journal
https://read.qxmd.com/read/37247938/metabolic-changes-in-blood-derived-extracellular-vesicles-of-malnourished-breast-cancer-patients
#1
JOURNAL ARTICLE
Judith Buentzel, Matthias Schulz, Lena Aperdannier, Annalen Bleckmann, Claudia Binder
BACKGROUND/AIM: Cancer cachexia describes a multifactorial wasting syndrome marked by a metabolic imbalance leading to the loss of muscle and fat tissue. Extracellular vesicles (EV) provide unique insights into their parental cells' metabolism. The value of these vesicles as diagnostic tools in cancer cachexia has not been investigated so far. PATIENTS AND METHODS: A previously analyzed metabolomics dataset on large EV from breast cancer patients was used for analyzing the metabolomic changes in patients with malnutrition...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247937/the-suppressive-effect-of-rebastinib-on-triple-negative-breast-cancer-tumors-involves-multiple-mechanisms-of-action
#2
JOURNAL ARTICLE
Kunxian Feng, Chengfang Jian, Haihua Xiao, Huangyu Jiang, Jinping Yang, Mengli Yang, Andre Sun, Wenming Song, Alexander V Chestkov, Natalya I Vasilevich, Lichun Sun
BACKGROUND/AIM: High resistance of triple-negative breast cancer has prompted scientists to look for new targets susceptible to treatment. CDK16 has been suggested as a promising target whose inhibition can lead to tumor growth suppression. Rebastinib, a potent inhibitor of CDK16, has been reported to exhibit anti-tumor activity both in vitro and in vivo. MATERIALS AND METHODS: The anticancer activity of rebastinib was studied in vitro using cell proliferation, cell cycle arrest and cell apoptosis assays and in vivo in xenograft tumor models using MDA-MB-231 and MDA-MB-468-derived tumors...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247936/successful-treatment-of-refractory-enterocutaneous-fistula-after-esophagectomy-using-soft-coagulation-by-an-endoscopic-and-percutaneous-approach-a-case-report
#3
JOURNAL ARTICLE
Shuhei Ito, Kippei Ohgaki, Tetsuro Kawazoe, Huanlin Wang, Yasuharu Okamoto, Eisuke Adachi, Yoichi Ikeda
BACKGROUND/AIM: Anastomotic leakage (AL) is a serious complication after esophagectomy, and the refractory fistula (RF) following AL is therapeutically challenging with no optimal management strategies known. Thus, new therapeutic options are required for treating RF. CASE REPORT: A 67-year-old man who underwent endoscopic mucosal dissection was subjected to subtotal esophagectomy and reconstruction with a gastric tube through the retrosternal route with cervical anastomosis as additional therapy...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247935/clinicopathological-factors-influencing-resection-margin-involvement-during-mohs-micrographic-surgery-for-skin-tumors
#4
JOURNAL ARTICLE
Jinah Chu, Yumin Chung, Seoung Wan Chae, Young-Jun Choi, Hyun-Soo Kim, Sung-Im DO
BACKGROUND/AIM: Mohs micrographic surgery (MMS) is a specialized procedure for removing skin tumors. Intraoperative assessment of the resection margin (RM) status using frozen section examination is a crucial component of MMS. This study aimed to identify significant clinicopathological characteristics that could help surgeons determine the optimal surgical extent. PATIENTS AND METHODS: One hundred and fifty-one patients with primary skin tumors were included. The relationship between RM involvement and the clinico-pathological characteristics was analyzed for each histological type...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247934/clinical-significance-of-pre-treatment-circumferential-tumor-location-in-patients-with-cstage-ib-iii-esophageal-squamous-cell-cancer
#5
JOURNAL ARTICLE
Shinsuke Nagasawa, Takashi Oshima, Kentaro Hara, Masato Nakazono, Yuta Kumazu, Toru Aoyama, Takanobu Yamada, Takashi Ogata, Yasushi Rino, Aya Saito, Tomoyuki Yokose, Heike I Grabsch
BACKGROUND/AIM: To determine the clinical significance of pre-treatment circumferential tumor location within the esophageal wall in patients with locally advanced esophageal squamous cell carcinoma who underwent curative resection after neoadjuvant chemotherapy. PATIENTS AND METHODS: Patients (n=96) with cStage IB-III esophageal squamous cell carcinoma who underwent curative resection after neoadjuvant chemotherapy were categorized into two groups based on the circumferential tumor location within the esophageal wall on diagnostic endoscopy: left or anterior wall group (L/A patients, n=49); right or posterior wall group (R/P patients, n=47)...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247933/dose-dependent-effects-of-unintended-splenic-irradiation-after-neoadjuvant-radiochemotherapy-for-esophageal-cancer
