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S Gerald Sandler, Willy A Flegel
No abstract text is available yet for this article.
April 22, 2019: Transfusion
Richard O Francis, Sonia Mahajan, Francesca Rapido, Francesca La Carpia, Mark Soffing, Chaitanya Divgi, Randy Yeh, Akiva Mintz, Lenhurst Leslie, Irina Agrest, Matthew S Karafin, Yelena Ginzburg, Beth H Shaz, Steven L Spitalnik, Joseph Schwartz, Tiffany Thomas, Xiaoyun Fu, Pascal Amireault, Pierre Buffet, James C Zimring, Angelo D'Alessandro, Eldad A Hod
BACKGROUND: The chromium-51-labeled posttransfusion recovery (PTR) study has been the gold-standard test for assessing red blood cell (RBC) quality. Despite guiding RBC storage development for decades, it has several potential sources for error. METHODS: Four healthy adult volunteers each donated an autologous, leukoreduced RBC unit, aliquots were radiolabeled with technetium-99m after 1 and 6 weeks of storage, and then infused. Subjects were imaged by single-photon-emission computed tomography immediately and 4 hours after infusion...
April 19, 2019: Transfusion
David Allan, Jeffrey Kiernan, Loren Gragert, Nicholas Dibdin, Daniel Bartlett, Todd Campbell, Karen Mostert, Michael Halpenny, Kathy Ganz, Martin Maiers, Tanya Petraszko, Heidi Elmoazzen
BACKGROUND: Launched in 2013, Canadian Blood Services' Cord Blood Bank (CBS' CBB) has built a high-quality, ethnically diverse cord blood repository that aims to reduce ethnic disparity in accessing suitable units for transplantation. METHODS AND RESULTS: As of December 2016, 2000 units have been banked. The self-reported maternal ethnicity was 58% non-Caucasian. Overall, 26% of units were classified as multi-ethnicity with Caucasian (84%) most frequently observed in combination with Asian, First Nations (predominant indigenous peoples in Canada south of the Arctic Circle), or African ethnicity...
April 19, 2019: Transfusion
Matthew A Warner, Kalli K Schaefer, Nageswar Madde, Jennifer M Burt, Andrew A Higgins, Daryl J Kor
BACKGROUND: The prevention of excessive allogeneic red blood cell (RBC) transfusion is an important component of patient blood management initiatives. In this investigation, changes in transfusion behaviors following modification of computerized physician order entry (CPOE) procedures for RBC transfusions to a single-unit default quantity were assessed. STUDY DESIGN AND METHODS: This is an observational cohort study of adults for whom nonemergency allogeneic RBC transfusions were ordered in the 2 years before and 2 years after the date of modification of the CPOE system to a single-unit default (June 18, 2015)...
April 19, 2019: Transfusion
Emilia Sippert, Evgeniya Volkova, Gregory A Denomme, Meihong Liu, Zhugong Liu, Maria Rios
No abstract text is available yet for this article.
April 19, 2019: Transfusion
Alexander P J Vlaar, Pearl Toy, Mark Fung, Mark R Looney, Nicole P Juffermans, Juergen Bux, Paula Bolton-Maggs, Anna L Peters, Christopher C Silliman, Daryl J Kor, Steve Kleinman
BACKGROUND: Transfusion-related acute lung injury (TRALI) is a serious complication of blood transfusion and is among the leading causes of transfusion-related morbidity and mortality in most developed countries. In the past decade, the pathophysiology of this potentially life-threatening syndrome has been increasingly elucidated, large cohort studies have identified associated patient conditions and transfusion risk factors, and preventive strategies have been successfully implemented...
April 16, 2019: Transfusion
Takashi Ushiki, Hatsue Tsuneyama, Masayoshi Masuko, Takashi Kozakai, Takuya Kasami, Tomoyuki Tanaka, Makoto Uchikawa, Toshiki Kitajima, Emiko Kasai, Tae Komata, Takayuki Katagiri, Masami Kamimura, Kenji Sato, Ichiro Fuse, Kenichi Ogasawara, Koh Nakata
BACKGROUND: The Rh complex contributes to cell membrane structural integrity of erythrocytes. Rhnull syndrome is characterized by the absence of the Rh antigen on the erythrocyte membrane, resulting in chronic hemolytic anemia. We recently came across 3 Rhnull phenotype probands within two families with the same novel RHAG mutation in the Japanese population. MATERIALS AND METHODS: Detailed Rh phenotyping by hemagglutination was performed using monoclonal and polyclonal anti-D, -C, -c, -E, and -e; monoclonal and polyclonal anti-Rh17 antibodies; and polyclonal anti-Rh29 antibodies...
