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Bioscience Reports

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https://read.qxmd.com/read/30782785/the-selective-hdac6-inhibitor-nexturastat-a-induces-apoptosis-overcomes-drug-resistance-and-inhibits-tumor-growth-in-multiple-myeloma
#1
Xiaoyang Sun, Yu Xie, Xiaoshen Sun, Yao Yao, Hujun Li, Zhenyu Li, Ruosi Yao, Kailin Xu
Multiple myeloma (MM) is a hematological malignancy of plasma cells that produce a monoclonal immunoglobulin protein. Despite significant advances in the treatment of MM, challenges such as resistance to therapy remain. Currently, inhibition of histone deacetylases (HDACs) is emerging as a potential method for treating cancers. Numerous HDAC inhibitors are being studied for use in monotherapy or in conjunction with other agents for MM. In this study, we investigated the anti-myeloma effect of Nexturastat A (NexA), a novel selective HDAC6 inhibitor...
February 19, 2019: Bioscience Reports
https://read.qxmd.com/read/30782784/investigation-of-dacomitinib-on-reducing-cell-necrosis-and-enhancing-cell-apoptosis-in-c6-glioma-rat-model-by-mri
#2
Wang-Sheng Chen, Lan Hong, Fei Wang, Jian-Jun Li
BACKGROUND: Glioma is one of the most epidemic and obstinate types of cancer in the central nervous system with poor survival rate. Dacomitinib inhibited cell viability and proliferation of  EGFR -amplified glioma. In the present study, the regional effects of Dacomitinib on tumor necrosis was investigated. METHODS: A C6 rat glioma model was evaluated using proton magnetic resonance spectroscopy (1H-MRS), diffusion weighted imaging (DWI), morphological T2-weighted imaging (T2W)...
February 19, 2019: Bioscience Reports
https://read.qxmd.com/read/30782783/the-association-of-foxp3-gene-polymorphisms-with-cancer-susceptibility-a-comprehensive-systemic-review-and-meta-analysis
#3
Yan Chen, Xiaoxue Qi, Ce Bian, Chen Ling, Tao Yi, Xiyan Mu, Xia Zhao
The role of forkhead box P3 (FOXP3) protein in tumorigenesis has long been controversial and existing data on the association between FOXP3 gene polymorphisms and cancer susceptibility were inconsistent. Here, we conducted a meta-analysis to better clarify the relationship. A comprehensive search of studies published from July 2008 to June 2018 was conducted. The statistical analyses of the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (95%CIs) were performed using the Revman 5.2 software...
February 19, 2019: Bioscience Reports
https://read.qxmd.com/read/30777932/akirin1-promotes-myoblast-differentiation-by-modulating-multiple-myoblast-differentiation-factors
#4
Wenqiang Sun, Shenqiang Hu, Jiwei Hu, Jiamin Qiu, Shuang Yang, Bo Hu, Xiang Gan, Hehe Liu, Liang Li, Jiwen Wang
Akirin1 is found to be involved in myoblast differentiation. However, the mechanism by which the Akirin1 gene regulates myoblast differentiation still remains unclear. In this study, we found that ectopic expression of Akirin1 promoted myoblast differentiation by increasing the expression of MRF4 and MEF2B mRNA. Additionally, we showed that ectopic Akirin1 induced cell cycle arrest by up-regulating p21 mRNA. To further uncover the mechanism by which Akirin1 promotes myoblast differentiation, we showed that the enhanced Akirin1 increased the mRNA expression of P38α...
February 18, 2019: Bioscience Reports
https://read.qxmd.com/read/30777931/the-terminalia-laxiflora-modulates-the-neurotoxicity-induced-by-fipronil-in-male-albino-rats
#5
A A Khalaf, Mona Galal, Marwa Ibrahim, A A Abd Allah, Mostafa M Afify, Rasha Refaat
The extensive use of fipronil (FPN) may trigger hazards to more than insects. The present investigation was carried out to evaluate the abrogating role of Terminalia laxiflora methanol extract against the neurotoxic effects provoked by FPN. Fourty male albino rats rats were assigned into four equal groups. The first group served as control, the second one was orally administered with FPN (10.5mg/kg BW), the third group was given combination of FPN and T.laxiflora methanol extract (TLE) (100 mg/kg BW) and the fourth one was orally given TLE...
