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Journal of Bioenergetics and Biomembranes

Hong-Mei Li, Jian Miao, Meilin Zhu, Meijia Gao, Yiqun Dai, Qiang Huo, Tao Ma, Cheng-Zhu Wu
Hypoxia inducible factor-1α (HIF-1α) plays a central role in cell survival, invasion, metastasis and angiogenesis, and also is emerging as an important target in anti-cancer drug discovery. In the present study, bishonokiol A, a dimeric neolignan isolated from Magnolia grandiflora, was identified as a novel HIF-1α inhibitor. We here demonstrated that in a dose-dependent manner, bishonokiol A inhibited metastasis-related cell invasion and migration of cobalt chloride (CoCl2 )-induced MCF-7 and MDA-MB-231 cells, associating with the reduction in HIF-1α levels...
May 6, 2019: Journal of Bioenergetics and Biomembranes
Ludmila P Dolgacheva, Alexey V Berezhnov, Evgeniya I Fedotova, Valery P Zinchenko, Andrey Y Abramov
DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against neurodegeneration in Parkinson's disease. Wild type DJ-1 can acts as oxidative stress sensor and as an antioxidant. DJ-1 exhibits the properties of molecular chaperone, protease, glyoxalase, transcriptional regulator that protects mitochondria from oxidative stress. DJ-1 increases the expression of two mitochondrial uncoupling proteins (UCP 4 and UCP5), that decrease mitochondrial membrane potential and leads to the suppression of ROS production, optimizes of a number of mitochondrial functions, and is regarded as protection for the neuronal cell survival...
May 3, 2019: Journal of Bioenergetics and Biomembranes
M Favia, L de Bari, R Lassandro, Anna Atlante
Direct and indirect evidences show that elevated glucose concentrations in airway surface liquid (ASL) promote lung infection by pathogens, playing a role in the progression of the Cystic Fibrosis (CF) disease. The joint action of transporter/s for glucose and of the cellular enzymes is essential in order to try to lower ASL glucose level. Inside the cell, the glycolysis and the pentose phosphate pathway (PPP) compete for the utilization of glucose-6-phosphate (G6P), the product in which glucose, after entry within the cell and phosphorylation, is trapped...
April 27, 2019: Journal of Bioenergetics and Biomembranes
Mikhail V Dubinin, Anton O Svinin, Aleksander A Vedernikov, Vlada S Starinets, Kirill S Tenkov, Konstantin N Belosludtsev, Victor N Samartsev
The article considers the comparative analysis of the functional activity of mitochondria isolated from the liver of grass snakes, Natrix natrix (Linnaeus, 1758) that were kept at different temperatures (23-26 °C and 4-5 °C). It was found that liver mitochondria of hypothermia-exposed grass snakes are characterized by weak coupling of oxidative phosphorylation as compared to mitochondria of active animals which is caused by inhibition of succinate-fuelled respiration in ADP-stimulated state, as well as by activation of basal non-phosphorylating rate...
April 13, 2019: Journal of Bioenergetics and Biomembranes
Sriram Ravindran, Gino A Kurian
Sodium thiosulfate preconditioning (SIPC) was recently reported to be cardioprotective due to its ability to inhibit caspase-3 activation, chelate calcium ions and scavenge free radicals. However, the rationale behind its ability to improve the contractility of isolated rat heart challenged with ischemia-reperfusion injury (IR) is not well understood. As mitochondrial preservation is implicated in cardioprotection against IR, the present study was conceived to identify whether the cardioprotective effects of SIPC is associated with mitochondrial preservation...
March 30, 2019: Journal of Bioenergetics and Biomembranes
Seyed Jalal Hosseinimehr, Zahar Safavi, Sahar Kangarani Farahani, Zohreh Noaparst, Arash Ghasemi, Hossein Asgarian-Omran
Despite radiotherapy is an effective regimen in cancer treatment, resistance to tumor therapy still is a major challenge to radiotherapy and results in cancer recurrence and metastasis. Then the sensitization of tumor cells to ionizing radiation (IR) would be beneficial in cancer treatment. The aim of this study was to evaluate the synergistic effect of mefenamic acid (MEF) on colon cancer cell (HT-29) exposure to IR. HT-29 cells were treated with MEF and then exposed to IR. The synergistic effect of MEF is evaluated by clonogenic assay and flow cytometry...
