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Lasers in Surgery and Medicine

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https://read.qxmd.com/read/31094015/non-invasive-reflectance-spectroscopy-for-normal-and-cancerous-skin-cells-refractive-index-determination-an-in-vitro-study
#1
Afshan Shirkavand, Shirin Farivar, Ezeddin Mohajerani, Leila Ataie-Fashtami, Mohammad H Ghazimoradi
BACKGROUND AND OBJECTIVE: Optical reflectance spectroscopy is a non-invasive technique for optical characterization of biological samples. Any alteration in a cell from normal or carcinogenic causes will change its refractive index. The aim of this study is to develop a computerized program for extraction of a refractive index of normal and cancerous skin cell lines, including melanoma, fibroblast, and adipose cells, using visible near-infrared reflectance spectra and the Kramers-Kronig (K-K) relations...
May 15, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/31090100/effects-of-different-980-nm-diode-laser-parameters-in-hepatectomy
#2
Tao Ma, Yi-Chao Chai, Hao-Yang Zhu, Huan Chen, Yue Wang, Qing-Shan Li, Li-Hui Pang, Rong-Qian Wu, Yi Lv, Ding-Hui Dong
BACKGROUND AND OBJECTIVE: Despite the successful application of laser in animal experiments and clinics, the adjustment of laser parameters during surgery is still unclear. This study aimed to investigate the effect of different 980-nm diode laser parameters in hepatectomy. This could provide a clear protocol for using 980-nm diode laser in hepatectomy. STUDY DESIGN/MATERIALS AND METHODS: In total, 48 Sprague-Dawley rats were used to explore the effects of different 980-nm diode laser parameters in hepatectomy, by setting different parameter combinations...
May 14, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/31090089/acne-treatment-with-light-absorbing-gold-microparticles-and-optical-pulses-an-open-label-european-multi-centered-study-in-moderate-to-moderately-severe-acne-vulgaris-patients
#3
Christine Sofie Krohn Fuchs, Christiane Bay, Maurice Adatto, Hans Lomholt, Merete Haedersdal
BACKGROUND AND OBJECTIVE: Recently, a novel acne treatment based on selective photothermolysis of pilosebaceous units with follicular delivery of inert gold microparticles as an exogenous chromophore and diode laser pulses has been developed. To evaluate the efficacy and safety of a single monotherapy treatment regimen with gold microparticles and diode laser exposure in patients with moderate and moderately severe acne. Further, to evaluate the added benefit of a second treatment regimen combined with pharmaceutical acne treatment in patients with inadequate initial response...
May 14, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/31090088/the-first-in-vivo-needle-based-optical-coherence-tomography-in-human-prostate-a-safety-and-feasibility-study
#4
Abel Swaan, Christophe K Mannaerts, Berrend G Muller, Rob Aa van Kollenburg, Marit Lucas, C Dilara Savci-Heijink, Ton G van Leeuwen, Theo M de Reijke, Daniel M de Bruin
OBJECTIVE: To demonstrate the safety and feasibility of clinical in vivo needle-based optical coherence tomography (OCT) imaging of the prostate. MATERIALS AND METHODS: Two patients with prostate cancer underwent each two percutaneous in vivo needle-based OCT measurements before transperineal template mapping biopsy. The OCT probe was introduced via a needle and positioned under ultrasound guidance. To test the safety, adverse events were recorded during and after the procedure...
May 14, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/31090087/efficacy-of-combined-intense-pulsed-light-ipl-with-fractional-co-2-laser-ablation-in-the-treatment-of-large-hypertrophic-scars-a-prospective-randomized-control-trial
#5
Alexander A Daoud, Chloe Gianatasio, Ashley Rudnick, Mary Michael, JillS Waibel
BACKGROUND AND OBJECTIVES: Scar rehabilitation is a complex process that incorporates medical, surgical, and physical therapeutic measures to best restore function and visual normalcy. Lasers have emerged as essential tools in the management of scars, with devices available to address scar size, dyschromia, and contour irregularities. As different lasers treat these different features, multi-laser, same session therapeutic approaches may offer a more comprehensive approach to scar revision...
