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Journal of Neurochemistry

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https://read.qxmd.com/read/30874310/understanding-depression-the-hippocampus-might-hold-the-answer-in-a-creb-regulated-transcription-coactivator-an-editorial-for-aav-mediated-over-expression-of-crtc1-in-the-hippocampal-dentate-gyrus-ameliorates-lipopolysaccharide-induced-depression-like-behavior
#1
EDITORIAL
Randall L Davis
The pathophysiology of major depressive disorders is not completely understood. In this issue of Journal of Neurochemistry, Ni and colleagues investigate the role of cyclic adenosine monophosphate response element-binding protein (CREB)-dependent signaling in the hippocampus on depressive-like behaviors. This editorial highlights the key findings reported by Ni et al., (2018) and how they demonstrated the importance of CREB-regulated transcription cofactor 1 in LPS-induced neuroinflammation and depressive-like behaviors...
March 15, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30851210/ionized-calcium-in-human-cerebrospinal-fluid-and-its-influence-on-intrinsic-and-synaptic-excitability-of-hippocampal-pyramidal-neurons-in-the-rat
#2
My Forsberg, Henrik Seth, Andreas Björefeldt, Tim Lyckenvik, Mats Andersson, Pontus Wasling, Henrik Zetterberg, Eric Hanse
It is well known that the extracellular concentration of calcium affects neuronal excitability and synaptic transmission. Less is known about the physiological concentration of extracellular calcium in the brain. In electrophysiological brain slice experiments, the artificial cerebrospinal fluid (aCSF) traditionally contains relatively high concentrations of calcium (2-4 mM) to support synaptic transmission and suppress neuronal excitability. Using an ion-selective electrode, we determined the fraction of ionized calcium in healthy human cerebrospinal fluid (hCSF) to 1...
March 9, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30851189/neuroprotective-effects-of-an-engineered-commensal-bacterium-in-the-mptp-parkinson-disease-mouse-model-via-producing-glp-1
#3
Xin Fang, Puyuan Tian, Xiaoxiao Zhao, Chunling Jiang, Tingtao Chen
While glucagon-like peptide-1 (GLP-1) was reported to have a positive impact on Parkinson disease, its extremely short half-life greatly hindered its clinical use. In the present study, the mouse strain MG1363-pMG36e-GLP-1 was engineered to continuously express GLP-1 to treat Parkinson disease in a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-treated Parkinson disease model. In our study, oral supplementation with MG1363-pMG36e-GLP-1 significantly (p < 0.05) reduced MPTP-induced locomotor impairments, increased tyrosine hydroxylase (T-OH)-positive neurons, suppressed microglia and astrocyte activation and downregulated expression of several inflammation-related molecules...
March 9, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30828804/crosstalk-between-mitochondria-calcium-channels-and-actin-cytoskeleton-modulates-noradrenergic-activity-of-locus-coeruleus-neurons
#4
Ramatis B de Oliveira, Lyvia L Petiz, Rebecca Lim, Janusz Lipski, Fernanda S Gravina, Alan M Brichta, Robert J Callister, Richardson N Leão, Dirk F van Helden
Locus coeruleus (LC) is the name of a group of large sized neurons located at the brain stem, which provide the main source of noradrenaline to the central nervous system, virtually, innervating the whole brain. All noradrenergic signalling provided by this nucleus is dependent on an intrinsic pacemaker process. Our study aims to understand how noradrenergic neurons finely tune their pacemaker processes and regulate their activities. Here we present that mitochondrial perturbation in the LC from mice, inhibits spontaneous firing by a hyperpolarizing response that involves Ca2+ entry via L-type Ca2+ channels and the actin cytoskeleton...
March 3, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30825322/the-effect-of-electroconvulsive-seizure-on-survival-neuronal-differentiation-and-expression-of-the-maturation-marker-in-the-adult-mouse-hippocampus
#5
Miyuki Ueno, Mami Sugimoto, Keisuke Ohtsubo, Naoto Sakai, Akane Endoh, Kisako Shikano, Yuki Imoto, Eri Segi-Nishida
Electroconvulsive seizure (ECS), a model of electroconvulsive therapy in rodents, strongly increases neurogenesis in the adult hippocampus. Neurogenesis is a multi-step process that spans proliferation, survival, neuronal differentiation, and functional maturation. Our previous study demonstrated that ECS stimulates the proliferation of neural stem-like cells. However, the contribution of ECS to survival, neuronal differentiation, and maturation in newborn cells remains unknown. To evaluate the effect of ECS on these processes, we labeled newborn cells with bromodeoxyuridine (BrdU) before ECS treatment to determine the cell age and examined the survival rate and expression of cellular markers in the BrdU-labeled cells...
