Lasers in Surgery and Medicine

Roy Lauterbach, Hanin Dabaja, Emad Matanes, Ilan Gruenwald, Lior Lowenstein
BACKGROUND AND OBJECTIVES: Vaginal laxity lacks standardized diagnosis and severity criteria. It is considered as a subjective complaint that reflects decreased sexual satisfaction due to vaginal loosening. Treatment modalities have included physiotherapy and plastic surgery. Recently, laser treatments have also gained popularity as a means of relieving gynecological complaints such as pelvic organ prolapse, stress urinary incontinence, and genitourinary syndrome of menopause. The aim of the current study was to evaluate the efficacy of CO2 laser treatment in women for whom a decrease in sexual sensation during intercourse and vaginal loosening were their primary complaints...
May 26, 2020: Lasers in Surgery and Medicine
Yulia M Alexandrovskaya, Olga I Baum, Alexey V Yuzhakov, Valery M Svistushkin, Alexey V Buzmakov, Yuriy S Krivonosov, Boris S Roshchin, Denis A Zolotov
BACKGROUND AND OBJECTIVE: The laser-induced stress relaxation provides new prospects to obtain stable long fragments of costal cartilage for autoimplantation avoiding the risk of spontaneous deformation and poor engraftment. However, the age-related alterations of cartilage may sufficiently influence its interaction with infrared (IR) laser radiation and disrupt the effectiveness and safety of the technique. The aim of the work is to study the influence of the structural quality of costal cartilage on its interaction with IR laser and efficiency of obtaining of curved implants for trachea surgery...
May 25, 2020: Lasers in Surgery and Medicine
Gi H Seong, Eun M Jin, Tae U Ryu, Myung H Kim, Byung C Park, Seung P Hong
BACKGROUND AND OBJECTIVES: To evaluate the safety and effectiveness of combined fractional radiofrequency microneedling (FRM) and fractional carbon dioxide (FCO2 ) laser treatment for striae distensae and to compare the results to those of FRM alone and those of FCO2 alone. STUDY DESIGN/MATERIALS AND METHODS: Adult women (Fitzpatrick skin types III-IV) with striae distensae on the abdomen or calf were enrolled in this study. Each lesion was divided into three regions, with each region assigned to one of the three treatments (FCO2 , FRM, or combined FCO2 and FRM)...
May 22, 2020: Lasers in Surgery and Medicine
Wenjing Xi, Yixin Xie, Zheng Zhang, Ke Li, Jingyan Wang, Jie Li, Shaoqing Feng, C Scott Hultman, Ying Liu, Yixin Zhang
BACKGROUND AND OBJECTIVES: There has been reports on fractional CO2 laser successfully improving contracture scars that impair the function of a joint. It seems that certain contracture problems could be solved by laser instead of surgery. However, the clinical application could be difficult when the efficacy of the method remains unknown. The purpose of this study is to report the releasing capacity of the fractional CO2 laser on contracture scars based on a defined treatment method...
May 20, 2020: Lasers in Surgery and Medicine
Sang Ju Lee, Hye Sung Han, Jun Ki Hong, Kui Young Park, Seong Jun Seo
BACKGROUND AND OBJECTIVE: Until recently, quality-switched nanosecond lasers have been the workhorse lasers in treating pigmented lesions. However, the recently commercialized picosecond lasers have provided physicians with a novel method to manage pigmented lesions. Most recently, the first picosecond laser with a 730-nm wavelength was developed to specifically target melanin and melanocytes. STUDY DESIGN/MATERIALS AND METHODS: We report on two Asian patients with freckles, lentigines, and melasma who were successfully treated with a novel 730-nm Ti:Sapphire picosecond laser (Picoway®; Syneron Candela, Corp)...
May 14, 2020: Lasers in Surgery and Medicine
Mingyang Wang, Yu Qin, Tao Wang, Jeffrey S Orringer, Yannis M Paulus, Xinmai Yang, Xueding Wang
BACKGROUND AND OBJECTIVES: We have developed a novel anti-vascular technique, termed photo-mediated ultrasound therapy (PUT), which utilizes nanosecond duration laser pulses synchronized with ultrasound bursts to remove the microvasculature through cavitation. The objective of the current study is to explore the potential of PUT in removing subcutaneous microvessels. STUDY DESIGN/MATERIALS AND METHODS: The auricular blood vessels of two New Zealand white rabbits were treated by PUT with a peak negative ultrasound pressure of 0...
May 11, 2020: Lasers in Surgery and Medicine
Christopher B Zachary, A Jay Burns, Linda D Pham, Joel N Jimenez Lozano
BACKGROUND AND OBJECTIVES: A previous pre-clinical study on electromagnetic muscle stimulation (EMMS) suggested that fat cell apoptosis occurs following treatment in a porcine model. While EMMS can induce changes in muscle, the effect on fat tissue is not established. This clinical study sought to assess adipose tissue response to EMMS in comparison to cryolipolysis treatment. STUDY DESIGN/MATERIALS AND METHODS: Study subjects were recruited prior to abdominoplasty to receive body contouring treatments and subsequently to obtain tissue for histological analysis...