#6
JOURNAL ARTICLE
Eren Celik, Christian Baues, Maike Trommer, Jiaqi Fan, Lukas Nadjiri, Johannes Rosenbrock, Philipp Linde
BACKGROUND/AIM: The aim of this study was to investigate the relationship between radiation exposure to the spleen, dose-dependent organ changes, and their possible influence on clinical and oncological outcome. Furthermore, to provide evidence and sensitivity for considering the spleen as an relevant organ at risk. PATIENTS AND METHODS: A total of 93 patients with carcinoma of the distal esophagus or gastroesophageal junction were selected for this retrospective study...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247932/role-of-1p-19q-codeletion-in-diffuse-low-grade-glioma-tumour-prognosis
#7
JOURNAL ARTICLE
Pietro Familiari, Pierfrancesco Lapolla, Veronica Picotti, Mauro Palmieri, Alessandro Pesce, Giulia Carosi, Michela Relucenti, Stefania Nottola, Francesca Gianno, Simone Minasi, Manila Antonelli, Alessandro Frati, Antonio Santoro, Giancarlo D'Andrea, Placido Bruzzaniti, Biagia LA Pira
BACKGROUND/AIM: In the latest 2021 WHO classification of central nervous system tumours (CNS), gliomas that present isocitrate dehydrogenase (IDH) mutations are defined as diffuse low-grade gliomas (DLGGs). IDH mutations are commonly observed in this tumour type. The Extent of Resection (EOR) positively influence survival; however, it is still debated whether the predictive value of EOR is independent of the 1p/19q co-deletion. We carried out a retrospective analysis on patients operated on for DLGG at the Sant'Andrea University Hospital Sapienza University of Rome, correlating the outcome with the presence of 1p/19q co-deletion and EOR...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247931/selective-inhibition-of-l-type-amino-acid-transporter-1-suppresses-cell-proliferation-in-ovarian-clear-cell-carcinoma
#8
JOURNAL ARTICLE
Masaki Sekine, Iemasa Koh, Kosuke Nakamoto, Suguru Nosaka, Katsuyuki Tomono, Jun Sugimoto, Yoshiki Kudo
BACKGROUND/AIM: Ovarian clear cell carcinoma (OCCC) is a histological type of ovarian cancer that is refractory to chemotherapy and has poor prognosis, which necessitates the development of novel treatment therapies. In this study, we focused on L-type amino acid transporter 1 (LAT1), which is involved in cancer growth, and investigated the effect of its selective inhibition on cell proliferation in OCCC. MATERIALS AND METHODS: The inhibitory effect of nanvuranlat (JPH203), a LAT1 selective inhibitor, on the cellular uptake of [3 H] leucine was evaluated using the OCCC cell line JHOC9, which expresses the LAT1 protein...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247930/clinical-outcomes-of-intensity-modulated-carbon-ion-radiotherapy-for-bone-and-soft-tissue-tumors
#9
JOURNAL ARTICLE
Yosuke Takakusagi, Hiroaki Koge, Kio Kano, Satoshi Shima, Keisuke Tsuchida, Nobutaka Mizoguchi, Daisaku Yoshida, Tadashi Kamada, Hiroyuki Katoh
BACKGROUND/AIM: Carbon-ion radiotherapy (CIRT) for bone and soft tissue tumors (BSTs) has been reported to have favorable clinical outcomes. Intensity-modulated CIRT (IMCT) techniques have been developed to further reduce dose delivery to adjacent organs compared to conventional CIRT. We retrospectively analyzed the clinical results of IMCT for BSTs and investigated treatment efficacy and toxicity. PATIENTS AND METHODS: This study included 9 consecutive BSTs patients who underwent IMCT at the Kanagawa Cancer Center from January 2016 to April 2021...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247929/possible-false-results-with-cobas-%C3%A2-egfr-mutation-test-v2-and-oncomine-dx-target-test-for-egfr-mutation
#10
JOURNAL ARTICLE
Kensuke Kanaoka, Akihiro Tamiya, Yuji Inagaki, Yoshihiko Taniguchi, Keiko Nakao, Maiko Takeda, Yoshinobu Matsuda, Kyoichi Okishio, Shigeki Shimizu
BACKGROUND/AIM: Disparities in the results of next-generation sequencing-based multiplex gene panel tests and those of single-gene tests when detecting epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC) have been reported. However, the possible underlying causes have not been investigated. The aim of this study was to explore the possibilities and causes of false results obtained using cobas® EGFR Mutation Test v2 (cobas® EGFR) and Oncomine Dx Target Test (ODxTT)...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247928/casein-kinase-2%C3%AE-augments-oxaliplatin-resistance-in-colorectal-cancer-cells-by-increasing-abce1-expression
#11
JOURNAL ARTICLE
Chul Won Yun, Jun Hee Lee, Sang Hun Lee
