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Lasers in Surgery and Medicine | Page 2

Pawinee Rerknimitr, Yada Suphankong, Ratchathorn Panchaprateep, Stephen J Kerr, Pravit Asawanonda
OBJECTIVES: To investigate the efficacy of pulsed-dye laser (PDL) as an adjunctive treatment for facial papulopustular eruptions from EGFR inhibitors (EGFRi). METHODS: Fourteen patients with facial acneiform eruptions were recruited. Half side of the face was randomized to receive PDL treatment while the other side served as a control. The treatments were delivered every 2 weeks for 4 sessions. The patients were seen at baseline, weeks 2, 4, 6, 8, and 10. Erythema index (EI) measured by colorimeter, the papulopustular lesion count and physician global assessment (PGA) were obtained...
March 7, 2019: Lasers in Surgery and Medicine
Christine S K Fuchs, Vinzent Kevin Ortner, Mette Mogensen, Peter Alshede Philipsen, Merete Haedersdal
INTRODUCTION: Topical application of gold microparticles (GMPs) for selective photothermolysis is a recently FDA-cleared therapy for acne vulgaris. Current evidence indicates the potential of optical imaging to non-invasively visualize GMPs and describe photothermal tissue effects. OBJECTIVES: To qualitatively and quantitatively describe GMP delivery in vivo and visualize laser-mediated thermal effects of GMPs in facial skin of acne patients and healthy participants, using reflectance confocal microscopy (RCM) and optical coherence tomography (OCT)...
March 5, 2019: Lasers in Surgery and Medicine
Chao Zhang, Wei Feng, Yusha Li, Jurgen Kürths, Tingting Yu, Oxana Semyachkina-Glushkovskaya, Dan Zhu
BACKGROUND: Photodynamic therapy (PDT), a minimally invasive therapeutic tool, has been an important option for post-surgical treatment of malignant gliomas (MGs) in both adult and young patients. Recent studies have shown that PDT can also open the blood-brain barrier (BBB). However, there are no optimized parameters of PDT for patients at different ages. To determine whether there are age differences in PDT effects on the BBB, we studied PDT-related BBB opening through the optical clearing skull window in healthy 4- and 8-week-old mice...
February 27, 2019: Lasers in Surgery and Medicine
Cíntia Gobbato, André Gobbato, Tainah B Magalhães, Gustavo D Mendes, Jaime O Ilha, Ronilson A Moreno, Natalícia J Antunes, Gilberto De Nucci
BACKGROUND AND OBJECTIVES: Nanotechnology may increase the speed of penetration into the skin. This study evaluated the efficacy, safety, and pharmacokinetics of a novel topical anesthetic nanocapsule formulation (2 g) containing 2.5% lidocaine and 2.5% prilocaine (nanorap-test formulation) compared to placebo (control formulation) in skin types I-III patients of both sexes submitted to the ablative fractional CO2 laser treatment. METHODS: The patients (n = 120) included in this double-blind, single-center, randomized trial, received topical application of 2 g of the test formulation (50 mg lidocaine + 50 mg prilocaine) and placebo on the forehead region...
February 27, 2019: Lasers in Surgery and Medicine
Chikako Kaminaka, Naoya Mikita, Yutaka Inaba, Kayo Kunimoto, Hisako Okuhira, Masatoshi Jinnin, Bunsho Kao, Ryuzaburo Tanino, Kensuke Tanioka, Toshio Shimokawa, Yuki Yamamoto
BACKGROUND AND OBJECTIVES: Microwave treatment is an effective non-invasive treatment option for primary axillary hyperhidrosis (PAH), but the treatment parameters vary and no histopathological studies have been performed to validate clinical outcomes. This study investigated its efficacy and safety and histopathological changes after a single microwave treatment at the maximum energy level for PAH in Asians. MATERIALS AND METHODS: A prospective, clinical, and histological split-area randomized controlled trial (RCT) was performed in Japan...
