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Lasers in Surgery and Medicine

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https://read.qxmd.com/read/30924953/lasers-and-energy-based-devices-marketed-for-vaginal-rejuvenation-a-cross-sectional-analysis-of-the-maude-database
#1
Jusleen Ahluwalia, Mathew M Avram, Arisa E Ortiz
INTRODUCTION: The FDA issued a statement on July 30, 2018, expressing concern over the marketing of lasers and energy-based devices to promote "vaginal rejuvenation." The FDA stated that there is insufficient data to recommend this modality for optimization of sexual function and alleviation of genitourinary syndrome of menopause (GSM)-related symptoms in postmenopausal or postpartum women. This analysis aims to characterize the mandatory and voluntary reports concerning laser and energy-based procedures marketed for vaginal rejuvenation...
March 29, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30919507/propionibacterium-acnes-susceptibility-to-low-level-449-nm-blue-light-photobiomodulation
#2
Jeffrey M Boyd, Kelly A Lewis, Nisa Mohammed, Primit Desai, Mackenzie Purdy, Wen-Hwa Li, Tara Fourre, Davide Miksa, Sharron Crane, Michael Southall, Ali Fassih
BACKGROUND AND OBJECTIVE: Recent advances in low-level light devices have opened new treatment options for mild to moderate acne patients. Light therapies have been used to treat a variety of skin conditions over the years but were typically only available as treatments provided by professional clinicians. Clinical application of blue light has proven to be effective for a broader spectral range and at lower fluences than previously utilized. Herein, we tested the hypothesis that sub-milliwatt/cm2 levels of long-wave blue light (449 nm) effectively kills Propionibacterium acnes, a causative agent of acne vulgaris, in vitro...
March 28, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30919487/grading-upper-tract-urothelial-carcinoma-with-the-attenuation-coefficient-of-in-vivo-optical-coherence-tomography
#3
Jan Erik Freund, Dirk J Faber, Mieke T Bus, Ton G van Leeuwen, Daniel M de Bruin
INTRODUCTION: With catheter based optical coherence tomography (OCT), high resolution images of the upper urinary tract can be obtained, thereby facilitating the detection of upper tract urothelial carcinomas (UTUC). We hypothesized that the attenuation coefficient of the OCT signal (μOCT ) is related to the histopathologic grade of the tumor. OBJECTIVES: In this study, we aimed to define the μOCT cut-off for discriminating high grade and low grade papillary UTUC...
March 28, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30908718/drug-penetration-enhancement-techniques-in-ablative-fractional-laser-assisted-cutaneous-delivery-of-indocyanine-green
#4
Arne A Meesters, Marilin J Nieboer, Mitra Almasian, Giota Georgiou, Menno A de Rie, Rudolf M Verdaasdonk, Albert Wolkerstorfer
BACKGROUND AND OBJECTIVES: Topical drug delivery can be increased by pretreatment of the skin with ablative fractional laser (AFXL). Several physical penetration enhancement techniques have been investigated to further improve AFXL-assisted drug delivery. This study investigated the influence of three of these techniques, namely massage, acoustic pressure wave treatment, and pressure vacuum alterations (PVP) on the distribution of the fluorescent drug indocyanine green (ICG) at different depths in the skin after topical application on AFXL pretreated skin...
March 25, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30889289/dose-response-of-human-follicles-during-laser-based-hair-removal-ex-vivo-photoepilation-model-with-classification-system-embracing-morphological-and-histological-features
#5
Marijke A A van Vlimmeren, Bianca Raafs, Gillian Westgate, Linda G M Beijens, Natallia E Uzunbajakava
OBJECTIVES: Photoepilation is a commonly used technology in home-use devices (HUDs) and in professional systems to remove unwanted body hair using pulses of laser or intense pulsed light (IPL). Albeit HUDs and professional systems operate at different fluences and treatment regimes, both demonstrate high hair reduction. The underlying mechanisms, however, remain unknown partly due to high divergence of the existing literature data. The objective of this study was to develop an ex vivo photoepilation model with a set of criteria evaluating response to light pulses; and to investigate dose-response behavior of hair follicles (HFs) subjected to a range of fluences...
