Amanda Luise Alves Nascimento, Ari Souza Guimarães, Tauane Dos Santos Rocha, Marilia Oliveira Fonseca Goulart, Jadriane de Almeida Xavier, Josué Carinhanha Caldas Santos
Hemoglobin (Hb) is a hemeprotein found inside erythrocytes and is crucial in transporting oxygen and carbon dioxide in our bodies. In erythrocytes (Ery), the main energy source is glucose metabolized through glycolysis. However, a fraction of Hb can undergo glycation, in which a free amine group from the protein spontaneously binds to the carbonyl of glucose in the bloodstream, resulting in the formation of glycated hemoglobin (HbA1c), widely used as a marker for diabetes. Glycation leads to structural and conformational changes, compromising the function of proteins, and is intensified in the event of hyperglycemia...
2024: Vitamins and Hormones