudo, Masanori Matusda, Jun Itakura, Hideki Fujii, Daisuke Ichikawa
BACKGROUND/AIM: Although perioperative management and operative techniques for pancreatic surgery have improved, postoperative pancreatic fistula (POPF) remains the major cause of morbidity and mortality following distal pancreatectomy (DP). The purpose of this study was to evaluate the superiority of the reinforced stapler compared to the bare triple row stapler. PATIENTS AND METHODS: A total of 93 patients who underwent DP at the First Department of Surgery at Yamanashi University were examined...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711988/prognostic-value-of-adjuvant-chemotherapy-following-pancreaticoduodenectomy-in-elderly-patients-with-pancreatic-cancer
#12
Sang Hyun Shin, Yejong Park, Dae Wook Hwang, Ki Byung Song, Jae Hoon Lee, Jaewoo Kwon, Changhoon Yoo, Shadi Alshammary, Song Cheol Kim
BACKGROUND/AIM: The aim of this study was to investigate the relationship between age and long-term survival among patients who underwent pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC). PATIENTS AND METHODS: A total of 916 patients who underwent PD for curative resection of PDAC were included in this study. Patients were divided into younger (n=726, <70 years) and older (n=190, ≥70 years), and the overall survival (OS) between the two groups was compared...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711987/usefulness-of-implementing-comprehensive-pharmaceutical-care-for-metastatic-renal-cell-carcinoma-outpatients-treated-with-pazopanib
#13
Maki Todo, Suguru Shirotake, Koshiro Nishimoto, Yota Yasumizu, Gou Kaneko, Hideyuki Kondo, Takashi Okabe, Hideki Makabe, Masafumi Oyama
BACKGROUND: Pazopanib is an effective treatment option for renal cell carcinoma (RCC). However, the therapy is often limited by the appearance of adverse events (AEs), including nausea/vomiting, hepatic impairment, hand-foot syndrome, diarrhea, hypertension and oral mucositis. Early management of AEs is, therefore, extremely important in order to maximize treatment outcomes. PATIENTS AND METHODS: This non-randomized controlled before-and-after study was carried out to evaluate the effectiveness of our comprehensive pharmaceutical interventions in 37 outpatients receiving pazopanib for RCC (experimental group)...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711986/significance-of-lateral-pelvic-lymph-node-size-in-predicting-metastasis-and-prognosis-in-rectal-cancer
#14
Dongha Lee, Takeru Matsuda, Kimihiro Yamashita, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Takumi Fukumoto, Yoshihiro Kakeji
AIM: To evaluate the clinical significance of lateral pelvic lymph node (LLN) size in predicting pathological metastasis and prognosis in rectal cancer treated with preoperative chemoradiotherapy (CRT) followed by surgery. PATIENTS AND METHODS: Fifty-two patients with rectal cancer who underwent curative surgery after preoperative CRT were included. Fifteen patients underwent total mesorectal excision (TME) alone, while 37 patients underwent TME with LLN dissection for clinical LLN metastasis...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711985/adverse-effects-of-preoperative-sarcopenia-on-postoperative-complications-of-patients-with-gastric-cancer
#15
Tatsuro Tamura, Katsunobu Sakurai, Mikio Nambara, Yuichiro Miki, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Masaichi Ohira
BACKGROUND: Sarcopenia is known to have an important influence on postoperative complications in several diseases, and on the prognosis of patients with cancer. However, whether sarcopenia is associated with complications and prognosis after gastrectomy in patients with gastric cancer remains controversial. This study evaluated the impact of the preoperative muscle mass on postoperative complications of gastric cancer surgery. MATERIALS AND METHODS: The muscle mass of 153 patients who underwent gastrectomy for gastric cancer from January 2014 to August 2016 was assessed before surgery by a multifrequency bioelectrical impedance analysis (In Body 3...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711984/postoperative-pneumonia-after-esophagectomy-and-systemic-inflammatory-response-syndrome
#16
Shinichi Asaka, Takeshi Shimakawa, Kentaro Yamaguchi, Takao Katsube, Takebumi Usui, Hajime Yokomizo, Shunichi Shiozawa, Yoshihiko Naritaka