March 7, 2019: Journal of Bioenergetics and Biomembranes
Jingwen Yang, Guangting Li, Kaibei Bao, Weihua Liu, Yaozhi Zhang, Weijen Ting
The anti-cancer role of local anesthetics has garnered attention in recent years because increasing evidence show that local anesthetics reduce the risk of tumor metastasis and recurrence. Angiogenesis, the formation of new blood vessels, is fundamental for tumor growth and metastasis. The role of local anesthetics on tumor angiogenesis still remains unknown. Using human lung tumor-associated endothelial cell (HLT-EC) and angiogenesis models, our work shows that ropivacaine at the clinically relevant concentration is active against multiple biological functions of HLT-EC but not lung tumor cells...
March 7, 2019: Journal of Bioenergetics and Biomembranes
Avipsha Sarkar, Shampa Sen
Vasoactive intestinal polypeptide receptor 1 (VPAC1) and epidermal growth factor receptor (EGFR) are associated with signal transduction pathways relevant to neuroblastoma, cancer of breast, prostate and lungs. In order to identify appropriate ligand analogues for simultaneous inhibition of EGFR and VPAC1, in-silico homology modelling of VPAC1 and its characterization by molecular interaction studies have been undertaken. Homology modelling was performed with the Swiss Model and validation of the predicted 3D structure was carried out using PROCHECK and RAMPAGE...
February 27, 2019: Journal of Bioenergetics and Biomembranes
Ofelia Mendez-Romero, Salvador Uribe-Carvajal, Natalia Chiquete-Felix, Adriana Muhlia-Almazan
Mitochondrial uncoupling proteins (UCP) transport protons from the intermembrane space to the mitochondrial matrix uncoupling oxidative phosphorylation. In mammals, these proteins have been implicated in several cellular functions ranging from thermoregulation to antioxidant defense. In contrast, their invertebrate homologs have been much less studied despite the great diversity of species. In this study, two transcripts encoding mitochondrial uncoupling proteins were, for the first time, characterized in crustaceans...
February 22, 2019: Journal of Bioenergetics and Biomembranes
Valéria Sutti Nunes, Patrícia Miralda Cazita, Sérgio Catanozi, Edna Regina Nakandakare, Eder Carlos Rocha Quintão
Phytosterol metabolism is unknown in the hypercholesterolemia of genetic origin. We investigated the metabolism of phytosterols in a cholesterol-free, phytosterol-containing standard diet in hypercholesterolemic mice knockouts for low density lipoprotein receptor (LDLR) and apolipoprotein E (apoE) mice compared to wild-type mice (controls). Phytosterols were measured in mice tissues by GCMS. ApoE-KO mice absorbed less phytosterols than LDLR-KO and the latter absorbed less phytosterols than control mice, because the intestinal campesterol content was low in both KO mice, and sitosterol was low in the intestine in apoE-KO mice as compared to LDLR-KO mice...
April 2019: Journal of Bioenergetics and Biomembranes
Eun Ju Cho, Su Jong Yu, Kyungmin Kim, Heki Cho, Young Youn Cho, Yun Bin Lee, Jeong-Hoon Lee, Yoon Jun Kim, Hyewon Youn, Jung-Hwan Yoon
Hypoxic conditions, which large or infiltrative hypovascular tumors may encounter, also produce acidic environments. Carbonic anhydrase-IX (CA-IX), an enzyme involved in lowering pH, is overexpressed in hepatocellular carcinoma (HCC). In the present study, whether inhibition of CA-IX enhances the efficacy of a hexokinase II inhibitor in an in vivo murine model was examined and its prognostic implication in HCC patients was investigated. CA-IX expression was evaluated using quantitative real-time PCR and western blot analysis using human HCC cell lines...
February 12, 2019: Journal of Bioenergetics and Biomembranes
David M Coppola
No abstract text is available yet for this article.
February 8, 2019: Journal of Bioenergetics and Biomembranes
Jon K Cherry, Cheryl A Woolhead
The folding and targeting of hydrophobic transmembrane domains poses a major challenge to the cell. Several membrane proteins have been shown to gain some degree of secondary structure within the ribosome tunnel and to retain this conformation throughout maturation. However, there is little information on one of the largest classes of eukaryotic membrane proteins; the G protein-coupled receptors (GPCRs). In this study we show that the signal anchor domain of GPR35 remains in an extended conformation whilst exiting the ribosome tunnel, the polypeptide chain then forms interactions with components of the SRP targeting pathway, and the Sec61 translocon, resulting in a compacted conformation prior to integration into the ER membrane...
