Ya-Ting Wang, Xiao-Le Wang, Lan Lei, Yi Zhang
RATIONALE: Depression is a prevalent psychiatric disease, and ginsenoside Rg1 is a bioactive compound extracted from the root of Panax ginseng C.A.Mey. To systematically investigate the effectiveness of Rg1 in rodent models of depression and provide evidence-based references for treating depression. METHODS: Electronic searches for rodent studies were performed from inception to October 2022, e.g., PUBMED and EMBASE. Data extraction and quality evaluation were performed for the references, and meta-analysis was performed on the selected data using Review Manager 5...
July 23, 2024: Psychopharmacology
Magdalena Kolasa, Agnieszka Nikiforuk, Agata Korlatowicz, Joanna Solich, Agnieszka Potasiewicz, Marta Dziedzicka-Wasylewska, Ryszard Bugno, Adam Hogendorf, Andrzej Bojarski, Agata Faron-Górecka
No abstract text is available yet for this article.
July 20, 2024: Psychopharmacology
Jessica T Jacobs, Rafael S Maior, Hannah F Waguespack, Carolina Campos-Rodriguez, Ludise Malkova, Patrick A Forcelli
Serotonin signaling plays critical roles in social and emotional behaviors. Likewise, decades of research demonstrate that the amygdala is a prime modulator of social behavior. Permanent excitotoxic lesions and transient amygdala inactivation consistently increase social behaviors in non-human primates. In rodents, acute systemic administration of drugs that increase serotonin signaling is associated with decreased social interactions. However, in primates, the direct involvement of serotonin signaling in the amygdala, particularly in affiliative social interaction, remains unexplored...
July 18, 2024: Psychopharmacology
Karline da Costa Rodrigues, Meliza da Conceição Oliveira, Beatriz Fuzinato Dos Santos, Nelson Luís de Campos Domingues, Mariana Gallio Fronza, Lucielli Savegnago, Ethel Antunes Wilhelm, Cristiane Luchese
RATIONALE: The compound 5-((4-methoxyphenyl)thio)benzo[c][1,2,5]thiadiazole (MTDZ) has recently been shown to inhibit in vitro acetylcholinesterase activity, reduce cognitive damage, and improve neuropsychic behavior in mice, making it a promising molecule to treat depression. OBJECTIVES: This study investigated the antidepressant-like action of MTDZ in mice and its potential mechanisms of action. RESULTS: Molecular docking assays were performed and suggested a potential inhibition of monoamine oxidase A (MAO-A) by MTDZ...
July 15, 2024: Psychopharmacology
Mark A Smith, Samantha P Armas, Jacob D Camp, Hannah N Carlson
RATIONALE: Preclinical studies report that drug use and social contact mutually influence the reinforcing effects of one another. Most of these studies have used same-sex dyads exclusively, and the role of factors related to biological sex and hormonal fluctuations are not well understood. OBJECTIVES: The purpose of this study was to examine the reinforcing effects of cocaine and social contact with an opposite-sex partner in male and female rats, and how these effects are modulated by ovarian hormones...
July 12, 2024: Psychopharmacology
Samuel F Acuff, Justin C Strickland, Kirsten Smith, Matt Field
RATIONALE: Theories of addiction guide scientific progress, funding priorities, and policy development and ultimately shape how people experiencing or recovering from addiction are perceived and treated. Choice theories of addiction are heterogenous, and different models have divergent implications. This breeds confusion among laypeople, scientists, practitioners, and policymakers and reduces the utility of robust findings that have the potential to reduce the global burden of addiction-associated harms...
July 11, 2024: Psychopharmacology
Elise J Heesbeen, Tatum van Kampen, P Monika Verdouw, Caspar van Lissa, Elisabeth Y Bijlsma, Lucianne Groenink
RATIONALE: Selective serotonin reuptake inhibitors (SSRIs) are the first choice of treatment for anxiety-like disorders. However, which aspects of anxiety are affected by SSRIs is not yet fully understood. OBJECTIVE: We aimed to systematically review the effect of six clinically effective SSRIs on four aspects of unconditioned anxiety: approach-avoidance behaviour (elevated plus maze), repetitive behaviour (marble burying), distress behaviour (ultrasonic vocalization), and activation of the autonomous nervous system (stress-induced hyperthermia)...
