journal
https://read.qxmd.com/read/38849155/the-development-of-cannabinoids-as-therapeutic-agents-in-the-united-states
#1
JOURNAL ARTICLE
Conor H Murray, Brenda M Gannon, Peter J Winsauer, Ziva D Cooper, Marcus S Delatte
Cannabis is one of the oldest and widely used substances in the world. Cannabinoids within the cannabis plant, known as phytocannabinoids, mediate cannabis' effects through interactions with the body's endogenous cannabinoid system. This endogenous system, the endocannabinoid system, has important roles in physical and mental health. These roles point to the potential to develop cannabinoids as therapeutic agents, while underscoring the risks related to interfering with the endogenous system during non-medical use...
June 7, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38719480/-generation-of-comprehensive-gpcr-transducer-deficient-cell-lines-to-dissect-complexity-of-gpcr-signaling
#2
JOURNAL ARTICLE
Ayaki Saito, Ryoji Kise, Asuka Inoue
G-protein-coupled receptors (GPCRs) compose the largest family of transmembrane receptors and are targets of approximately one-third of FDA approved drugs owing to their involvement in almost all physiological processes. GPCR signaling occurs through the activation of heterotrimeric G-protein complexes and β-arrestins, both of which serve as transducers resulting in distinct cellular responses. Despite seeming simple at first glance, accumulating evidence indicates that activation of either transducer is not a straightforward process, as a stimulation of a single molecule has the potential to activate multiple signaling branches...
May 7, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38719481/-novel-and-emerging-treatments-to-target-pathophysiological-mechanisms-in-various-phenotypes-of-ms
#3
JOURNAL ARTICLE
Gabriel Bsteh, Assunta Dal Bianco, Tobias Zrzavy, Thomas Berger
The objective is to comprehensively review on novel pharmacotherapies used in multiple sclerosis (MS) and the possibilities they may carry for therapeutic improvement. Specifically, we discuss pathophysiological mechanisms worth targeting in MS ranging from well-known targets such as autoinflammation and demyelination to more novel and advanced targets such as neuroaxonal damage and repair. To set the stage, a brief overview of clinical MS phenotypes is provided followed by a comprehensive recapitulation of both clinical and paraclinical outcomes available to assess the effectiveness of treatments in achieving these targets...
May 6, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38622001/precision-medicine-in-rheumatic-diseases-unlocking-the-potential-of-antibody-drug-conjugates
#4
JOURNAL ARTICLE
Zhiwen Huang, Zachary Braunstein, Jun Chen, Yingying Wei, Xiaoquan Rao, Lingli Dong, Jixin Zhong
In the era of precision medicine, Antibody-Drug Conjugates (ADCs) have emerged as a cutting-edge therapeutic strategy. These innovative compounds combine the precision of monoclonal antibodies with the potent cell-killing or immune-modulating abilities of attached drug payloads. This unique strategy not only reduces off-target toxicity but also enhances the therapeutic effectiveness of drugs. Beyond their well-established role in oncology, ADCs are now showing promising potential in addressing the unmet needs in the therapeutics of rheumatic diseases...
April 15, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38697859/new-advances-in-the-pharmacology-and-toxicology-of-lithium-a-neurobiologically-oriented-overview
#5
REVIEW
Analia Bortolozzi, Giovanna Fico, Michael Berk, Marco Solmi, Michele Fornaro, Joao Quevedo, Carlos A Zarate, Lars V Kessing, Eduard Vieta, Andre F Carvalho
Over the last six decades, lithium has been considered the gold standard treatment for the long-term management of bipolar disorder due to its efficacy in preventing both manic and depressive episodes as well as suicidal behaviors. Nevertheless, despite numerous observed effects on various cellular pathways and biologic systems, the precise mechanism through which lithium stabilizes mood remains elusive. Furthermore, there is recent support for the therapeutic potential of lithium in other brain diseases. This review offers a comprehensive examination of contemporary understanding and predominant theories concerning the diverse mechanisms underlying lithium's effects...
May 2, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38697858/adrenoceptor-desensitization-current-understanding-of-mechanisms
#6
REVIEW
Dina Maaliki, Aneese A Jaffa, Suzanne Nasser, Amirhossein Sahebkar, Ali H Eid
G-protein coupled receptors (GPCRs) transduce a wide range of extracellular signals. They are key players in the majority of biologic functions including vision, olfaction, chemotaxis, and immunity. However, as essential as most of them are to body function and homeostasis, overactivation of GPCRs has been implicated in many pathologic diseases such as cancer, asthma, and heart failure (HF). Therefore, an important feature of G protein signaling systems is the ability to control GPCR responsiveness, and one key process to control overstimulation involves initiating receptor desensitization...
