Edward O List, Silvana Duran-Ortiz, Prateek Kulkarni, Emily Davis, Patricia Mora-Criollo, Darlene E Berryman, John J Kopchick
Much of our understanding of growth hormone's (GH)'s numerous activities stems from studies utilizing GH receptor (GHR) knockout mice. More recently, the role of GH action has been examined by creating mice with tissue-specific or temporal GHR disruption. To date, 37 distinct GHR knockout mouse lines have been created. Targeted tissues include fat, liver, muscle, heart, bone, brain, macrophage, intestine, hematopoietic stem cells, pancreatic β cells, and inducible multi-tissue "global" disruption at various ages...
2023: Vitamins and Hormones