February 27, 2019: Lasers in Surgery and Medicine
Yaxuan Zhou, Robert C Lee, Sara Finkleman, Alizera Sadr, Eric J Seibel
BACKGROUND AND OBJECTIVE: A safer alternative method to radiographic imaging is needed. We present a multispectral near-infrared scanning fiber endoscope (nirSFE) for dental imaging which is designed to be the smallest imaging probe with near-infrared (NIR) imaging (1200-2000 nm). MATERIALS AND METHODS: The prototype nirSFE is designed for wide-field forward viewing of scanned laser illumination at 1310, 1460, or 1550 nm. Artificial lesions with varying sizes and locations were prepared on proximal surfaces of extracted human teeth to examine capability and limitation of this new dental imaging modality...
February 27, 2019: Lasers in Surgery and Medicine
(no author information available yet)
No abstract text is available yet for this article.
March 2019: Lasers in Surgery and Medicine
(no author information available yet)
No abstract text is available yet for this article.
March 2019: Lasers in Surgery and Medicine
(no author information available yet)
No abstract text is available yet for this article.
March 2019: Lasers in Surgery and Medicine
Burcu Tunc, Murat Gulsoy
BACKGROUND: With exciting developments in fiber laser technology, studies investigating the use of lasers in neurosurgery have been increasing in the recent years. Fiber lasers are advantageous in many ways; first of all they are compact and they provide a more comfortable environment in the operating room due to feasibility of coupling laser light to different cross-sectioned fibers. Thulium fiber (Tm:fiber) lasers have been under investigation for medical applications since 2005 due to their spectral proximity to the water absorption peak...
February 19, 2019: Lasers in Surgery and Medicine
Sabrina Cavin, Tina Riedel, Petra Rosskopfova, Michel Gonzalez, Greg Baldini, Matthieu Zellweger, Georges Wagnières, Paul J Dyson, Hans-Beat Ris, Thorsten Krueger, Jean Y Perentes
Vascular-targeted low-dose photodynamic therapy (L-PDT) was shown to improve chemotherapy distribution in malignant pleural tumors such as malignant pleural mesothelioma (MPM). However, the mechanisms triggered by L-PDT on the tumor vasculature are still debated. In pericyte and endothelial cell co-cultures, we show that pericytes exhibit enhanced sensitivity towards L-PDT compared to endothelial cells, displaying actin stress fibers and cellular contraction via Rho/ROCK kinase signaling myosin light chain and focal adhesion kinase phosphorylation (MLC-P, FAK-P)...
February 19, 2019: Lasers in Surgery and Medicine
Juan Tovar-Huamani, Felipe Mercado-Olivares, Jose Antonio Grandez-Urbina, Rafael Pichardo-Rodriguez, Marco Tovar-Huamani, Herney García-Perdomo
OBJECTIVE: This PUBA study aimed to assess the efficacy of fractional CO2 laser in the treatment of genitourinary syndrome of menopause (GSM). METHODS: GSM symptoms were assessed before, 1 month after the first session and 1 month after the third session of laser (3 sessions with a 30 days interval between them) in 60 women (median, interquartile range: 55, 49-69). Subjective (visual analog scale) and objective (Vaginal Health Index, VHIS; Vaginal Maturity Index/Frost Index; Spanish Overactive Bladder Questionnaire-Short Form, USMEX Spanish OAB-qSF and Female Sexual Function Index, FSFI) measures were used during the study period to assess CO2 fractionated laser treatment outcomes compared to baseline...
February 19, 2019: Lasers in Surgery and Medicine
(no author information available yet)
No abstract text is available yet for this article.
February 2019: Lasers in Surgery and Medicine
(no author information available yet)
No abstract text is available yet for this article.