February 18, 2019: Bioscience Reports
https://read.qxmd.com/read/30777930/opn-gene-locus-is-associated-with-the-risk-of-knee-osteoarthritis-a-case-control-study
#6
Houlai Shang, Yuedong Hao, Wenhao Hu, Xiaohui Hu, Qing Jin
BACKGROUND/AIMS: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). METHODS: The purpose of this case-control study was to investigate the association between OPN gene rs11730582 polymorphism and knee OA risk in a Chinese population. Genotyping was analyzed using standard polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). RESULTS: This study found that C allele or CC genotype of OPN gene rs11730582 polymorphism was related to decreased risk for knee OA...
February 18, 2019: Bioscience Reports
https://read.qxmd.com/read/30777929/mir-20a-5p-regulates-gemcitabine-chemosensitivity-by-targeting-rrm2-in-pancreatic-cancer-cells-and-serves-as-a-predictor-for-gemcitabine-based-chemotherapy
#7
Huimin Lu, Shan Lu, Dujiang Yang, Ling Zhang, Jun Ye, Mao Li, Weiming Hu
Ribonucleotide reductase subunit M2 ( RRM2 ) acts as an important gemcitabine resistance-related gene in pancreatic cancer (PC). Here, we aimed to investigate the potential microRNA which regulates gemcitabine chemosensitivity by targeting RRM2 and explore the clinical significance of candidate miRNA in PC. MTT assay and Western blot analysis revealed that long-time gemcitabine treatment in PC cells induced drug resistance and RRM2 increase, and silence of RRM2 blocked gemcitabine resistance. Among the predicted eight RRM2-related microRNAs, the expression of miR-20a-5p showed the most significant discrepancy between gemcitabine-resistant cells and parental cells...
February 18, 2019: Bioscience Reports
https://read.qxmd.com/read/30777928/association-between-adipoq-gene-variants-and-knee-osteoarthritis-in-a-chinese-population
#8
Houlai Shang, Yuedong Hao, Wenhao Hu, Xiaohui Hu, Qing Jin
A study from Thailand showed no significant association between the adiponectin (ADIPOQ) gene rs1501299 polymorphism and knee osteoarthritis (OA) risk. To investigate this association in a Chinese population, we conducted this case-control study involving 372 knee OA patients and 453 controls. Genotyping via standard polymerase chain reaction and restriction fragment length polymorphism showed that TT genotype (TT vs. GG: adjusted OR (95%CI) = 1.70(1.01-2.86)) or T allele (T vs. G: adjusted OR (95%CI) =1.26(1...
February 18, 2019: Bioscience Reports
https://read.qxmd.com/read/30777927/association-between-peroxisome-proliferator-activated-receptor-gamma-2-gene-pro12ala-polymorphisms-and-risk-of-hypertension-an-updated-meta-analysis
#9
Miao Zhang, Jianping Zhang, Lifeng Li, Qiang Wang, Limin Feng
Previous studies investigate the relationship between peroxisome proliferator-activated receptor γ-2 (PPAR) gene Pro12Ala polymorphisms and risk of hypertension. However, the number of available studies was extremely limited. We updated this evidence and given more significant results. We performed comprehensive computer-based searches in the PubMed, Web of Science, Embase, Google Scholar, the Cochrane library, Wanfang database, China National Knowledge Infrastructure, and China Biological Medicine Database...
February 18, 2019: Bioscience Reports
https://read.qxmd.com/read/30777926/interaction-between-gdf5-gene-polymorphisms-and-environment-factors-increased-the-risk-of-knee-osteoarthritis-a-case-control-study
#10
Sujie Zhang, Juan Wang, Hongliang Ji, Helei Jia, Dongsheng Guan
Using a case-control design, we assessed the association between single nucleotide polymorphisms of growth and differentiation factor 5 (GDF5) / rs143383 gene and interaction with environments and knee osteoarthritis. We recruited 288 knee osteoarthritis patients from the First clinical college, Henan University of Chinese Medicine between June 2017 and May 2018. There was significant difference in genotype distribution between case group and control group (χ2 =22.661, P =0.000). The minor C allele was significantly higher in the case group than that in the control group (20...