January 31, 2019: Journal of Bioenergetics and Biomembranes
Karine Leitão Lima Thiers, João Hermínio Martins da Silva, Geraldo Rodrigues Sartori, Clesivan Pereira Dos Santos, Kátia Daniella da Cruz Saraiva, André Luiz Maia Roque, Birgit Arnholdt-Schmitt, José Hélio Costa
Plant plastoquinol oxidase (PTOX) is a chloroplast oxidoreductase involved in carotenoid biosynthesis, chlororespiration, and response to environmental stresses. The present study aimed to gain insight of the potential role of nucleotide/amino acid changes linked to environmental adaptation in PTOX gene/protein from Arabidopsis thaliana accessions. SNPs in the single-copy PTOX gene were identified in 1190 accessions of Arabidopsis using the Columbia-0 PTOX as a reference. The identified SNPs were correlated with geographical distribution of the accessions according to altitude, climate, and rainfall...
January 7, 2019: Journal of Bioenergetics and Biomembranes
N Jennifer Klinedinst, Rosemary Schuh, Steven J Kittner, William T Regenold, Glenn Kehs, Christine Hoch, Alisha Hackney, Gary Fiskum
Approximately half of stroke survivors suffer from clinically significant fatigue, contributing to poor quality of life, depression, dependency, and increased mortality. The etiology of post-stroke fatigue is not well understood and treatment is limited. This study tested the hypothesis that systemic aerobic energy metabolism, as reflected by platelet oxygen consumption, is negatively associated with fatigue and systemic inflammation is positively associated with fatigue in chronic ischemic stroke survivors...
January 7, 2019: Journal of Bioenergetics and Biomembranes
Nia Petrova, Svetla Todinova, Momchil Paunov, Lászlo Kovács, Stefka Taneva, Sashka Krumova
Thylakoids are highly protein-enriched membranes that harbor a number of multicomponent photosynthetic complexes. Similarly to other biological membranes the protein constituents are heterogeneously distributed laterally in the plane of the membrane, however the specific segregation into stacked (grana patches) and unstacked (stroma lamellae) membrane layers is a unique feature of the thylakoid. Both the lateral and the vertical arrangements of the integral membrane proteins within the three-dimensional thylakoid ultrastructure are thought to have important physiological function...
January 3, 2019: Journal of Bioenergetics and Biomembranes
C Huart, Ph Rombaux, T Hummel
The topic of human adult neural plasticity and neurogenesis is of great interest for medical and scientific community, but it is also largely debated. In the last years, an increasing interest has been paid to the olfactory system, and particularly to the plasticity of the olfactory bulb (OB). While the molecular/cellular mechanisms underlying OB plasticity remain a matter of debate, measurements of the OB using magnetic resonance imaging clearly indicate that it is a highly plastic structure. In this review, we present results regarding the plasticity of the human adult olfactory system...
January 3, 2019: Journal of Bioenergetics and Biomembranes
Leila Motlagh Scholle, Annemarie Thaele, Marie Beckers, Beate Meinhardt, Stephan Zierz
The phospholipid environment of the mitochondrial inner membrane, which contains large amounts of cardiolipin, could play a key role in transport of the long chain fatty acids. In the present study, the pre-incubation of cardiolipin with the wild type carnitine palmitoyltransferase (CPT) II led to a more than 1.5-fold increase of enzyme activity at physiological temperatures. At higher temperatures, however, there was a pronounced loss of activity. The most frequent variant S113L showed even at 37 °C a great activity loss...
January 3, 2019: Journal of Bioenergetics and Biomembranes
Eryn Slankster, Seth R Odell, Dennis Mathew
Most animals depend upon olfaction to find food, mates, and to avoid predators. An animal's olfactory circuit helps it sense its olfactory environment and generate critical behavioral responses. The general architecture of the olfactory circuit, which is conserved across species, is made up of a few different neuronal types including first-order receptor neurons, second- and third-order neurons, and local interneurons. Each neuronal type differs in their morphology, physiology, and neurochemistry. However, several recent studies have suggested that there is intrinsic diversity even among neurons of the same type and that this diversity is important for neural function...
January 2, 2019: Journal of Bioenergetics and Biomembranes
(no author information available yet)
No abstract text is available yet for this article.
December 13, 2018: Journal of Bioenergetics and Biomembranes
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