BACKGROUND/AIM: Antitumor drug resistance is a major hurdle in treating patients with malignant tumors. Casein kinase 2α (CK2α) expression is highly enhanced in oxaliplatin-resistant CRC cells. We investigated whether CK2α expression is associated with oxaliplatin resistance in CRC cells. MATERIALS AND METHODS: To determine the effect of CK2α on drug resistance in CRC, we assessed the cell viability, adenosine triphosphate-binding cassette (ABC) transporter expression, apoptosis, and sphere formation according to CK2α expression in oxaliplatin-resistant CRC cells...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247927/serum-starvation-induces-matrix-metalloproteinase-9-expression-in-nasopharyngeal-carcinoma-cells-through-the-erk-ap1-pathway-in-vitro
#12
JOURNAL ARTICLE
Yen-Ting Wu, Chung-Chi Hsu, Bu-Miin Huang, Yun-Ching Chang, Cheng-Han Lin, Yu-Yan Lan
BACKGROUND/AIM: Although clinical medicine has significantly progressed in treating nasopharyngeal carcinoma (NPC) in recent years, many patients still have poor prognoses due to distant metastasis. It is still relatively unclear why NPC has a highly metastatic ability. Especially whether the tumor microenvironment affects the invasion and metastasis of NPC still needs to be cleared. In this study, serum starvation was used to simulate nutrient deficiency in the tumor microenvironment to explore whether nutrient deficiency affects the malignancy of NPC cells...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247926/pancreatic-stromal-cell-derived-oncostatin-m-confers-drug-resistance-to-a-multi-tyrosine-kinase-inhibitor-in-pancreatic-cancer-cells
#13
JOURNAL ARTICLE
Daisuke Tatsuda, Junjiro Yoshida, Tomokazu Ohishi, Manabu Kawada
BACKGROUND/AIM: Pancreatic cancer is known to have one of the worst prognoses of all cancers, and its tumor cells are highly resistant to chemotherapeutic drugs. Pancreatic cancer cells coexist with stromal cells; however, their involvement in anticancer drug resistance remains poorly understood. Thus, in this study, we analyzed drug sensitivity using an in vitro co-culture system containing pancreatic cancer cells and stromal cells treated with a compound library. MATERIALS AND METHODS: We examined the viability of the pancreatic cancer cell lines BxPC-3, Capan-1, and Panc-1 against compounds in an in vitro co-culture model containing pancreatic stromal cells (PSCs) and analyzed the protein expression for drug resistance by western blotting...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247925/clinicopathological-characteristics-and-prognosis-of-mucinous-gastric-cancer
#14
JOURNAL ARTICLE
Keisuke Komori, Kazuki Kano, Shuji Ando, Hayato Watanabe, Kosuke Takahashi, Yukio Maezawa, Hirohito Fujikawa, Sho Sawazaki, Masakatsu Numata, Toru Aoyama, Takanobu Yamada, Hiroshi Tamagawa, Norio Yukawa, Yasushi Rino, Takashi Ogata, Takashi Oshima
BACKGROUND/AIM: Mucinous gastric carcinoma (MGC) has a poor prognosis. Due to the differences in clinicopathology factors between MGC and non-MGC (NMGC), it is difficult to compare them. In this study, we compared the clinicopathological characteristics and prognosis of MGC and NMGC patients. PATIENTS AND METHODS: For gastric carcinoma (GC), 3,042 gastrectomy patients were included in the study and divided into the MGC (n=86) and NMGC (n=2,956) groups. The characteristics and prognoses of patients in both groups were compared before and after (both groups, n=86) propensity score matching...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247924/robotic-retroperitoneal-versus-transperitoneal-partial-nephrectomy-outcomes-and-learning-curve
#15
JOURNAL ARTICLE
Nicolas Fischer, Tobias Kowalke, Manuela A Hoffmann, Daniel Porres
BACKGROUND/AIM: The robotic retroperitoneal approach for renal mass surgery was introduced in 2018 at the Department of Urology in the clinic of Leverkusen, Germany. Clinical criteria for the choice of the access site (trans- vs. retroperitoneal) are not clearly defined. The aim of this study was to explore the learning curve and the impact of the access site on clinical outcome, in order to elucidate which preoperative clinical criteria should be taken into account when choosing the renal approach site...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247923/-kras-mutation-analysis-using-cell-free-dna-of-pancreatic-cancer
#16
JOURNAL ARTICLE
Yorihiko Takase, Yoshiki Naito, Akihiko Kawahara, Yoshinobu Okabe, Eiji Sadashima, Hideyuki Abe, Jun Akiba