February 18, 2019: Bioscience Reports
https://read.qxmd.com/read/30770400/identification-potential-plasma-biomarkers-and-metabolic-dysfunction-for-unstable-angina-pectoris-and-its-complication-based-on-global-metabolomics
#11
Juan Wang, Wenjuan Xu, Huihui Zhao, Jianxin Chen, Bin Zhu, Xueli Li, Dong Deng, Jinping Wang, Junjie Liu, Yingting Yu, Hongbin Xiao, Wei Wang
Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are many advantages in understanding the pathophysiology of UA, the identification of biomarkers for the diagnosis, prognosis, and treatment of UA remains a challenge in the clinic. A global metabolomics research based on ultra performance liquid chromatography (UPLC) combined with time of flight mass spectrometry (Q-TOF/MS) was performed to discover the metabolic profile of health controls, UA patients, and UA patients with diabetes mellitus (DM), and screen for potential biomarkers...
February 15, 2019: Bioscience Reports
https://read.qxmd.com/read/30765615/associations-of-cyp1-polymorphisms-with-risk-of-prostate-cancer-an-updated-meta-analysis
#12
Wei Zhu, Hailang Liu, Xinguang Wang, Jinjin Lu, Huiping Zhang, Shaogang Wang, Weimin Yang
BACKGROUND: Previous studies on the association between CYP1 polymorphisms and the susceptibility of prostate cancer showed inconsistent results. This study was conducted to derive a better estimation of the association. METHODS: A systematic search was carried out using the PubMed, EMBASE, Cochrane Library and CNKI databases for relevant articles published till August 15, 2018. Odds ratios, and 95% confidence intervals were obtained by fixed-effect or random-effect model...
February 14, 2019: Bioscience Reports
https://read.qxmd.com/read/30765614/the-associations-between-toll-like-receptor-4-gene-polymorphisms-and-hepatitis-c-virus-infection-a-systematic-and-meta-analysis
#13
Narttaya Chaiwiang, Teera Poyomtip
BACKGROUND AND OBJECTIVE: The hepatitis C virus (HCV) is able to cause a life-threatening disease relating to lethal hepatocellular carcinoma. Previous, Toll-like receptor polymorphisms were proposed as promising biomarker for HCV-related hepatocellular carcinoma and disease progression. This study aimed to summarize the association of TLR4 polymorphisms and HCV infection through meta-analysis. METHODS: We applied a systematic review and meta-analysis performed by using PubMed, EMBASE, and Web of Science searches...
February 14, 2019: Bioscience Reports
https://read.qxmd.com/read/30765613/association-between-ace-gene-i-d-polymorphism-and-knee-osteoarthritis-in-a-chinese-population
#14
Genjun Chen, Shengping Hu, Zhen Lai, Binsong Qiu
Osteoarthritis (OA) is a degenerative joint disease characterized by joint destruction with cartilage loss and occasional gross derangement of joint integrity. In recent years, several studies have reported the association between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and knee osteoarthritis (OA). However, the results were conflicting. To determine the association between ACE gene I/D polymorphism and knee OA, we conducted a hospital-based case-control study with 282 knee OA cases and 316 controls to investigate the association between ACE gene I/D polymorphism and knee OA susceptibility in a Chinese Han population...
February 14, 2019: Bioscience Reports
https://read.qxmd.com/read/30765612/the-value-of-cone-beam-ct-guided-radiofrequency-ablation-in-the-treatment-of-pulmonary-malignancies-%C3%A2-3-cm
#15
Zi-Jun Xiang, Yi Wang, En-Fu Du, Lin Xu, Bin Jiang, Huili Li, Yun Wang, Ning Cui
The aim of this study is to explore the safety and efficacy of Cone-Beam computed tomography (CBCT) guided radiofrequency ablation (RFA) in the treatment of pulmonary malignancies. 31 patients with pulmonary malignant tumors (≤ 3 cmin diameter) were enrolled to this study. Total 43 CBCT guided RFA treatments were performed, including 7 patients undergoing multiple treatments. The target tumor puncture success rate, tumor remission rate, postoperative cumulative survival rate, tumor-free survival rate and complication rate were analyzed...
