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European Journal of Pediatrics

Maria Chiara Supino, Danilo Buonsenso, Simona Scateni, Barbara Scialanga, Maria Alessia Mesturino, Caterina Bock, Antonio Chiaretti, Emanuele Giglioni, Antonino Reale, Anna Maria Musolino
Bronchiolitis is the most common cause of hospitalization of children in the first year of life. The lung ultrasound is a new diagnostic tool which is inexpensive, non-invasive, rapid, and easily repeatable. Our prospective study was conducted in the emergency department and all patients underwent a routine clinical evaluation and lung ultrasound by the pediatricians who defined the clinical and the ultrasound score. We enrolled 76 infants (median age 90 days [IQR 62-183], 53.9% males). In nasopharyngeal aspirates, the respiratory syncytial virus was isolated in 33 patients...
February 12, 2019: European Journal of Pediatrics
Nathalie Guffon, Pierre Journeau, Anaïs Brassier, Juliane Leger, Bertrand Chevallier
Growth impairment together with bone and joint involvement is common to most patients with mucopolysaccharidosis (MPS) disorders. The genetic basis for these metabolic disorders involves various enzyme deficiencies responsible for the catabolism of glycosaminoglycans (GAGs). The incomplete degradation and subsequent accumulation of GAGs result in progressive tissue damage throughout the body. Bone ossification is particularly affected, with the consequent onset of dysostosis multiplex which is the underlying cause of short stature...
February 11, 2019: European Journal of Pediatrics
(no author information available yet)
No abstract text is available yet for this article.
February 9, 2019: European Journal of Pediatrics
Eran Lavi, Alex Gileles-Hillel, Natalia Simanovsky, Dina Averbuch, Isaiah D Wexler, Yackov Berkun
Pyogenic sacroiliitis (PS) is rare with less than 100 pediatric cases reported in the medical literature. To better characterize PS in the pediatric population, we investigated a series of children presenting with PS. Retrospective data analysis was done at an academic tertiary center between the years of 2000 and 2017. All hospitalized children ≤ 16 years of age with PS were evaluated. Of the 894 children hospitalized with osteoarticular infections, 18 were diagnosed with PS (2%) and are included in the review...
February 7, 2019: European Journal of Pediatrics
Tanja H Kakebeeke, Aziz Chaouch, Elisa Knaier, Jon Caflisch, Valentin Rousson, Remo H Largo, Oskar G Jenni
There is a need for a quick, qualitative, reliable, and easy tool to assess gross motor development for practitioners. The aim of this cross-sectional study is to present the Zurich Neuromotor Assessment-Q (ZNA-Q), which assesses static and dynamic balance in children between 3 and 6 years of age in less than 5 min. A total of 216 children (103 boys; 113 girls; median age 4 years, 4 months; interquartile range 1 year, 3 months) were enrolled from day-care centers, kindergartens, and schools, and were tested with 5 different gross motor tasks: standing on one leg, tandem stance, hopping on one leg, walking on a straight line, and jumping sideways...
February 7, 2019: European Journal of Pediatrics
Anouk F M van Gijzen, Elsbeth D M Rouers, Florens Q M P van Douveren, Jeanne Dieleman, Johannes G E Hendriks, Feico J J Halbertsma, Levinus A Bok
Guidelines for children with Down syndrome (DS) suggest to perform an annual hip screening to enable early detection of developmental dysplasia of the hip (DDH). How to perform this screening is not described. Delayed detection can result in disabling osteoarthritis of the hip. Therefore, we determined the association between clinical history, physical, and radiological examination in diagnosing DDH in children with DS. Referral centers for children with DS were interviewed to explore variety of hip examination throughout the Netherlands...
February 1, 2019: European Journal of Pediatrics
Ilker Ufuk Sayıcı, Filiz Simsek Orhon, Seda Topçu, Betul Ulukol, Sevgi Baskan
The aims of this study were to determine bisphenol A (BPA) levels in breast milk and urine specimens of healthy mother and exclusively breastfed infant pairs having no known BPA exposure, and also to examine the relationship between BPA levels and possible BPA exposure history. Forty mothers and their 1-2-month-old exclusively breastfeed infant were included in the study. The questionnaires about sociodemographic characteristics and possible BPA exposure history were filled out. Breast milk and urine samples were taken...