July 9, 2024: Psychopharmacology
Denis Lissitsa, May Hovers, Michal Shamuilova, Tal Ezrapour, Leehe Peled-Avron
RATIONALE: Sexuality is a central aspect of being human that encompasses many facets. Cannabis, a widely used psychoactive substance, has been associated with various effects on sexuality. The relationship between cannabis and sexuality is complex and multifaceted, involving physiological, psychological, and social factors. OBJECTIVES: This review aims to provide an overview of the current literature on the effects of cannabis on several sexual functions, including sexual desire, arousal, orgasm, and sexual satisfaction...
July 8, 2024: Psychopharmacology
Suprit Parida, R Ross MacLean, Ralitza Gueorguieva, Mehmet Sofuoglu
RATIONALE: No previous studies examined the discriminative stimulus effects of intravenous (IV) nicotine in humans. OBJECTIVES: To evaluate a pulsed IV nicotine infusion procedure designed to mimic inhaled nicotine delivery and to identify a range of nicotine doses that may capture the threshold doses for the subjective and discriminative stimulus effects of nicotine. By determining these thresholds, we can gain valuable insights into the addictive threshold of nicotine...
July 6, 2024: Psychopharmacology
Alexander D Maitland, Shelby A McGriff, Grant C Glatfelter, Charles W Schindler, Michael H Baumann
RATIONALE: The potent synthetic opioid fentanyl, and its analogs, continue to drive opioid-related overdoses. Although the pharmacology of fentanyl is well characterized, there is little information about the reinforcing effects of clandestine fentanyl analogs (FAs). OBJECTIVES: Here, we compared the effects of fentanyl and the FAs acetylfentanyl, butyrylfentanyl, and cyclopropylfentanyl on drug self-administration in male and female rats. These FAs feature chemical modifications at the carbonyl moiety of the fentanyl scaffold...
July 5, 2024: Psychopharmacology
Kolasa Magdalena, Nikiforuk Agnieszka, Korlatowicz Agata, Solich Joanna, Potasiewicz Agnieszka, Marta Dziedzicka-Wasylewska, Bugno Ryszard, Hogendorf Adam, Bojarski Andrzej, Faron-Górecka Agata
RATIONALE: Our study aimed to unravel the unknown mechanisms behind the exceptional efficacy of Psilocybin (PSI) in treating treatment-resistant depression (TRD). Focusing on Wistar-Kyoto (WKY) rats with a TRD phenotype and Wistar (WIS) rats as a normative comparison, we investigated behavioral and neuroplasticity-related responses to PSI, striving to shed light on the distinctive features of its antidepressant effects. OBJECTIVES: We set out to assess the behavioral impact of acute and prolonged PSI administration on WKY and WIS rats, employing Novel Object Recognition (NORT), Social Interaction (SI), and Forced Swimming Test (FST)...
July 4, 2024: Psychopharmacology
Monserrat Armenta-Resendiz, Jordan S Carter, Zachariah Hunter, Makoto Taniguchi, Carmela M Reichel, Antonieta Lavin
Intact executive functions are required for proper performance of cognitive tasks and relies on balance of excitatory and inhibitory (E/I) transmission in the medial prefrontal cortex (mPFC). Hypofrontality is a state of decreased activity in the mPFC and is seen in several neuropsychiatric conditions, including substance use disorders. People who chronically use methamphetamine (meth) develop hypofrontality and concurrent changes in cognitive processing across several domains. Despite the fact that there are sex difference in substance use disorders, few studies have considered sex as a biological variable regarding meth-mediated hypoactivity in mPFC and concurrent cognitive deficits...
July 2, 2024: Psychopharmacology
Kenichi Oga, Manabu Fuchikami, Hironori Kobayashi, Tatsuhiro Miyagi, Sho Fujita, Satoshi Fujita, Satoshi Okada, Shigeru Morinobu
RATIONALE: Since the precise mechanisms of posttraumatic stress disorder (PTSD) remain unknown, effective treatment interventions have not yet been established. Impaired extinction of fear memory (EFM) is one of the core symptoms of PTSD and is associated with stress-induced epigenetic change in gene expression. OBJECTIVES: In this study, we examined whether the involvement of histone H3 lysine 9 dimethylation (H3K9me2) in EFM is mediated through brain-derived neurotrophic factor (BDNF) expression in the hippocampus, and whether BIX01294, a selective G9a and GLP histone methyltransferase inhibitor, could be treatment for impaired EFM in an animal model of PTSD...