May 14, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/31074497/the-value-of-confocal-laser-endoscopy-in-assessing-the-quality-of-duodenal-ulcer-healing
#6
Jianfang Rong, Liang Zhang, Wangdi Liao, Yong Xie, Nonghua Lu, Xu Shu
BACKGROUND AND OBJECTIVE: Confocal laser endomicroscopy (CLE) is a novel endoscopic technique that can image cells and subcellular layers of the gastric mucosa in vivo. We aimed to investigate the value of CLE in assessing the quality of ulcer healing (QOUH) and preliminarily establish evaluation criteria. MATERIALS AND METHODS: Patients with duodenal ulcers were enrolled. After duodenal ulcer healing, we compared the value of CLE and white light endoscopy (WLE) in assessing the QOUH by using the histopathological diagnosis as the gold standard...
May 10, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/31067361/mass-spectrometric-lipid-profiles-of-picosecond-infrared-laser-generated-tissue-aerosols-discriminate-different-brain-tissues
#7
Marcus Wurlitzer, Elisabeth Hessling, Karsten Rinas, MarcelineManka Fuh, Hannes Petersen, Franz Ricklefs, Katrin Lamszus, Jan Regelsberger, Stephanie Maier, Sebastian Kruber, Nils-Owe Hansen, RJDwayne Miller, Hartmut Schlüter
BACKGROUND AND OBJECTIVES: A picosecond infrared laser (PIRL) has recently been demonstrated to cut biological tissue without scar formation based on the minimal destructive action on the surrounding cells. During cutting with PIRL, the irradiated tissue is ablated by a cold vaporization process termed desorption by impulsive vibrational excitation. In the resulting aerosol, all molecules are dissolved in small droplets and even labile biomolecules like proteins remain intact after ablation...
May 8, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/31067360/feasibility-of-a-video-mosaicking-approach-to-extend-the-field-of-view-for-reflectance-confocal-microscopy-in-the-oral-cavity-in-vivo
#8
Gary Peterson, Daniella Karassawa Zanoni, Marco Ardigo, Jocelyn C Migliacci, Snehal G Patel, Milind Rajadhyaksha
BACKGROUND: Reflectance confocal microscopy (RCM) is a developing approach for noninvasive detection of oral lesions with label-free contrast and cellular-level resolution. For access into the oral cavity, confocal microscopes are being configured with small-diameter telescopic probes and small objective lenses. However, a small probe and objective lens allows for a rather small field-of-view relative to the large areas of tissue that must be examined for diagnosis. To extend the field-of-view for intraoral RCM imaging, we are investigating a video-mosaicking approach...
May 8, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/31033008/effects-of-preoperative-extracorporeal-shockwave-therapy-on-scar-formation-a-pilot-study-on-24-subjects-undergoing-abdominoplasty-surgery
#9
Elisabeth Russe, Gottfried Wechselberger, Karl Schwaiger, Klemens Heinrich, Michaela Hladik, Heike Traintinger
OBJECTIVES: Extracorporeal shockwave therapy (ESWT) has been demonstrated as a feasible noninvasive method to improve wound healing. This effect was demonstrated to result from increased perfusion and angiogenesis due to systemic growth factor expression. We, therefore, hypothesized that preoperative ESWT reduces scar formation after surgery. METHODS: A prospective, controlled pilot study on 24 patients undergoing abdominoplasty was conducted and the efficacy of preoperative unfocused, low energy EWST was evaluated...
April 29, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30924953/lasers-and-energy-based-devices-marketed-for-vaginal-rejuvenation-a-cross-sectional-analysis-of-the-maude-database
#10
Jusleen Ahluwalia, Mathew M Avram, Arisa E Ortiz
INTRODUCTION: The FDA issued a statement on July 30, 2018, expressing concern over the marketing of lasers and energy-based devices to promote "vaginal rejuvenation." The FDA stated that there is insufficient data to recommend this modality for optimization of sexual function and alleviation of genitourinary syndrome of menopause (GSM)-related symptoms in postmenopausal or postpartum women. This analysis aims to characterize the mandatory and voluntary reports concerning laser and energy-based procedures marketed for vaginal rejuvenation...
