journal
https://read.qxmd.com/read/38795022/isohemagglutinin-titration-in-pooled-and-apheresis-platelets
#1
JOURNAL ARTICLE
QingYun Hua, Bruce W Lyon, Jennifer Duke, Amanda Felske, Karen Hobbs, Ryan Holman, Ghazala Radwi, Davinder Sidhu, Gwen Clarke, Susan Nahirniak
BACKGROUND: Platelet inventory constraints necessitate ABO-incompatible platelet transfusion. Many minimize the hemolytic impact by confirming low titre (LT) donor isohemagglutinins. This process is costly. Pathogen-reduced platelets (PRP) in platelet additive solutions (PAS) will dilute plasma and decrease high-titre isohemagglutinins (HT). We determined the proportion of HT platelets and incompatible transfusions for units suspended in plasma to reassess the need for titres following introduction of PRP/PAS...
May 25, 2024: Transfusion
https://read.qxmd.com/read/38783709/the-impact-of-simulation-based-training-on-medical-students-whole-blood-transfusion-abilities
#2
JOURNAL ARTICLE
Rebekah Cole, Cynthia Shen, Jonathan Shumaker, Kevin J Matthews, Zachery L Brown, Joshua Cuestas, Sherri L Rudinsky
BACKGROUND: Whole blood transfusion has been found to increase the likelihood of patient survival within both military and civilian medicine contexts. However, no whole blood transfusion training curriculum currently exists within undergraduate or graduate medical education in the United States. The purpose of our study was to: (1) determine the impact of simulation-based training on medical students' abilities to conduct whole blood transfusions; and (2) determine the impact of simulation-based training on medical students' confidence in conducting whole blood transfusions...
May 23, 2024: Transfusion
https://read.qxmd.com/read/38778519/platelets-visible-in-automated-red-cell-exchange-waste-bag
#3
JOURNAL ARTICLE
A Javanbakht, H Cassidy, M King, C Miller, T Sommers, R Jacob
No abstract text is available yet for this article.
May 22, 2024: Transfusion
https://read.qxmd.com/read/38778511/a-monthly-roundup-of-key-articles-in-other-journals
#4
JOURNAL ARTICLE
Caitlin McOmish
No abstract text is available yet for this article.
May 22, 2024: Transfusion
https://read.qxmd.com/read/38769631/opportunities-to-improve-feedback-to-reduce-blood-component-wastage-results-of-a-national-scheme-evaluation
#5
JOURNAL ARTICLE
Sophie Staples, Hayley Evans, Jill Caulfield, Matthew Bend, Robbie Foy, Michael F Murphy, Simon J Stanworth
BACKGROUND: Blood components are costly and scarce. The Blood Stocks Management Scheme (BSMS) was established in the United Kingdom (UK) to support hospital transfusion services and national blood services through collection, analysis, and monthly feedback of data on blood component inventory and wastage management. There is a growing evidence base on how best to deliver feedback for quality improvement. We assessed the quality and utility of the monthly BSMS component reports. METHODS: We assessed the content of BSMS reports issued in March 2023 against established criteria for effective feedback...
May 20, 2024: Transfusion
https://read.qxmd.com/read/38767410/how-do-transfusion-services-manage-patients-taking-therapies-such-as-anti-cd38-and-anti-cd47-known-to-interfere-with-red-blood-cell-compatibility-testing
#6
JOURNAL ARTICLE
Michael F Murphy, Srijana Rajbhandary, Sharon Carayiannis, Claudia S Cohn
BACKGROUND: Drugs such as daratumumab (Darzalex, anti-CD38) and Hu5F9-G4 (magrolimab, anti-CD47) may interfere with red blood cell compatibility testing as CD38 and CD47 are expressed on red blood cells. STUDY DESIGN AND METHODS: A survey of AABB member transfusion services was undertaken to understand their experiences of managing patients taking therapeutic monoclonal antibodies that are known to interfere with blood grouping and compatibility testing. RESULTS: The survey was distributed to the contact person at US-based AABB member transfusion services...
May 20, 2024: Transfusion
https://read.qxmd.com/read/38757806/biotin-labeling-allows-for-post-transfusion-functional-assessment-of-stored-human-platelets-in-mice
#7
JOURNAL ARTICLE
S Lawrence Bailey, Martin Bochenek, Aastha Chauhan, Brandon Miller, Moritz Stolla
BACKGROUND: Platelet radiolabeling with radioisotopes is currently used for human platelet recovery and survival studies. Biotinylation enables ex vivo post-transfusion platelet function testing. Whether platelet biotinylation itself affects platelet function is controversial. STUDY DESIGN AND METHODS: Platelet concentrates from healthy humans were stored for 6 days. Samples were obtained at 1 or 2 and 6 days, and platelets were labeled following a radiolabeling protocol using saline instead of radioactive indium-111 (sham radiolabeling [sham-RL])...