February 2019: Lasers in Surgery and Medicine
Daniel J Callaghan, Lauren M Bonati, Murad Alam, Kimberly Jerdan, Mark B Taylor, Jeffrey S Dover
OBJECTIVES: Measure the sound levels produced by various lasers commonly used during routine outpatient cosmetic surgery to determine whether or not their use exceeds exposure levels set forth by the US National Institute for Occupational Safety and Health (NIOSH) and the US Occupational Safety and Health Administration (OSHA). MATERIALS AND METHODS: Using two different meters, the sound levels of lasers commonly used in cosmetic surgery were recorded during various procedures for several indications: tattoo removal, treatment of lentigines and pigmented lesions, facial erythema and vascular lesions, hair removal and resurfacing of acne scars, and photoaging...
February 1, 2019: Lasers in Surgery and Medicine
Seung Hyun Chun, Bo Young Kim, Sheila Natari, Il-Hwan Kim
BACKGROUND: Needle-free pneumatic injections have been recently introduced to the field of dermatology to inject such substances as hyaluronic acid. However, data on the influence of various pneumatic injection parameters on collagen synthesis are lacking. OBJECTIVE: Compare the effect of diameter, pressure, and volume of a pneumatic injection jet on collagen synthesis and fluid dispersion pattern using a rat model. Investigate if the total work force of the injection jet is useful in predicting the degree of collagen synthesis...
February 1, 2019: Lasers in Surgery and Medicine
Mert Calis, Tugrul Tolga Demirtas, Gokhan Sert, Gulseren Irmak, Menemse Gumusderelioglu, Ayten Turkkani, Ayse Nur Çakar, Figen Ozgur
OBJECTIVE: The aim of this study was to evaluate the effect of relatively novel approach of application of polychromatic light waves on flap survival of experimental musculocutaneous flap model and to investigate efficacy of this modality as a delay procedure to increase vascularization of zone 4 of transverse rectus abdominis musculocutaneous (TRAM) flap. METHODS: Twenty-one Wistar rats were randomized and divided into 3 experimental groups (n = 7 each). In group 1 (control group), after being raised, the TRAM flap was sutured back to its bed without any further intervention...
February 1, 2019: Lasers in Surgery and Medicine
Tugce Borekci, Suleyman Emre Meseli, Ulku Noyan, Bahar Eren Kuru, Leyla Kuru
OBJECTIVES: Generalized aggressive periodontitis (GAgP) is a distinct type of periodontal disease characterized by rapid loss of attachment and alveolar bone occurring in young individuals. Photodynamic therapy (PDT) was introduced in periodontology as an adjunctive approach to non-surgical periodontal treatment (NPT) in periodontitis patients. In this trial, the aim was to evaluate the clinical and microbiological effects of adjunctive PDT to NPT in patients with GAgP. METHODS: In this prospective controlled clinical study, 24 systemically healthy, non-smoking subjects with GAgP were enrolled...
February 2019: Lasers in Surgery and Medicine
J Matthew Knight, Gerd Kautz
BACKGROUND: While skin aging is triggered by multiple factors and typically presents with multiple manifestations, conventional treatment regimens deploy a single treatment modality. Typical approaches exploit ablative techniques, which involve considerable patient discomfort and downtime and can induce adverse events. Non-ablative fractionated laser (NAFL) resurfacing promotes neocollagenesis, with significantly fewer complications and discomfort. At the same time, intense pulsed light (IPL) therapies have a marked impact on skin tone, with an effect on collagen deposition...
February 2019: Lasers in Surgery and Medicine
Godfrey Town, Natalia V Botchkareva, Natallia E Uzunbajakava, Tom Nuijs, Marijke van Vlimmeren, Caerwyn Ash, Christine Dierickx
OBJECTIVES: This review has the following objectives: Firstly, it provides an explanation of the evolution of laser/intense pulsed light (IPL) hair reduction modalities from high fluence professional devices to low fluence home-use appliances. Secondly, it summarises published literature reviews on home-use devices (HUDs) as evidence of their growing credibility. Thirdly, it proposes mechanistic differences in light delivery regimes and the resulting divergences in mode of action. MATERIALS AND METHODS: An extensive literature search was performed to review the progress of laser/IPL-induced hair reduction and determine what evidence is available to explain the mode of action of professional and HUDs for hair removal...
January 25, 2019: Lasers in Surgery and Medicine
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