March 29, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30919507/propionibacterium-acnes-susceptibility-to-low-level-449-nm-blue-light-photobiomodulation
#11
Jeffrey M Boyd, Kelly A Lewis, Nisa Mohammed, Primit Desai, Mackenzie Purdy, Wen-Hwa Li, Tara Fourre, Davide Miksa, Sharron Crane, Michael Southall, Ali Fassih
BACKGROUND AND OBJECTIVE: Recent advances in low-level light devices have opened new treatment options for mild to moderate acne patients. Light therapies have been used to treat a variety of skin conditions over the years but were typically only available as treatments provided by professional clinicians. Clinical application of blue light has proven to be effective for a broader spectral range and at lower fluences than previously utilized. Herein, we tested the hypothesis that sub-milliwatt/cm2 levels of long-wave blue light (449 nm) effectively kills Propionibacterium acnes, a causative agent of acne vulgaris, in vitro...
March 28, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30919487/grading-upper-tract-urothelial-carcinoma-with-the-attenuation-coefficient-of-in-vivo-optical-coherence-tomography
#12
Jan Erik Freund, Dirk J Faber, Mieke T Bus, Ton G van Leeuwen, Daniel M de Bruin
INTRODUCTION: With catheter based optical coherence tomography (OCT), high resolution images of the upper urinary tract can be obtained, thereby facilitating the detection of upper tract urothelial carcinomas (UTUC). We hypothesized that the attenuation coefficient of the OCT signal (μOCT ) is related to the histopathologic grade of the tumor. OBJECTIVES: In this study, we aimed to define the μOCT cut-off for discriminating high grade and low grade papillary UTUC...
March 28, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30908718/drug-penetration-enhancement-techniques-in-ablative-fractional-laser-assisted-cutaneous-delivery-of-indocyanine-green
#13
Arne A Meesters, Marilin J Nieboer, Mitra Almasian, Giota Georgiou, Menno A de Rie, Rudolf M Verdaasdonk, Albert Wolkerstorfer
BACKGROUND AND OBJECTIVES: Topical drug delivery can be increased by pretreatment of the skin with ablative fractional laser (AFXL). Several physical penetration enhancement techniques have been investigated to further improve AFXL-assisted drug delivery. This study investigated the influence of three of these techniques, namely massage, acoustic pressure wave treatment, and pressure vacuum alterations (PVP) on the distribution of the fluorescent drug indocyanine green (ICG) at different depths in the skin after topical application on AFXL pretreated skin...
March 25, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30889289/dose-response-of-human-follicles-during-laser-based-hair-removal-ex-vivo-photoepilation-model-with-classification-system-embracing-morphological-and-histological-features
#14
Marijke A A van Vlimmeren, Bianca Raafs, Gillian Westgate, Linda G M Beijens, Natallia E Uzunbajakava
OBJECTIVES: Photoepilation is a commonly used technology in home-use devices (HUDs) and in professional systems to remove unwanted body hair using pulses of laser or intense pulsed light (IPL). Albeit HUDs and professional systems operate at different fluences and treatment regimes, both demonstrate high hair reduction. The underlying mechanisms, however, remain unknown partly due to high divergence of the existing literature data. The objective of this study was to develop an ex vivo photoepilation model with a set of criteria evaluating response to light pulses; and to investigate dose-response behavior of hair follicles (HFs) subjected to a range of fluences...
March 19, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30883841/the-effect-of-melanin-on-in-vivo-optical-coherence-tomography-of-the-skin-in-a-multiethnic-cohort
#15
Chloe Ekelem, Junxiao Yu, Dorsa Heydarlou, Emon Heidari, Ella Csuka, Zhongping Chen, Natasha Atanaskova Mesinkovska
BACKGROUND: Noninvasive real-time assessment of living tissue is quickly becoming invaluable for bolstering histologic and dermatoscopic measures of cutaneous conditions. While many skin researchers have explored the utility of noninvasive imaging in inflammatory and malignant skin conditions, there is yet to be a definitive and direct assessment of the effects of melanin on the quality of optical coherence tomography (OCT) imaging and its accuracy in multiethnic patient populations. We conducted a study to evaluate the effects of melanin on the quality of in vivo OCT imaging...