May 8, 2020: Lasers in Surgery and Medicine
Sheila Natari, Ko Eun Kim, Sook In Ryu, Ji Hyun Park, Il-Hwan Kim
BACKGROUND AND OBJECTIVES: Many light and radiofrequency-based rejuvenation devices have claimed to increase collagen production in the skin dermal tissue. However, there has not been enough scientific evidence to prove whether the result is just a profibrotic response or not. We aimed to find the optimal skin rejuvenation device that shows true neocollagenesis. STUDY DESIGN/MATERIALS AND METHODS: We evaluated dermal collagen thickness and gene expression of procollagen type 1, 3, matrix metalloproteinase-3 (MMP-3), and transforming growth factor-β (TGF-β) resulting from different energy-based devices in a rat model in vivo...
May 7, 2020: Lasers in Surgery and Medicine
Emil A Tanghetti, David J Goldberg, Jeffrey S Dover, Roy G Geronemus, Zane Bai, Nancy Alvandi, Stuart D Shanler
BACKGROUND AND OBJECTIVES: The objectives of this study were to evaluate the safety, tolerability, and efficacy of oxymetazoline hydrochloride cream, 1% (oxymetazoline) when used as an adjunctive treatment with energy-based therapy for patients with moderate to severe facial erythema associated with rosacea. STUDY DESIGN/MATERIALS AND METHODS: In this Phase 4, multicenter, interventional, open-label study, eligible patients received one of four energy-based therapies (potassium titanyl phosphate laser, intense pulsed light therapy, pulsed-dye laser Vbeam Perfecta, or pulsed-dye laser Cynergy) on day 1 and day 29 and once-daily application of oxymetazoline on days 3 through 27 and days 31 through 56...
May 6, 2020: Lasers in Surgery and Medicine
J David Holcomb, Michael Kelly, Tiffani K Hamilton, Joseph B DeLozier
BACKGROUND AND OBJECTIVES: A novel helium plasma device was evaluated for efficacy and safety for dermal resurfacing ( Identifier: NCT03286283). The helium plasma device delivers energy in a controlled, bimodal fashion that when compared with the nitrogen plasma predicate device in a porcine animal model demonstrated a more limited depth of thermal effect but a greater skin tissue contraction. STUDY DESIGN/MATERIALS AND METHODS: Fifty-five eligible subjects seeking improvement in facial rhytids were enrolled for study at one of three investigational sites...
April 29, 2020: Lasers in Surgery and Medicine
Jung E Kim, Jeong Y Hong, Ho J Lee, Sung Y Lee, Hyun J Kim
BACKGROUND AND OBJECTIVES: Combined sequential treatments with multiple modalities such as lasers and soft-tissue fillers are commonly required for the treatment of atrophic acne scars. Recently, fractional treatment with picosecond-domain lasers has proven to be effective for skin rejuvenation and scar treatment. However, little is known about the effects of picosecond-domain fractional laser treatment over hyaluronic acid fillers (HAFs). We aimed to evaluate the in vivo tissue responses to 1064 nm picosecond-domain fractional neodymium:yttrium-aluminum-garnet (Nd:YAG) laser treatments using microlens array (MLA) applied over pre-injected HAF in rats...
April 29, 2020: Lasers in Surgery and Medicine
Lianru Zang, Yu Zhou, Jia Kang, ChengLi Song
BACKGROUND AND OBJECTIVES: The finite element method was used, and experiments were performed to analyze the effect of different electrode spacings and power combinations on the electrical and thermal aspects of biological tissues during bipolar radiofrequency (RF) fat dissolution. Through these efforts, this study also attempted to develop a reasonable electrode spacing and power combination that can achieve fat dissolution effects, the RF energy of which will not thermally damage the tissue...
April 28, 2020: Lasers in Surgery and Medicine
Shaiane S Tomazoni, Leonardo O P Costa, Jon Joensen, Martin B Stausholm, Ingvill F Naterstad, Malin Ernberg, Ernesto Cesar P Leal-Junior, Jan M Bjordal
BACKGROUND AND OBJECTIVES: Non-specific low back pain (LBP) is responsible for triggering increased biomarkers levels. In this way, photobiomodulation therapy (PBMT) may be an interesting alternative to treat these patients. One of the possible biological mechanisms of PBMT involved to decrease pain intensity in patients with musculoskeletal disorders is modulation of the inflammatory mediators' levels. The aim of this study was to evaluate the effects of PBMT compared with placebo on inflammatory mediators' levels and pain intensity in patients with chronic non-specific LBP...