April 16, 2019: Transfusion
Ling Li, Shanhai Ou, Chengyin Huang, Xueyong Zhou, Hongwei Ge, Jianping Li, Jinfeng Zeng, Alyssa Zhou, Liu He, Quming Xu, Jie Wu, Longhuo Li, Chenghui Wang, Liang Zang, Liqin Huang, Libin Niu, Hui Han, Gang Zhang, Jianhua Wan, Fang Wang, Ting Xu, Binghai Zhao, Liqiong Qian, Yanyun Wu, Zhong Liu
BACKGROUND: China has not yet incorporated routine human T-lymphotropic virus (HTLV)-1/2 blood donor screening, even though HTLV has been reported in the southeastern coastal region. This study was conducted to investigate the prevalence of HTLV in five major regions across of China. METHODS: From January 2016 to December 2017, blood samples were collected in 20 blood centers located in different regions of China. These samples were screened for HTLV-1/2 antibodies using enzyme-linked immunosorbent assay (ELISA)...
April 15, 2019: Transfusion
Caitlin McOmish
No abstract text is available yet for this article.
April 15, 2019: Transfusion
Roger Belizaire, Johnathan Mack, Stephan Kadauke, Yeowon Kim, Susan Saidman, Robert S Makar
BACKGROUND: Alloantibodies recognizing human leukocyte antigens (HLA) can cause immune-mediated refractoriness to platelet transfusion. An association between HLA alloimmunization and red blood cell (RBC) alloimmunization has been suggested but remains uncertain. STUDY DESIGN AND METHODS: We tested for HLA alloantibodies in 660 patients with and without RBC alloantibodies. Calculated panel reactive antibody (cPRA) values were determined for HLA alloimmunized patients...
April 13, 2019: Transfusion
Sherrill J Slichter, Lynda Fitzpatrick, Barbara Osborne, Todd Christoffel, Irena Gettinger, Esther Pellham, S Lawrence Bailey, Mary Kay Jones, Maryanne C Herzig, Andrew P Cap
BACKGROUND: Ordinarily, whole blood (WB) is separated into components before storage. We assessed the posttransfusion viability and function of platelets (PLTs) if they were stored within WB at 4°C. STUDY DESIGN AND METHODS: Whole blood was obtained from 30 normal subjects and stored at 4°C without agitation for 12 days and for 10, 15, or 22 days with agitation. After WB storage, a PLT concentrate was prepared, and a fresh PLT sample was obtained from each donor...
April 12, 2019: Transfusion
Nasha Elavia, Sandhya R Panch, Andrew McManus, Thejaswi Bikkani, James Szymanski, Steven L Highfill, Ping Jin, Jennifer Brudno, James Kochenderfer, David F Stroncek
BACKGROUND: When manufacturing chimeric antigen receptor (CAR) T cells using anti-CD3/anti-CD28 beads, ex vivo T-cell expansion is dependent on the composition of leukocytes used in the manufacturing process. We investigated the effects of leukocyte composition on CAR T-cell expansion and characteristics using an alternative manufacturing method. METHODS: Anti-B-cell maturation antigen and CD19-CAR T cells were manufactured using autologous peripheral blood mononuclear cell (PBMNC) concentrates...
April 11, 2019: Transfusion
Genevieve Marcoux, Audrey Magron, Caroline Sut, Audree Laroche, Sandrine Laradi, Hind Hamzeh-Cognasse, Isabelle Allaeys, Ophelie Cabon, Anne-Sophie Julien, Olivier Garraud, Fabrice Cognasse, Eric Boilard
BACKGROUND: Whereas platelet transfusion is a common medical procedure, inflammation still occurs in a fraction of transfused individuals despite the absence of any apparent infectious agents. Platelets can shed membrane vesicles, called extracellular vesicles (EVs), some of which contain mitochondria (mito+EV). With its content of damage-associated molecular pattern (DAMP), the mitochondrion can stimulate the innate immune system. Mitochondrial DNA (mtDNA) is a recognized DAMP detected in the extracellular milieu in numerous inflammatory conditions and in platelet concentrates...
April 11, 2019: Transfusion
Thelma T Gonçalez, Ester C Sabino, Zhanna Kaidarova, Anna Barbara F Carneiro-Proietti, Carolina Miranda, Paula Loureiro, Maria Esther Lopes, Cesar de Almeida-Neto, Karen S Schlumpf, David J Wright, Edward L Murphy, Brian Custer
BACKGROUND: Predonation donor deferral is used to select donors with presumed lower risk for transfused transmitted infections. The contribution to blood safety from this practice has not been reported previously for Brazil. STUDY DESIGN AND METHODS: At four large Brazilian blood centers from September 2010 to March 2011, donors who were deferred due to responses on eligibility questions were invited to provide a blood sample to test for HIV, hepatitis C virus, hepatitis B virus, human T-lymphotropic virus, syphilis, and Trypanosoma cruzi and complete an audio computer-assisted structured interview on risk behaviors...