February 1, 2019: European Journal of Pediatrics
Rozeta Sokou, Aikaterini Konstantinidi, Charikleia Stefanaki, Andreas G Tsantes, Stavroula Parastatidou, Katerina Lampropoulou, George Katsaras, Evagelia Tavoulari, Nicoletta Iacovidou, Elias Kyriakou, Antonios Gounaris, Stefanos Bonovas, Argirios E Tsantes
Scarce data exists about the hemostatic status of small for gestational age (SGA) neonates. We aimed at evaluating the hemostatic profile of SGA neonates, using thromboelastometry (TEM). This is an observational study performed in a Greek tertiary General Hospital during an 18-month period. Ninety-three neonates were included in the study: 48 appropriate for gestational age weight (AGA) neonates and 45 SGA neonates Extrinsically activated TEM (ex-TEM) parameters, such as clotting time, clot formation time, amplitude recorded at 5 and 10 min, a angle, maximum clot firmness, lysis index at 60 min, and also platelet count, were used for the evaluation of the hemostatic profile in all neonates...
February 1, 2019: European Journal of Pediatrics
Víctor García-Nieto, Victoria E García-Rodríguez, María Isabel Luis-Yanes, Margarita Monge, Pedro Arango-Sancho, Eduardo H Garin
Severe (grades IV and V) vesicoureteral reflux (VUR) is a risk factor for acute pyelonephritis, renal scars, and renal failure. This study evaluates albumin and N-acetylglucosaminidase (NAG) urinary excretion, and renal concentrating ability as screening tools to select patients for voiding cystourethrogram (VCUG). Children (111 M, 52 F) aged 10.97 ± 21.17 months (mean + SD), diagnosed with UTI, and who had undergone renal ultrasound and a VCUG, underwent a desmopressin test and had albumin/creatinine and NAG/creatinine urinary excretion measured...
January 31, 2019: European Journal of Pediatrics
Pierre Bakhache, Brigitte Virey, Christina Bienenfeld
A prospective, observational, survey of pediatricians and general practitioners (GPs) was conducted to assess pediatric vaccination knowledge and practices. The survey was distributed by email to 1069 pediatricians and 1700 GPs and completed by 151 pediatricians (14.1%) and 201 GPs (11.8%). Knowledge of the vaccination calendar was very good (99% overall). Of the respondents, 98% were confident in vaccine efficacy. Eight-one percent of pediatricians and 62% of GPs agreed that recommended vaccinations should become obligatory; all prescribed hexavalent vaccines often or always...
January 31, 2019: European Journal of Pediatrics
Helena Moreira-Silva, Inês Maio, Anabela Bandeira, Esmeralda Gomes-Martins, Ermelinda Santos-Silva
Metabolic liver diseases (MLD) are an important group of disorders presenting with neonatal cholestasis (NC). The spectrum of liver involvement is wide and the presumptive diagnosis is traditionally based on clinical and laboratory findings. Recently, next-generation sequencing (NGS) panels have emerged as an appealing tool to diagnose neonatal/infantile cholestatic disorders. The aim of this study was to identify clinical phenotypes of liver injury and contribute to find a diagnostic methodology that integrates new molecular diagnostic tools...
January 28, 2019: European Journal of Pediatrics
Engelina Spaans, Kornelis J J van Hateren, Klaas H Groenier, Henk J G Bilo, Nanne Kleefstra, Paul L P Brand
The Abstract section and the in the Results sections of the original version of this article, unfortunately, contained errors. The correct data are now shown in this article.
January 25, 2019: European Journal of Pediatrics
Lucile Cadot, Hélène Bruguière, Estelle Jumas-Bilak, Marie-Noëlle Didelot, Agnès Masnou, Gaëlle de Barry, Gilles Cambonie, Sylvie Parer, Sara Romano-Bertrand
In the context of a 3-month extended-spectrum beta-lactamase-producing Klebsiella pneumonia (ESBL-KP) outbreak in a neonatal care center (NCC), hygiene practices and hospital environment were investigated. ESBL-KP strains isolated from patients and environment were compared by molecular typing. The density of incidence of multi-drug-resistant bacteria (MDRB) was calculated from January 2014 to September 2016. The 3-month ESBL-KP outbreak involved 19 patients. Clinical strains from the 19 patients displayed the same molecular profile between them, and with a strain isolated from an incubator after cleaning...
January 23, 2019: European Journal of Pediatrics
Alberto Di Mascio, Benedetta Bossini, Egidio Barbi, Franca Benini, Giorgio Cozzi
Procedural sedation and analgesia with ketamine are part of daily practice for children undergoing painful procedures in the paediatric emergency department (ED) of North America. A massive number of studies demonstrate ketamine's safety and efficacy in the hands of trained ED paediatricians, with few severe adverse events (SAEs) recorded. Since there are no data on ketamine's usage in Italian paediatric EDs, we created a survey to examine procedural sedation with ketamine in the EDs of the Italian PIPER (Pain in Paediatric Emergency Room) group, which includes 36 paediatric EDs providing 1...