May 2, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38697857/prostaglandin-e2-in-the-tumor-microenvironment-a-convoluted-affair-mediated-by-ep-receptors-2-and-4
#7
REVIEW
Ana Santiso, Akos Heinemann, Julia Kargl
The involvement of the prostaglandin E2 (PGE2) system in cancer progression has long been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with pleiotropic effects in the human body. High levels of intratumoral PGE2 and overexpression of the key metabolic enzymes of PGE2 have been observed and suggested to contribute to tumor progression. This has been claimed for different types of solid tumors, including, but not limited to, lung, breast, and colon cancer. PGE2 has direct effects on tumor cells and angiogenesis that are known to promote tumor development...
May 2, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38697856/molecular-pathways-governing-the-termination-of-liver-regeneration
#8
REVIEW
Lianne R de Haan, Rowan F van Golen, Michal Heger
The liver has the unique capacity to regenerate, and up to 70% of the liver can be removed without detrimental consequences to the organism. Liver regeneration is a complex process involving multiple signaling networks and organs. Liver regeneration proceeds through three phases: the initiation phase, the growth phase, and the termination phase. Termination of liver regeneration occurs when the liver reaches a liver-to-body weight that is required for homeostasis, the so-called "hepatostat." The initiation and growth phases have been the subject of many studies...
May 2, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38697855/steatotic-liver-disease-pathophysiology-and-emerging-pharmacotherapies
#9
REVIEW
Michail Kokkorakis, Emir Muzurović, Špela Volčanšek, Marlene Chakhtoura, Michael A Hill, Dimitri P Mikhailidis, Christos S Mantzoros
Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype. Consequently, the metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH) therapeutic pipeline is expanding rapidly and in multiple directions. In parallel, noninvasive tools for diagnosing and monitoring responses to therapeutic interventions are being studied, and clinically feasible findings are being explored as primary outcomes in interventional trials. The realization that distinct subgroups exist under the umbrella of SLD should guide more precise and personalized treatment recommendations and facilitate advancements in pharmacotherapeutics...
May 2, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38697854/mdm2-inhibitors-for-cancer-therapy-the-past-present-and-future
#10
REVIEW
Wei Wang, Najah Albadari, Yi Du, Josef F Fowler, Hannah T Sang, Wa Xian, Frank McKeon, Wei Li, Jia Zhou, Ruiwen Zhang
Since its discovery over 35 years ago, MDM2 has emerged as an attractive target for the development of cancer therapy. MDM2's activities extend from carcinogenesis to immunity to the response to various cancer therapies. Since the report of the first MDM2 inhibitor more than 30 years ago, various approaches to inhibit MDM2 have been attempted, with hundreds of small-molecule inhibitors evaluated in preclinical studies and numerous molecules tested in clinical trials. Although many MDM2 inhibitors and degraders have been evaluated in clinical trials, there is currently no Food and Drug Administration (FDA)-approved MDM2 inhibitor on the market...
May 2, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38697853/a-chance-to-grow-and-excel-as-an-associate-editor-of-pharmacological-reviews-editorial
#11
EDITORIAL
Ali H Eid
No abstract text is available yet for this article.
May 2, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38351075/emergence-of-extracellular-vesicles-as-liquid-biopsy-for-neurological-disorders-boom-or-bust
#12
REVIEW
Ashish Kumar, Michael A Nader, Gagan Deep
Extracellular vesicles (EVs) have emerged as an attractive liquid biopsy approach in the diagnosis and prognosis of multiple diseases and disorders. The feasibility of enriching specific subpopulations of EVs from biofluids based on their unique surface markers has opened novel opportunities to gain molecular insight from various tissues and organs, including the brain. Over the past decade, EVs in bodily fluids have been extensively studied for biomarkers associated with various neurological disorders, such as Alzheimer's disease, Parkinson's disease, schizophrenia, bipolar disorder, major depressive disorders, substance use disorders, human immunodeficiency virus-associated neurocognitive disorder, and cancer/treatment-induced neurodegeneration...