March 19, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30883841/the-effect-of-melanin-on-in-vivo-optical-coherence-tomography-of-the-skin-in-a-multiethnic-cohort
#6
Chloe Ekelem, Junxiao Yu, Dorsa Heydarlou, Emon Heidari, Ella Csuka, Zhongping Chen, Natasha Atanaskova Mesinkovska
BACKGROUND: Noninvasive real-time assessment of living tissue is quickly becoming invaluable for bolstering histologic and dermatoscopic measures of cutaneous conditions. While many skin researchers have explored the utility of noninvasive imaging in inflammatory and malignant skin conditions, there is yet to be a definitive and direct assessment of the effects of melanin on the quality of optical coherence tomography (OCT) imaging and its accuracy in multiethnic patient populations. We conducted a study to evaluate the effects of melanin on the quality of in vivo OCT imaging...
March 18, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30883832/transcranial-photobiomodulation-prevents-anxiety-and-depression-via-changing-serotonin-and-nitric-oxide-levels-in-brain-of-depression-model-mice-a-study-of-three-different-doses-of-810-nm-laser
#7
Emad Eshaghi, Saeed Sadigh-Eteghad, Gisou Mohaddes, Seyed Hossein Rasta
OBJECTIVES: The effectiveness of transcranial photobiomodulation (TPBM) in treating anxiety and depression disorders is a demonstrated and identified issue. However, the optimum therapeutic dose and the underlying mechanism of action are not fully understood. In this study, the therapeutic effects of three different near-infrared (NIR) doses on anxiety- and depression-like behaviors as well as cerebral levels of serotonin (5-HT) and nitric oxide (NO) were evaluated in a mouse model of chronic restraint stress (CRS)...
March 18, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30860297/enhanced-laser-surface-ablation-with-an-integrated-photoacoustic-imaging-and-high-intensity-focused-ultrasound-system
#8
David Hazlewood, Xinmai Yang
BACKGROUND AND OBJECTIVE: Combined laser and ultrasound treatments have been found to have synergistic effects, which may be of particular note in dermatology. We aim to investigate the potential of this technology for dermatology through in vitro and ex vivo experiments. METHODS: In vitro tissue phantoms made of agar and tattoo ink and tattooed ex vivo chicken breast tissue were used. An integrated photoacoustic imaging and high intensity focused ultrasound (HIFU) system, using a 5-ns tunable OPO laser system and a 5 MHz HIFU transducer, was used to perform photoacoustic analysis to identify the optical contrast, and perform combined laser and ultrasound ablation...
March 12, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30860283/predictive-value-of-dermoscopy-for-the-treatment-of-port-wine-stains-with-large-spot-532-nm-laser
#9
Bartłomiej Kwiek, Michał Rożalski, Julia Sieczych, Łukasz Paluch, Cezary Kowalewski, Marcin Ambroziak
OBJECTIVE: We wanted to evaluate dermoscopy as a tool to predict the efficacy of port-wine stain (PWS) laser treatment. STUDY DESIGN AND METHODS: Large spot 532 nm laser was used for the treatment of 67 PWS. Efficacy was assessed with an objective 3D digital imaging analysis. Dermoscopy images were taken before the treatment and analyzed semi quantitatively for features and patterns. RESULTS: The following dermoscopic features: "superficial vessels," "deep vessels," "deep lakes," "superficial lakes," and "thick vessels total" were identified as positive determinants of maximal global clearance effect (GCEmax), whereas "thin long vessels," "bright background total," "whitish veil," "white circles," and "perifollicular erythema" were found to be negative determinants...
March 12, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30843244/characterization-of-the-transmission-behavior-of-dental-filling-materials-and-cements-for-the-diode-lasers-and-the-nd-yag-laser-s-wavelengths
#10
Rolf Diebolder, Carmen U Schmid, Ralph G Luthardt, Heike Rudolph, Katharina Kuhn
OBJECTIVES: Diode lasers and the Nd:YAG laser are used in periodontal therapy and soft tissue surgery. Dental filling materials or cements might be inadvertently damaged. The underlying mechanism of the damage is based on the dental material's specific transmission and thus absorption behavior. MATERIALS AND METHODS: Twenty-four material representatives for composites, glass ionomer cements and other material classes (e.g., compomer) were processed to 100 μm and 200 μm planar specimens and spectroscopically measured for their collimated transmission in the photo spectrometer Varian Cary 5000...
