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JOURNAL ARTICLE
Abhilash Unnikrishnan, Atul Shekhar, Dharmendra Kumar, Raksha Jaipurkar, Gaurav Sikri, Krishan Singh, Rahul Manral
BACKGROUND OBJECTIVES: High-altitude headache (HAH) and headache in acute mountain sickness (AMS) are common among lowlanders ascending to the high altitude and are often confused with one another. A pilot study was undertaken to analyze HAH and AMS cases in Indian lowlanders ascending to Leh city (3500 m) in western Himalayas. METHODS: A total number of 1228 Indian lowlanders, who ascended (fresh and re-inductees) by air and acclimatized, participated in this pilot study...
March 21, 2024: Indian Journal of Medical Research
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JOURNAL ARTICLE
Pragya D Yadav, Viren Sardana, Gururaj Rao Deshpande, Pradnya V Shinde, Jeromie Wesley Vivian Thangaraj, Leyanna S George, Gajanan N Sapkal, Deepak Y Patil, Rima R Sahay, Anita M Shete, Madhavi Joshi, Manoj Murhekar, Sheela Godbole, Nivedita Gupta, Satyartha Prakash, Mamta Rathore, Rajat Ujjainiya, Ajay Pratap Singh, Aastha Mishra, Debasis Dash, Kumardeep Chaudhary, Shantanu Sengupta
BACKGROUND OBJECTIVES: The Omicron sub-lineages are known to have higher infectivity, immune escape and lower virulence. During December 2022 - January 2023 and March - April 2023, India witnessed increased SARS-CoV-2 infections, mostly due to newer Omicron sub-lineages. With this unprecedented rise in cases, we assessed the neutralization potential of individuals vaccinated with ChAdOx1 nCoV (Covishield) and BBV152 (Covaxin) against emerging Omicron sub-lineages. METHODS: Neutralizing antibody responses were measured in the sera collected from individuals six months post-two doses (n=88) of Covishield (n=44) or Covaxin (n=44) and post-three doses (n=102) of Covishield (n=46) or Covaxin (n=56) booster dose against prototype B...
March 21, 2024: Indian Journal of Medical Research
#3
JOURNAL ARTICLE
Madhumathi Jayaprakasam, Ravindra Mohan Pandey, Hansraj Choudhary, Sivakumar Shanmugam, Gomathi N Sivaramakrishnan, Nivedita Gupta
BACKGROUND OBJECTIVES: Tuberculosis (TB) continues to be the second most-leading cause of death due to a single infectious agent as of 2022 after COVID-19. Many affordable new molecular diagnostic tools are being developed for early and more accurate diagnosis, especially for low-resource settings in low- and middle-income countries. In this context, there is a need to develop a standardized protocol for validation of new diagnostic tools. Here, we describe a generic protocol for multi-centric clinical evaluation of molecular diagnostic tests for adult pulmonary TB...
March 20, 2024: Indian Journal of Medical Research
#4
JOURNAL ARTICLE
R Govindarajan, S Gowri Sankar, M Senthil Kumar, V Rajamannar, R Krishnamoorthi, A Alwin Prem Anand, Ashwani Kumar, P Philip Samuel
BACKGROUND OBJECTIVES: Scrub typhus, caused by Orientia tsutsugamushi present in small mammals harbouring the ectoparasites. A study was undertaken to detect the pathogen present in small mammals and its ectoparasites in the scrub typhus-reported areas. METHODS: The small mammals (rodents/shrews) and its ectoparasites were screened for O. tsutsugamushi using nested PCR amplification of the groEL gene. Small mammals were collected by trapping and screened for ectoparasites (mites, ticks and fleas) by combing method...
March 15, 2024: Indian Journal of Medical Research
#5
JOURNAL ARTICLE
Safiya Arfi, Prateek Sharma, Kunal Das, Yogendra Bhaskar, Isha Goel, Harpreet Singh, Rajashree Das
No abstract text is available yet for this article.
March 14, 2024: Indian Journal of Medical Research
#6
JOURNAL ARTICLE
Sudeep Gupta
No abstract text is available yet for this article.
February 22, 2024: Indian Journal of Medical Research
#7
JOURNAL ARTICLE
Manju Mathew, Subhash Chandran Bhaskaran Pillai
BACKGROUND OBJECTIVES: Rhabdomyolysis in tropics has a unique aetiology and clinical profile. The objective of this study was to determine the aetiology and clinical outcomes of rhabdomyolysis and validate the McMahon risk prediction score in affected individuals from south India. METHODS: A retrospective study of affected individuals with rhabdomyolysis admitted to a tertiary care hospital in south India, between January 2015 and June 2020, was undertaken. In-patients who were ≥15 yr in age and had creatinine phosphokinase ≥5000 U/l were included in the study...