BACKGROUND/AIM: The aim of this study was to determine the association between post-esophagectomy pneumonia and the presence of pathogenic organisms in the sputum or pharynx and postoperative systemic inflammatory response syndrome (SIRS). MATERIALS AND METHODS: This retrospective study included 98 patients diagnosed with esophageal cancer who had undergone esophagectomy. RESULTS: Postoperative pneumonia was observed in 24 patients (24.5%)...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711983/impact-of-metabolic-parameters-of-18-f-fluorodeoxyglucose-positron-emission-tomography-after-hepatic-resection-in-patients-with-intrahepatic-cholangiocarcinoma
#17
Norifumi Harimoto, Kouki Hoshino, Ryo Muranushi, Kei Hagiwara, Takahiro Yamanaka, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Hiroshi Tanaka, Akira Watanabe, Norio Kubo, Kenichirou Araki, Hiroyasu Tomonaga, Tetsuya Higuchi, Yoshito Tsushima, Ken Shirabe
BACKGROUND: The aim of this study was to identify the prognostic impact of metabolic parameters of 18 F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) in patients with intrahepatic cholangiocarcinoma (IHCC) undergoing hepatic resection. PATIENTS AND METHODS: Twenty-four patients with IHCC who underwent surgical resection were enrolled and 18 F-FDG PET parameters maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured, as well as overall and recurrence-free survival...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711982/impact-of-repeated-hepatectomy-on-liver-regeneration-in-hepatocellular-carcinoma-a-propensity-score-based-analysis
#18
Kota Arima, Hidetoshi Nitta, Toru Beppu, Shigeki Nakagawa, Hirohisa Okabe, Katsunori Imai, Akira Chikamoto, Yo-Ichi Yamashita, Yasuyuki Yamashita, Hideo Baba
BACKGROUND: Repeated hepatectomy is one of the most curative treatments for recurrent hepatocellular carcinoma (HCC). However, it is not clear whether the remnant liver has the same regenerative ability in repeated hepatectomy. This study assessed the regenerative ability of remnant liver after primary and secondary hepatectomy. PATIENTS AND METHODS: This study retrospectively assessed 118 patients who underwent curative anatomical liver resection for HCC. The liver regeneration rate (LRR) was calculated by SYNAPSE-VINCENT based on dynamic computed tomography before and 1 month after liver resection...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711981/low-molecular-weight-protein-tyrosine-phosphatase-is-a-possible-biomarker-for-predicting-postoperative-biochemical-recurrence-in-prostate-cancer-with-negative-surgical-margins
#19
Hirofumi Kurose, Kosuke Ueda, Reiichiro Kondo, Sachiko Ogasawara, Hironori Kusano, Sakiko Sanada, Yoshiki Naito, Jun Akiba, Tatsuyuki Kakuma, Tsukasa Igawa, Hirohisa Yano
BACKGROUND/AIM: For prostate cancer, positive surgical margins are considered an important predictor of biochemical recurrence. However, biochemical recurrence is observed in approximately 20% of cases, even with negative surgical margins, and some cases require salvage therapy. The elevated expression of low-molecular-weight protein tyrosine phosphatase (LMW-PTP, MW 18 kDa) is associated with a poor prognosis of certain cancers. In this study, we investigated whether the LMW-PTP expression levels could be used as a biomarker of recurrence in prostate cancer with negative surgical margins...
February 2019: Anticancer Research
https://read.qxmd.com/read/30711980/county-median-family-income-is-an-independent-prognostic-factor-for-stage-iv-anaplastic-thyroid-cancer
#20
M U Li, Sophi Gu, Rui Mao, Ying Ning, Nitin Trivedi, Ahmad Siddiqui, Pengyang Li, Lihong Huo
BACKGROUND/AIM: Advanced anaplastic thyroid cancer (ATC) is a rare, but highly aggressive malignancy, and its prognostic factors need to be further explored. We examined socioeconomic factors' predictive effect for survival performance in stage IV ATC patients. MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results database, we collected 1,048 cases with stage IV anaplastic thyroid cancer (ATC) from 2004 to 2015. Demographic, clinical, and socioeconomic factors were evaluated using univariate and multivariate analyses...
February 2019: Anticancer Research
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