February 13, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38351074/the-arylamine-n-acetyltransferases-as-therapeutic-targets-in-metabolic-diseases-associated-with-mitochondrial-dysfunction
#13
REVIEW
Chandra Choudhury, Melinder K Gill, Courtney E McAleese, Neville J Butcher, Shyuan T Ngo, Frederik J Steyn, Rodney F Minchin
In humans, there are two arylamine N-acetyltransferase genes that encode functional enzymes ( NAT1 and NAT2 ) as well as one pseudogene, all of which are located together on chromosome 8. Although they were first identified by their role in the acetylation of drugs and other xenobiotics, recent studies have shown strong associations for both enzymes in a variety of diseases, including cancer, cardiovascular disease, and diabetes. There is growing evidence that this association may be causal. Consistently, NAT1 and NAT2 are shown to be required for healthy mitochondria...
February 13, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38351073/a-25-year-journey-as-author-and-associate-editor-of-pharmacological-reviews-editorial
#14
EDITORIAL
Martin C Michel
No abstract text is available yet for this article.
February 13, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38351072/protecting-human-and-animal-health-the-road-from-animal-models-to-new-approach-methods
#15
REVIEW
Barbara L F Kaplan, Alan M Hoberman, William Slikker, Mary Alice Smith, Emanuela Corsini, Thomas B Knudsen, M Sue Marty, Sonya K Sobrian, Suzanne C Fitzpatrick, Marcia H Ratner, Donna L Mendrick
Animals and animal models have been invaluable for our current understanding of human and animal biology, including physiology, pharmacology, biochemistry, and disease pathology. However, there are increasing concerns with continued use of animals in basic biomedical, pharmacological, and regulatory research to provide safety assessments for drugs and chemicals. There are concerns that animals do not provide sufficient information on toxicity and/or efficacy to protect the target population, so scientists are utilizing the principles of replacement, reduction, and refinement (the 3Rs) and increasing the development and application of new approach methods (NAMs)...
February 13, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38351071/the-role-of-g-protein-coupled-receptors-and-receptor-kinases-in-pancreatic-%C3%AE-cell-function-and-diabetes
#16
REVIEW
Matthew J Varney, Jeffrey L Benovic
Type 2 diabetes (T2D) mellitus has emerged as a major global health concern that has accelerated in recent years due to poor diet and lifestyle. Afflicted individuals have high blood glucose levels that stem from the inability of the pancreas to make enough insulin to meet demand. Although medication can help to maintain normal blood glucose levels in individuals with chronic disease, many of these medicines are outdated, have severe side effects, and often become less efficacious over time, necessitating the need for insulin therapy...
February 13, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38351070/leveraging-lymphatic-system-targeting-in-systemic-lupus-erythematosus-for-improved-clinical-outcomes
#17
REVIEW
K T Babalola, M Arora, R Ganugula, S K Agarwal, C Mohan, M N V Ravi Kumar
The role of advanced drug delivery strategies in drug repositioning and minimizing drug attrition rates, when applied early in drug discovery, is poised to increase the translational impact of various therapeutic strategies in disease prevention and treatment. In this context, drug delivery to the lymphatic system is gaining prominence not only to improve the systemic bioavailability of various pharmaceutical drugs but also to target certain specific diseases associated with the lymphatic system. Although the role of the lymphatic system in lupus is known, very little is done to target drugs to yield improved clinical benefits...
February 13, 2024: Pharmacological Reviews
https://read.qxmd.com/read/38101936/correction-to-goods-and-bads-of-the-endocannabinoid-system-as-a-therapeutic-target-lessons-learned-after-30-years
#18
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 15, 2023: Pharmacological Reviews
https://read.qxmd.com/read/38101935/correction-to-oxycodone-a-current-perspective-on-its-pharmacology-abuse-and-pharmacotherapeutic-developments
#19
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 15, 2023: Pharmacological Reviews
https://read.qxmd.com/read/38101934/nonhormonal-male-contraceptive-development-strategies-for-progress
#20
REVIEW
Logan Nickels, Wei Yan
Despite the widely demonstrated public health benefits of contraception, limited contraceptive options are available for men, placing both the contraceptive burden and opportunity solely on women. This review outlines the need for an increased focus on male contraceptive development and highlights several related topics, including the perspectives of women and men on male contraceptives, historical challenges, and reasons behind the persistent delays in male contraceptive development. It also discusses the importance of serendipitous observations in drug discovery and the limitations of depleting sperm or spermatogenic cells as a contraceptive approach...
December 15, 2023: Pharmacological Reviews
journal
journal
24997
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.