March 2, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30802950/nuclear-factor-kappa-%C3%AE-as-a-therapeutic-target-for-alzheimer-s-disease
#6
REVIEW
Niraj Kumar Jha, Saurabh Kumar Jha, Rohan Kar, Parma Nand, Kumari Swati, Vineet Kumar Goswami
Alzheimer's disease (AD) is a typical progressive, chronic neurodegenerative disorder with worldwide prevailance. t. Its clinical manifestation involves the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs). NFTs occur in brain tissues as a result of both Aβ agglomeration and Tau phosphorylation. Although there is no known cure for AD, research into possible cures and treatment options continues using cell-cultures and model animals/organisms. The Nuclear Factor-Kappa β (NF-κβ) plays an active role in the progression of AD...
February 25, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30802942/analysis-of-long-non-coding-rna-expression-profiles-in-neonatal-rats-with-hypoxic-ischemic-brain-damage
#7
Han Zhou, Xuan Wang, Rui Cheng, Xuewen Hou, Ying Chen, Yun Feng, Jie Qiu
Hypoxic-ischemic brain damage (HIBD) which is a common cause of acute mortality and neurological dysfunction in neonates still lacks effective therapeutic methods. Long non-coding RNAs (lncRNAs) were demonstrated to play a crucial role in many diseases. To give a foundation for subsequent functional studies of lncRNAs in HIBD, we investigated the profiling of lncRNAs and messenger RNAs (mRNAs) using neonatal HIBD rat model. Six neonatal rats were divided into sham-operated group (n=3) and HIBD group (n=3) randomly...
February 25, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30786027/riluzole-promotes-neurological-function-recovery-and-inhibits-damage-extension-in-rats-following-spinal-cord-injury-a-meta-analysis-and-systematic-review
#8
REVIEW
Long-Yun Zhou, Zi-Rui Tian, Min Yao, Xu-Qing Chen, Yong-Jia Song, Jie Ye, Nan-Xing Yi, Xue-Jun Cui, Yong-Jun Wang
Spinal cord injury (SCI) is a devastating condition that has few treatment options. Riluzole, a sodium channel blocker used to treat amyotrophic lateral sclerosis, has been initially trialed in human SCI. We performed a systematic review to critically assess the efficacy of riluzole in locomotor recovery and damage extension in SCI rat models, and the potential for clinical translation. PubMed, Embase, Cochrane Library, and Chinese databases were searched from their inception date to March 2018. Two reviewers independently selected animal studies that evaluated neurological recovery and lesion area following riluzole treatment in SCI rat models, extracted data and assessed methodological quality...
February 20, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30776097/gm1-promotes-trka-mediated-neuroblastoma-cell-differentiation-by-occupying-a-plasma-membrane-domain-different-from-trka
#9
Elena Chiricozzi, Erika Di Biase, Margherita Maggioni, Giulia Lunghi, Maria Fazzari, Diego Yuri Pomè, Riccardo Casellato, Nicoletta Loberto, Laura Mauri, Sandro Sonnino
Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA-GM1 oligosaccharide complex at the cell surface. To study the TrkA-GM1 interaction, we synthesized two radioactive GM1 derivatives presenting a photoactivable nitrophenylazide group at the end of lipid moiety, 1 or at position 6 of external galactose, 2; and a radioactive oligosaccharide portion of GM1 carrying the nitrophenylazide group at position 1 of glucose, 3...
February 18, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30748001/viral-vector-mediated-cre-recombinase-expression-in-substantia-nigra-induces-lesions-of-the-nigrostriatal-pathway-associated-with-perturbations-of-dopamine-related-behaviors-and-hallmarks-of-programmed-cell-death
#10
Sara Rezai Amin, Carole Gruszczynski, Bruno P Guiard, Jacques Callebert, Jean-Marie Launay, Franck Louis, Catalina Betancur, Vincent Vialou, Sophie Gautron
Cre/loxP recombination is a widely used approach to study gene function in vivo, using mice models expressing the Cre recombinase under the control of specific promoters or through viral delivery of Cre-expressing constructs. A profuse literature on transgenic mouse lines points out the deleterious effects of Cre expression in various cell types and tissues, presumably by acting on illegitimate loxP-like sites present in the genome. However, most studies reporting the consequences of Cre-lox gene invalidation often omit adequate controls to exclude the potential toxic effects of Cre, compromising the interpretation of data...