February 22, 2024: Indian Journal of Medical Research
#8
JOURNAL ARTICLE
M A Ashwini, Amrita Pattanaik, Reeta S Mani
Rabies is a lethal viral disease transmitted through the bite of rabid animals. India has a high burden of rabies, contributing to a significant proportion of the global deaths. However, under-reporting of the disease is prevalent due to lack of laboratory confirmation. Laboratory diagnosis of rabies plays a crucial role in differentiating the disease from clinical mimics, initiation of appropriate care, implementing infection control measures and informing disease surveillance. This review provides an overview of the recent advancements in laboratory diagnosis of rabies, aimed at updating physicians involved in diagnosis and management of rabies cases in India...
February 20, 2024: Indian Journal of Medical Research
#9
JOURNAL ARTICLE
Rajesh Bhatia
No abstract text is available yet for this article.
February 20, 2024: Indian Journal of Medical Research
#10
JOURNAL ARTICLE
Manickam Ponnaiah, Tarun Bhatnagar, Rizwan Suliankachi Abdulkader, Rajalakshmi Elumalai, Janani Surya, Kathiresan Jeyashree, Muthusamy Santhosh Kumar, Ranjithkumar Govindaraju, Jeromie Wesley Vivian Thangaraj, Hari Krishan Aggarwal, Suresh Balan, Tridip Dutta Baruah, Ayan Basu, Yogita Bavaskar, Ajeet Singh Bhadoria, Ashish Bhalla, Pankaj Bhardwaj, Rachana Bhat, Jaya Chakravarty, Gina Maryann Chandy, Bal Kishan Gupta, Rakesh Kakkar, Ali Hasan Faiz Karnam, Sushila Kataria, Janakkumar Khambholja, Dewesh Kumar, Nithin Kumar, Monaliza Lyngdoh, M Selva Meena, Kedar Mehta, M P Sheethal, Subhasis Mukherjee, Anuj Mundra, Arun Murugan, Seetharaman Narayanan, Balamurugan Nathan, Jutika Ojah, Pushpa Patil, Sunita Pawar, A Charles Pon Ruban, R Vadivelu, Rishabh Kumar Rana, S Nagendra Boopathy, S Priya, Saroj Kumar Sahoo, Arti Shah, Mohammad Shameem, Karthikeyan Shanmugam, Sachin K Shivnitwar, Abhishek Singhai, Saurabh Srivastava, Sudheera Sulgante, Arunansu Talukdar, Alka Verma, Rajaat Vohra, Rabbanie Tariq Wani, Bhargavi Bathula, Gayathri Kumari, Divya Saravana Kumar, Aishwariya Narasimhan, N C Krupa, Thirumaran Senguttuvan, Parvathi Surendran, Dharsikaa Tamilmani, Alka Turuk, Gunjan Kumar, Aparna Murkherjee, Rakesh Aggarwal, Manoj Vasant Murhekar
No abstract text is available yet for this article.
February 15, 2024: Indian Journal of Medical Research
#11
JOURNAL ARTICLE
Bhaskaran Raman, Sai Mahesh Vajjala
No abstract text is available yet for this article.
February 15, 2024: Indian Journal of Medical Research
#12
JOURNAL ARTICLE
Tanmoy Jana, Debasree Sarkar, Debayan Ganguli, Sandip Kumar Mukherjee, Rahul Shubhra Mandal, Santasabuj Das
BACKGROUND OBJECTIVES: Discovery of new antibiotics is the need of the hour to treat infectious diseases. An ever-increasing repertoire of multidrug-resistant pathogens poses an imminent threat to human lives across the globe. However, the low success rate of the existing approaches and technologies for antibiotic discovery remains a major bottleneck. In silico methods like machine learning (ML) deem more promising to meet the above challenges compared with the conventional experimental approaches...
February 9, 2024: Indian Journal of Medical Research
#13
JOURNAL ARTICLE
Sumanth Gandra, Anil K Vasudevan, David K Warren, Sanjeev K Singh
No abstract text is available yet for this article.