April 24, 2020: Lasers in Surgery and Medicine
Macrene R Alexiades
BACKGROUND AND OBJECTIVES: More studies are needed to assess the long-term safety profile and clinical outcomes of lasers and energy-based devices to treat the symptoms associated with vulvovaginal atrophy. This study evaluated a series of three fractional CO2 laser treatments to the vulva and vagina with a 1-year follow-up in a postmenopausal population. STUDY DESIGN/MATERIALS AND METHODS: In this prospective, self-controlled, open-label clinical study, 18 postmenopausal females with atrophic vaginitis received 3 monthly treatments to the vulva and vagina with a fractional CO2 laser system and 1-, 3-, 6-, and 12-month follow-up...
April 23, 2020: Lasers in Surgery and Medicine
Travis W Sawyer, Jennifer W Koevary, Caitlin C Howard, Olivia J Austin, Photini F S Rice, Gabrielle V Hutchens, Setsuko K Chambers, Denise C Connolly, Jennifer K Barton
BACKGROUND AND OBJECTIVES: To determine the efficacy of targeted fluorescent biomarkers and multiphoton imaging to characterize early changes in ovarian tissue with the onset of cancer. STUDY DESIGN/MATERIALS AND METHODS: A transgenic TgMISIIR-TAg mouse was used as an animal model for ovarian cancer. Mice were injected with fluorescent dyes to bind to the folate receptor α, matrix metalloproteinases, and integrins. Half of the mice were treated with 4-vinylcyclohexene diepoxide (VCD) to simulate menopause...
April 20, 2020: Lasers in Surgery and Medicine
Ragia H Weshahy, Dalia G Aly, Suzan Shalaby, Faisal N Mohammed, Khadiga S Sayed
BACKGROUND AND OBJECTIVES: To investigate the therapeutic efficacy and safety of growth factors combined with fractional carbon dioxide (CO2 ) laser in comparison with fractional CO2 alone in a sample of patients with facial mature burn scars. STUDY DESIGN/MATERIALS AND METHODS: Fifteen Egyptian patients with bilateral facial burn scars were treated with six sessions of fractional CO2 laser at 6-week intervals. Following each laser session, a topical growth factors cocktail was applied to one side of the face in a split-face manner...
April 16, 2020: Lasers in Surgery and Medicine
Shereen O Tawfic, Amira El-Tawdy, Suzan Shalaby, Ahmed Foad, Olfat Shaker, Safinaz S Sayed, Dina Metwally
BACKGROUND: Keloids and hypertrophic scars are challenging to both patients and physicians. They can be aesthetically disfiguring, functionally debilitating, and emotionally distressing. Lasers have introduced new mechanisms to improve scars both on aesthetic and symptomatic levels. AIM OF WORK: Comparing the efficacy of fractional CO2 laser, long-pulsed Nd:YAG laser and their combination in the treatment of hypertrophic scars and keloids on clinical, histopathological, and biochemical basis...
April 15, 2020: Lasers in Surgery and Medicine
Nabil M Abdel-Aal, Ahmed E Elerian, Ayman M Elmakaky, Dina M A Alhamaky
BACKGROUND AND OBJECTIVES: To investigate the adding effect of Cryolipolysis to a low-calorie diet program on lipid profile, liver enzymes, body mass index, waist-to-hip ratio, and volume reduction of subcutaneous fat tissue in central obese women. STUDY DESIGN/MATERIALS AND METHODS: Sixty central obese women were randomly divided into two equal groups. Women in the control group received prescribed low-calorie diet regimen only, while women in the study group received three Cryolipolysis sessions plus the same dietary regimen for 3 months...
April 15, 2020: Lasers in Surgery and Medicine
Douglas C Wu, L T Jones, Monica Boen, Marwan Al-Haddad, Mitchel P Goldman
BACKGROUND AND OBJECTIVE: Fractionated lasers are a popular therapeutic option for facial photorejuvenation. In this study, we compare the safety, tolerability, and efficacy of a fractionated frequency-doubled 1064/532 nm picosecond Nd:YAG fractionated picosecond laser (FPL) versus a fractionated 1927 nm thulium fiber laser (TFL) for facial rejuvenation. STUDY DESIGN/MATERIALS AND METHODS: This was a double-blind, randomized, split-face comparison study involving 20 subjects...
April 14, 2020: Lasers in Surgery and Medicine
Douglas C Wu, Mitchel P Goldman, Heidi Wat, Henry H L Chan
BACKGROUND AND OBJECTIVES: The use of picosecond laser in dermatology was originally focused on optimizing the removal of unwanted tattoos. Subsequent advances in this technology have broadened its clinical indications to include treatment of benign pigmented lesions, photodamage, melasma, and scar revision. In this systematic review, evidence-based recommendations are developed for the use of picosecond laser in dermatology. STUDY DESIGN/MATERIALS AND METHODS: A comprehensive search of the English language literature was performed up to and including November 2019...
April 13, 2020: Lasers in Surgery and Medicine
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