February 12, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30734931/pink1-regulates-fkbp5-interaction-with-akt-phlpp-and-protects-neurons-from-neurotoxin-stress-induced-by-mpp
#11
Wassamon Boonying, Alvin Joselin, En Huang, Dianbo Qu, Farzaneh Safarpour, Grace O Iyirhiaro, Yasmilde Rodriguez Gonzalez, Steve M Callaghan, Ruth S Slack, Daniel Figeys, Young-Hwa Chung, David S Park
Loss of function mutations in the PTEN-induced putative kinase 1 (Pink1) gene have been linked with an autosomal recessive familial form of early onset Parkinson's disease (PD). However, the underlying mechanism(s) responsible for degeneration remains elusive. Presently, using co-immunoprecipitation in HEK (Human embryonic kidney) 293 cells, we show that Pink1 endogenously interacts with FK506-binding protein 51 (FKBP51) FKBP5 and directly phosphorylates FKBP5 at Serine in an in vitro kinase assay. Both FKBP5 and Pink1 have been previously associated with protein kinase B (AKT) regulation...
February 8, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30734928/role-of-brain-jnk2-in-the-control-of-the-insulin-receptor-and-its-relationship-with-cognitive-performance-in-a-high-fat-diet-preclinical-model
#12
Oriol Busquets, Àuria Eritja, Blanca M López, Miren Ettcheto, Patricia R Manzine, Rubén D Castro-Torres, Ester Verdaguer, Jordi Olloquequi, Manuel Vázquez-Carrera, Carme Auladell, Jaume Folch, Antoni Camins
Insulin resistance has negative consequences on the physiological functioning of the nervous system. The appearance of Type 3 Diabetes in the brain leads to the development of the sporadic form of Alzheimer's disease. The c-Jun N-terminal Kinases (JNK), a subfamily of the Mitogen Activated Protein Kinases, are enzymes composed by three different isoforms with differential modulatory activity against the insulin receptor (IR) and its substrate. This research focused on understanding the regulatory role of JNK2 on the IR, as well as study the effect of a High-Fat Diet (HFD) in the brain...
February 8, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30734300/obituary-kazuhiro-ikenaka-1952-2018
#13
Akio Wanaka, Andrew J Lawrence, Yukio Yoneda, Bernard Zalc, Alfreda Stadlin, Juana Maria Pasquini, Philip M Beart
Kazuhiro Ikenaka, affectionately known as Kaz to friends and colleagues, an internationally renowned neuroscientist and substantial contributor to professional societies, died on October 27th , 2018. Kaz was at this time the President of the International Society for Neurochemistry (ISN) and he passed away after a long fight against cancer. He was posthumously awarded the Order of the Sacred Treasure, Golden Rays, for his dedicated service to Japanese Society. Kaz was an outstanding leader, mentor and friend, and our deepest sympathies are extended to his wife Yumiko, his sons Yoshinori and Kensuke, and family...
February 8, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30790293/sex-hormones-modulate-pathogenic-processes-in-experimental-traumatic-brain-injury
#14
Christina Gölz, Florian Paul Kirchhoff, Jana Westerhorstmann, Matthias Schmidt, Tobias Hirnet, Gabriele M Rune, Roland A Bender, Michael K E Schäfer
Clinical and animal studies have revealed sex-specific differences in histopathological and neurological outcome after traumatic brain injury (TBI). The impact of perioperative administration of sex steroid inhibitors on TBI is still elusive. Here, we subjected male and female C57Bl/6N mice to the controlled cortical impact (CCI) model of TBI and applied pharmacological inhibitors of steroid hormone synthesis, that is, letrozole (LET, inhibiting estradiol synthesis by aromatase) and finasteride (FIN, inhibiting dihydrotestosterone synthesis by 5α-reductase), respectively, starting 72 h prior CCI, and continuing for a further 48 h after CCI...
February 5, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30720873/cerebrospinal-fluid-levels-of-synaptic-and-neuronal-integrity-correlate-with-gray-matter-volume-and-amyloid-load-in-the-precuneus-of-cognitively-intact-older-adults
#15
Jolien Schaeverbeke, Benjamin Gille, Katarzyna Adamczuk, Hugo Vanderstichele, Emeric Chassaing, Rose Bruffaerts, Veerle Neyens, Erik Stoops, Jos Tournoy, Rik Vandenberghe, Koen Poesen
The main pathophysiological alterations of Alzheimer's disease (AD) include loss of neuronal and synaptic integrity, amyloidogenic processing and neuroinflammation. Similar alterations can, however, also be observed in cognitively intact older subjects and may prelude the clinical manifestation of AD. The objectives of this prospective cross-sectional study in a cohort of 38 cognitively intact older adults were twofold: (i) to investigate the latent relationship among cerebrospinal fluid (CSF) biomarkers reflecting the main pathophysiological processes of AD, and (ii) to assess the correlation between these biomarkers and gray matter volume as well as amyloid load...