March 7, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30843235/quantitative-proteomic-analysis-of-dermal-papilla-from-male-androgenetic-alopecia-comparing-before-and-after-treatment-with-low-level-laser-therapy
#11
Ratchathorn Panchaprateep, Trairak Pisitkun, Nuttiya Kalpongnukul
BACKGROUND: Currently, low-level laser therapy (LLLT) has been approved as a new treatment for androgenetic alopecia (AGA). However, it has not been elucidated how LLLT promotes hair growth in vivo. OBJECTIVES: To investigate the change in protein expression from dermal papilla (DP) tissues in male AGA patients after LLLT treatment using liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis. METHODS: This is an open-label, prospective, single-arm study obtained punch scalp biopsy specimens from patients with AGA before and after LLLT treatment...
March 7, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30843231/pulsed-dye-laser-as-an-adjuvant-treatment-for-papulopustular-eruptions-from-epidermal-growth-factor-receptor-inhibitors-a-randomized-blinded-split-faced-controlled-trial
#12
Pawinee Rerknimitr, Yada Suphankong, Ratchathorn Panchaprateep, Stephen J Kerr, Pravit Asawanonda
OBJECTIVES: To investigate the efficacy of pulsed-dye laser (PDL) as an adjunctive treatment for facial papulopustular eruptions from EGFR inhibitors (EGFRi). METHODS: Fourteen patients with facial acneiform eruptions were recruited. Half side of the face was randomized to receive PDL treatment while the other side served as a control. The treatments were delivered every 2 weeks for 4 sessions. The patients were seen at baseline, weeks 2, 4, 6, 8, and 10. Erythema index (EI) measured by colorimeter, the papulopustular lesion count and physician global assessment (PGA) were obtained...
March 7, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30835885/transfollicular-delivery-of-gold-microparticles-in-healthy-skin-and-acne-vulgaris-assessed-by-in-vivo-reflectance-confocal-microscopy-and-optical-coherence-tomography
#13
Christine S K Fuchs, Vinzent Kevin Ortner, Mette Mogensen, Peter Alshede Philipsen, Merete Haedersdal
INTRODUCTION: Topical application of gold microparticles (GMPs) for selective photothermolysis is a recently FDA-cleared therapy for acne vulgaris. Current evidence indicates the potential of optical imaging to non-invasively visualize GMPs and describe photothermal tissue effects. OBJECTIVES: To qualitatively and quantitatively describe GMP delivery in vivo and visualize laser-mediated thermal effects of GMPs in facial skin of acne patients and healthy participants, using reflectance confocal microscopy (RCM) and optical coherence tomography (OCT)...
March 5, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30811633/age-differences-in-photodynamic-therapy-mediated-opening-of-the-blood-brain-barrier-through-the-optical-clearing-skull-window-in-mice
#14
Chao Zhang, Wei Feng, Yusha Li, Jurgen Kürths, Tingting Yu, Oxana Semyachkina-Glushkovskaya, Dan Zhu
BACKGROUND: Photodynamic therapy (PDT), a minimally invasive therapeutic tool, has been an important option for post-surgical treatment of malignant gliomas (MGs) in both adult and young patients. Recent studies have shown that PDT can also open the blood-brain barrier (BBB). However, there are no optimized parameters of PDT for patients at different ages. To determine whether there are age differences in PDT effects on the BBB, we studied PDT-related BBB opening through the optical clearing skull window in healthy 4- and 8-week-old mice...
February 27, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30811630/randomized-double-blind-phase-iii-clinical-study-of-a-novel-nanotechnological-topical-anesthetic-formulation-containing-lidocaine-25-mg-g-and-prilocaine-25-mg-g-nanorap-in-skin-phototypes-i-iii-patients-with-ablative-fractional-co-2-laser-treatment-indication
#15
Cíntia Gobbato, André Gobbato, Tainah B Magalhães, Gustavo D Mendes, Jaime O Ilha, Ronilson A Moreno, Natalícia J Antunes, Gilberto De Nucci
BACKGROUND AND OBJECTIVES: Nanotechnology may increase the speed of penetration into the skin. This study evaluated the efficacy, safety, and pharmacokinetics of a novel topical anesthetic nanocapsule formulation (2 g) containing 2.5% lidocaine and 2.5% prilocaine (nanorap-test formulation) compared to placebo (control formulation) in skin types I-III patients of both sexes submitted to the ablative fractional CO2 laser treatment. METHODS: The patients (n = 120) included in this double-blind, single-center, randomized trial, received topical application of 2 g of the test formulation (50 mg lidocaine + 50 mg prilocaine) and placebo on the forehead region...