May 17, 2024: Transfusion
https://read.qxmd.com/read/38757763/implementation-of-sexual-risk-behavior-donor-screening-in-canada
#8
JOURNAL ARTICLE
Mindy Goldman, Antoine Lewin, Christian Renaud, Sheila F O'Brien
BACKGROUND: The two Canadian blood suppliers, Canadian Blood Services and Héma-Québec, removed the time-based deferral for men who have sex with men and adopted criteria assessing sexual risk behaviors. We report the impact of these changes on the safety and adequacy of the Canadian blood supply. STUDY DESIGN AND METHODS: Since 2022, all donors are asked if (1) they have had a new partner and (2) more than one sexual partner in the last 3 months...
May 17, 2024: Transfusion
https://read.qxmd.com/read/38752406/measurement-of-lead-mercury-and-cadmium-in-blood-donors-in-canada
#9
JOURNAL ARTICLE
Narges Hadjesfandiari, Katherine Serrano, Tomas Richardson-Sanchez, Vilte E Barakauskas, Qi-Long Yi, Michael Murphy, Dana V Devine
BACKGROUND: Fetal and neonatal exposure to lead is associated with irreversible adverse effects on neural development. There is no reliable threshold for lead effect, so limiting exposure is recommended. A significant correlation has been reported between post-transfusion blood lead level (BLL) in infants and lead levels in transfused RBC units. We measured levels of lead, mercury, and cadmium, in Canadian donor blood to investigate if concerning levels for neonatal transfusion exist...
May 16, 2024: Transfusion
https://read.qxmd.com/read/38752381/reducing-blood-product-wastage-through-the-inter-hospital-redistribution-of-near-outdate-inventory
#10
JOURNAL ARTICLE
Omar I Hajjaj, Dimpy Modi, Tracy Cameron, Rebecca Barty, Wendy Owens, Nancy Heddle, Liying Zhang, Troy Thompson, Jeannie Callum
BACKGROUND: Hospital transfusion services order blood products to satisfy orders and maintain inventory levels during unexpected periods of increased blood demand. Surplus inventory may outdate before being allocated to a recipient. Blood product outdating is the largest contributor to blood wastage. STUDY DESIGN: A province-wide redistribution program was designed and implemented to redistribute near-outdate plasma protein and related blood products from low-usage to high-usage hospitals...
May 16, 2024: Transfusion
https://read.qxmd.com/read/38752347/temporal-dynamics-of-in-vitro-hemostatic-function-in-platelets-cryopreserved-using-a-novel-approach-for-rapid-issuance
#11
JOURNAL ARTICLE
Patrick S L Kwan, Susy Kirwan, Alice Tuinukuafe, Sarah Morley
BACKGROUND: Current procedures for thawing and issuing of cryopreserved platelets (CPPs) are laborious and have remained challenging in emergency settings such as blood banks and military operations. In this prospective study, a novel processing method designed to facilitate the rapid issuance of CPPs with no postthaw handling required was developed and functionally characterized in parallel with standard CPPs manufactured. STUDY DESIGN AND METHODS: Double-dose plateletpheresis units (n = 42) were cryopreserved at -80°C in 5%-6% dimethyl sulfoxide to produce matched pairs thawed successively over a 27-month period for comparison between two processing arms...
May 16, 2024: Transfusion
https://read.qxmd.com/read/38746954/hybrid-cord-blood-banking-in-a-private-public-partnership-women-s-perspectives
#12
JOURNAL ARTICLE
Jessica Laue, Johanna Ambühl, Daniel Surbek
BACKGROUND: The increasing demand for umbilical cord blood (UCB) used in stem cell transplantation led to the establishment of cord blood (CB) banks worldwide. These include public foreign donor banks and private family-directed donor banks. Recently, our department has introduced a third banking model within a private-public-partnership. This hybrid banking allows for storage of family-directed CB units, while also getting Human leukocyte antigen (HLA)-typed and included in the national stem cell donor registry...
May 15, 2024: Transfusion
https://read.qxmd.com/read/38745533/characterization-of-the-263k-derived-microsomal-fraction-a-source-of-prions-for-nanofiltration-validation-studies
#13
JOURNAL ARTICLE
Steve Simoneau, Angélique Igel, Danica Ciric, Mohammed Moudjou, Sergey Tcherniuk, Vincent Béringue, Human Rezaei, Benoit Flan
BACKGROUND: The manufacturing processes of plasma products include steps that can remove prions. The efficacy of these steps is measured in validation studies using animal brain-derived prion materials called spikes. Because the nature of the prion agent in blood is not known, the relevance of these spikes, particularly with steps that are based on retention mechanisms such as nanofiltration, is important to investigate. STUDY DESIGN AND METHODS: The aggregation and sizes of PrPres assemblies of microsomal fractions (MFs) extracted from 263K-infected hamster brains were analyzed using velocity gradients...
May 15, 2024: Transfusion
https://read.qxmd.com/read/38745532/the-impact-of-social-media-intervention-based-on-functional-motivation-on-repeat-blood-donation-behavior-a-prospective-randomized-controlled-trial-study
#14
JOURNAL ARTICLE
Chang Gao, Haokun Mei, Xiaofang Mao
BACKGROUND: Blood plays an irreplaceable role in medical care. Low retention rate among blood donors is the major issue in China. Various functional motivations can encourage blood donors to participate in blood donation. Therefore, it is necessary to conduct research studies on re-donate behavior based on functional motivations. This study aimed to evaluate the impact of social media intervention based on functional motivation, to discover effective intervention methods to improve re-donate rate among nonregular blood donors...