February 14, 2019: Bioscience Reports
https://read.qxmd.com/read/30765611/overexpression-of-bub1b-ccna2-cdc20-and-cdk1-in-tumor-tissues-predicts-poor-survival-in-pancreatic-ductal-adenocarcinoma
#16
Shu Dong, Fei Huang, Hao Zhang, Qiwen Chen
Overexpressed genes in tumors usually contributed to aggressiveness in pancreatic ductal adenocarcinoma (PDAC). Using Gene Expression Omnibus (GEO) profiles including GSE46234, GSE71989 and GSE107610, we detected overexpressed genes in tumors with R program, which were enriched by Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene ontology (GO) and Reactome pathway databases. Then, we performed a survival analysis of enriched genes based on TCGA profile. Our results revealed that high BUB1B, CCNA2, CDC20 and CDK1 expression in tumors was significantly associated with worse overall survival (OS) (Log rank P = 0...
February 14, 2019: Bioscience Reports
https://read.qxmd.com/read/30760632/human-g-protein-coupled-receptor-30-gpr30-is-n-glycosylated-and-n-terminal-domain-asparagine-44-is-required-for-receptor-structure-and-activity
#17
Ernesto Gonzalez de Valdivia, Caroline Sandén, Robin Kahn, Björn Olde, Fredrik L M Leeb-Lundberg
GPR30, or G protein-coupled estrogen receptor (GPER), is a G protein-coupled receptor (GPCR) that is currently attracting considerable attention in breast cancer and cardiometabolic regulation. The receptor was reported to be a novel membrane estrogen receptor mediating rapid non-genomic responses. However, questions remain about both the cognate ligand and the subcellular localization of receptor activity. Here, we used HEK293 cells ectopically expressing N-terminally FLAG-tagged human GPR30 and three unique antibodies (Ab) specifically targeting the receptor N-terminal domain (N-domain) to investigate the role of N -glycosylation in receptor maturation and activity, the latter assayed by constitutive receptor-stimulated ERK1/2 activity...
February 13, 2019: Bioscience Reports
https://read.qxmd.com/read/30760631/stk33-erk2-signal-pathway-contribute-the-tumorigenesis-of-colorectal-cancer-hct15-cells
#18
Shengjun Zhang, Haoyu Wu, Kaiyu Wang, Min Li Liu
Serine/threonine kinase 33 (STK33) is a serine/threonine kinase, and participates in many apoptotic process. Herein, we found that the extracellular signal-regulated kinase 2 (ERK2) was a substrate of STK33. STK33 phosphorylated ERK2and increased the activity of ERK2 and promote the tumorigenesis of colorectal cancer HCT15 cells. Clinical simple showed that STK33 was highly expression in colorectal cells and tissues.  Ex vivo and  in vivo studies demonstrated that STK33 accelerate tumorigenic properties in NCM460 cells and athymic nude rats...
February 13, 2019: Bioscience Reports
https://read.qxmd.com/read/30760630/increase-of-glandular-epithelial-cell-clusters-by-an-external-volume-expansion-device-promotes-adipose-tissue-regeneration-by-recruiting-macrophages
#19
Xihang Chen, Yunfan He, Anqi Xu, Zilong Deng, Jinwei Feng, Feng Lu, Yi Yuan
BACKGROUND: There is a clinical need for the use of engineered adipose tissue in place of surgical reconstruction. We previously found that the external volume expansion (EVE) device increased special cell clusters in well-vascularized connective stroma during adipose regeneration. However, the origin of these cell clusters and their role in adipose tissue regeneration remains unknown. AIM: In this study, we evaluated EVE in the construction of expanded prefabricated adipose tissue (EPAT) in a rat model...
February 13, 2019: Bioscience Reports
https://read.qxmd.com/read/30745457/ablation-of-both-cx40-and-panx1-results-in-similar-cardiovascular-phenotypes-exhibited-in-cx40-knockout-mice
#20
Nicole M Novielli-Kuntz, Meghan Jelen, Kevin Barr, Leon J Delailo, Qingping Feng, Brant E Isakson, Robert Gros, Dale W Laird
Connexins (Cxs) and pannexins (Panxs) are highly-regulated large-pore channel-forming proteins that participate in cellular communication via small molecular exchange with the extracellular microenvironment, or in the case of connexins, directly between cells. Given the putative functional overlap between single membrane-spanning connexin hemichannels and Panx channels, and cardiovascular system prevalence, we generated the first Cx40-/- Panx1-/- mouse with the anticipation that this genetic modification would lead to a severe cardiovascular phenotype...
February 11, 2019: Bioscience Reports
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