S Harikrishnan, Prathap Chandra Rath, Vijay Bang, Theresa McDonagh, Elijah Ogola, Hugo Silva, Bijoy G Rajbanshi, Anidu Pathirana, G Andre Ng, Cathleen Biga, Thomas F L├╝scher, Ramesh Daggubati, Shirley Adivi, Debabrata Roy, P S Banerjee, M K Das
Heart failure (HF) is emerging as a major public health problem both in high- and low - income countries. The mortality and morbidity due to HF is substantially higher in low-middle income countries (LMICs). Accessibility, availability and affordability issues affect the guideline directed therapy implementation in HF care in those countries. This call to action urges all those concerned to initiate preventive strategies as early as possible, so that we can reduce HF-related morbidity and mortality. The most important step is to have better prevention and treatment strategies for diseases such as hypertension, ischemic heart disease (IHD), type-2 diabetes, and rheumatic heart disease (RHD) which predispose to the development of HF...
April 10, 2024: Indian Heart Journal
Dr Abhishek Kumar, Dr Kader Muneer, Dr Naeem Qureshi
OBJECTIVE: The primary objective of the study was to investigate the correlation between high-sensitivity troponin I (hsTropI) levels during hospitalization and the prognostic outcome in patients with non-acute coronary syndrome (non-ACS) acute heart failure, over a follow-up period of one year. The secondary objective was to assess and characterize acute heart failure during index hospitalization. METHODS: High sensitivity troponin I value was noted both at the time of admission and discharge...
April 9, 2024: Indian Heart Journal
Mohit D Gupta, Vishal Batra, Subrat Muduli, Girish Mp, Shekhar Kunal, Ankit Bansal, Ankur Gautam, Rajeev Kumar Malhotra, Dixit Goyal, Arman Qamar, Jamal Yusuf
BACKGROUND: Despite significant progress in primary prevention, rates of myocardial infarction (MI) in South Asian population is alarmingly high. OBJECTIVES: We sought to compare risk factor profiles and outcomes between individuals with ST-Segment Elevation Myocardial Infarction (STEMI) in young (<50 years) and old (≥50 years) age groups. METHODS: North India STEMI Registry (NORIN-STEMI) is a prospective observational registry of patients hospitalised with STEMI...
April 2, 2024: Indian Heart Journal
Shantanu P Sengupta, Jagdish Chander Mohan, Dhananjay Raje, Nitin Burkule, Madhu Shukla
BACKGROUND: Left atrial (LA) volume indexing for body surface area (BSA) is the common practice. Since LA volume index is of cardiovascular pathophysiologic significance, it is suggested that indexing for other body size parameters be explored to evaluate a more appropriate alternative method. The aims of this study were to find normal and the best cutoff values for LA volume indexed for multiple body size parameters in normal Indian subjects. METHODS: Data from the multicentric prospective INDEA study conducted through 2018 to 2020 was reviewed and subjects without known cardiac disease and completely normal echocardiograms that had the left atrial volume (LAV) measured by biplane Simpson's method were included...
April 2, 2024: Indian Heart Journal
Hendry Purnasidha Bagaswoto, Yuwinda Prima Ardelia, Budi Yuli Setianto
No abstract text is available yet for this article.
April 1, 2024: Indian Heart Journal
Ashish Kumar, Mariam Shariff, Aayush Singal, Vivek Bhat, John Stulak, Grant Reed, Ankur Kalra
OBJECTIVE: Despite the development of dedicated, two-stent strategies, including the double kissing (DK) crush technique, the ideal technique for coronary artery bifurcation stenting has not been identified. We aimed to compare and determine the absolute risk difference (ARD) of the DK crush technique alone versus provisional stenting approaches for coronary bifurcation lesions, using the Bayesian technique. METHOD: We queried PubMed/MEDLINE to identify randomized controlled trials (RCTs) that compared DK crush technique with provisional stenting for bifurcation lesions, published till January 2023...
March 25, 2024: Indian Heart Journal
Vineetha Kanneganti, Ajay Bahl, Manoj Kumar Rohit, Saurabh Mehrotra
BACKGROUND: Implantable cardioverter defibrillators (ICD) are often used as primary prevention strategy for sudden cardiac death (SCD) in young individuals. This study analyzed appropriate therapies, complications and inappropriate shocks in the real-world Indian population. METHODS: All patients in the cardiomyopathy cohort under follow up who had ICD implanted as a primary prevention strategy were studied. The objective was to assess the incidence of appropriate ICD therapies, inappropriate therapies and complications...
