Hedieh Shahpasand-Kroner, Ibrar Siddique, Ravinder Malik, Gabriel Linares, Magdalena I Ivanova, Justin Ichida, Tatjana Weil, Jan Münch, Elsa Sanchez-Garcia, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan
Lysine-selective molecular tweezers (MTs) are supramolecular host molecules displaying a remarkably broad spectrum of biological activities. MTs act as inhibitors of the self-assembly and toxicity of amyloidogenic proteins using a unique mechanism. They destroy viral membranes and inhibit infection by enveloped viruses, such as HIV-1 and SARS-CoV-2, by mechanisms unrelated to their action on protein self-assembly. They also disrupt biofilm of Gram-positive bacteria. The efficacy and safety of MTs have been demonstrated in vitro , in cell culture, and in vivo , suggesting that these versatile compounds are attractive therapeutic candidates for various diseases, infections, and injuries...
December 22, 2022: Pharmacological Reviews