February 27, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30811620/clinical-and-histological-evaluation-of-a-single-high-energy-microwave-treatment-for-primary-axillary-hyperhidrosis-in-asians-a-prospective-randomized-controlled-split-area-comparative-trial
#16
Chikako Kaminaka, Naoya Mikita, Yutaka Inaba, Kayo Kunimoto, Hisako Okuhira, Masatoshi Jinnin, Bunsho Kao, Ryuzaburo Tanino, Kensuke Tanioka, Toshio Shimokawa, Yuki Yamamoto
BACKGROUND AND OBJECTIVES: Microwave treatment is an effective non-invasive treatment option for primary axillary hyperhidrosis (PAH), but the treatment parameters vary and no histopathological studies have been performed to validate clinical outcomes. This study investigated its efficacy and safety and histopathological changes after a single microwave treatment at the maximum energy level for PAH in Asians. MATERIALS AND METHODS: A prospective, clinical, and histological split-area randomized controlled trial (RCT) was performed in Japan...
February 27, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30810236/near-infrared-multispectral-endoscopic-imaging-of-deep-artificial-interproximal-lesions-in-extracted-teeth
#17
Yaxuan Zhou, Robert C Lee, Sara Finkleman, Alizera Sadr, Eric J Seibel
BACKGROUND AND OBJECTIVE: A safer alternative method to radiographic imaging is needed. We present a multispectral near-infrared scanning fiber endoscope (nirSFE) for dental imaging which is designed to be the smallest imaging probe with near-infrared (NIR) imaging (1200-2000 nm). MATERIALS AND METHODS: The prototype nirSFE is designed for wide-field forward viewing of scanned laser illumination at 1310, 1460, or 1550 nm. Artificial lesions with varying sizes and locations were prepared on proximal surfaces of extracted human teeth to examine capability and limitation of this new dental imaging modality...
February 27, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30779367/stereotaxic-laser-brain-surgery-with-1940-nm-tm-fiber-laser-an-in-vivo-study
#18
Burcu Tunc, Murat Gulsoy
BACKGROUND: With exciting developments in fiber laser technology, studies investigating the use of lasers in neurosurgery have been increasing in the recent years. Fiber lasers are advantageous in many ways; first of all they are compact and they provide a more comfortable environment in the operating room due to feasibility of coupling laser light to different cross-sectioned fibers. Thulium fiber (Tm:fiber) lasers have been under investigation for medical applications since 2005 due to their spectral proximity to the water absorption peak...
February 19, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30779366/vascular-targeted-low-dose-photodynamic-therapy-stabilizes-tumor-vessels-by-modulating-pericyte-contractility
#19
Sabrina Cavin, Tina Riedel, Petra Rosskopfova, Michel Gonzalez, Greg Baldini, Matthieu Zellweger, Georges Wagnières, Paul J Dyson, Hans-Beat Ris, Thorsten Krueger, Jean Y Perentes
Vascular-targeted low-dose photodynamic therapy (L-PDT) was shown to improve chemotherapy distribution in malignant pleural tumors such as malignant pleural mesothelioma (MPM). However, the mechanisms triggered by L-PDT on the tumor vasculature are still debated. In pericyte and endothelial cell co-cultures, we show that pericytes exhibit enhanced sensitivity towards L-PDT compared to endothelial cells, displaying actin stress fibers and cellular contraction via Rho/ROCK kinase signaling myosin light chain and focal adhesion kinase phosphorylation (MLC-P, FAK-P)...
February 19, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30779363/efficacy-of-fractional-co-2-laser-in-the-treatment-of-genitourinary-syndrome-of-menopause-in-latin-american-population-first-peruvian-experience
#20
Juan Tovar-Huamani, Felipe Mercado-Olivares, Jose Antonio Grandez-Urbina, Rafael Pichardo-Rodriguez, Marco Tovar-Huamani, Herney García-Perdomo
OBJECTIVE: This PUBA study aimed to assess the efficacy of fractional CO2 laser in the treatment of genitourinary syndrome of menopause (GSM). METHODS: GSM symptoms were assessed before, 1 month after the first session and 1 month after the third session of laser (3 sessions with a 30 days interval between them) in 60 women (median, interquartile range: 55, 49-69). Subjective (visual analog scale) and objective (Vaginal Health Index, VHIS; Vaginal Maturity Index/Frost Index; Spanish Overactive Bladder Questionnaire-Short Form, USMEX Spanish OAB-qSF and Female Sexual Function Index, FSFI) measures were used during the study period to assess CO2 fractionated laser treatment outcomes compared to baseline...
February 19, 2019: Lasers in Surgery and Medicine
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