March 22, 2024: Indian Heart Journal
Pranesh Rajamuthiah, Sabari Krishnan B B, Sharon Benita Antony, Teena Koshy
BACKGROUND: Indians are known to have the highest rates of coronary artery disease (CAD), with the conventional risk factors failing to explain the increased risk. Possible candidate genes to study both the environmental and genetic risk associated with CAD is the glutathione S-transferase (GST) family, as it is involved in detoxification. METHODS: This case-control assessed the association between GSTM1 and GSTT1 polymorphisms in Indian patients with CAD. Fifty patients with CAD and 50 healthy volunteers were genotyped for the two polymorphisms by polymerase chain reaction...
March 18, 2024: Indian Heart Journal
Justin Paul Gnanaraj, Steaphen Anne Princy
Cardiovascular disease complicates 1-4% of pregnancies. Women with heart disease going through pregnancy are on the increase. While global maternal deaths during pregnancy are decreasing, India remains a significant contributor to maternal deaths in the world. Cardiovascular disease during pregnancy is the leading cause of maternal mortality in developed nations, and this trend is expected soon in India, with the ongoing obstetric transition. Research in developed nations indicates that a high proportion of maternal mortality related to heart disease is preventable...
March 18, 2024: Indian Heart Journal
Avik Ray, Ahmad Najmi, Gaurav Khandelwal, Ratinder Jhaj, Balakrishnan Sadasivam
Evidence on comparative effectiveness and safety of prasugrel and ticagrelor post-percutaneous transluminal coronary angioplasty is scarce in Indian population. In a 1:1 propensity score-matched cohort with 71 individuals in each group, the incidence of a composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or coronary revascularization was not significantly different in prasugrel and ticagrelor group (7.04% vs 9.86%; absolute difference, 2.8%; HR, 0.65; 95% CI, 0.21-2.1; p = 0...
March 12, 2024: Indian Heart Journal
Santhosh Satheesh, Ritesh Kumar, Ajith Ananthakrishna Pillai, Raja Selvaraj, Sreekumaran Nair, Dhivya Priya
BACKGROUND: The data on prognostic values of SYNTAX score II in patients undergoing percutaneous coronary intervention is limited. We report predictive utility of SYNTAX score II in relation to in hospital and 1 year mortality of the patients undergoing percutaneous coronary intervention. METHODS: This was a cohort study of patients who underwent percutaneous coronary intervention (PCI) at a single centre from January 2018 to December 2019. In hospital and 12-month events and mortality was analysed among 1000 patients...
March 5, 2024: Indian Heart Journal
Rakesh Yadav, Geetika Yadav
No abstract text is available yet for this article.
March 2, 2024: Indian Heart Journal
A K Pancholia, Nitin Kumar Kabra, Rajeev Gupta
Accurate measurement of various lipids- total cholesterol, cholesterol lipoproteins and triglycerides- is important for coronary artery disease (CAD) prevention and management. Over the years many technologies have developed for their accurate measurements and in recent years the assays have been internationally standardised. Most of the guidelines recommend measurement of non fasting levels of total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), non-HDL cholesterol (non-HDL-C) and triglycerides (TG) for risk estimation and guiding treatment...
February 29, 2024: Indian Heart Journal
Ishtiyaq Masood, Imran Hafeez, Aamir Rashid, Vamiq Rasool, Shahood Ajaz, Mohd Iqbal Dar, Feroz Shaheen, Ajaz Lone, Hilal Rather, Sheikh Jan Mohammad, Nisar Tramboo
INTRODUCTION: Identifying an Infarct-related artery (IRA)in Non-STEMI is sometimes tricky. Besides, myocardial infarction with non-obstructive coronary arteries (MINOCA) mimickers are often labeled as myocardial infarction. Late Gadolinium enhancement (LGE) on cardiac MRI can help in identifying IRA besides MINOCA mimickers. AIMS: To study the role of LGE on cardiac MRI(CMR) in NSTEMI. MATERIAL METHODS: It was a prospective observational, double-blinded study...