BACKGROUND/AIM: Detection of pancreatic cancer using small samples of the pancreas obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) remains a challenge. The purpose of this study was to investigate whether the detection of KRAS mutations in cell-free DNA (cfDNA) extracted from supernatants of liquid-based fixed cytology (LBC) specimens obtained using EUS-FNA in solid pancreatic cancer can be an auxiliary test for differential diagnosis. The purpose of this study was to investigate whether the detection of KRAS mutations in cell-free DNA (cfDNA) extracted from supernatants of liquid-based fixed cytology (LBC) specimens obtained using EUS-FNA in solid pancreatic cancer can be an auxiliary test for differential diagnosis...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247922/development-of-anti-gd2-antibody-producing-mesenchymal-stem-cells-as-cellular-immunotherapy
#17
JOURNAL ARTICLE
Masafumi Iguchi, Shigeki Yagyu, Kosuke Kambe, Mayumi Higashi, Shigehisa Fumino, Tsunao Kishida, Tomoko Iehara, Osam Mazda, Tatsuro Tajiri
BACKGROUND/AIM: Using the tyrosine hydroxylase (TH)-MYCN mouse neuroblastoma (NB) model, we have previously reported the accumulation of mouse mesenchymal stem cells (mMSCs) on tumors in vivo and the antitumor effect of mMSCs transfected with a small molecule (IFN-β) expression gene. In this study, we have developed novel MSCs secreting anti-disialoganglioside GD2 antibody (anti-GD2-MSCs) and evaluated their antitumor effects in vitro. MATERIALS AND METHODS: We generated an anti-GD2 antibody construct (14...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247921/attenuative-effect-of-diallyl-trisulfide-on-caspase-activity-in-tnf-%C3%AE-induced-triple-negative-breast-cancer-cells
#18
JOURNAL ARTICLE
Konan J W Kanga, Lambert H B Kanga, Patricia Mendonca, Karam F A Soliman, Dominique T Ferguson, Sarah L Reed, Selina Darling-Reed
BACKGROUND/AIM: Diallyl trisulfide (DATS) has been shown to prevent and inhibit carcinogenesis in cancer cells. We have previously shown DATS's ability to decrease the percentage of viable cells, inhibit cell migration and modulate genes involved in the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and mitogen-activated protein kinase (MAPK) signaling. MATERIALS AND METHODS: This study aimed to compare the efficacy of DATS in tumor necrosis factor alpha (TNF-α) induced MDA-MB-231 and MDA-MB-468 cells and investigate its role in cell-death signaling via cell cycle, flow cytometry, and caspase assay...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247920/cd44-positive-cancer-stem-like-cells-as-a-potential-source-of-peritoneal-metastasis-after-surgery
#19
JOURNAL ARTICLE
Andreas Michael Sihombing, Satoshi Murata, Miyuki Shimoji, Toru Miyake, Katsushi Takebayashi, Hirokazu Kodama, Aya Tokuda, Masatsugu Kojima, Tomoyuki Ueki, Naomi Kitamura, Mina Kitamura, Eiji Mekata, Masaji Tani
BACKGROUND/AIM: The role of CD44 in gastric cancer-derived peritoneal metastasis is currently unknown. It was previously shown that viable, tumorigenic cancer cells are spilled into the peritoneal cavity during surgery, providing a potential cause of peritoneal recurrence after surgery. The purpose of this study was to elucidate the mechanism of peritoneal metastasis of gastric cancer through the expression of CD44 and to propose a method for preventing peritoneal recurrence. MATERIALS AND METHODS: Gastric cancer cell line MKN-45 was sorted into CD44+ and CD44- cells and then injected intraperitoneally into NOD/ShiJic-scidJcl mice...
June 2023: Anticancer Research
https://read.qxmd.com/read/37247919/impact-of-radiation-dose-on-treatment-of-maxillary-cancer-with-superselective-intra-arterial-cisplatin-with-radiotherapy
#20
JOURNAL ARTICLE
Kenta Konishi, Mika Kamiya, Keiichi Ohira, Masanori Hirata, Kohei Wakabayashi, Tsutomu Ikenohira, Takashi Kosugi, Takasuke Ushio, Atsushi Imai, Daiki Mochizuki, Yuki Yamaguchi, Yukichi Tanahashi, Kiyoshi Misawa, Satoshi Goshima, Katsumasa Nakamura
BACKGROUND/AIM: Maxillary sinus cancer is a relatively rare disease, and treatment is still evolving. We compared the efficacy of superselective intra-arterial infusion of high-dose cisplatin (CDDP) with concomitant radiotherapy (RADPLAT) using three-dimensional conformal radiotherapy (3DCRT) or intensity-modulated radiotherapy (IMRT) and analyzed the relationship between the total radiation dose and the treatment outcome in localized maxillary sinus cancer. PATIENTS AND METHODS: We reviewed the cases of 58 patients with localized maxillary sinus cancer treated with RADPLAT at our institution from March 2004 to November 2020...
June 2023: Anticancer Research
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