May 15, 2024: Transfusion
https://read.qxmd.com/read/38742837/alternative-strategies-for-emergency-blood-transfusion-in-low-resource-settings-a-scoping-review
#15
REVIEW
Anusha Jayaram, Rohini Dutta, Eric K Kim, Anshul Mahajan, Alaska Pendleton, Priyansh Nathani, Deepa Kizhakke Veetil, Ramona Stossberger, Craig D McClain, Mandeep Grewal, Anita Gadgil, Nobhojit Roy, Nakul P Raykar
No abstract text is available yet for this article.
May 14, 2024: Transfusion
https://read.qxmd.com/read/38721846/a-lower-fibrinogen-threshold-does-not-lead-to-increased-bleeding-risk-in-patients-receiving-therapeutic-plasma-exchange-a-prospective-single-center-analysis
#16
JOURNAL ARTICLE
Amelework Wodajo, Ravi Sarode, Shiney Valiyaparambil, Christopher Webb, Nicole De Simone, Dill Rebecca, Amena Usmani
BACKGROUND: Plasma exchange (PLEX) therapy is indicated for several disorders. The 5% albumin is often used as a sole replacement fluid during most PLEX. However, each 1.0 plasma volume exchange depletes coagulation factors by ~65%. Although most coagulation factors recover to hemostatic levels within 24 h post-PLEX, fibrinogen requires 48-72 h to recover. Fibrinogen is the key coagulation protein for hemostasis. Therefore, fibrinogen is often monitored during the acute course of PLEX, and plasma is supplemented to prevent bleeding if fibrinogen is <100 mg/dL...
May 9, 2024: Transfusion
https://read.qxmd.com/read/38716883/correction-to-comparison-of-automated-solid-phase-vs-manual-saline-indirect-antiglobulin-test-methodology-for-non-abo-antibody-titration-implications-for-perinatal-antibody-monitoring
#17
https://read.qxmd.com/read/38716879/in-vivo-genotoxicity-assessment-of-n-9-acridinyl-b-alanine-hydrochloride-s-300-using-a-validated-pig-a-mutagenesis-assay
#18
JOURNAL ARTICLE
Anne North, Katherine Ling, Guillaume Ricaud, Leon F Stankowski, Jennifer A Daly, Stanley Bentow, Laurence Corash, Richard J Benjamin, Nina Mufti
BACKGROUND: N-(-9 acridinyl)-b-alanine hydrochloride (S-300) is the main byproduct of red blood cell (RBC) amustaline/glutathione(GSH) pathogen reduction, currently undergoing phase III US clinical trials following successful European studies(1-3). Phosphatidylinositol glycan, class A (Pig-a) X-linked gene mutagenesis is a validated mammalian in vivo mutation assay for genotoxicity, assessed as clonal loss of glycosylphosphatidylinositol-linked CD59 cell-surface molecules on reticulocytes (RETs) and RBCs...
May 8, 2024: Transfusion
https://read.qxmd.com/read/38716878/a-further-update-on-mortality-and-morbidity-in-patients-with-very-low-hemoglobin-levels-who-decline-blood-transfusion
#19
JOURNAL ARTICLE
Petra Seeber, Kevin M Trentino, Kevin Murray, Matthias Lucas
BACKGROUND: In the past two decades, researchers have published mortality and morbidity rates in patients with very low hemoglobin levels declining blood transfusion. The clinical knowledge and tools available for the management of patients who decline transfusions have grown since these publications. The aim of our study was to provide a further update on outcomes associated with severe anemia in these patients. STUDY DESIGN AND METHODS: A retrospective observational study of patients declining allogeneic blood transfusions with nadir hemoglobin levels ≤8 g/dL treated at The Institute for Blood Management, HELIOS Klinikum Gotha, Germany...
May 8, 2024: Transfusion
https://read.qxmd.com/read/38708765/adverse-effects-of-therapeutic-phlebotomies-prospective-study-of-587-procedures
#20
JOURNAL ARTICLE
Iñigo Romón, Juan Domíguez-García, Carlos Fernández, Marisa Carretón, Noelia Martínez, Laura Calzada, Miguel A Cortés, Gala A Mendez, Irene Gorostidi, Montserrat Briz, Enrique Ocio
BACKGROUND: Therapeutic phlebotomy (TP), a widely used medical procedure, can be performed on diverse patients with iron overload or polyglobulia. However, its adverse events are not well known as most of the information on phlebotomy is derived from healthy blood donors (0.1%-5.3%). In contrast, TP is applicable to a broader, more complex population with comorbidities and old age. To ascertain the incidence of adverse events in phlebotomies, we conducted a prospective study on patients who attended our Unit...
May 6, 2024: Transfusion
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