February 24, 2024: Indian Heart Journal
Preyangsee Dutta, Dwaipayan Saha, Mrudul Earle, Chandra Prakash Prasad, Mayank Singh, Mrinalini Darswal, Vipul Aggarwal, Nitish Naik, Rakesh Yadav, Abhishek Shankar, Abhijit Chakraborty
Cardiovascular diseases (CVD) remain a major global health challenge, with an escalating impact on mortality despite advancements in managing conventional risk factors. This review investigates the intricate relationship between human papillomavirus (HPV) and CVD, shedding light on a novel aspect of cardiovascular health. Despite significant progress in understanding and managing traditional CVD risk factors, a substantial proportion of CVD cases lack these conventional markers. Recent research has unveiled HPV, a prevalent sexually transmitted infection, as a potential unconventional risk factor for CVD...
February 20, 2024: Indian Heart Journal
Aseem Basha, Sivasubramanian Ramakrishnan
Indians have a pattern of atherogenic dyslipidaemia characterised by not so high LDL-C but elevated small, dense LDL-C, elevated triglyceride levels and low HDL-C levels. In addition, different lipid-lowering drugs exhibit pharmacokinetic variability in Indians, which may have implications on the optimum doses required to achieve the desired LDL-C levels. Currently the management of dyslipidaemia in Indians are based on the landmark trials, which largely included western population. This review focusses on major clinical trials of lipid lowering drugs with special reference to the Indian population...
February 20, 2024: Indian Heart Journal
Jamshed J Dalal, Tabassum Khan
Indians have early onset atherosclerotic cardiovascular disease and acquire the risk factors at a younger age, and hence we need to aggressively address the management of dyslipidemia in the young. Cholesterol levels early in life will influence the development of atherosclerosis. Young atherosclerotic cardiovascular disease (ASCVD) patients (18-40 yrs) should receive lipid-lowering drugs to reduce LDL-C<55 mg. Due to the asymptomatic nature of dyslipidemia, early screening will enable the implementation of management strategies which will decrease future cardiovascular events...
February 12, 2024: Indian Heart Journal
Sonali Sharma, Kiran Gaur, Rajeev Gupta
Dyslipidemias are the most important coronary artery disease (CAD) risk factor. High total cholesterol and its principal subtypes: low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (NHDL) cholesterol are the most important. Epidemiological and Mendelian randomization studies have confirmed role of raised triglycerides and lipoprotein(a). INTERHEART study reported a significant association of raised ApoB/ApoA1, total-, LDL-, and NHDL-cholesterol in South Asians. Prospective Urban Rural Epidemiology (PURE) study identified raised NHDL cholesterol as the most important risk factor...
February 12, 2024: Indian Heart Journal
Siqi Hu, Hua Fan, Shenghui Zhang, Chen Chen, Yao You, Chunyi Wang, Jie Li, Lin Luo, Yongran Cheng, Mengyun Zhou, Xuezhi Zhao, Wen Wen, Tao Tan, Fangfang Xu, Xinyan Fu, Juan Chen, Xingwei Zhang, Mingwei Wang, Jiake Tang
BACKGROUND: Coronary heart disease (CHD) is a common heart disease and a leading cause of death in developed countries and some developing countries such as China. It is recognized as a multifactorial disease, with dyslipidemia being closely associated with the progression of coronary atherosclerosis. Numerous studies have confirmed the relationship between a single indicator of low-density lipoprotein cholesterol (LDL-C) or high-density lipoprotein cholesterol (HDL-C) and CHD. However, the association between LDL-C to HDL-C ratio (LHR) and CHD remains unclear...
February 9, 2024: Indian Heart Journal
Jayagopal P B, Prafulla G Kerkar
Dyslipidemia management in situations like pregnancy, in diseases like rheumatoid arthritis, human immunodeficiency virus (HIV) disease, chronic liver disease, and in the elderly are challenging scenarios. Pregnancy is a contraindication for many drugs. The interaction of various drugs used in HIV infection and rheumatoid arthritis makes it even more difficult to treat with conventional and approved drugs for dyslipidemia. Elderly and chronic renal failure patients often do not tolerate the drugs very well and the data of dyslipidemia management is very different...
February 7, 2024: Indian Heart Journal
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