April 9, 2019: Transfusion
Lilian Castilho, Carolina Bonet Bub, Maria Giselda Aravechia, José Mauro Kutner, Isabelle Berlivet, Claude Férec, Yann Fichou
No abstract text is available yet for this article.
April 9, 2019: Transfusion
Oliver Grottke, Olga Moser, Ahmed Farrag, Miriam Elbracht, Thorsten Orlikowsky, Sonja Trepels-Kottek
BACKGROUND: Factor X (FX) deficiency (FXD) is an extremely rare autosomal recessive hereditary hematologic disorder, affecting approximately one in 1,000,000 of the general population. CASE REPORT: This case report describes an infant with hereditary severe FXD who presented with a spontaneous, life-threatening intracranial hemorrhage and was treated with the first licensed plasma-derived FX (pdFX) concentrate. On admission, laboratory assays showed severe coagulopathy of unknown cause; the patient was empirically treated using a multimodal hemostatic approach with prothrombin complex concentrate, fresh-frozen plasma, and tranexamic acid...
April 9, 2019: Transfusion
Karen Gastecki, Ryan Shanley, Julie Welbig, Claudia Cohn, Claudio G Brunstein
BACKGROUND: The risk of transfusion reactions (TR) and the cost of blood has led to efforts to reduce blood use. We changed our practice to transfuse just one instead of two units of red blood cells (RBC) when hemoglobin ≤8 g/dL due to patient blood management (PBM) recommendations. METHODS AND MATERIALS: We compared RBC utilization in patients receiving allogeneic HCT in the 10 months before (control arm) and 13 months after implementation of this new practice (intervention arm)...
April 8, 2019: Transfusion
Mikiko Soejima, Yoshiro Koda
BACKGROUND: The human FUT2 gene, which encodes a secretor type α(1,2)fucosyltransferase, is reported to have several population-specific single-nucleotide polymorphisms (SNPs) and copy number variations. However, little is known about genetic variation of FUT2 in Native Americans. STUDY DESIGN AND METHODS: To detect SNPs and copy number variations of the FUT2 gene in Peruvians, direct sequencing and digital polymerase chain reaction were performed. Haplotypes of observed SNPs were estimated by PHASE software or cloning into plasmids...
April 8, 2019: Transfusion
Yulia Lin, Everad Tilokee, Sophie Chargé, Asim Alam, Christine Cserti-Gazdewich, Wendy Lau, Christie Lee, Lani Lieberman, Paula Nixon, Wendy Owens, Katerina Pavenski, Jacob Pendergrast, Elianna Saidenberg, Nadine Shehata, Robert Skeate, Qi-Long Yi, David Conrad, Jill Dudebout, Cyrus C Hsia, Michael Murphy, Oksana Prokopchuk-Gauk, Akshay Shah, Ziad Solh, Jacqueline Trudeau, Michelle P Zeller, Jeannie Callum
BACKGROUND: The optimal method of providing transfusion medicine (TM) education has not been determined. Transfusion Camp was established in 2012 at the University of Toronto as a centrally delivered TM education program for postgraduate trainees. The impact of Transfusion Camp on knowledge, attitudes, and self-reported behavior was evaluated. METHODS: Didactic lectures (delivered locally, by webinar, or recorded) and locally facilitated team-based learning seminars were delivered over 5 days during the academic year to 8 sites: 7 in Canada and 1 in the United Kingdom...
April 4, 2019: Transfusion
Eduardo Arellano-Rodrigo, Victor Fernandez-Gallego, Irene López-Vilchez, Patricia Molina, Maribel Díaz-Ricart, M Urooj Zafar, Juan J Badimon, Joanne van Ryn, Ginés Escolar
BACKGROUND: Comparative studies on the restoration of hemostasis with different reversal agents after dabigatran therapy have not been performed. We compared the efficacy and prothrombotic potential of the specific antidote idarucizumab with that of previously recommended non-specific procoagulant concentrates. STUDY DESIGN AND METHODS: We explored the in vitro effects of dabigatran (184 ng/mL) on fibrin and platelet-aggregate formation onto a damaged vessel under flow conditions (600 s-1 )...
April 4, 2019: Transfusion
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