February 5, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30720866/pet-imaging-of-dopamine-release-in-the-frontal-cortex-of-manganese-exposed-non-human-primates
#16
T R Guilarte, C-L Yeh, J L McGlothan, Juan Perez, P Finley, Y Zhou, D F Wong, U Dydak, J S Schneider
Humans and non-human primates exposed to excess levels of manganese (Mn) exhibit deficits in working memory and attention. Frontal cortex and fronto-striatal networks are implicated in working memory and these circuits rely on dopamine for optimal performance. Here, we aimed to determine if chronic Mn exposure alters in vivo dopamine release (DAR) in the frontal cortex of non-human primates. We used [11 C]-FLB457 Positron Emission Tomography (PET) with amphetamine (AMPH) challenge to measure DAR in Cynomolgus macaques...
February 5, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30716176/l-dopa-modulates-brain-iron-dopaminergic-neurodegeneration-and-motor-dysfunction-in-iron-overload-and-mutant-alpha-synuclein-mouse-models-of-parkinson-s-disease
#17
Jessica L Billings, Sarah L Gordon, Tristan Rawling, Philip A Doble, Ashley I Bush, Paul A Adlard, David I Finkelstein, Dominic J Hare
Treatment with the dopamine (DA) precursor L-3,4-dihydroxyphenylalanine (L-DOPA) provides symptomatic relief arising from DA denervation in Parkinson's disease. Mounting evidence that DA autooxidation to neurotoxic quinones is involved in Parkinson's disease pathogenesis has raised concern about potentiation of oxidative stress by L-DOPA. The rate of DA quinone formation increases in the presence of excess redox-active iron (Fe), which is a pathological hallmark of Parkinson's disease. Conversely, L-DOPA has pH-dependent Fe-chelating properties, and may act to 'redox silence' Fe and partially allay DA autoxidation...
February 4, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30716174/endogenous-trpa1-and-trpv1-activity-potentiates-glutamatergic-input-to-spinal-lamina-i-neurons-in-inflammatory-pain
#18
Yuying Huang, Shao-Rui Chen, Hong Chen, Hui-Lin Pan
Inflammatory pain is associated with peripheral and central sensitization, but the underlying synaptic plasticity at the spinal cord level is poorly understood. Transient receptor potential (TRP) channels expressed at peripheral nerve endings, including TRPA1 and TRPV1, can detect nociceptive stimuli. In this study, we determined the contribution of presynaptic TRPA1 and TRPV1 at the spinal cord level to regulating nociceptive drive in chronic inflammatory pain induced by treatment with complete Freund's adjuvant (CFA) in rats...
February 4, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30714137/tyrosine-hydroxylase-phosphorylation-in-vivo
#19
REVIEW
Peter R Dunkley, Phillip W Dickson
Tyrosine Hydroxylase (TH) is the rate limiting enzyme in the synthesis of the catecholamines dopamine, noradrenaline and adrenaline. One of the major mechanisms for controlling the activity of TH is protein phosphorylation. TH is phosphorylated at serine (Ser) residues Ser8, Ser19, Ser31 and Ser40. There have been a number of previous reviews focused on TH phosphorylation in vitro and in situ. This review on TH phosphorylation in vivo has three main sections focusing on: (1) the methods used to investigate TH phosphorylation in vivo; including the animals used, the sacrifice procedures, the tissue preparation, the measurement of TH protein levels and TH phosphorylation and the measurement of TH activation...
February 3, 2019: Journal of Neurochemistry
https://read.qxmd.com/read/30702755/differential-responses-to-increasing-numbers-of-mild-traumatic-brain-injury-in-a-rodent-closed-head-injury-model
#20
Brooke Fehily, Carole A Bartlett, Stephen Lydiard, Michael Archer, Hannah Milbourn, Maimuna Majimbi, Jan M Hemmi, Sarah A Dunlop, Nathanael J Yates, Melinda Fitzgerald
Following mild traumatic brain injury (mTBI), further mild impacts can exacerbate negative outcomes. To compare chronic damage and deficits following increasing numbers of repeated mTBIs, a closed-head weight-drop model of repeated mTBI was used to deliver 1, 2 or 3 mTBIs to adult female rats at 24 h intervals. Outcomes were assessed at 3 months following the first mTBI. No gross motor, sensory or reflex deficits were identified (p > 0.05), consistent with current literature. Cognitive function assessed using a Morris water maze revealed chronic memory deficits following 1 and 2, but not 3 mTBI compared to shams (p ≤ 0...
January 31, 2019: Journal of Neurochemistry
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