March 18, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30883832/transcranial-photobiomodulation-prevents-anxiety-and-depression-via-changing-serotonin-and-nitric-oxide-levels-in-brain-of-depression-model-mice-a-study-of-three-different-doses-of-810-nm-laser
#16
Emad Eshaghi, Saeed Sadigh-Eteghad, Gisou Mohaddes, Seyed Hossein Rasta
OBJECTIVES: The effectiveness of transcranial photobiomodulation (TPBM) in treating anxiety and depression disorders is a demonstrated and identified issue. However, the optimum therapeutic dose and the underlying mechanism of action are not fully understood. In this study, the therapeutic effects of three different near-infrared (NIR) doses on anxiety- and depression-like behaviors as well as cerebral levels of serotonin (5-HT) and nitric oxide (NO) were evaluated in a mouse model of chronic restraint stress (CRS)...
March 18, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30860297/enhanced-laser-surface-ablation-with-an-integrated-photoacoustic-imaging-and-high-intensity-focused-ultrasound-system
#17
David Hazlewood, Xinmai Yang
BACKGROUND AND OBJECTIVE: Combined laser and ultrasound treatments have been found to have synergistic effects, which may be of particular note in dermatology. We aim to investigate the potential of this technology for dermatology through in vitro and ex vivo experiments. METHODS: In vitro tissue phantoms made of agar and tattoo ink and tattooed ex vivo chicken breast tissue were used. An integrated photoacoustic imaging and high intensity focused ultrasound (HIFU) system, using a 5-ns tunable OPO laser system and a 5 MHz HIFU transducer, was used to perform photoacoustic analysis to identify the optical contrast, and perform combined laser and ultrasound ablation...
March 12, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30860283/predictive-value-of-dermoscopy-for-the-treatment-of-port-wine-stains-with-large-spot-532-nm-laser
#18
Bartłomiej Kwiek, Michał Rożalski, Julia Sieczych, Łukasz Paluch, Cezary Kowalewski, Marcin Ambroziak
OBJECTIVE: We wanted to evaluate dermoscopy as a tool to predict the efficacy of port-wine stain (PWS) laser treatment. STUDY DESIGN AND METHODS: Large spot 532 nm laser was used for the treatment of 67 PWS. Efficacy was assessed with an objective 3D digital imaging analysis. Dermoscopy images were taken before the treatment and analyzed semi quantitatively for features and patterns. RESULTS: The following dermoscopic features: "superficial vessels," "deep vessels," "deep lakes," "superficial lakes," and "thick vessels total" were identified as positive determinants of maximal global clearance effect (GCEmax), whereas "thin long vessels," "bright background total," "whitish veil," "white circles," and "perifollicular erythema" were found to be negative determinants...
March 12, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30843244/characterization-of-the-transmission-behavior-of-dental-filling-materials-and-cements-for-the-diode-lasers-and-the-nd-yag-laser-s-wavelengths
#19
Rolf Diebolder, Carmen U Schmid, Ralph G Luthardt, Heike Rudolph, Katharina Kuhn
OBJECTIVES: Diode lasers and the Nd:YAG laser are used in periodontal therapy and soft tissue surgery. Dental filling materials or cements might be inadvertently damaged. The underlying mechanism of the damage is based on the dental material's specific transmission and thus absorption behavior. MATERIALS AND METHODS: Twenty-four material representatives for composites, glass ionomer cements and other material classes (e.g., compomer) were processed to 100 μm and 200 μm planar specimens and spectroscopically measured for their collimated transmission in the photo spectrometer Varian Cary 5000...
March 7, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30843235/quantitative-proteomic-analysis-of-dermal-papilla-from-male-androgenetic-alopecia-comparing-before-and-after-treatment-with-low-level-laser-therapy
#20
Ratchathorn Panchaprateep, Trairak Pisitkun, Nuttiya Kalpongnukul
BACKGROUND: Currently, low-level laser therapy (LLLT) has been approved as a new treatment for androgenetic alopecia (AGA). However, it has not been elucidated how LLLT promotes hair growth in vivo. OBJECTIVES: To investigate the change in protein expression from dermal papilla (DP) tissues in male AGA patients after LLLT treatment using liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis. METHODS: This is an open-label, prospective, single-arm study obtained punch scalp biopsy specimens from patients with AGA before and after LLLT treatment...
March 7, 2019: Lasers in Surgery and Medicine
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