June 28, 2024: Psychopharmacology
Amanda M Wunsch, Eun-Kyung Hwang, Jonathan R Funke, Raines Baker, Alana Moutier, Mike Milovanovic, Thomas A Green, Marina E Wolf
RATIONALE: Incubation of cocaine craving refers to the progressive intensification of cue-induced craving during abstinence from cocaine self-administration. We showed previously that homomeric GluA1 Ca2+ -permeable AMPARs (CP-AMPAR) accumulate in excitatory synapses of nucleus accumbens core (NAcc) medium spiny neurons (MSN) after ∼1 month of abstinence and thereafter their activation is required for expression of incubation. Therefore, it is important to understand mechanisms underlying CP-AMPAR plasticity...
June 27, 2024: Psychopharmacology
Huili Zhu, Longyu Wang, Xiaoxuan Wang, Yishan Yao, Peilan Zhou, Ruibin Su
RATIONALE: The phenylalkylamine hallucinogen (-)-2,5-dimethoxy-4-methylamphetamine (DOM) exhibits an inverted U-shaped dose-response curve for both head twitch response (HTR) and locomotor activity in mice. Accumulated studies suggest that HTR and locomotor hyperactivity induced by DOM are mainly caused by the activation of serotonin 5-hydroxytryptamine 2 A receptor (5-HT2A receptor). However, the mechanisms underlying the biphasic dose response of HTR and locomotor activity induced by DOM, particularly at high doses, remain unclear...
June 25, 2024: Psychopharmacology
Aya M Fayoud, Hisham Ahmed Orebi, Iman Abdelhady Elshnoudy, Mai Alaaeldin Temraz Elsebaie, Mariam Mahmoud Mohamed Elewidi, Hamdy Khaled Sabra
No abstract text is available yet for this article.
June 22, 2024: Psychopharmacology
Abdelrahim Alqudah, Esam Qnais, Omar Gammoh, Yousra Bseiso, Mohammed Wedyan, Mohammad Alqudah, Muna Oqal, Rawan Abudalo, Taher Hatahet
RATIONALE: Early-life maternal separation can lead to anxiety-like and depression-like behaviors in mice reared under maternal separation conditions. Scopoletin, a compound with anti-inflammatory and antidepressant properties, may offer therapeutic benefits, but its effectiveness against behaviors induced by maternal separation during adulthood remains unexplored. OBJECTIVES: This study investigates scopoletin's efficacy in alleviating anxiety-like and depression-like phenotypes in male mice subjected to early-life maternal separation...
June 18, 2024: Psychopharmacology
Jeremy Metha, Yijun Ji, Clemens Braun, Janet R Nicholson, Luis De Lecea, Carsten Murawski, Daniel Hoyer, Laura H Jacobson
RATIONALE: Motivation and inhibitory control are dominantly regulated by the dopaminergic (DA) and noradrenergic (NA) systems, respectively. Hypothalamic hypocretin (orexin) neurons provide afferent inputs to DA and NA nuclei and hypocretin-1 receptors (HcrtR1) are implicated in reward and addiction. However, the role of the HcrtR1 in inhibitory control is not well understood. OBJECTIVES: To determine the effects of HcrtR1 antagonism and motivational state in inhibitory control using the go/no-go task in mice...
June 18, 2024: Psychopharmacology
Anders Fink-Jensen, Gitta Wörtwein, Mette Kruse Klausen, Jens Juul Holst, Bolette Hartmann, Morgan Thomsen, Maurice Ptito, Amy Beierschmitt, Roberta M Palmour
RATIONALE: Glucagon-like peptide-1 (GLP-1) receptor agonists reduce alcohol consumption in rodents and non-human primates. Semaglutide is a new long-acting GLP-1 receptor agonist, widely used in the clinic against type 2 diabetes and obesity. It is also reported to reduce alcohol intake in rodents. OBJECTIVES: This study investigates the possible inhibitory effect of semaglutide on alcohol intake in alcohol-preferring African green monkeys. METHODS: We performed a vehicle-controlled study on male monkeys that had demonstrated a preference for alcohol...
June 17, 2024: Psychopharmacology
Kamal Ranjbar, Alireza Komaki, Bayan Fayazi, Ebrahim Zarrinkalam
No abstract text is available yet for this article.
June 14, 2024: Psychopharmacology
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