February 9, 2024: Indian Journal of Medical Research
#14
JOURNAL ARTICLE
Komal Wadhwa, Shilpa Malik, Srinigila Balaji, Ramachandran Thiruvengadam, Murali Dharan Bashyam, Prasanta Kumar Bhattacharya, Bijayini Behera, Pankaj Bhardwaj, Nidhan K Biswas, Asim Das, Anindya Dey, Dhiraj Dhotre, Mary Dias, Pankaj Dubey, Shreelekha Dutta, Ravisekhar Gadepalli, Mudita Gosain, Kalal Iravaty Goud, Neeraj Kumar Gupta, Nitesh Gupta, Pradipta Jana, Deepak Jena, Elizabeth John, Arunkumar Karunanidhi, S Muhammad Salim Khan, Sahil Khattar, Abhilash Prabhakar Kundavaram Paul, Shakti Kumar, Arindam Maitra, Nikhil Modi, Mahesh Moorthy, Savitha Nagaraj, Dasaradhi Palakodeti, Anil Kumar Pandey, Aparna Pandey, Sunil Kumar Raghav, Suresh Ramasubban, Sreevatsan Raghavan, S Harikrishnan, S Krishnamoorthy, Selvaraj Selvamurugan, Raman Sardana, Yogesh Shouche, Akanksha Singh, Arvind Kumar Singh, V Ramasubramaniyan, Monika Yadav, Danish Zahoor, Suneetha Narreddy, Shinjini Bhatnagar, Nitya Wadhwa, Bhabatosh Das, Pramod Kumar Garg
BACKGROUND OBJECTIVES: The clinical course of COVID-19 and its prognosis are influenced by both viral and host factors. The objectives of this study were to develop a nationwide platform to investigate the molecular epidemiology of SARS-CoV-2 (Severe acute respiratory syndrome Corona virus 2) and correlate the severity and clinical outcomes of COVID-19 with virus variants. METHODS: A nationwide, longitudinal, prospective cohort study was conducted from September 2021 to December 2022 at 14 hospitals across the country that were linked to a viral sequencing laboratory under the Indian SARS-CoV-2 Genomics Consortium...
February 9, 2024: Indian Journal of Medical Research
#15
JOURNAL ARTICLE
Sahajal Dhooria, Amanjit Bal, Riya Sharma, Nidhi Prabhakar, Siddhant Arora, Inderpaul Singh Sehgal, Dharambir Kashyap, Mandeep Garg, Ashish Bhalla, Ashutosh Nath Aggarwal, Ritesh Agarwal
No abstract text is available yet for this article.
February 9, 2024: Indian Journal of Medical Research
#16
JOURNAL ARTICLE
Vishwa Mohan Katoch
No abstract text is available yet for this article.
February 7, 2024: Indian Journal of Medical Research
#17
JOURNAL ARTICLE
Suprabhat Giri, Sushrut Ingawale, Sidharth Harindanath, Mohit Jain, Pranav Garg, Harish Darak, Sanjay Kumar, Aditya Kale, Akash Shukla
BACKGROUND OBJECTIVES: Alcohol is one of most common aetiologies of cirrhosis and decompensated cirrhosis is linked to higher morbidity and death rates. This study looked at the outcomes and mortality associated risk variables of individuals with alcoholic cirrhosis who had hospitalization with their first episode of decompensation. METHODS: Individuals with alcoholic cirrhosis who were hospitalized with the first episode of decompensation [acute decompensation (AD) or acute-on-chronic liver failure (ACLF)] were included in the study and were prospectively followed up until death or 90 days, whichever was earlier...
February 1, 2024: Indian Journal of Medical Research
#18
JOURNAL ARTICLE
P Ajantha, Man Mohan Puri, Devika Tayal, U Khalid
BACKGROUND OBJECTIVES: Tuberculosis (TB) is a major global cause of ill health. Sputum microscopy for confirmation of presumptive pulmonary TB (PTB) has a reportedly low sensitivity of 22-43 per cent for single smear and up to 60 per cent under optimal conditions. National TB Elimination Programme in India recommends the use of cartridge-based nucleic acid amplification test (CBNAAT) and culture for microbiological confirmation in presumptive PTB individuals with sputum smear negative test...
February 1, 2024: Indian Journal of Medical Research
#19
JOURNAL ARTICLE
Swati Chugh, Goutam Panda, Smruti Mokal, Hasmukh Jain, Bhausaheb Bagal, Nehal Khanna, Sridhar Epari, Sachin Punatar, Lingaraj Nayak, Anant Gokarn, Naveen Khattry, Manju Sengar, Siddhartha Laskar, Jayant S Goda
BACKGROUND OBJECTIVES: The role of consolidation radiation therapy (CRT) after complete metabolic response to chemotherapy in advanced-stage (stage III and IV) Hodgkin lymphoma (HL) is controversial. This study was undertaken to assess the clinical outcomes in terms of event free survival, local failure free survival and overall survival in individuals with advanced HL treated with chemotherapy and CRT. METHODS: A retrospective review was conducted to study the long-term clinical outcomes in individuals diagnosed with HL and treated with chemotherapy and CRT from 2012 to 2016 at a tertiary cancer care hospital in India...
February 1, 2024: Indian Journal of Medical Research
#20
JOURNAL ARTICLE
Rajbala Yadav, Ajay Vir Singh, Shweta Kushwaha, Devendra Singh Chauhan
From an initial thought of being used as a cellular garbage bin to a promising target for liquid biopsies, the role of exosomes has drastically evolved in just a few years of their discovery in 1983. Exosomes are naturally secreted nano-sized vesicles, abundant in all types of body fluids and can be isolated intact even from the stored biological samples. Being stable carriers of genetic material (cellular DNA, mRNA and miRNA) and having specific cargo (signature content of originating cells), exosomes play a crucial role in pathogenesis and have been identified as a novel source of biomarkers in a variety of disease conditions...
February 1, 2024: Indian Journal of Medical Research
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