January 22, 2019: European Journal of Pediatrics
Francoise van Kampen, Amerik de Mol, Jacqueline Korstanje, Femke Maingay-de Groof, Linda van Meurs-Asseler, Helene Stas, Richard Willemsen, Aeilko Zwinderman, Gerlinde Stoelhorst
Most premature infants are hospitalised until they no longer need monitoring of vital parameters and are independent of nasogastric tube feeding (NTF). Hospital admission time easily reaches a length of multiple months in extremely preterm infants, but also in late preterms, in whom drinking may be the only problem, hospital admission time can reach weeks. This is a very stressful time for both parents and child. Parents in the Albert Schweitzer Hospital (ASH) are taught to give their child NTF. When monitoring is no longer necessary, the child can be discharged with NTF, with home care by paediatric nurses...
January 22, 2019: European Journal of Pediatrics
Iuri Corsini, Niccolò Parri, Caterina Coviello, Valentina Leonardi, Carlo Dani
Congenital diaphragmatic hernia (CDH) occurs in approximately 1 in 2500 to 5000 infants. The use of lung ultrasound (LUS) for its diagnosis has been reported in only two case reports. The aim of this study was to report the LUS pattern of CDH in a case series of infants with respiratory distress. This case series was part of a cohort enrolled in a larger prospective observational study. LUS was performed at the point-of-care during the first 24 h of life of the neonates and its operation time was measured...
January 21, 2019: European Journal of Pediatrics
Sonia Chindamo, Alessandra Buja, Elisa DeBattisti, Alberto Terraneo, Elena Marini, Luis Javier Gomez Perez, Linda Marconi, Vincenzo Baldo, Gianpiero Chiamenti, Mattia Doria, Flavia Ceschin, Emanuela Malorgio, Mara Tommasi, Milena Sperotto, Roberto Buzzetti, Luigi Gallimberti
Several studies over the years have demonstrated the association between lack of sleep in children and certain physical, psychological, and behavioral disorders. The aim of this study was to disentangle the association between new screen-based electronic devices and sleep problems in toddlers, adjusting for other covariates already known to be associated with sleep quality. We conducted a cross-sectional study with the aid of a national sample of 1117 toddlers. Parents reported children's sleeping habits such as total sleep time and sleep onset latency, recreational activities, bedtime routines, and temperament...
January 16, 2019: European Journal of Pediatrics
Giuseppe Riva, Matteo Sensini, Federica Peradotto, Carlo Scolfaro, Gianpaolo Di Rosa, Paolo Tavormina
Pediatric neck masses are a common occurrence and often represent a diagnostic challenge. The primary aim of this retrospective study was to evaluate the clinical and radiological features of neck masses in children and how they can drive diagnosis. The secondary aim was to create a diagnostic algorithm based on clinical features. We evaluated 190 children with neck masses who needed hospitalization. Clinical data and imaging findings were collected. The patients were divided into six groups: congenital/developmental lesions, tumors, acute and subacute lymphadenopathies, chronic nonspecific lymphadenopathies, cat-scratch disease, and mycobacteriosis...
January 14, 2019: European Journal of Pediatrics
Ted M T van Hinsbergh, Stephanie C M de Crom, Robert Lindeboom, Marceline A M van Furth, Charlie C Obihara
This multicenter prospective cohort study describes the impact of human parechovirus meningitis on gross-motor neurodevelopment of young children. Gross-motor function was measured using Alberta Infant Motor Scale. Of a total of 38 eligible children < 10 months of age at onset, nine cases had clinical evidence of meningitis and polymerase chain reaction positive for human parechovirus in cerebrospinal fluid; 11 had no meningitis and polymerase chain reaction positive for human parechovirus in nasopharyngeal aspirate, blood, urine, or feces; and in 18, no pathogen was identified (reference group)...
January 14, 2019: European Journal of Pediatrics
Koos Korsten, Maarten O Blanken, Brigitte J M Buiteman, Elisabeth E Nibbelke, Christiana A Naaktgeboren, Louis J Bont, Joanne G Wildenbeest
Severe respiratory syncytial virus (RSV) infection during infancy is associated with ongoing respiratory morbidity. In a large birth cohort of 2210 healthy preterm infants born at 32-35 weeks of gestation, we aimed to determine the role of atopy in the link between RSV hospitalization and current wheeze at age 6. We defined current wheeze as parent-reported wheeze or the use of respiratory medication in the past 12 months. Based on a positive family history of atopic disease, we distinguished between children with and without atopic predisposition...
January 12, 2019: European Journal of Pediatrics
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